CN114929268A - 4-1bbl辅助的重组修饰的安卡拉痘苗病毒(mva)的医疗用途 - Google Patents

4-1bbl辅助的重组修饰的安卡拉痘苗病毒(mva)的医疗用途 Download PDF

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CN114929268A
CN114929268A CN202080092410.7A CN202080092410A CN114929268A CN 114929268 A CN114929268 A CN 114929268A CN 202080092410 A CN202080092410 A CN 202080092410A CN 114929268 A CN114929268 A CN 114929268A
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tumor
mva
leu
pro
ser
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M·欣特贝格尔
J·梅迪纳埃切韦尔斯
M·哈比扬
于尔根·豪斯曼
M·卡拉
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Bavarian Nordic AS
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    • C12N2710/24141Use of virus, viral particle or viral elements as a vector
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CN202080092410.7A 2019-11-20 2020-11-20 4-1bbl辅助的重组修饰的安卡拉痘苗病毒(mva)的医疗用途 Pending CN114929268A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP19210369.5 2019-11-20
EP19210369 2019-11-20
EP20191226.8 2020-08-14
EP20191226 2020-08-14
EP20193706.7 2020-08-31
EP20193706 2020-08-31
PCT/EP2020/082888 WO2021099572A1 (en) 2019-11-20 2020-11-20 Medical uses of 4-1bbl adjuvanted recombinant modified vaccinia virus ankara (mva)

Publications (1)

Publication Number Publication Date
CN114929268A true CN114929268A (zh) 2022-08-19

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CN202080092410.7A Pending CN114929268A (zh) 2019-11-20 2020-11-20 4-1bbl辅助的重组修饰的安卡拉痘苗病毒(mva)的医疗用途

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US (1) US20230059344A1 (https=)
EP (1) EP4061404A1 (https=)
JP (1) JP7670705B2 (https=)
KR (1) KR20220116191A (https=)
CN (1) CN114929268A (https=)
AU (1) AU2020388973A1 (https=)
BR (1) BR112022009797A2 (https=)
CA (1) CA3159666A1 (https=)
IL (1) IL293012A (https=)
MX (1) MX2022005601A (https=)
WO (1) WO2021099572A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111050790A (zh) * 2017-08-24 2020-04-21 巴法里安诺迪克有限公司 通过静脉内施用重组mva和抗体治疗癌症的组合疗法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12194157B2 (en) 2020-04-09 2025-01-14 Finncure Oy Carrier for targeted delivery to a host
FI20215508A1 (en) 2020-04-09 2021-10-10 Niemelae Erik Johan Mimetic nanoparticles to prevent the spread of new coronaviruses and reduce the rate of infection
CN117004579B (zh) * 2023-06-29 2024-11-15 苏州恩立维生物科技有限公司 重组溶瘤牛痘病毒及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014037124A1 (en) * 2012-09-04 2014-03-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
CN106456747A (zh) * 2014-05-13 2017-02-22 巴法里安诺迪克有限公司 用表达肿瘤抗原的重组痘病毒和免疫检查点分子拮抗剂或激动剂治疗癌症的组合疗法
WO2017120577A1 (en) * 2016-01-08 2017-07-13 Geovax Inc. Compositions and methods for generating an immune response to a tumor associated antigen
CN109152827A (zh) * 2016-02-25 2019-01-04 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
WO2019038388A1 (en) * 2017-08-24 2019-02-28 Bavarian Nordic A/S POLYTHERAPY FOR THE TREATMENT OF CANCER BY INTRAVENOUS ADMINISTRATION OF RECOMBINANT MVA AND ANTIBODY

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969609B1 (en) * 1998-12-09 2005-11-29 The United States Of America As Represented By The Department Of Health And Human Serivces Recombinant vector expressing multiple costimulatory molecules and uses thereof
UA76731C2 (uk) 2000-11-23 2006-09-15 Баваріан Нордік А/С Штам mva-bn модифікованого вірусу коров'ячої віспи ankara, фармацевтична композиція, вакцина, застосування mva-bn для приготування лікарського препарату та для приготування вакцини, спосіб введення гомологічної і/або гетерологічної послідовності нуклеїнової кислоти в клітини-мішені in vitro, спосіб одержання пептиду або білка, спосіб одержання mva-bn, клітина, набір для основної/бустерної імунізації
EP2345665A3 (en) 2001-12-04 2012-02-15 Bavarian Nordic A/S Flavivirus NS1 subunit vaccine
US8691502B2 (en) * 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
MX367100B (es) * 2012-02-17 2019-08-05 The Children´S Hospital Of Philadelphia Composiciones del vector aav y metodos para su transferencia genetica a celulas, organos y tejidos.
CA2942501A1 (en) * 2014-03-17 2015-09-24 Tapimmune Inc. Nucleic acid molecule vaccine compositions and uses thereof
WO2017152042A2 (en) * 2016-03-04 2017-09-08 New York University Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity
US20190345516A1 (en) * 2018-03-12 2019-11-14 Musc Foundation For Research Development Methods for treating eye disease
CA3119503A1 (en) 2018-11-20 2020-05-28 Bavarian Nordic A/S Therapy for treating cancer with an intratumoral and/or intravenous administration of a recombinant mva encoding 4-1bbl (cd137l) and/or cd40l

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014037124A1 (en) * 2012-09-04 2014-03-13 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
US20150202272A1 (en) * 2012-09-04 2015-07-23 Bavarian Nordic A/S Methods and compositions for enhancing vaccine immune responses
CN106456747A (zh) * 2014-05-13 2017-02-22 巴法里安诺迪克有限公司 用表达肿瘤抗原的重组痘病毒和免疫检查点分子拮抗剂或激动剂治疗癌症的组合疗法
WO2017120577A1 (en) * 2016-01-08 2017-07-13 Geovax Inc. Compositions and methods for generating an immune response to a tumor associated antigen
CN109071592A (zh) * 2016-01-08 2018-12-21 吉奥瓦科斯公司 用于产生对肿瘤相关抗原的免疫应答的组合物和方法
CN109152827A (zh) * 2016-02-25 2019-01-04 纪念斯隆凯特琳癌症中心 重组mva或表达人flt3l的mvaδe3l及其作为抗固体肿瘤的免疫治疗剂的用途
WO2019038388A1 (en) * 2017-08-24 2019-02-28 Bavarian Nordic A/S POLYTHERAPY FOR THE TREATMENT OF CANCER BY INTRAVENOUS ADMINISTRATION OF RECOMBINANT MVA AND ANTIBODY

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHIE KUDO-SAITO等: "4-1BB ligand enhances tumor-specific immunity of poxvirus vaccines", VACCINE, 5 June 2006 (2006-06-05), pages 1 - 20 *
FLORIE BERTRAND等: "Blocking Tumor Necrosis Factor a Enhances CD8 T-cell–Dependent Immunity in Experimental Melanoma", MICROENVIRONMENT AND IMMUNOLOGY, 15 July 2015 (2015-07-15), pages 2619 - 2628 *
MARÍA GONZALEZ-CAO 等: "Human endogenous retroviruses and cancer", CANCER BIOL MED., 31 December 2016 (2016-12-31), pages 483 - 488 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111050790A (zh) * 2017-08-24 2020-04-21 巴法里安诺迪克有限公司 通过静脉内施用重组mva和抗体治疗癌症的组合疗法
CN111050790B (zh) * 2017-08-24 2024-07-12 巴法里安诺迪克有限公司 通过静脉内施用重组mva和抗体治疗癌症的组合疗法

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MX2022005601A (es) 2022-08-15
JP2023503858A (ja) 2023-02-01
EP4061404A1 (en) 2022-09-28
CA3159666A1 (en) 2021-05-27
KR20220116191A (ko) 2022-08-22
WO2021099572A1 (en) 2021-05-27
IL293012A (en) 2022-07-01
BR112022009797A2 (pt) 2022-08-16
AU2020388973A1 (en) 2022-05-26
JP7670705B2 (ja) 2025-04-30
US20230059344A1 (en) 2023-02-23

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