CN114887013A - Tibetan medicine Manuo series soup appetizing granules and preparation method thereof - Google Patents
Tibetan medicine Manuo series soup appetizing granules and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Tibetan medicine Manuo series soup appetizing particle and a preparation method thereof, wherein the Tibetan medicine Manuo series soup appetizing particle is prepared from Tibetan medicinal materials in parts by weight: 5-10 parts of Tibetan costustoot, 5-10 parts of tinospora sinensis, 5-10 parts of raspberry, 10-20 parts of pomegranate seed, 5-10 parts of round cardamom and 5-10 parts of long pepper, and is prepared by a specific method. The obtained granule has better therapeutic effect than decoction prepared by conventional decoction method, and has the advantages of low dosage, and convenient carrying, storage and administration.
Description
The application is a divisional application with the application number of CN202011090089.7, the application date of 10 and 13 in 2020, the publication number of CN112121133A and the publication date of 12 and 15 in 2020.
Technical Field
The invention belongs to the field of Tibetan medicines, and particularly relates to Tibetan medicine Manuo series soup appetizing granules and a preparation method thereof.
Technical Field
The Tibetan medicine science has developed for thousands of years and becomes an important component of the Chinese medicine and pharmacology treasury, and the Tibetan medicine has unique medicinal material resources, complex and various processing processes, precious medicines, unique and magical curative effects, and wide research and development values and industrial development prospects. Wherein, the series of Tibetan medicine 'Ma Nuo series decoction' is the earliest Tibetan medicine ancient book of medical books recorded in the 7 th century of the public yuan, and 70 or more prescriptions in the book. 2258 clinical prescriptions are collected in the four medical classics of 8 th century, and the compatibility rules, the prescription structure, the treatment principles, and the medication taboo of 8 major dosage forms such as decoction and powder are discussed in more detail, so as to form a systematic and remarkable curative effect Tibetan medicine classic prescription system. The basic prescription of the 'Ma Nuo Tang' is composed of 3 medicinal materials of Tibetan costustoot, ramulus Uncariae cum uncis and tinospora sinensis, has the effects of relieving exterior syndrome and inducing perspiration, is used for treating diseases such as pestilence, early stage of influenza, aversion to cold, headache, joint ache, rheumatoid arthritis, fever and the like, and is praised as a mother of Tibetan medicinal decoction. The Guyuan l4 century Tibetan medicine Nanpai pioneer Suka-Niangmu duojie carries out many years of intensive research on the Manuo series soup, accords with the medicine application method of the Tibetan medicine clinical syndrome differentiation and treatment characteristics, has the effects of' main medicines (such as the ramulus Uncariae cum uncis, the tinospora sinensis and the Tibetan costustoot) and auxiliary medicines (changed along with the symptoms), finally summarizes and develops more than 100 Manuo series preparations of the Manuo series soup, can treat various diseases such as nephropathy, liver and gallbladder diseases, lung diseases, intestinal tract diseases, cardiovascular and cerebrovascular diseases, rheumatism, xuolong diseases and the like, and thousands of years of clinical application proves that the preparations have obvious curative effects on diseases such as cardiovascular and cerebrovascular diseases, liver and gallbladder diseases, immune system diseases and the like and are generally concerned by the world medical field. The 'Manuo decoction' series of prescriptions are most suitable for the application method based on the characteristics of Tibetan medicine clinical syndrome differentiation, and different series of prescriptions are adopted for treatment according to different diseases, individual differences of patients, ages, sexes, regional environments and seasons. The characteristic advantages of Tibetan medicines are fully exerted, more and better Manuo series preparations are required to be developed, and through years of research and clinical verification, the invention develops a Tibetan medicine Manuo series appetizing particle which has the effects of treating liver and stomach fullness, indigestion and pain after eating.
Disclosure of Invention
The invention aims to provide Tibetan medicine Manuo series soup appetizing particles, and particularly provides a preparation method of the Tibetan medicine Manuo series soup appetizing particles.
The invention relates to Tibetan medicine Manuo series decoction appetizing granules which are prepared from the following Tibetan medicine materials in parts by weight: 5-10 parts of Tibetan costustoot, 5-10 parts of tinospora sinensis, 5-10 parts of raspberry, 10-20 parts of pomegranate seed, 5-10 parts of round cardamom and 5-10 parts of long pepper.
Preferably, the Tibetan medicine Manuo series decoction appetizing granules are prepared from the following Tibetan medicine materials in parts by weight: 8 parts of Tibetan costustoot, 8 parts of tinospora sinensis, 8 parts of raspberry, 15 parts of pomegranate seed, 8 parts of round cardamom and 8 parts of long pepper.
In particular, the present invention provides a process for preparing the Tibetan medicine moruo series soup appetizing granules of the present invention, comprising the steps of:
1) cleaning Tibetan radix aucklandiae, removing impurities from semen Granati, drying, sterilizing, pulverizing respectively, and sieving with 120 mesh sieve to obtain Tibetan radix aucklandiae powder and semen Granati powder;
2) removing bark and medulla of ramulus Uncariae cum uncis, removing bark of caulis tinosporae sinensis, and removing impurities from fructus Amomi rotundus and fructus Piperis Longi;
3) extracting the treated ramulus Uncariae cum uncis, caulis tinosporae, fructus Amomi rotundus and fructus Piperis Longi of step 2) with water vapor, collecting volatile oil, extracting the residue with water, decocting twice, mixing extractive solutions, standing overnight, and filtering to obtain filtrate;
4) concentrating the filtrate obtained in the step 3) under reduced pressure, controlling the temperature to be not more than 65 ℃ until the relative density (normal temperature) d is 1.3-1.35, and refrigerating the obtained extract for later use;
5) mixing the extract of step 4) with the Tibetan wood incense powder and pomegranate seed powder of step 1) to prepare a soft material, drying, crushing, sieving with a 100-mesh sieve, uniformly mixing, adding 95% ethanol, and granulating with a 12-mesh sieve;
6) drying the granules obtained by granulating in the step at 60-70 ℃, sieving the dried granules with a 10-mesh sieve and a 60-mesh sieve to remove coarse granules and fine powder, crushing the coarse granules, adding the fine powder, granulating again according to the method, drying, mixing, spraying the volatile oil collected in the step 3), standing for more than 30 minutes, and subpackaging to obtain the appetizing granules.
The method of the invention comprises the steps of 1) drying, which comprises the steps of placing the medicinal materials in a drying chamber, controlling the temperature at 70-80 ℃ for drying, and sterilizing, which comprises the steps of cutting or crushing the medicinal materials, placing the cut or crushed medicinal materials in an irradiation chamber, irradiating and sterilizing by using an ultraviolet lamp, wherein the laying thickness is less than or equal to 5cm, turning over once every 30 minutes by irradiation, and the irradiation time is 300 minutes; the water boiling extraction in the step 3) is carried out twice, and comprises the steps of adding 10 times of water for boiling extraction for 120 minutes for the first time, adding 8 times of water for boiling extraction for 90 minutes for the second time, and combining the water boiling liquids of the two times; and (5) drying, wherein the temperature of a drying box is 70 ℃, and the drying in the step 6) also comprises timely turning over in the drying process to prevent agglomeration.
The Tibetan medicine Manuo series decoction appetizing granules are 2g per bag.
The Tibetan medicine Manuo decoction appetizing granules are an improved preparation of traditional preparation type decoction, and have the advantages of stable process, convenience in carrying, controllable quality, stable curative effect and the like compared with the traditional decoction.
The Tibetan medicine Manuo decoction appetizing granules have the clinical application of clearing away heat and promoting appetite, and are used for treating inappetence, gastrectasia, stomach cold, stomachache and the like caused by pyrexia and stomach fire weakness. The dosage is 1 bag at a time, 1-2 times a day, and 2 g/bag.
Drawings
Fig. 1 is a schematic diagram of a preparation process of Tibetan medicine Manuo series granules for promoting appetite.
Detailed Description
The following examples are merely representative for purposes of illustration and further understanding of the nature of the invention, and are not intended to limit the scope of the invention in any way.
Example 1 formula of Tibetan medicine Manuo decoction appetizing granules:
8 parts of Tibetan costustoot, 8 parts of tinospora sinensis, 8 parts of raspberry, 15 parts of pomegranate seed, 8 parts of round cardamom and 8 parts of long pepper.
The preparation process comprises the following steps:
1. pretreatment of raw materials:
(1) rinsing Tibet inula root with clear water, and removing impurities from pomegranate seed. Controlling the temperature of a drying chamber at 70-80 ℃ for drying, placing the dried product in an irradiation chamber after cutting or coarse crushing, irradiating and sterilizing the product by using an ultraviolet lamp, wherein the laying thickness is less than or equal to 5cm, and the irradiation is turned over once every 30 minutes for 300 minutes. Pulverizing in a pulverizer, and sieving with 120 mesh sieve.
(2) Peeling off the bark of the ramulus Uncariae cum uncis, and removing the pulp part; peeling off the outer skin of the tinospora sinensis; removing impurities from fructus Amomi rotundus and fructus Piperis Longi; the following operations were carried out by washing with clean water and boiling in water once.
2. Extraction:
extracting oil from the four processed medicinal materials with steam, storing, decocting the residue with water twice, decocting with 10 times of water for 120 min for the first time, decocting with 8 times of water for 90 min for the second time, mixing the decoctions, standing overnight, and filtering.
3. Concentration:
concentrating the extract under reduced pressure at a temperature not higher than 65 deg.C until the relative density (normal temperature) d is 1.3-1.35, and refrigerating for use.
4. And (3) granulating:
mixing the above extract paste with Tibetan radix aucklandiae and semen Granati powder, making into soft material, and drying in a drying oven at 70 deg.C. Pulverizing the dry extract, sieving with 100 mesh sieve, mixing the medicinal powders, adding 95% ethanol, and granulating with 12 mesh sieve.
5. And (3) drying:
drying the prepared particles at 60-70 ℃, and turning over in time in the drying process to prevent agglomeration. Sieving the dried granules with 10 mesh sieve and 60 mesh sieve to remove coarse granules and fine powder, pulverizing the coarse granules, adding fine powder, granulating again according to the above method, drying, mixing, spraying volatile oil, standing for more than 30 min, and packaging.
Example 2 formula of Tibetan medicine Manuo decoction appetizing granules
See the following Table
The preparation process comprises the following steps:
prepared according to the procedure of example 1.
Example 3 comparison of effects
Comparing the efficacy of the granules of the invention, the traditional decoction and the granules of the comparative formula prepared according to the formula of example 1: through clinical verification, the granule has the same or slightly better curative effect on treating liver and stomach fullness, indigestion and pain after eating compared with the traditional decoction, but the granule is more convenient to carry, store and take than the decoction. Compared with the granules of the invention, the granules of the comparative prescription have no effect on the treatment of the liver and stomach fullness, indigestion and pain after eating.
Claims (8)
1. A Tibetan medicine Manuo decoction appetizing granule is prepared from the following Tibetan medicine materials in parts by weight: 5-10 parts of Tibetan costustoot, 5-10 parts of tinospora sinensis, 5-10 parts of raspberry, 10-20 parts of pomegranate seeds, 5-10 parts of round cardamom and 5-10 parts of long pepper, wherein the appetizing granules are prepared by the following method, and the method comprises the following steps:
1) cleaning Tibetan radix aucklandiae, removing impurities from semen Granati, drying, sterilizing, pulverizing respectively, and sieving with 120 mesh sieve to obtain Tibetan radix aucklandiae powder and semen Granati powder;
2) removing bark and medulla of ramulus Uncariae cum uncis, removing bark of caulis tinosporae sinensis, and removing impurities from fructus Amomi rotundus and fructus Piperis Longi;
3) extracting the treated ramulus Uncariae cum uncis, caulis tinosporae, fructus Amomi rotundus and fructus Piperis Longi of step 2) with water vapor, collecting volatile oil, extracting the residue with water, decocting twice, mixing extractive solutions, standing overnight, and filtering to obtain filtrate;
4) concentrating the filtrate obtained in the step 3) under reduced pressure, controlling the temperature to be not more than 65 ℃ until the relative density (normal temperature) d is 1.3-1.35, and refrigerating the obtained extract for later use;
5) mixing the extract of step 4) with the Tibetan wood incense powder and pomegranate seed powder of step 1) to prepare a soft material, drying, crushing, sieving with a 100-mesh sieve, uniformly mixing, adding 95% ethanol, and granulating with a 12-mesh sieve;
6) drying the granules obtained by the step of granulating at 60-70 ℃, sieving the dried granules with a 10-mesh sieve and a 60-mesh sieve to remove coarse granules and fine powder, crushing the coarse granules, adding the fine powder, granulating again according to the method, drying, mixing, spraying the volatile oil collected in the step 3), standing for more than 30 minutes, and subpackaging to obtain the appetizing granules.
2. The appetizing granules as claimed in claim 1, which are prepared from the following Tibetan medicines in parts by weight: 8 parts of Tibetan costustoot, 8 parts of tinospora sinensis, 8 parts of raspberry, 15 parts of pomegranate seed, 8 parts of round cardamom and 8 parts of long pepper.
3. The appetizing granule as claimed in claim 1, wherein the drying in step 1) comprises drying the medicinal materials in a drying chamber at a temperature of 70-80 ℃.
4. The appetizing granules as claimed in claim 1, wherein the sterilization in step 1) comprises the steps of cutting or crushing the medicinal materials, placing the cut or crushed medicinal materials in an irradiation chamber, irradiating and sterilizing the medicinal materials by using an ultraviolet lamp, wherein the laying thickness is less than or equal to 5cm, and the irradiation is turned once every 30 minutes, and the irradiation time is 300 minutes.
5. The appetizing granules as claimed in claim 1, wherein the water boiling extraction in the step 3) is performed twice, and comprises the steps of adding 10 times of water for 120 minutes for boiling extraction in the first time, adding 8 times of water for boiling extraction in the second time for 90 minutes, and combining the two water boiling liquids.
6. An appetizing granule as claimed in claim 1, wherein the drying in step 5) is carried out at a drying oven temperature of 70 ℃.
7. The appetizing article of claim 1, wherein the drying in step 6) further comprises turning over in time during the drying process to prevent agglomeration.
8. The appetizing particle of claim 1 in a dose of 2 g/bag.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210585478.XA CN114887013A (en) | 2020-10-13 | 2020-10-13 | Tibetan medicine Manuo series soup appetizing granules and preparation method thereof |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210585478.XA CN114887013A (en) | 2020-10-13 | 2020-10-13 | Tibetan medicine Manuo series soup appetizing granules and preparation method thereof |
| CN202011090089.7A CN112121133A (en) | 2020-10-13 | 2020-10-13 | Tibetan medicine Manuo series soup appetizing granules and preparation method thereof |
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| 东知多杰等: "浅论藏药"玛诺系汤"系列方剂的发展现状", 《中国民族医药杂志》 * |
| 贡保东知等: "基于数据挖掘和整合药理学平台的藏医治疗脾胃病用药规律及作用机制", 《中国中药杂志》 * |
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