CN114887536B - High-flux passive mixing device and method with short mixing distance - Google Patents

High-flux passive mixing device and method with short mixing distance Download PDF

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CN114887536B
CN114887536B CN202210543024.6A CN202210543024A CN114887536B CN 114887536 B CN114887536 B CN 114887536B CN 202210543024 A CN202210543024 A CN 202210543024A CN 114887536 B CN114887536 B CN 114887536B
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channel
inlet
premixing
pentagon
unit
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CN114887536A (en
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孙佳佳
史宗谦
钟明杰
马语欣
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Xian Jiaotong University
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Xian Jiaotong University
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/405—Methods of mixing liquids with liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/45—Mixing liquids with liquids; Emulsifying using flow mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)

Abstract

The invention discloses a high-flux passive mixing device with a short mixing distance and a method thereof, wherein the device comprises a first inlet of a micro-channel, a second inlet of the micro-channel, a third inlet of the micro-channel, a pentagonal premixing unit, a linear channel barrier, an omega-shaped channel barrier, a micro-channel outlet and two pentagonal contraction and expansion channel units which are connected in series; the device comprises a pentagon-shaped shrinkage expansion channel unit, a pentagon-shaped premixing unit, a micro-channel first inlet, a micro-channel second inlet, a micro-channel third inlet, a pentagon-shaped shrinkage expansion channel unit, a micro-channel third inlet, a linear channel barrier and an omega-shaped channel barrier, wherein the linear channel barrier and the omega-shaped channel barrier are located in the interior of the pentagon-shaped shrinkage expansion channel unit, the tail end of the linear channel barrier is located in an area surrounded by the omega-shaped channel barrier, the inlet of the pentagon-shaped shrinkage expansion channel unit located at the head end is communicated with the outlet of the pentagon-shaped premixing unit and the head end of the linear channel barrier, the inlet of the pentagon-shaped premixing unit is communicated with the micro-channel first inlet, the micro-channel second inlet and the micro-channel third inlet.

Description

High-flux passive mixing device and method with short mixing distance
Technical Field
The invention relates to the technical field of micro-fluidic technology, in particular to a high-flux passive mixing device with a short mixing distance and a method thereof.
Background
Microfluidic systems are widely used in microchip experimental analysis systems due to their rapid sample analysis time, small sample consumption, high output throughput, portability, etc. In the biomedical field, chemical reactions of samples, DNA detection, cell lysis, biological screening, etc. all depend on the mixing efficiency between different reagents. In order to improve the detection performance of microchip analysis systems, it has been a major concern for researchers to increase the mixing efficiency between different samples while also shortening the mixing distance.
The mixing mechanism of the sample is mainly dependent on molecular diffusion due to the laminar flow characteristics of the fluid in the microfluidic system, which increases the time and length of mixing, which is incompatible with the miniaturization of the microfluidic system. To solve this problem, various methods for enhancing the mixing of the sample have been proposed, and can be broadly classified into active mixing and passive mixing. Wherein the active mixing is mainly by means of the action of external fields (such as electric field, magnetic field, thermal field, ultrasonic field, microwave field, etc.) to enhance the mixing of different samples. However, this method is mostly limited to low flux, and it consumes a lot of external energy during use, and the structure is also complicated and difficult to process. The passive mixing is realized by introducing chaotic convection by means of the design of a microfluidic channel structure, and the passive mixing method is often used for a microchip experimental analysis system due to the characteristics of simple operation, easy integration, no external energy consumption and the like.
However, the existing passive mixers can achieve better mixing effect under the condition of higher flux, but the mixing distance is long, so that the interior of the micro-fluid channel presents a large pressure drop, which is very unfavorable for developing a highly integrated microchip experiment analysis system.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a high-flux passive mixing device and a method with a short mixing distance, which can change the flow direction of a flow field so as to increase the contact area between different fluids, thereby realizing the high-flux short-distance high-flux mixing of different solutions.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a high throughput passive mixing device with short mixing distance comprising a microchannel first inlet, a microchannel second inlet, a microchannel third inlet, a pentagonal premix unit, a linear channel barrier, an omega-shaped channel barrier, a microchannel outlet, and two pentagonal convergent-divergent channel units in series;
the device comprises a pentagon-shaped shrinkage expansion channel unit, a pentagon-shaped premixing unit, a micro-channel first inlet, a micro-channel second inlet, a micro-channel third inlet, a pentagon-shaped shrinkage expansion channel unit, a micro-channel third inlet, a linear channel barrier and an omega-shaped channel barrier, wherein the linear channel barrier and the omega-shaped channel barrier are located in the interior of the pentagon-shaped shrinkage expansion channel unit, the tail end of the linear channel barrier is located in an area surrounded by the omega-shaped channel barrier, the inlet of the pentagon-shaped shrinkage expansion channel unit located at the head end is communicated with the outlet of the pentagon-shaped premixing unit and the head end of the linear channel barrier, the inlet of the pentagon-shaped premixing unit is communicated with the micro-channel first inlet, the micro-channel second inlet and the micro-channel third inlet.
Further, the pentagonal shrink expansion channel unit has a width w at the shrink structure b 50 μm.
Further, the length L of the pentagonal contraction and expansion channel unit along the x-axis direction r 550 μm.
Further, the central axis of the constriction structure in the pentagonal constriction expansion passage unit is kept horizontal to the center of the omega-shaped passage obstacle.
Further, the distance L between the omega-shaped channel barrier and the inlet of the pentagonal convergent-divergent channel unit 1 50 μm.
Further, the inner radius R of the middle circular arc part of the omega-shaped channel barrier 1 170 μm, outer radius R 2 220 μm, length L of rectangular portions at both ends of the omega-shaped channel barrier 2 100 μm, width w 1 50 μm.
Further, the short side length L of the linear passage barrier d Length of long side L=260 μm c =310 μm, width w d ＝20μm。
Further, the total mixing length L of the high-throughput passive mixing device along the x-axis direction is 1.15mm.
Further, the pentagon premix unit comprises a first premix side, a second premix side, a third premix side, a fourth premix side and a fifth premix side, wherein the inlet of the pentagon premix unit is positioned at the middle position of the first premix side, the first premix side is positioned on the same straight line with the first inlet of the micro channel and the third inlet of the micro channel, the second inlet of the micro channel is vertical to the first premix side, the second premix side and the third premix side are vertical to the first premix side, the fourth premix side and the fifth premix side are respectively arranged at an obtuse angle with the second premix side and the third premix side, and the intersection of the fourth premix side and the fifth premix side is used as an outlet of the pentagon premix unit;
the pentagon shrink expansion channel unit comprises a first side, a second side, a third side, a fourth side and a fifth side, wherein an inlet of the pentagon shrink expansion channel unit is positioned at the middle position of the first side, the second side and the third side are perpendicular to the first side, the fourth side and the fifth side are respectively arranged at an obtuse angle with the second side and the third side, and an intersection of the fourth side and the fifth side is used as an outlet of the pentagon shrink expansion channel unit.
A high throughput passive mixing method with short mixing distance comprising the steps of:
injecting the solution A to be mixed, the solution B to be mixed and the solution C to be mixed into a pentagon premixing unit through the first inlet of the micro-channel, the second inlet of the micro-channel and the third inlet of the micro-channel respectively, premixing the solution A to be mixed, flowing into the pentagon contraction and expansion channel unit through the pentagon premixing unit, and touching the linear channel barrier and the omega-shaped channel barrier positioned in the pentagon contraction and expansion channel unit to finish high-efficiency mixing; the mixed solution is collected at the microchannel outlet.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, the pentagon premixing unit is adopted to premix the solution to be mixed, the pentagon shrinkage and expansion channel unit, the linear channel barrier and the omega-shaped channel barrier are combined to promote the mixing of different solutions, and the dean vortex effect of the shrinkage and expansion channel and the stretching and folding effect of the linear channel barrier and the omega-shaped channel barrier on the movement of the fluid are utilized, so that the mixing distance is greatly shortened on the premise of ensuring the high-flux and high-efficiency mixing of different solutions, the pressure drop in the micro-channel is reduced, and the higher mixing efficiency can still be kept when the flux of the solution at the inlet of the channel is changed from hundred mu L/h to hundred mL/h, thereby laying a foundation for developing a microchip experimental analysis system with high integration level.
Further, in the present invention, the straight line shapeThe end of the microchannel barrier is arranged inside the area surrounded by the omega-shaped channel barrier and is spaced from the inner wall of the omega-shaped channel barrier by a distance w c =150 μm, which is smaller than the inner diameter R of the omega-channel barrier 1 The solution passing through the premixing unit flows to the inside of the omega-shaped channel barrier under the action of the linear channel barrier, and deflects in the flowing direction in the area surrounded by the omega-shaped channel barrier, even vortex is generated, so that the mixing efficiency among different solutions is greatly improved.
Further, the inner radius R of the omega-shaped channel barrier in the invention 1 170 μm, outer radius R 2 220 μm, and the distance L between the barrier of the omega-shaped channel and the entrance of the pentagonal convergent-divergent channel unit 1 The gap between the omega-shaped channel barrier and the fourth side and the fifth side of the pentagonal contraction and expansion channel unit is greatly compressed by 50 mu m, so that the contact area between different solutions is increased, and the mixing efficiency is greatly improved.
Drawings
FIG. 1 is a schematic diagram of a high throughput passive mixing apparatus with short mixing distance according to the present invention;
fig. 2 is a top view of a passive mixing device and associated geometric parameters.
In the figure, 1-microchannel first inlet; 2-microchannel second inlet; 3-microchannel third inlet; 4-pentagonal premix unit; 5-linear passage barriers; 6-omega-channel barriers; 7-microchannel outlet; 8-pentagonal constricting expansion channel unit.
Detailed Description
Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art. It should be noted that, without conflict, the embodiments of the present invention and features of the embodiments may be combined with each other. The invention will be described in detail below with reference to the drawings in connection with embodiments.
As shown in fig. 1, the present invention provides a short mixing distance high throughput passive mixing device comprising a microchannel first inlet 1, a microchannel second inlet 2, a microchannel third inlet 3, a pentagonal premix unit 4, a linear channel barrier 5, an omega-shaped channel barrier 6, a microchannel outlet 7, and two pentagonal convergent-divergent channel units 8 connected in series; the linear channel barriers 5 and the omega-shaped channel barriers 6 are positioned in the pentagon shrinkage and expansion channel units 8, the tail ends of the linear channel barriers 5 are positioned in the area surrounded by the omega-shaped channel barriers 6, the inlet of the pentagon shrinkage and expansion channel units 8 positioned at the head ends is communicated with the outlet of the pentagon premixing unit 4 and the head ends of the linear channel barriers 5, the inlet of the pentagon premixing unit is communicated with the first inlet 1 of the micro-channel, the second inlet 2 of the micro-channel and the third inlet 3 of the micro-channel, and the outlet of the pentagon shrinkage and expansion channel units 8 positioned at the tail ends is communicated with the outlet 7 of the micro-channel.
As shown in fig. 2, the pentagonal constricting and expanding channel element 8 has a width w at the constriction thereof b 50 μm; length L of the pentagonal shrink expansion passage unit 8 in the x-axis direction r 550 μm; the central axis of the contraction structure in the pentagonal contraction and expansion channel unit 8 is kept horizontal with the center of the omega-shaped channel barrier 6; distance L of the omega-shaped passage obstacle 6 from the entrance of the pentagonal convergent-divergent passage unit 8 1 50 μm; the inner radius R of the omega-shaped channel barrier 6 1 170 μm, outer radius R 2 220 μm long L 2 100 μm, width w 1 50 μm; short side length L of the straight-line passage obstacle 5 d Length of long side L=260 μm c =310 μm, width w d =20 μm; the total mixing length L of the high-throughput passive mixing device along the x-axis direction was 1.15mm.
The pentagon premix unit 4 comprises a first premix side, a second premix side, a third premix side, a fourth premix side and a fifth premix side, the inlet of the pentagon premix unit 4 is positioned at the middle position of the first premix side, the first premix side is positioned on the same straight line with the first inlet 1 of the micro channel and the third inlet 3 of the micro channel, the second inlet 2 of the micro channel is vertical to the first premix side, the second premix side and the third premix side are vertical to the first premix side, the fourth premix side and the fifth premix side are respectively arranged at an obtuse angle with the second premix side and the third premix side, and the intersection of the fourth premix side and the fifth premix side is used as an outlet of the pentagon premix unit 4; the pentagon shrink expansion channel unit 8 comprises a first side, a second side, a third side, a fourth side and a fifth side, wherein an inlet of the pentagon shrink expansion channel unit 8 is located at the middle position of the first side, the second side and the third side are perpendicular to the first side, the fourth side and the fifth side are respectively arranged at an obtuse angle with the second side and the third side, and an intersection of the fourth side and the fifth side serves as an outlet of the pentagon shrink expansion channel unit 8.
The invention utilizes micro-nano lithography technology to realize the processing of the mixing device, comprising the processing and packaging of pentagonal contraction and expansion channel units 8, linear channel barriers 5 and omega-shaped channel barriers 6. And manufacturing molds of pentagonal shrinkage and expansion micro-channel units 8, linear channel barriers 5 and omega-shaped channel barrier units 6 on a silicon substrate based on a micro-nano lithography technology, then obtaining micro-fluid channels by using a PDMS reverse molding technology, and finally packaging the micro-fluid channels and a glass slide together by means of an oxygen plasma bonding technology.
A high throughput passive mixing method with short mixing distance comprising the steps of:
step one: injecting the solution to be mixed a, the solution to be mixed B and the solution to be mixed C into the pentagonal premix unit 4 through the first inlet 1, the second inlet 2 and the third inlet 3 of the micro-channel, respectively, using an injection device (an external injection pump capable of adjusting the flow rate of the inlet of the channel);
step two: the premix liquid in the pentagonal premix unit 4 flows into the pentagonal convergent-divergent passage unit 8 structure, and then touches the linear passage barrier 5 at the inlet of the pentagonal convergent-divergent passage unit 8 and the omega-shaped passage barrier 6 inside thereof to accomplish high-efficiency mixing;
step three: a mixed solution sample is collected at the microchannel outlet 7.
The following are specific examples:
the high-flux passive mixing method with short mixing distance provided by the invention comprises the following steps:
step one: injecting a solution A to be mixed, a solution B to be mixed and a solution C to be mixed into a mixing device with the total length L along the x-axis direction of 1.15mm through a first inlet 1 of a micro-channel, a second inlet 2 of the micro-channel and a third inlet 3 of the micro-channel by using an external injection pump, and firstly, enabling the solution A to be mixed, the solution B to be mixed and the solution C to enter a pentagonal premixing unit 4 for premixing, wherein the flow rate of the inlets of the channels can be adjusted by the external injection pump, so that rapid mixing under different fluxes can be realized;
step two: the premix liquid in the pentagonal premix unit 4 flows into the pentagonal shrink expansion channel unit 8 structure, wherein the width w at the shrink structure in the pentagonal shrink expansion channel unit 8 b 50 μm, length L along x-axis direction r 550 μm and the structural center of which is kept horizontal with the center of the omega-shaped passage barrier 6, the linear passage barrier being located at both sides of the inlet of the pentagonal-shaped convergent-divergent passage unit 8, thereby causing the liquid A, B, C to be mixed to touch the omega-shaped passage barrier 6 and the linear passage barrier 5 located inside the pentagonal-shaped convergent-divergent passage unit 8 to accomplish high-efficiency mixing, wherein the short side length L of the linear passage barrier 5 in the x-direction d 260 μm, length of long side L c 310 μm, width w d The longest width of the omega-shaped channel barrier 6 in the y-axis direction is 440 μm (i.e., twice R 2 ) Distance L of omega-shaped passage obstacle 6 from entrance of pentagonal convergent-divergent passage unit 8 1 50 μm, inner radius R of omega-channel barrier 6 1 170 μm, outer radius R 2 220 μm;
step three: a mixed solution sample is collected at the microchannel outlet 7.
According to the invention, the pentagonal shrinkage expansion channel unit 8, the linear channel barrier 5 and the omega-shaped channel barrier 6 are utilized to change the flow direction of fluid, so that high-flux mixing among different solutions is realized, after the solutions to be mixed are respectively injected into the channels from three inlets, the high-flux short-distance mixing of the different solutions is realized by utilizing the chaotic convection effect caused by the change of the channel geometric structure, the distribution of a flow field is changed by introducing a dean vortex in the structure of the pentagonal shrinkage expansion channel unit 8, and the linear channel barrier 5 and the omega-shaped channel barrier 6 exert the stretching folding effect on the fluid by changing the flow direction of the flow field, so that the contact area among different fluids is increased, and thus, the high-flux high-efficiency mixing among different solutions is realized, and the mixing distance is greatly shortened.
Finally, it should be noted that: the above embodiments are merely preferred embodiments of the present invention for illustrating the technical solution of the present invention, and are not limiting, but are not limiting of the scope of the present invention; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the corresponding technical solutions; that is, even though the main design concept and spirit of the present invention is modified or finished in an insubstantial manner, the technical problem solved by the present invention is still consistent with the present invention, and all the technical problems are included in the protection scope of the present invention; in addition, the technical scheme of the invention is directly or indirectly applied to other related technical fields, and the technical scheme is included in the scope of the invention.

Claims (8)

1. A high-throughput passive mixing device with short mixing distance, characterized by comprising a microchannel first inlet (1), a microchannel second inlet (2), a microchannel third inlet (3), a pentagonal premix unit (4), a linear channel barrier (5), an omega-shaped channel barrier (6), a microchannel outlet (7) and two pentagonal convergent-divergent channel units (8) connected in series;
the linear channel barriers (5) and the omega-shaped channel barriers (6) are positioned in the pentagon shrinkage and expansion channel units (8), the tail ends of the linear channel barriers (5) are positioned in the area surrounded by the omega-shaped channel barriers (6), the inlet of the pentagon shrinkage and expansion channel units (8) positioned at the head end is communicated with the outlet of the pentagon premixing unit (4) and the head end of the linear channel barriers (5), the inlet of the pentagon premixing unit is communicated with the first inlet (1) of the micro-channel, the second inlet (2) of the micro-channel and the third inlet (3) of the micro-channel, and the outlet of the pentagon shrinkage and expansion channel units (8) positioned at the tail ends is communicated with the outlet (7) of the micro-channel;
the central axis of the contraction structure in the pentagonal contraction and expansion channel unit (8) is kept horizontal with the center of the omega-shaped channel barrier (6);
the pentagon-shaped premixing unit (4) comprises a first premixing edge, a second premixing edge, a third premixing edge, a fourth premixing edge and a fifth premixing edge, wherein an inlet of the pentagon-shaped premixing unit (4) is positioned at the middle position of the first premixing edge, the first premixing edge is positioned on the same straight line with a first micro-channel inlet (1) and a third micro-channel inlet (3), a second micro-channel inlet (2) is perpendicular to the first premixing edge, the second premixing edge and the third premixing edge are perpendicular to the first premixing edge, the fourth premixing edge and the fifth premixing edge are respectively arranged at an obtuse angle with the second premixing edge and the third premixing edge, and the intersection of the fourth premixing edge and the fifth premixing edge is used as an outlet of the pentagon-shaped premixing unit (4);
the pentagon shrink expansion channel unit (8) comprises a first side, a second side, a third side, a fourth side and a fifth side, wherein an inlet of the pentagon shrink expansion channel unit (8) is located at the middle position of the first side, the second side and the third side are perpendicular to the first side, the fourth side and the fifth side are respectively arranged at an obtuse angle with the second side and the third side, and an intersection of the fourth side and the fifth side serves as an outlet of the pentagon shrink expansion channel unit (8).
2. A device according to claim 1 havingA short mixing distance high throughput passive mixing device, characterized in that the width w of the constriction in the pentagonal constriction expansion channel unit (8) is b 50 μm.
3. A high-throughput passive mixing apparatus with short mixing distance according to claim 1, characterized in that the pentagonal convergent-divergent passage unit (8) has a length L in x-axis direction r 550 μm.
4. A high throughput passive mixing apparatus with short mixing distance according to claim 1, characterized in that the omega-shaped channel barrier (6) is at a distance L from the entrance of the pentagonal convergent-divergent channel unit (8) 1 50 μm.
5. A high-throughput passive mixing apparatus with short mixing distance according to claim 1, characterized in that the inner radius R of the middle circular arc part of the omega-shaped channel barrier (6) 1 170 μm, outer radius R 2 220 μm, length L of rectangular portions at both ends of the omega-shaped passage barrier (6) 2 100 μm, width w 1 50 μm.
6. A high-throughput passive mixing apparatus with short mixing distance according to claim 1, characterized in that the short side length L of the linear channel barrier (5) d Length of long side L=260 μm c =310 μm, width w d ＝20μm。
7. A high-throughput passive mixing apparatus with short mixing distance according to claim 1, characterized in that the total mixing length L of the high-throughput passive mixing apparatus in the x-axis direction is 1.15mm.
8. A high-throughput passive mixing method with short mixing distance, characterized in that it is based on a high-throughput passive mixing device with short mixing distance according to any of claims 1-7, comprising the steps of:
injecting the solution A to be mixed, the solution B to be mixed and the solution C to be mixed into a pentagon premixing unit (4) through a first inlet (1) of a micro-channel, a second inlet (2) of the micro-channel and a third inlet (3) of the micro-channel respectively, premixing the solution A and the solution B to be mixed by the pentagon premixing unit (4) and flowing into a pentagon shrinkage expansion channel unit (8), and touching a linear channel barrier (5) and an omega-shaped channel barrier (6) positioned inside the pentagon shrinkage expansion channel unit (8) to finish high-efficiency mixing; the mixed solution is collected at the microchannel outlet (7).
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