CN114949983B

CN114949983B - Filter roller structure, filter equipment for bio-pharmaceuticals and use method of filter equipment

Info

Publication number: CN114949983B
Application number: CN202210786691.7A
Authority: CN
Inventors: 叶新; 沈文光; 王保军; 王春民
Original assignee: Jiangsu Feiyu Medical Technology Co ltd
Current assignee: Jiangsu Feiyu Medical Technology Co ltd
Priority date: 2022-07-04
Filing date: 2022-07-04
Publication date: 2022-11-11
Anticipated expiration: 2042-07-04
Also published as: CN114949983A

Abstract

The invention relates to the technical field of biological pharmacy, in particular to a filtering roller structure, filtering equipment for biological pharmacy and a using method thereof, wherein the filtering roller structure comprises: the device comprises a supporting base, an outer sleeve rotatably arranged on the supporting base, and a filtering roller and a feeding roller which are sequentially overlapped and sleeved in the outer sleeve; one end of the filtering roller, which is far away from the collecting box body, extends out of the outer sleeve, the feeding roller is arranged at the extended shaft section of the filtering roller, and the hollow cavity of the feeding roller sequentially comprises a material distributing cavity, a drainage cavity and a partition filtering cavity; the shaft section department in branch material chamber stretches out in filtering drum, and drainage chamber and wall filter chamber correspond the setting in filtering drum's buffer memory material chamber department, and the one end that buffer memory material chamber was kept away from to the outer sleeve is equipped with ejection of compact filtration pore, and filtering drum is equipped with the filter screen. The invention adopts the form of combining the rotatably arranged multiple layers of filtering rollers, improves the turbulence degree in the filtering process, strengthens the filtering effect at the filter screen structure, enlarges the filtering area and improves the filtering speed.

Description

Filter roller structure, filter equipment for bio-pharmaceuticals and use method of filter equipment

The invention relates to the technical field of biological pharmacy, in particular to a filtering roller structure, filtering equipment for biological pharmacy and a using method of the filtering equipment.

Background

2, 4-dichloro-5-fluorobenzoyl chloride is an important chemical raw material, and is a key intermediate for synthesizing broad-spectrum antibiotics-ciprofloxacin, enrofloxacin, norfloxacin and other medicaments. With the expanding demand for such drugs, the demand for 2, 4-dichloro-5-fluorobenzoyl chloride, an intermediate in its synthesis, is increasing.

In the traditional process for preparing the 2, 4-dichloro-5-fluorobenzoyl chloride, the 2, 4-dichloro-5-fluorobenzene is taken as an initial raw material, and a target product is obtained through friedel-crafts reaction, advanced oxidation and acyl chlorination with acetyl chloride, the production process is long in route, multiple in steps, too high in activity of used oxidants, difficult to control accurately, numerous in side reactions and large in product purification difficulty, and high-pollution and high-risk raw materials such as potassium permanganate and thionyl chloride adopted in the process are driven by market and environmental protection double pressure, so that the traditional process cannot meet the requirement of green large-scale production of the 2, 4-dichloro-5-fluorobenzoyl chloride.

In order to comprehensively realize comprehensive utilization and green production of the whole process flow, 2, 4-dichloro-5-fluorobenzoyl chloride is produced by adopting a carbon tetrachloride and controllable hydrolysis method, a dimer byproduct of the 2, 4-dichloro-5-fluorobenzoyl chloride produced by a carbon tetrachloride method is subjected to catalytic hydrolysis and alkaline hydrolysis to convert the byproduct into raw materials of 2, 4-dichloro-5-fluorobenzene and 2, 4-dichloro-5-fluorobenzoyl chloride, the generation of the byproduct is reduced, the amplification effect generated in the production process is avoided, the impurity removal efficiency in the rectification process is improved, meanwhile, aluminum chloride and ferric chloride in reaction residual liquid are recovered by a sedimentation technology to prepare a solution which is degraded and used as a flocculating agent for water treatment, the emission is reduced to the greatest extent, and the green and pollution-free production flow is realized.

In controllable hydrolysis process, through adjusting PH, make aluminium, iron element change aluminium hydroxide and strong iron oxide in the mixed solution, aluminium hydroxide and iron hydroxide can cause the influence to the rectifying column in being present in the mixed solution to influence the inside reaction rate of rectifying column, further influence final medicine purity, consequently can cool off, filter the mixed solution that obtains after hydrolysising usually.

Common filtration equipment among the prior art generally is tank structure, and its inside top-down sets up multilayer filter unit, and when mixed liquid introduced filtration equipment, mixed liquid flows through multilayer filter screen in proper order and realizes filtering the back, realizes the process of filtrating and filter residue separation to improve the purity that gets into solution in the rectifying column.

However when mixed liquid gets into jar body, because the filter screen generally sets up to planar structure, the mixed liquid of inflow can be along the direction whereabouts of feed inlet, makes certain department atress on the filter screen great and causes the damage to the filter screen to in filtering process, stop for a bit raw materials can cause the jam to the filter screen on the filter screen, make filterable filter surface area reduce, thereby influence filterable speed.

In view of the above problems, the present inventors have actively studied and innovated based on practical experience and professional knowledge that has been abundant for many years in engineering applications of such products, in order to create a filtering drum structure, a filtering apparatus for biopharmaceuticals, and a method of using the same, so that the filtering apparatus has higher practicability.

Disclosure of Invention

The technical problem to be solved by the invention is as follows: provides a filtering roller structure, filtering equipment for bio-pharmaceuticals and a using method thereof, which effectively solve the problems in the background art.

In order to achieve the purpose, the technical scheme adopted by the invention is as follows: a filter drum construction comprising: the device comprises a supporting base, an outer sleeve rotatably arranged on the supporting base, and a filtering roller and a feeding roller which are sequentially overlapped and sleeved in the outer sleeve;

a collecting box body is arranged at one end of the outer sleeve, the filtering roller and one end of the feeding roller, which are far away from the feeding hole;

one end part of the filtering roller, far away from the collecting box body, extends out of the outer sleeve, the feeding roller is arranged at a shaft section of the filtering roller, which extends out of the outer sleeve, and the feeding roller is positioned in a hollow cavity of the feeding roller and sequentially comprises a distributing cavity, a drainage cavity and a partition filtering cavity;

the filter drum is characterized in that a shaft section of the material distribution cavity extends out of the filter drum, the drainage cavity and the partition filter cavity are correspondingly arranged at a cache material cavity of the filter drum, one end, far away from the cache material cavity, of the outer sleeve is provided with a discharge filter hole, and the filter drum is axially and upwardly arranged at the shaft section between the cache material cavity and the discharge filter hole and is provided with a filter screen.

Further, the supporting base comprises a frame body, and a supporting guide assembly and a driving assembly which are arranged on the frame body;

the supporting and guiding assembly comprises a guiding ring, a supporting wheel set and a guiding wheel set;

the driving assembly comprises a driving ring and a driving structure, wherein teeth are arranged on the annular surface on the outer side of the driving ring, and a gear on the driving structure is meshed with the teeth;

the guide ring and the drive ring are coaxially fixed on the outer sleeve through a connecting structure, two rollers on the support wheel set abut against the outer cylindrical surface of the guide ring, two rotating wheels of the guide wheel set abut against two side surfaces of the guide ring, the axes of the two rollers are parallel to the axis of the guide ring, and the axes of the two rotating wheels are perpendicular to the axis of the guide ring.

Furthermore, a plurality of connecting structures are arranged along the circumferential direction, and each connecting structure comprises two symmetrically arranged bridging plates and a connecting flat plate for connecting the two bridging plates;

and a buffer cavity is formed at the joint of the two bridging plates and the connecting flat plate, faces the outer sleeve and is not in contact with the outer sleeve.

Furthermore, a plurality of helical blades are arranged on the inner wall of the material distributing cavity along the circumferential direction;

guide plates are arranged on the inner wall of the drainage cavity in a one-to-one correspondence mode with the spiral blades;

a filtering sieve pore is arranged at the shaft section of the partition filtering cavity, and a first-stage partition filtering section and a second-stage partition filtering section are arranged on the partition filtering cavity in the direction far away from the material distribution cavity;

the filtering device comprises a primary partition filtering section, a secondary partition filtering section and a filtering shaft section, wherein two adjacent filtering shaft sections located in the primary partition filtering section are gathered inwards, two adjacent filtering shaft sections of the secondary partition filtering section are diffused outwards, and the diameter of the primary partition filtering section is smaller than that of the secondary partition filtering section.

Furthermore, a collecting cavity corresponding to the outer sleeve, the filtering roller and the feeding roller one by one is arranged in the collecting box body;

one end part of the filtering roller, which is far away from the buffer material cavity, is flush with one end of the discharge filtering hole on the outer sleeve;

one end of the feeding roller, which is far away from the feeding hole, extends out of the filtering roller and extends into the corresponding collecting cavity.

Further, the feeding roller is rotatably arranged inside the filtering roller;

and a driving structure is arranged on the feeding roller and used for driving the feeding roller to rotate around the outer sleeve in the direction opposite to the direction of the outer sleeve.

The invention also provides a filtering device for bio-pharmaceuticals, which adopts the filtering roller structure and further comprises:

the bearing seat is used for placing the filtering roller structure;

the feeding unit is arranged at one end of the feeding roller and used for feeding the feeding roller;

the bearing seat is provided with an axial driving piece and a jacking assembly, the axial driving piece is arranged below the supporting base, and the jacking assembly is arranged between the axial driving piece and the supporting base and is connected with one end of the supporting base, which is far away from the feeding unit;

when the axial driving piece drives the supporting base to move towards the direction far away from the feeding unit until the supporting base is separated from the feeding unit, the jacking assembly drives one end, close to the feeding roller, of the supporting base to slightly lift upwards, and the screened filter residues in the feeding roller are cleaned.

Further, the feeding unit comprises a feeding tank, a feeding port and a feeding port, wherein the feeding port and the feeding port are arranged on the feeding tank and are positioned in the same vertical plane;

a feeding adjusting plate is arranged at the feeding port inside the feeding tank, one end of the feeding adjusting plate close to the feeding port is arranged below the feeding port and hinged with the inner wall of the feeding tank;

the other end of the feeding adjusting plate is suspended in the feeding tank through a pull rod;

when the pull rod pulls the feeding adjusting plate to rotate to the top around the hinge shaft, the raw material in the feeding tank is directly discharged from a lower outlet and circularly enters the feeding tank, and at the moment, the feeding port is in a material-free state;

when the pull rod pushes the feeding adjusting plate to rotate downwards, raw materials fall onto the feeding adjusting plate and enter the feeding roller along the feeding hole.

Further, the axial driving piece comprises a driving motor, a screw rod and a bearing plate, the bearing plate is in threaded connection with the screw rod, and the bearing plate slides in a sliding groove of the bearing seat along the axial direction of the screw rod;

the jacking assembly is arranged on the bearing plate and is connected with one end, close to the feeding roller, of the supporting base, and the other end of the supporting base is connected with the bearing plate through a fixed support;

when the bearing plate drives the supporting base to slide to a state of being separated from the feeding unit, the jacking assembly enables one end, located on the feeding roller, of the supporting base to slightly lift upwards.

The invention also provides a method of using a filtration apparatus for biopharmaceuticals, the method comprising the steps of:

the mixed liquid enters a feeding tank, a feeding adjusting plate rotates to be in a horizontal state, and the mixed liquid enters a feeding roller from the feeding adjusting plate through a feeding port;

the feeding roller is driven to rotate, the mixed liquid enters the partition filter cavity after passing through the material distribution cavity and the drainage cavity, primary filtering and screening are carried out on the mixed liquid, filtered filter residues enter the corresponding collection cavity of the collection box body, and filtered filter liquid enters the buffer material cavity of the filtering roller;

the outer sleeve rotates and drives the filtering roller to synchronously rotate, so that filtrate in the buffer material cavity enters a filter screen of the filtering roller for secondary filtering, the filtrate obtained by the secondary filtering enters the outer sleeve, and filtered filter residues enter a collecting cavity corresponding to the collecting box body;

under the rotation action of the outer sleeve, the medicine enters the corresponding collection cavity of the collection box body from the discharge filter hole at the end part along the inner wall;

when the filter residue in the feeding roller is excessive and can not be discharged in time, the feeding adjusting plate in the feeding tank rotates to the top, the mixed liquid in the feeding tank is discharged from the outlet below, the axial driving piece drives the feeding port of the supporting base translation to the filtering roller and the feeding tank to be in a separation state, and the jacking assembly enables one end of the supporting base positioned on the feeding roller to be lifted upwards.

The beneficial effects of the invention are as follows: according to the invention, a form of combining a plurality of layers of filtering rollers which are rotatably arranged is adopted, when the mixed liquid is filtered, the mixed liquid is directly subjected to primary filtering through the partition filtering cavity of the feeding roller, is subjected to secondary filtering through the filtering roller, and finally enters the collecting cavity through the discharging filtering hole at the end part of the outer sleeve, so that the turbulence degree in the filtering process is improved, the filtering effect at the filter screen structure is enhanced, the filtering area is enlarged, and the filtering speed is improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments described in the present invention, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram of a filter drum structure according to an embodiment of the present invention;

FIG. 2 is a schematic illustration of a filtration process in an embodiment of the present invention;

FIG. 3 is a schematic structural diagram of a support base according to an embodiment of the present invention;

FIG. 4 is a schematic structural view of a support guide assembly and a drive assembly in an embodiment of the present invention;

FIG. 5 is a partial enlarged view of FIG. 4 at A;

FIG. 6 is a schematic view of the position of the guide ring and the support wheel set according to the embodiment of the present invention;

FIG. 7 is a schematic view of the position of the guide ring and the guide wheel set according to the embodiment of the present invention;

FIG. 8 is a schematic view of the adjustment of the support and guide wheel sets in an embodiment of the present invention;

FIG. 9 is an enlarged view of a portion of FIG. 1 at B;

FIG. 10 is a schematic view of the feed drum and the outer sleeve and the filter drum rotating in an embodiment of the present invention;

FIG. 11 is a schematic view showing the construction of a filtering apparatus for biopharmaceutical use in an embodiment of the present invention;

FIG. 12 is a schematic illustration of the residue discharge of the filtering apparatus for bio-pharmaceuticals in the embodiment of the present invention;

FIG. 13 is a schematic view of the tension rod and the feed adjustment plate during filtration according to the embodiment of the present invention;

FIG. 14 is a schematic view of the tension rod and the feed adjustment plate of the embodiment of the present invention during slag discharge;

FIG. 15 is a schematic view of an axial drive member according to an embodiment of the present invention.

Reference numerals: 1. a support base; 11. a frame body; 12. supporting a guide assembly; 121. a guide ring; 122. a support wheel set; 123. a guide wheel set; 13. a drive assembly; 131. a drive ring; 132. a drive structure; 2. an outer sleeve; 21. a discharge filter hole; 3. a filter drum; 31. caching a material cavity; 32. a filter screen; 4. a feed drum; 41. a material distributing cavity; 42. a drainage lumen; 43. separating the filter cavity; 431. a first stage partition filtration section; 432. a secondary partition filtering section; 5. a collection box body; 6. a connecting structure; 61. a bridging plate; 62. connecting the flat plates; 100. a bearing seat; 200. a feed unit; 210. a feed tank; 220. a feeding port; 230. a feeding adjusting plate; 300. an axial drive member; 310. a drive motor; 320. a screw rod; 330. carrying a plate; 400. a jacking assembly;

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.

It will be understood that when an element is referred to as being "secured to" another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "left," "right," and the like as used herein are for illustrative purposes only and do not represent the only embodiments.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

The filtering drum structure as shown in fig. 1 to 10 includes: the device comprises a supporting base 1, an outer sleeve 2 rotatably arranged on the supporting base 1, and a filtering roller 3 and a feeding roller 4 which are sequentially overlapped and sleeved in the outer sleeve 2; a collecting box body 5 is arranged at one end of the outer sleeve 2, the filtering roller 3 and the feeding roller 4 far away from the feeding hole; one end part of the filtering roller 3, which is far away from the collecting box body 5, extends out of the outer sleeve 2, the feeding roller 4 is arranged at the shaft section of the filtering roller 3, which extends out of the outer sleeve 2, and the hollow cavity of the feeding roller 4 sequentially comprises a distributing cavity 41, a drainage cavity 42 and a partition filtering cavity 43;

the shaft section of the material distributing cavity 41 extends out of the filter drum 3, the drainage cavity 42 and the partition filter cavity 43 are correspondingly arranged at the buffer material cavity 31 of the filter drum 3, one end of the outer sleeve 2, which is far away from the buffer material cavity 31, is provided with the discharge filter hole 21, and the shaft section of the filter drum 3, which is axially located between the buffer material cavity 31 and the discharge filter hole 21, is provided with the filter screen 32.

Before the mixed liquid is filtered, a driving piece on a supporting base 1 is started to drive an outer sleeve 2 to rotate and drive a filtering roller 3 and a feeding roller 4 to rotate simultaneously, centrifugal force is not generated in the rotating process, the mixed liquid is always positioned below an axis, the mixed liquid is added into the feeding roller 4 until the rotation of the roller tends to be stable, the feeding roller 4 sequentially shunts, conducts and filters the mixed liquid under the action of rotating force, filtered filter residues are discharged into a collecting box body 5 from the other end, filtered liquid flows into a buffer material cavity 31 of the filtering roller 3 and is subjected to lower-level filtering in a filter screen 32 in the filtering roller 3, the filter residues are discharged into the collecting box body 5 from the other end, the filtered liquid enters the outer sleeve 2 and is finally discharged into the collecting box body 5 through a discharge filter hole 21; according to the invention, the filtering structure is designed into a form of combining the rotatably arranged multiple layers of filtering drums 3, when the mixed liquid is filtered, the mixed liquid directly passes through the partition filtering cavity 43 of the feeding drum 4 to be subjected to primary filtering, then passes through the filtering drum 3 to be subjected to secondary filtering, and finally enters the collecting cavity through the discharging filtering hole 21 at the end part of the outer sleeve 2, wherein the mesh number of the filtering net at the filtering drum 3 is larger than that of the filtering net at the partition filtering cavity 43, so that the filtering effect of the filtering net is enhanced, the filtering area is enlarged, and the filtering speed is improved.

In order to ensure the stability of the rotation of the outer sleeve 2, as shown in fig. 3-4, the supporting base 1 includes a frame body 11, and a supporting guide assembly 12 and a driving assembly 13 which are arranged on the frame body 11, the supporting guide assembly 12 performs a centering function on the outer sleeve 2 to prevent the outer sleeve 2 from deviating from the axis during the rotation process, on the basis of centering the outer sleeve 2, the driving assembly 13 rotates the outer sleeve 2, so as to further ensure the rotation reliability of the feeding roller 4 and the filtering roller 3, specifically, the supporting guide assembly 12 includes a guide ring 121, a supporting wheel set 122 and a guide wheel set 123; the driving assembly 13 comprises a driving ring 131 and a driving structure 132, wherein teeth are arranged on the outer circular ring surface of the driving ring 131, and a gear on the driving structure 132 is meshed with the teeth.

Wherein, the guide ring 121 and the drive ring 131 are both disposed coaxially with the outer sleeve 2, and there is an annular gap with the outer wall of the outer sleeve 2, and the guide ring 121 and the drive ring 131 are both fixed coaxially on the outer sleeve 2 through the connecting structure 6, as shown in fig. 5-7, two rollers of the support wheel set 122 abut against the outer cylindrical surface of the guide ring 121, two rollers of the guide wheel set 123 abut against the two side surfaces of the guide ring 121, and the axes of the two rollers are parallel to the axis of the guide ring 121, and the axes of the two rollers are perpendicular to the axis of the guide ring 121.

In the rotation process of the outer sleeve 2, two roller butts are below the axis of the guide ring 121, and the guide ring 121 is followed to generate equidirectional rotation, the linear distance between two butting points is smaller than the diameter of the outer cylindrical surface of the guide ring 121, and is greater than or equal to the radius of the outer cylindrical surface of the guide ring 121, two rotating wheels are arranged at two end faces of the guide ring 121, and are located under the axis, the outer cylindrical surfaces of the two rotating wheels are butted on two end faces of the guide ring 121, when the guide ring 121 rotates, the two rotating wheels generate reverse rotation, and through the arrangement of the four butting points, the rotation precision of the guide ring 121 is ensured. In addition, as shown in fig. 8, the two rollers are adjustable in a direction perpendicular to the axis of the guide ring 121, and the two rollers are adjustable in a direction parallel to the axial direction, so that the distance between the two rollers and the distance between the two rollers can be conveniently adjusted, the guide ring 121 is suitable for guide rings 121 with different diameters and thicknesses, and the universality of the device is improved.

As a preference of the above embodiment, in order to facilitate the assembly of the guide ring 121 and the drive ring 131, as shown in fig. 9, a plurality of the connecting structures 6 are provided in the circumferential direction, and include two bridging plates 61 symmetrically provided, and a connecting flat plate 62 for connecting the two bridging plates 61; the joints of the two bridging plates 61 and the connecting flat plate 62 form a buffer cavity facing the outer sleeve 2 and not contacting the outer sleeve 2.

Specifically, two bridging plates 61 are welded on the outer sleeve 2 in advance, and the connecting flat plate 62 is welded on the guide ring 121 or the drive ring 131, and in the connecting process, the connecting flat plate 62 is locked on the two bridging plates 61 through bolts, so that the convenience is improved, and in the locking process, diagonal locking is adopted, so that the coaxial precision can be adjusted in time.

In the working process of the feeding roller 4, the inflowing mixed liquid is divided, drained and filtered, and in order to stabilize the flow of the liquid entering the separation filter chamber 43, as shown in fig. 2, a plurality of helical blades are arranged on the inner wall of the material distribution chamber 41 along the circumferential direction; and the spiral blades on the inner wall of the drainage cavity 42 are provided with guide plates in a one-to-one correspondence manner; a filtering sieve hole is arranged at the shaft section of the partition filtering cavity 43, and a first-stage partition filtering section 431 and a second-stage partition filtering section 432 are arranged on the partition filtering cavity 43 towards the direction far away from the material separation cavity 41; two adjacent filtering shaft sections positioned in the first-stage partition filtering section 431 are gathered inwards, two adjacent filtering shaft sections of the second-stage partition filtering section 432 are diffused outwards, and the diameter of the first-stage partition filtering section 431 is smaller than that of the second-stage partition filtering section 432.

When the mixed liquid enters the partition filter cavity 43, the mixed liquid is throttled by the first-stage partition filter section 431, so that part of the mixed liquid is filtered by the first-stage partition filter section 431, and part of the mixed liquid enters the second-stage partition filter section 432 to form a rotational flow and is filtered, the turbulence degree of the filtering process is improved, the filtering effect is enhanced, the mesh numbers of the filter screens at the first-stage partition filter section 431 and the second-stage partition filter section 432 are the same, and the filtering requirement of flocculent solids in the mixed liquid is met.

On the basis of the above embodiment, as shown in fig. 2, the collection box 5 is provided with collection cavities corresponding to the outer sleeves 2, the filter drums 3 and the feeding drums 4 one by one; one end part of the filtering roller 3 far away from the buffer material cavity 31 is flush with one end of the discharging filtering hole 21 on the outer sleeve 2; the end of the feeding roller 4 far away from the feeding hole extends out of the filtering roller 3 and extends into the corresponding collecting cavity. Through the setting in a plurality of collection chambeies, collect multistage filterable filter residue alone, be convenient for filter the recycle of filter residue.

As a preference of the above embodiment, in order to increase the filtering rate of the feed roller 4, as shown in fig. 10, the feed roller 4 is rotatably disposed inside the filter roller 3; and a driving structure 132 is arranged on the feeding roller 4 and used for driving the feeding roller 4 to rotate around the outer sleeve 2 in the opposite direction, and when the feeding roller 4 and the filter roller 3 rotate in the opposite direction, an external suction flow is formed in the telescopic gap, so that the liquidity of the liquid in the feeding roller 4 is accelerated.

The present invention also provides a filtering apparatus for bio-pharmaceuticals, which employs the above filtering drum structure, as shown in fig. 11, the filtering apparatus further comprising: the filter drum structure comprises a bearing seat 100 and a feeding unit 200, wherein the bearing seat 100 is used for placing the filter drum 3 structure; the feeding unit 200 is arranged at one end of the feeding roller 4 and used for feeding the feeding roller 4; the bearing seat 100 is provided with an axial driving member 300 and a jacking assembly, the axial driving member 300 is arranged below the supporting base 1, and the jacking assembly 400 is arranged between the axial driving member 300 and the supporting base 1 and is connected with one end of the supporting base 1 far away from the feeding unit 200;

as shown in fig. 12, when the axial driving member 300 drives the supporting base 1 to move in a direction away from the feeding unit 200 until the supporting base is disengaged from the feeding unit 200, the lifting assembly drives one end of the supporting base 1 close to the feeding roller 4 to slightly lift upwards, so as to clean the screened filter residues in the feeding roller 4.

On the basis of the above embodiment, as shown in fig. 13-14, the feeding unit 200 includes a feeding tank 210, and a feeding port 220 and a feeding hole which are arranged on the feeding tank 210, the feeding port 220 and the feeding hole are located in the same vertical plane, the outer circumference of the end of the feeding port 220 is coated with a rubber layer, the rubber layer is filled in the telescopic gap between the feeding port 220 and the feeding roller 4, the leakage of liquid is prevented, the sealing effect is improved, and the feeding port 220 is located on the side surface of the feeding tank 210; a feeding adjusting plate 230 is arranged in the feeding tank 210 at the feeding port 220, one end of the feeding adjusting plate 230 close to the feeding port 220 is arranged below the feeding port 220 and hinged with the inner wall of the feeding tank 210; the other end of the feeding adjusting plate 230 is suspended in the feeding tank 210 through a pull rod, one end of the pull rod extends out of the feeding tank 210, the other end of the pull rod is arranged in a sliding groove of the feeding adjusting plate 230 in a sliding mode, when the pull rod pulls the feeding adjusting plate 230 to rotate around a hinge shaft to the uppermost side, raw materials in the feeding tank 210 are directly discharged from a lower outlet and circularly enter the feeding tank 210, and at the moment, a feeding port is in a material-free state; when the pull rod pushes the feeding adjustment plate 230 to rotate downward, the raw material falls onto the feeding adjustment plate 230 and enters the feeding roller 4 along the feeding port 220.

The specific implementation process, when the filter residue is excessive in feeding roller 4, and when self rotates and can not in time discharge the filter residue, need to set up filter roller 3 structure slope, operate without stopping in order to guarantee to produce the line, when needs clear up inside screening filter residue, manual or electronic pulling pull rod, the pull rod slides in the spout, make feeding regulating plate 230 rotate to the top, treat that the screening raw materials exports from the below, this moment, pay-off mouth 220 does not have raw materials to discharge, thereby clear away the screening filter residue, and when accomplishing the clearance of screening filter residue, promote the pull rod downstream, rotate feeding regulating plate 230 to the most horizontal state, the raw materials that get into in feed tank 210 gets into feeding roller 4 from pay-off mouth 220 in, wherein feeding regulating plate 230 removes to the horizontal state from the top, a part of raw materials is discharged from pay-off mouth 220, another part is discharged from the export below, through the turned angle who changes feeding regulating plate 230, can control the flow of pay-off mouth 220 department.

As a preferable example of the above embodiment, as shown in fig. 15, the axial driving member 300 includes a driving motor 310, a screw rod 320 and a bearing plate 330, the bearing plate 330 is screwed on the screw rod 320, and the bearing plate 330 slides in the sliding slot of the bearing base 100 along the axial direction of the screw rod 320; the jacking component is arranged on the bearing plate 330 and connected with one end of the supporting base 1 close to the feeding roller 4, the other end of the supporting base 1 is connected with the bearing plate 330 through a fixed support, and when the bearing plate 330 drives the supporting base 1 to slide to a state of being separated from the feeding unit 200, the jacking component enables one end of the supporting base 1, which is positioned on the feeding roller 4, to be lifted upwards slightly. The jacking structure adopts an air cylinder or a lead screw 320 nut or a jack and the like, in order to ensure the practicability of jacking, the driving end of the jacking structure can be hinged, the specific structure is not limited, and the structure capable of realizing jacking action is within the protection scope of the invention.

The invention also provides a use method of the filtering equipment for the bio-pharmaceuticals, and the use method of the filtering equipment comprises the following steps:

the mixed liquid enters the feeding tank 210, the feeding adjusting plate 230 rotates to be in a horizontal state, and the mixed liquid enters the feeding roller 4 from the feeding adjusting plate 230 through the feeding port 220;

the feeding roller 4 is driven to rotate, the mixed liquid enters the partition filtering cavity 43 after passing through the material distribution cavity 41 and the drainage cavity 42, primary filtering and screening are carried out on the mixed liquid, the filtered filter residues enter the corresponding collecting cavity of the collecting box body 5, and the filtered filtrate enters the buffer material cavity 31 of the filtering roller 3;

the outer sleeve 2 rotates and drives the filtering roller 3 to synchronously rotate, so that filtrate in the buffer material cavity 31 enters a filter screen 32 of the filtering roller 3 for secondary filtering, the filtrate obtained by the secondary filtering enters the outer sleeve 2, and the filtered filter residue enters a collecting cavity corresponding to the collecting box body 5;

under the rotation action of the outer sleeve 2, the medicine enters the corresponding collection cavity of the collection box body 5 from the discharge filter hole 21 at the end part along the inner wall;

when the excessive filter residue in the feeding roller 4 can not be discharged in time, the feeding adjusting plate 230 in the feeding tank 210 rotates to the top, the mixed liquid in the feeding tank 210 is discharged from the outlet below, the axial driving member 300 drives the supporting base 1 to move horizontally to a state that the filtering roller 3 is separated from the feeding port 220 of the feeding tank 210, and the jacking assembly enables one end of the supporting base 1, which is located in the feeding roller 4, to lift upwards.

It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A filter roller structure is characterized by comprising a supporting base, an outer sleeve rotatably arranged on the supporting base, and a filter roller and a feeding roller which are sequentially overlapped and sleeved in the outer sleeve;

one end of the filtering roller, which is far away from the collecting box body, extends out of the outer sleeve, the feeding roller is arranged at a shaft section of the filtering roller, which extends out of the outer sleeve, and the feeding roller is positioned in a hollow cavity of the feeding roller and sequentially comprises a distributing cavity, a drainage cavity and a partition filtering cavity;

the shaft section of the material distribution cavity extends out of the filtering roller, the drainage cavity and the partition filtering cavity are correspondingly arranged at the material caching cavity of the filtering roller, one end of the outer sleeve, far away from the material caching cavity, is provided with a material discharging filtering hole, and the filtering roller is axially provided with a filtering screen at the shaft section between the material caching cavity and the material discharging filtering hole;

a plurality of helical blades are arranged on the inner wall of the material distributing cavity along the circumferential direction;

guide plates are arranged on the inner wall of the drainage cavity in a one-to-one correspondence manner to the helical blades;

wherein, be located two adjacent filtration shaft sections that the one-level cuts off the fillter section are gathered together inwards, two adjacent filtration shaft sections that the second grade cuts off the fillter section spread outward, just the diameter that the one-level cut off the fillter section is less than the diameter that the second grade cut off the fillter section.

2. The filter drum structure according to claim 1, wherein the support base comprises a frame body, and a support guide assembly and a driving assembly provided on the frame body;

the guide ring and the drive ring are coaxially fixed on the outer side of the outer sleeve through a connecting structure, two idler wheels on the support wheel set abut against the outer cylindrical surface of the guide ring, two rotating wheels of the guide wheel set abut against two side surfaces of the guide ring, the axes of the two idler wheels are parallel to the axis of the guide ring, and the axes of the two rotating wheels are perpendicular to the axis of the guide ring.

3. The filtering cylinder structure according to claim 2, characterized in that the connecting structure is provided in plurality along the circumferential direction and comprises two symmetrically arranged bridging plates and a connecting flat plate for connecting the two bridging plates;

the connection part of the two bridging plates and the connection flat plate forms a buffer cavity, and the buffer cavity faces the outer sleeve and is not in contact with the outer sleeve.

4. The filter roller structure according to claim 1, wherein a collection chamber corresponding to the outer sleeve, the filter roller and the feed roller is arranged in the collection box;

one end of the filtering roller, which is far away from the buffer material cavity, is flush with one end of the discharge filtering hole in the outer sleeve;

5. The filter drum structure according to claim 1, wherein the feed drum is rotatably disposed inside the filter drum;

and a driving structure is arranged on the feeding roller and used for driving the feeding roller to rotate around the outer sleeve in the opposite direction.

6. A filtering apparatus for bio-pharmaceuticals, using the filtering drum structure of any one of claims 1 to 5, further comprising:

the bearing seat is used for placing the filtering roller structure;

the feeding unit is arranged at one end of the feeding roller and used for feeding materials to the feeding roller;

7. The filtration apparatus for bio-pharmaceuticals of claim 6, wherein the feed unit comprises a feed tank, and a feed port and a feed inlet disposed on the feed tank, the feed port and the feed inlet being located in a same vertical plane;

a feeding adjusting plate is arranged at the position, close to the feeding port, of the feeding tank, one end of the feeding adjusting plate is arranged below the feeding port and hinged with the inner wall of the feeding tank;

when the pull rod pulls the feeding adjusting plate to rotate around the hinge shaft to the uppermost part, the raw materials in the feeding tank are directly discharged from an outlet at the lower part and circularly enter the feeding tank, and at the moment, the feeding port is in a material-free state;

8. The filtration apparatus for bio-pharmaceuticals of claim 6, wherein the axial driving member comprises a driving motor, a lead screw, and a bearing plate, the bearing plate being screwed on the lead screw, the bearing plate sliding in a sliding groove of the bearing seat along an axial direction of the lead screw;

when the bearing plate drives the supporting base to slide to a state of being separated from the feeding unit, the jacking assembly enables one end, located on the feeding roller, of the supporting base to be lifted upwards.

9. A method of using a filtration apparatus for biopharmaceutical use according to any of claims 6-8, the method comprising the steps of: