CN114917280A - Glucosamine oral product and preparation method and application thereof - Google Patents
Glucosamine oral product and preparation method and application thereof Download PDFInfo
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- CN114917280A CN114917280A CN202210606785.1A CN202210606785A CN114917280A CN 114917280 A CN114917280 A CN 114917280A CN 202210606785 A CN202210606785 A CN 202210606785A CN 114917280 A CN114917280 A CN 114917280A
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- glucosamine
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- hawthorn
- oral
- preparation
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- 238000002360 preparation method Methods 0.000 title claims abstract description 37
- 229940028117 glucosamine oral product Drugs 0.000 title claims abstract description 23
- 241001092040 Crataegus Species 0.000 claims abstract description 88
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 88
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 88
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 88
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 88
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 88
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 88
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 88
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 88
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 88
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 88
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims abstract description 76
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims abstract description 76
- 229960002442 glucosamine Drugs 0.000 claims abstract description 76
- 235000005979 Citrus limon Nutrition 0.000 claims abstract description 25
- 244000131522 Citrus pyriformis Species 0.000 claims abstract description 25
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims abstract description 25
- 239000000843 powder Substances 0.000 claims abstract description 21
- 229920001817 Agar Polymers 0.000 claims abstract description 18
- 239000008272 agar Substances 0.000 claims abstract description 18
- 239000000047 product Substances 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 12
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 10
- 150000003839 salts Chemical class 0.000 claims abstract description 10
- 239000003765 sweetening agent Substances 0.000 claims abstract description 10
- 238000009835 boiling Methods 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 14
- 238000005520 cutting process Methods 0.000 claims description 12
- 238000004537 pulping Methods 0.000 claims description 12
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 235000010447 xylitol Nutrition 0.000 claims description 10
- 239000000811 xylitol Substances 0.000 claims description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 10
- 229960002675 xylitol Drugs 0.000 claims description 10
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 8
- 229960001911 glucosamine hydrochloride Drugs 0.000 claims description 8
- 235000013336 milk Nutrition 0.000 claims description 8
- 239000008267 milk Substances 0.000 claims description 8
- 210000004080 milk Anatomy 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 6
- 238000009740 moulding (composite fabrication) Methods 0.000 claims description 6
- MTDHILKWIRSIHB-UHFFFAOYSA-N (5-azaniumyl-3,4,6-trihydroxyoxan-2-yl)methyl sulfate Chemical compound NC1C(O)OC(COS(O)(=O)=O)C(O)C1O MTDHILKWIRSIHB-UHFFFAOYSA-N 0.000 claims description 5
- 229960002849 glucosamine sulfate Drugs 0.000 claims description 5
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 4
- 239000000796 flavoring agent Substances 0.000 claims description 4
- 235000013355 food flavoring agent Nutrition 0.000 claims description 4
- 235000021552 granulated sugar Nutrition 0.000 claims description 4
- 235000010241 potassium sorbate Nutrition 0.000 claims description 4
- 239000004302 potassium sorbate Substances 0.000 claims description 4
- 229940069338 potassium sorbate Drugs 0.000 claims description 4
- 239000003755 preservative agent Substances 0.000 claims description 4
- 230000002335 preservative effect Effects 0.000 claims description 4
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 claims description 4
- 235000010262 sodium metabisulphite Nutrition 0.000 claims description 4
- 235000010199 sorbic acid Nutrition 0.000 claims description 4
- 239000004334 sorbic acid Substances 0.000 claims description 4
- 229940075582 sorbic acid Drugs 0.000 claims description 4
- 235000021551 crystal sugar Nutrition 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- MCFVRESNTICQSJ-RJNTXXOISA-L calcium sorbate Chemical compound [Ca+2].C\C=C\C=C\C([O-])=O.C\C=C\C=C\C([O-])=O MCFVRESNTICQSJ-RJNTXXOISA-L 0.000 claims description 2
- 235000010244 calcium sorbate Nutrition 0.000 claims description 2
- 239000004303 calcium sorbate Substances 0.000 claims description 2
- 235000015203 fruit juice Nutrition 0.000 claims description 2
- 230000036541 health Effects 0.000 claims description 2
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 2
- 238000009472 formulation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 abstract description 8
- 235000019640 taste Nutrition 0.000 abstract description 8
- 230000029087 digestion Effects 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 239000002775 capsule Substances 0.000 abstract description 3
- 235000001497 healthy food Nutrition 0.000 abstract description 3
- 235000015097 nutrients Nutrition 0.000 abstract description 3
- 239000013588 oral product Substances 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 230000001502 supplementing effect Effects 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 230000001681 protective effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000000354 decomposition reaction Methods 0.000 description 6
- 229940023397 glucose oral product Drugs 0.000 description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 238000005303 weighing Methods 0.000 description 6
- 238000005286 illumination Methods 0.000 description 5
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 3
- 235000010419 agar Nutrition 0.000 description 3
- 235000015197 apple juice Nutrition 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 229910052938 sodium sulfate Inorganic materials 0.000 description 3
- 235000011152 sodium sulphate Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- 235000013944 peach juice Nutrition 0.000 description 2
- 229940001584 sodium metabisulfite Drugs 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 235000004936 Bromus mango Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000001212 derivatisation Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000008407 joint function Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229940023486 oral product Drugs 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 229940001607 sodium bisulfite Drugs 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 208000010731 swelling symptom Diseases 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
- A23L21/12—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products derived from fruit or vegetable solids
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Rheumatology (AREA)
- Mycology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Medical Informatics (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a glucosamine oral product and a preparation method and application thereof. The oral preparation comprises the following components in parts by weight: 20-26 parts of glucosamine and/or medically acceptable salt, 90-110 parts of hawthorn fruit powder, 37-45 parts of sweetener, 4-6 parts of lemon juice and 28-35 parts of agar. The glucosamine product disclosed by the invention is prepared by fusing glucosamine in a prepared hawthorn product, can be eaten as a healthy food, and has a better taste when being taken compared with the existing glucosamine oral products in the forms of capsules, chewable tablets and the like. In addition, the glucosamine product also has good effects of promoting digestion and supplementing rich nutrient substances, and can provide treatment for patients with poor digestion. In addition, the invention also utilizes the characteristics of dark color and acidity of the hawthorn, and the active ingredient glucosamine in the hawthorn plays a better protective role and prevents the hawthorn from being decomposed.
Description
Technical Field
The invention relates to the technical field of glucosamine products, in particular to a glucosamine oral preparation and a preparation method and application thereof.
Background
The glucosamine oral liquid has good anti-inflammatory and analgesic effects, is called as a scavenger in joint cavities, and can effectively eliminate inflammation, relieve pain and reduce the harm and influence of harmful factors on bodies. Research shows that the glucosamine capsule has direct anti-inflammatory effect, can relieve pain symptoms of bone and joints, improve joint functions and prevent the development of osteoarthritis. After the medicine is taken orally, osteoarthritis swelling symptoms can be well relieved, so that the movement function is increased. However, glucosamine is easily decomposed under the illumination condition, and the prepared oral product is not easy to store, so that the effective components in the product are reduced due to the decomposition of part of the glucosamine after long-time storage, and the treatment effect is influenced. In addition, the existing oral glucosamine product has the problems of poor taste and dislike taking by some patients.
Disclosure of Invention
Aiming at the problems, the invention provides a glucosamine oral product and a preparation method and application thereof. Compared with the traditional glucosamine oral product, the glucosamine oral product has better taste, and can play a better protection role on the glucosamine which is an effective component in the glucosamine oral product to prevent the glucosamine oral product from being decomposed. To achieve the above object, the present invention discloses the following aspects.
In a first aspect of the invention, a glucosamine oral preparation is disclosed, comprising the following components: 20-26 parts of glucosamine and/or medically acceptable salt, 90-110 parts of hawthorn fruit powder, 37-45 parts of sweetening agent, 4-6 parts of lemon juice and 28-35 parts of agar.
Preferably, the glucosamine oral preparation comprises the following components: 23 to 25 parts of glucosamine and/or medically acceptable salt, 98 to 104 parts of hawthorn, 40 to 43 parts of sweetener, 4.5 to 5.2 parts of lemon juice and 31 to 34 parts of agar.
Further, the glucosamine and/or medically acceptable salts include: glucosamine hydrochloride, glucosamine sulfate, glucosamine double salt, etc.
Further, the sweetener comprises any one of white granulated sugar, rock sugar, xylitol and the like. Preferably, the sweetener is xylitol, which is convenient for diabetics to take.
Further, 0.5-3.8 parts by weight of a flavoring agent is also included. Preferably, the flavoring agent comprises any one of fruit powder, fruit juice, milk, etc. to adjust the oral preparation of glucosamine with different tastes.
Further, the paint also comprises 0.5-3.0 parts by weight of preservative. Preferably, the preservative comprises: benzoic acid, sodium bisulfite, sodium metabisulfite, sorbic acid, potassium sorbate, calcium sorbate, etc.
In a second aspect of the present invention, a method for preparing said oral glucosamine preparation is disclosed, comprising the steps of:
(1) and putting the hawthorn pulp powder into boiling water, adding part of the lemon juice, and continuously boiling, wherein the lemon juice can prevent hawthorn from being oxidized, so that hawthorn pulp is obtained for later use.
(2) Pulping the hawthorn pulp, filtering after pulping, and removing filter residues to obtain hawthorn paste for later use.
(3) Adding the remaining components of sweetener, agar, glucosamine and/or pharmaceutically acceptable salt, and the rest lemon juice into the fructus crataegi paste, wherein the lemon juice can prevent glucosamine from being decomposed by oxidation. And then continuously heating and decocting, and cooling, forming and cutting the obtained hawthorn jam into blocks to obtain the glucosamine oral product.
Further, in the step (1), the boiling time is 3-5 min, so that the hawthorn pulp powder and water form hawthorn pulp.
Further, in the step (2), the hawthorn pulp is placed in a wall breaking machine for pulping, so that the hawthorn pulp is finer and smoother.
Further, in the step (3), heating and decocting are carried out until the hawthorn jam on the stirring tool cannot drip.
Further, the step (3) further comprises a step of vacuum drying the glucosamine oral product obtained after the cutting, so as to reduce the water content in the glucosamine oral product and improve the storage time. Optionally, the drying temperature is 50-60 ℃, and the time is 30-50 min.
In the third aspect of the invention, the application of the glucosamine oral preparation in the fields of medicine, rehabilitation, health care and the like is disclosed.
Compared with the prior art, the invention has the following beneficial effects: the glucosamine oral product provided by the invention is characterized in that glucosamine is fused in the prepared hawthorn product, and can be eaten as a healthy food, and compared with the existing glucosamine oral products in the forms of capsules, chewable tablets and the like, the glucosamine oral product provided by the invention has better taste when being taken, and can be conveniently adjusted into glucosamine products with different tastes by adding different additives, so that the glucosamine oral product has wider application range. In addition, the glucosamine oral preparation has good effects of promoting digestion and supplementing rich nutrients, and can be used for treating patients with poor digestion. In addition, the invention also utilizes the characteristics of dark color and acidity of hawthorn, and the active ingredient glucosamine in the hawthorn plays a better protection role and prevents the hawthorn from being decomposed, and the reasons are as follows: the glucosamine component in the glucosamine oral product is fused in the dark red or brown hawthorn main body, and the main body has very good natural light-shielding capacity, so that the decomposition of the glucosamine under the illumination condition can be reduced, meanwhile, the acidic hawthorn main body provides more stable storage space for the glucosamine and is also beneficial to reducing the decomposition of the glucosamine, and the measures in the two aspects effectively improve the storage time of the glucosamine oral product.
Detailed Description
It is to be understood that the following detailed description is exemplary and is intended to provide further explanation of the invention as claimed. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise. The invention will now be further illustrated by specific embodiments.
Example 1
A preparation method of glucosamine chewable tablets comprises the following steps:
(1) weighing the following components: 25 parts of glucosamine hydrochloride (sodium chloride), 104 parts of hawthorn fruit powder, 43 parts of xylitol, 5.2 parts of lemon juice, 34 parts of agar and 2.5 parts of milk.
(2) And (3) putting the hawthorn pulp powder into boiling water, then adding one half of the lemon juice, and continuously boiling for 5min to obtain hawthorn pulp for later use.
(3) Pulping the hawthorn pulp in a wall breaking machine for 1min, filtering after completion, and removing filter residues to obtain hawthorn paste for later use.
(4) Adding the xylitol, the agar, the milk, the glucosamine hydrochloride and the rest half of the lemon juice into the hawthorn paste, stirring, heating and decocting until the hawthorn jam does not drip on a stirring tool, pouring the obtained hawthorn jam into a mold for cooling and forming, then cutting into blocks, and vacuum-drying the amino glucose oral product obtained after cutting into blocks for 50min at 50 ℃ to obtain the amino glucose oral product.
Example 2
A preparation method of glucosamine chewable tablets comprises the following steps:
(1) weighing the following components: 23 parts of glucosamine sodium sulfate, 98 parts of hawthorn fruit powder, 40 parts of white granulated sugar, 4.5 parts of lemon juice, 31 parts of agar, 2.5 parts of apple juice and 2.0 parts of potassium sorbate.
(2) And (3) putting the hawthorn pulp powder into boiling water, then adding two thirds of the lemon juice, and continuously boiling for 4min to obtain hawthorn pulp for later use.
(3) Pulping the hawthorn pulp in a wall breaking machine for 1min, filtering after completion, and removing filter residues to obtain hawthorn paste for later use.
(4) Adding the white granulated sugar, the agar, the apple juice, the potassium sorbate, the glucosamine sulfate and the rest one third of the lemon juice into the hawthorn paste, stirring, heating and decocting until the hawthorn paste does not drip on a stirring tool, pouring the obtained hawthorn paste into a mold, cooling and molding, and cutting into pieces to obtain the glucosamine oral product.
Example 3
A preparation method of glucosamine chewable tablets comprises the following steps:
(1) weighing the following components: 26 parts of glucosamine sodium sulfate, 110 parts of hawthorn fruit powder, 45 parts of rock candy, 6 parts of lemon juice, 35 parts of agar, 2.5 parts of mango powder and 3 parts of sodium metabisulfite.
(2) And putting the hawthorn pulp powder into boiling water, adding two thirds of the lemon juice, and continuously boiling for 5min to obtain hawthorn pulp for later use.
(3) Pulping the hawthorn pulp in a wall breaking machine for 1min, filtering after completion, and removing filter residues to obtain hawthorn paste for later use.
(4) Adding the crystal sugar, agar, apple juice, sodium pyrosulfite, glucosamine sulfate and the remaining one third of the lemon juice into the hawthorn paste, stirring, heating and decocting until the hawthorn paste does not drip on a stirring tool, pouring the obtained hawthorn paste into a mold for cooling and molding, and then cutting into blocks to obtain the glucosamine oral product.
Example 4
A preparation method of glucosamine chewable tablets comprises the following steps:
(1) weighing the following components: 20 parts of glucosamine sodium sulfate, 90 parts of hawthorn fruit powder, 37 parts of rock candy, 4 parts of lemon juice, 28 parts of agar, 0.5 part of peach juice and 0.5 part of sorbic acid.
(2) And putting the hawthorn pulp powder into boiling water, adding one half of the lemon juice, and continuously boiling for 4min to obtain hawthorn pulp for later use.
(3) Pulping the hawthorn pulp in a wall breaking machine for 1min, filtering after completion, and removing filter residues to obtain hawthorn paste for later use.
(4) Adding the crystal sugar, agar, peach juice, sorbic acid, glucosamine sulfate and the rest half of the lemon juice into the hawthorn paste, stirring, heating and decocting until the hawthorn paste does not drip on a stirring tool, pouring the obtained hawthorn paste into a mold for cooling and forming, then cutting into blocks, and drying the amino glucose oral product obtained after cutting into blocks in vacuum at 60 ℃ for 30min to obtain the amino glucose oral product.
Example 5
A preparation method of glucosamine chewable tablets comprises the following steps:
(1) weighing the following components: 25 parts of glucosamine hydrochloride (sodium chloride), 104 parts of hawthorn fruit powder, 43 parts of xylitol, 34 parts of agar and 2.5 parts of milk.
(2) And (3) putting the hawthorn fruit powder into boiling water, and boiling for 5min to obtain hawthorn pulp for later use.
(3) Pulping the hawthorn pulp in a wall breaking machine for 1min, filtering after completion, and removing filter residues to obtain hawthorn paste for later use.
(4) And adding the xylitol, agar, milk and glucosamine hydrochloride into the hawthorn paste, stirring, heating and decocting until the hawthorn paste does not drip on a stirring tool, pouring the obtained hawthorn paste into a mould for cooling and forming, then cutting into blocks, and drying the cut oral glucosamine product in vacuum at 50 ℃ for 50min to obtain the oral glucosamine product.
Example 6
A preparation method of glucosamine chewable tablets comprises the following steps:
(1) weighing the following components: 25 parts of glucosamine hydrochloride (sodium chloride), 104 parts of hawthorn fruit powder, 43 parts of xylitol, 34 parts of agar and 2.5 parts of milk.
(2) And (3) putting the hawthorn pulp powder into boiling water, and boiling for 5min to obtain hawthorn pulp for later use.
(3) Pulping the hawthorn pulp in a wall breaking machine for 1min, filtering after completion, and removing filter residues to obtain hawthorn paste for later use.
(4) Adding the xylitol, the agar, the milk and the glucosamine hydrochloride into the hawthorn paste, adjusting the pH value of the system to 8.0 +/-0.2 by adopting sodium bicarbonate, stirring while heating and decocting until the hawthorn jam does not drip on a stirring tool, pouring the obtained hawthorn jam into a mold for cooling and forming, then cutting into blocks, and drying the amino glucose oral product obtained after cutting into blocks in vacuum at 50 ℃ for 50min to obtain the amino glucose oral product.
Performance testing
The stability of the oral glucosamine preparation of each of the above examples was tested by the following specific methods: the glucosamine oral preparation prepared in each embodiment is respectively placed in a transparent sealed box after disinfection and sterilization, finally the transparent sealed box is placed in an illumination environment (under indoor natural light in the daytime and under illumination of a 40W fluorescent lamp at night), and the content of the basal glucose in each test tube after being placed for 3 days is measured, wherein the measuring method is an RP-HPL derivatization method. In the calculation, the content immediately after the preparation was taken as an initial amount (retention rate is 1), and the retention rate of glucosamine was expressed by the ratio of the content at 5 days of light irradiation to the initial amount, and the results are recorded in the following table.
| Example number | 1 | 2 | 3 | 4 | 5 | 6 |
| Retention rate/%) | 97.46 | 98.07 | 97.17 | 97.75 | 83.29 | 74.62 |
From the above results, it can be seen that the glucosamine oral preparations prepared in examples 1-4 showed good stability under the test conditions, while the glucosamine oral preparations prepared in examples 5 and 6 showed poor stability due to: the glucosamine component in the glucosamine oral product prepared in the embodiment 1-4 is fused in a dark red or brown hawthorn main body, and the hawthorn main body has very good natural light-shielding capacity, so that the decomposition of the glucosamine under the illumination condition can be reduced, meanwhile, the acidic hawthorn main body provides a more stable storage space for the glucosamine and is also beneficial to reducing the decomposition of the glucosamine, and the storage time of the glucosamine oral product is effectively prolonged by the measures in the two aspects. Meanwhile, the lemon juice is added in the heating and boiling process to play a role in reducing decomposition of glucosamine. In addition, the glucosamine oral product integrates the glucosamine into the prepared hawthorn product, can be eaten as a healthy food, has better taste, can be conveniently adjusted into glucosamine products with different tastes by adding different additives, and has wider application range. In addition, the glucosamine oral preparation has good effects of promoting digestion and supplementing rich nutrients, and can be used for treating patients with poor digestion.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. An oral glucosamine preparation, which is characterized by comprising the following components: 20-26 parts of glucosamine and/or medically acceptable salt, 90-110 parts of hawthorn fruit powder, 37-45 parts of sweetener, 4-6 parts of lemon juice and 28-35 parts of agar.
2. The glucosamine oral preparation according to claim 1, wherein the glucosamine oral preparation comprises the following components: 23-25 parts of glucosamine and/or medically acceptable salt, 98-104 parts of hawthorn, 40-43 parts of sweetener, 4.5-5.2 parts of lemon juice and 31-34 parts of agar.
3. The glucosamine oral preparation according to claim 1, wherein said glucosamine and/or pharmaceutically acceptable salts comprise: glucosamine hydrochloride, glucosamine sulfate, and glucosamine double salt.
4. The oral glucosamine product of claim 1, wherein the sweetener comprises any one of white granulated sugar, crystal sugar, and xylitol; preferably, the sweetener is xylitol, which is convenient for diabetics to take.
5. The oral glucosamine preparation of claim 1, further comprising 0.5 to 3.8 parts by weight of a flavoring agent; preferably, the flavoring agent comprises any one of fruit powder, fruit juice and milk.
6. The oral glucosamine formulation according to claim 1, further comprising 0.5 to 3.0 parts by weight of a preservative; preferably, the preservative comprises: benzoic acid, sodium bisulfite, sodium pyrosulfite, sorbic acid, potassium sorbate, and calcium sorbate.
7. A method for preparing a glucosamine oral preparation, which is characterized in that the glucosamine oral preparation of any one of claims 1 to 6 is used as a raw material, and the method comprises the following steps:
(1) putting the hawthorn pulp powder into boiling water, then adding part of the lemon juice to continuously boil, wherein the lemon juice can prevent hawthorn from being oxidized to obtain hawthorn pulp for later use;
(2) pulping the hawthorn pulp, filtering after pulping, and removing filter residues to obtain hawthorn paste for later use;
(3) adding the rest components and the rest lemon juice into the hawthorn paste, then continuously heating and decocting, and cooling, forming and cutting the obtained hawthorn jam to obtain the glucosamine oral product.
8. The method for preparing oral glucosamine preparation according to claim 7, wherein in the step (1), the boiling time is 3-5 min;
preferably, in the step (2), the hawthorn pulp is placed in a wall breaking machine for pulping.
9. The method for preparing oral glucosamine preparations according to claim 7 or 8, wherein in the step (3), the hawthorn jam is heated and cooked until the hawthorn jam does not drip on the stirring tool;
preferably, the step (3) further comprises a step of vacuum drying the glucosamine oral product obtained after the dicing; more preferably, the drying temperature is 50-60 ℃ and the drying time is 30-50 min.
10. The glucosamine oral preparation according to any one of claims 1-6 or the glucosamine oral preparation obtained by the method according to any one of claims 7-9, and the application of the glucosamine oral preparation in the fields of medicine, rehabilitation and health care.
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Application publication date: 20220819 |