CN114903933A - 一种治疗羊附红细胞体病的中药及其制备方法和应用 - Google Patents
一种治疗羊附红细胞体病的中药及其制备方法和应用 Download PDFInfo
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Abstract
本发明提供一种治疗羊附红细胞体病的中药,所述中药的原料药为醉鱼草。本发明还提供其制备方法和应用。本发明的中药能够有效治疗羊附红细胞体病,原料来源于植物,制备方法简单,疗效好,中、高剂量组治愈率为90%,有效率为100%,为防治附红细胞体病提供了一种新药物。
Description
技术领域
本发明属于禽畜用药技术领域,具体涉及一种治疗羊附红细胞体病的中药及其制备方法和应用。
背景技术
附红细胞体病是由附红细胞体感染机体引起的一种人畜共患传染病。附红细胞体是寄生于红细胞表面、血浆及骨髓的一类微生物。猪较易发生附红细胞体病,该病临床上以发热、贫血、溶血性黄疸、呼吸困难、皮肤发红等为特征,造成动物机体免疫抑制、繁殖障碍、低出生成活率。
近年流行病调查发现,在甘肃省临夏州和兰州市羊群中附红细胞体检出率较高,在大多数情况下,附红细胞体感染导致机体处于无症状的亚临床感染状态,但其可能在外界环境压力条件下被激活。由于羊只流通频繁以及疾病重视度较低,导致两地附红细胞体检出较高,影响养殖户的经济收益,因此羊附红细胞体病应引起我们科技工作者的关注。
醉鱼草为醉鱼草(Buddleja lindleyanaFortune)是马钱科醉鱼草属灌木,分布于西南及江苏、安徽、浙江、江西、福建、湖北、湖南、广东、广西等地。具有祛风解毒,驱虫,化骨鲠之功效。常用于痄腮,痈肿瘰疬,蛔虫病,钩虫病,诸鱼骨鲠。但未见有将其用于治疗附红细胞体病的研究报道。
发明内容
为了解决现有技术中存在的问题,本发明提供了一种治疗羊附红细胞体病的中药,本发明还提供其制备方法和在治疗羊附红细胞体病中的应用。
本发明提供一种治疗羊附红细胞体病的中药,所述中药的原料药为醉鱼草。
本发明还提供上述的治疗羊附红细胞体病的中药的制备方法,将醉鱼草进行水提醇沉。
作为优选,在醉鱼草中加入药材重量的8-15倍重量水,煎煮3次,每次2小时,弃去药渣,合并煎煮液,浓缩至药材重量3倍,加入乙醇使含醇量达到75%,静置24小时,除去沉淀,回收乙醇,药液浓缩至1g/ml。
本发明还提供上述的中药在制备治疗羊附红细胞体病的药物中的应用。
本发明还提供一种药物,其有效成分为上述的中药。
作为优选,所述药物还包括医学上可接受的辅料。
作为优选,所述药物的剂型为口服液。
作为优选,使用时,将所述药物灌服。
作为优选,所述药物的使用剂量为:一次5ml-10ml/只,一日一次,连续用药三日。
作为进一步优选,所述药物的使用剂量为:一次5ml/只。
本发明的中药能够有效治疗羊附红细胞体病,原料来源于植物,制备方法简单,疗效好,治愈率为90%,有效率为100%。
具体实施方式
以下的实施例便于更好地理解本发明,但并不限定本发明。下述实施例中的实验方法,如无特殊说明,均为常规方法。下述实施例中所用的试验材料,如无特殊说明,均为市售。
本发明的治疗羊附红细胞体病的中药的制备方法如下:
将醉鱼草的地上部分置于不锈钢桶中,加入药材重量的8-15倍重量水,煎煮3次,每次2小时,弃去药渣,合并煎煮液,浓缩至药材重量3倍,加入乙醇使含醇量达到75%,静置24小时,除去沉淀,回收乙醇,药液浓缩至1g(生药)/ml,得到本发明的中药,剂型为口服液。
实施例1
本发明的治疗羊附红细胞体病的中药的制备方法如下:
在醉鱼草的地上部分中加入药材重量的10倍重量水,煎煮3次,每次2小时,弃去药渣,合并煎煮液,浓缩至药材重量3倍,加入乙醇使含醇量达到75%,静置24小时,除去沉淀,回收乙醇,药液浓缩至1g(生药)/ml,得到本发明的中药,剂型为口服液。
实施例2
本发明的治疗羊附红细胞体病的中药的制备方法如下:
将醉鱼草的地上部分置于不锈钢桶中,加入药材重量的8倍重量水,煎煮3次,每次2小时,弃去药渣,合并煎煮液,浓缩至药材重量3倍,加入乙醇使含醇量达到75%,静置24小时,除去沉淀,回收乙醇,药液浓缩至1g(生药)/ml,得到本发明的中药,剂型为口服液。
实施例3
本发明的治疗羊附红细胞体病的中药的制备方法如下:
将醉鱼草的地上部分置于不锈钢桶中,加入药材重量的15倍重量水,煎煮3次,每次2小时,弃去药渣,合并煎煮液,浓缩至药材重量3倍,加入乙醇使含醇量达到75%,静置24小时,除去沉淀,回收乙醇,药液浓缩至1g(生药)/ml,得到本发明的中药,剂型为口服液。
实施例4本发明的治疗羊附红细胞体病的中药的药效实验
1试验材料与方法:
1.1试验材料:
1.1.1试验动物:昆明种小白鼠,小白鼠经尾静脉采血制成鲜血压片镜检,确定无附红细胞体感染,体重18~22g,雌、雄各半,合格证号SCXK(甘)2020-0002,购自中国农业科学院兰州兽医研究所动物实验中心。
1.1.2试验仪器及试药:
光学显微镜(XSP-C104B),微量移液器,无菌注射器,PBS,生理盐水。试验药物:实施例1制备的醉鱼草口服液。对照药物:三氮脒(批号200401),由四川省环亚生物科技有限公司生产。
1.2体外药敏实验
于3张载玻片上分别滴加感染附红细胞体病的羊血悬液1滴,再分别滴加0.05g/L三氮脒、1.0g生药/L醉鱼草口服液及生理盐水各一滴,混匀并立即在在高倍显微镜下观察。
判定标准:
附红细胞体从红细胞表面脱落且血浆中的附红细胞体停止摆动,则判定为药物敏感。
药敏试验结果:
三氮脒于2min后使附红细胞体从红细胞上脱落,3min后血浆中的附红细胞体停止摆动;醉鱼草口服液3min后使附红细胞体从红细胞上脱落,4min后血浆中的附红细胞体停止摆动。生理盐水20min后仍附着在红细胞表面,并具有很强的运动性。
1.3人工感染小鼠药效试验:
将经PBS洗涤3次感染附红细胞体的羊血液样本,用等体积的灭菌生理盐水稀释作为感染样本。通过腹腔注射接种法对小白鼠接种0.5ml阳性血液样本。五天后,经尾静脉采血,加生理盐水置载玻片上,盖以盖玻片,滴香柏油后用油镜放大1000倍观察,在镜下观察,有带刺红细胞,或红细胞周围附着若干半圆形或圆形附着物,红细胞并有微微颤动,以及红细胞的皱缩、变形等,或在血浆中见有圆形或不定形大小不一的游动物体的情况,即认为感染成功。
试验分组,将感染成功的小白鼠随机分为5组,每组10只,第1组为药物低剂量治疗组,灌胃0.1ml/只;第2组为药物中剂量治疗组,灌胃0.2ml/只;第3组为药物高剂量治疗组,灌胃0.4ml/只,第4组为三氮脒治疗组,按每天5.0mg/kg体重腹腔注射;第5组每天0.4ml生理盐水体重腹腔注射,连用三天。
2疗效评价指标:
感染率的变化:试验前观察小白鼠,血液镜检20个视野,记录红细胞数,求出红细胞的感染率即(感染附红细胞体红细胞数/红细胞数)×100%,用药以后每组每天定时进行红细胞感染率的测定,连续测定3天。
3结果与分析:
药物治疗人工感染羊附红细胞体小白鼠实验结果见表1。
表1药物治疗人工感染羊附红细胞体小白鼠
由表1可以看出药物高中低组对人工感染的小白鼠均有不同程度的治疗作用,中剂量、高剂量组较好,与对照药物三氮脒接近。生理盐水组小白鼠红细胞感染率未有变化,提示小白鼠感染附红细胞体后不能自愈。
实施例5本发明的治疗羊附红细胞体病的中药的临床试验
1材料与方法:
1.1供试药物的制备:
试验药物:本发明实施例1制备的中药;对照药物:三氮脒(批号200401),四川省环亚生物科技有限公司生产。
1.2试验动物:
选取自然感染附红细胞体病的病羊43头,主要表现为食欲不振、倦怠,体温升高到40~41℃,眼结膜苍白、黄染,血液镜检可见附红细胞体。
1.3分组及用法、用量:
病羊分为四组,第1组10只病羊,为药物低剂量治疗组,灌服3ml/只,一日一次;第2组10只病羊,为药物中剂量治疗组,灌服5ml/只,一日一次;第3组10只病羊,灌服10ml/只,一日一次;第4组13只病羊,为三氮脒治疗组,按每天5.0mg/kg体重肌肉注射,以上各组均连续用药三天。
1.4治愈标准判定:
痊愈:临床症状消失,羊血液红细胞经悬滴法镜检未见附红细胞体。
好转:临床症状消失,羊血液红细胞经悬滴法镜检可见5%以下附红细胞体。
无效:临床症状未消失,羊血液红细胞经悬滴法镜检附红细胞体感染率未下降。
2结果:
本次共收治自然感染附红细胞体的患病羊43只,其中醉鱼草口服液低剂量组治疗10只,痊愈5只,好转3只,无效2只;醉鱼草口服液中剂量组治疗10只,治愈9只,好转1只;醉鱼草口服液高剂量组治疗10只,治愈9只,好转1只;三氮脒组治疗10只,治愈9只,好转1只。
本试验结果表明,醉鱼草口服液中、高剂量具有良好的治疗羊附红细胞体病的效果,与对照组三氮脒组疗效相同。
最后应说明的是:以上所述仅为本发明的优选实施例而已,并不用于限制本发明,尽管参照前述实施例对本发明进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.一种治疗羊附红细胞体病的中药,其特征在于:所述中药的原料药为醉鱼草。
2.权利要求1所述的治疗羊附红细胞体病的中药的制备方法,其特征在于:将醉鱼草进行水提醇沉。
3.根据权利要求2所述的治疗羊附红细胞体病的中药的制备方法,其特征在于:在醉鱼草中加入药材重量的8-15倍重量水,煎煮3次,每次2小时,弃去药渣,合并煎煮液,浓缩至药材重量3倍,加入乙醇使含醇量达到75%,静置24小时,除去沉淀,回收乙醇,药液浓缩至1g/ml。
4.权利要求1所述的中药在制备治疗羊附红细胞体病的药物中的应用。
5.一种药物,其有效成分为权利要求1所述的中药。
6.根据权利要求5所述的药物,其特征在于:所述药物还包括医学上可接受的辅料。
7.根据权利要求5所述的药物,其特征在于:所述药物的剂型为口服液。
8.根据权利要求5所述的药物,其特征在于:使用时,将所述药物灌服。
9.根据权利要求5所述的药物,其特征在于:所述药物的使用剂量为:一次5ml-10ml/只,一日一次,连续用药三日。
10.根据权利要求9所述的药物,其特征在于:所述药物的使用剂量为:一次5ml/只。
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