CN114886960A - Antibacterial and anti-inflammatory skin repair cream - Google Patents

Antibacterial and anti-inflammatory skin repair cream Download PDF

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Publication number
CN114886960A
CN114886960A CN202210558625.4A CN202210558625A CN114886960A CN 114886960 A CN114886960 A CN 114886960A CN 202210558625 A CN202210558625 A CN 202210558625A CN 114886960 A CN114886960 A CN 114886960A
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antibacterial
inflammatory skin
skin repair
repair cream
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庄五法
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dermatology (AREA)
  • Zoology (AREA)
  • Communicable Diseases (AREA)
  • Animal Husbandry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses an antibacterial and anti-inflammatory skin repair cream which is prepared from the following raw materials, by weight, 80-100 parts of glycerol; 5-10 parts of beeswax; 10-20 parts of distilled water; 5-20 parts of bee products; 5-15 parts of chitin; 0.01-0.1 part of orange oil; 0.01-0.1 part of peppermint oil, and has the effects of resisting bacteria, diminishing inflammation and quickly repairing skin.

Description

Antibacterial and anti-inflammatory skin repair cream
Technical Field
The invention relates to the field of bacteriostat, in particular to an antibacterial and anti-inflammatory skin repair cream.
Background
When a small wound appears on a human body, the wound is not deep and the epidermis is abraded, bleeding generally appears, and the wound plaster is mostly selected to be pasted on the small wound to achieve the effect of wound healing, but particularly in summer, the small wound is easy to contact with common escherichia coli, staphylococcus aureus, mucor, streptococcus and proteus in life to cause inflammation.
As is known, plant essential oil has a bactericidal effect on many bacteria and a broad spectrum of bactericidal strains, but each essential oil has different degrees of bactericidal effect on each bacteria, and if a complete bactericidal effect is to be achieved, high-concentration essential oil is generally selected, but the high-concentration essential oil has an allergic phenomenon on skin without wounds, enters human blood and can cause damage to human nerves, so that the high-concentration plant essential oil is not suitable to be used as an antibacterial agent for bleeding wounds.
Meanwhile, the adhesive bandage is pasted on the small wound, a gap is formed between the skin and the small wound, so that bacteria in life easily enter the small wound, and secondary infection is easily caused.
Disclosure of Invention
The invention aims to solve the technical problems in the related art to a certain extent at least aiming at the defects in the prior art, and provides the antibacterial and anti-inflammatory skin repair cream so as to achieve the aims of obviously resisting bacteria and diminishing inflammation and quickly repairing skin.
The antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5-10 parts of glycerol; 2-5 parts of beeswax; 80-100 parts of distilled water; 0.5-2 parts of chitin; 0.01-0.1 part of orange oil; 0.01-0.1 part of peppermint oil.
Further, the antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5-10 parts of glycerol; 2-5 parts of beeswax; 80-100 parts of distilled water; 2-5 parts of bee products; 0.5-2 parts of chitin; 0.01-0.1 part of orange oil; 0.01-0.1 part of peppermint oil.
Further, the antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials in parts by weight, 5 parts of glycerol; 2 parts of beeswax; 80 parts of distilled water; 2 parts of bee products; 0.5 part of chitin; 0.01 part of orange oil; and 0.01 part of peppermint oil.
Further, the antibacterial and anti-inflammatory skin repair cream is prepared from 8 parts by weight of glycerol; 4 parts of beeswax; 90 parts of distilled water; 3 parts of bee products; 1 part of chitin; 0.05 part of orange oil; and 0.05 part of mint oil.
Further, the antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials in parts by weight, 10 parts of glycerol; 5 parts of beeswax; 100 parts of distilled water; 5 parts of bee products; 2 parts of chitin; 0.1 part of orange oil; and 0.1 part of peppermint oil.
Further, the bee product is one or more of honey, bee pollen, propolis and royal jelly.
The technical effects of the invention are mainly reflected in the following aspects: the repairing paste can almost completely kill common escherichia coli, staphylococcus aureus, mucor, streptococcus and proteus in life.
On the basis of preventing inflammation caused by bacterial infection, the chitin, bee products, the orange essential oil and the mint essential oil can play roles in relieving pain of small wounds, quickly repairing skin and the like.
Detailed Description
The following detailed description of the embodiments of the present invention is intended to be illustrative, but not limiting, of the invention so that the technical solutions of the invention may be more easily understood and appreciated.
Example 1
The antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5 parts of glycerol; 2 parts of beeswax; 80 parts of distilled water; 2 parts of bee pollen; 0.5 part of chitin; 0.01 part of orange oil; 0.01 part of peppermint oil, and preparing the repairing paste A.
Example 2
The antibacterial and anti-inflammatory skin repair cream is prepared from 8 parts by weight of glycerin; 4 parts of beeswax; 90 parts of distilled water; 3 parts of honey; 1 part of chitin; 0.05 part of orange oil; and 0.05 part of peppermint oil to prepare a repairing paste B.
Example 3
The antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 10 parts of glycerol; 5 parts of beeswax; 100 parts of distilled water; 5 parts of propolis; 2 parts of chitin; 0.1 part of orange oil; and 0.1 part of peppermint oil is prepared into a repairing paste C.
Example 4
The antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5 parts of glycerol; 2 parts of beeswax; 100 parts of distilled water; 2 parts of royal jelly; 2 parts of chitin; 0.1 part of orange oil; and 0.1 part of peppermint oil to prepare a repairing paste D.
Example 5
The antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 10 parts of glycerol; 5 parts of beeswax; 80 parts of distilled water; 5 parts of royal jelly; 0.5 part of chitin; 0.01 part of orange oil; and 0.01 part of peppermint oil to prepare a repairing paste E.
Example 6
The antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5 parts of glycerol; 2 parts of beeswax; 80 parts of distilled water; 2 parts of bee pollen; 0.01 part of orange oil; and 0.01 part of peppermint oil to prepare a repairing paste F.
Example 7
The antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5 parts of glycerol; 2 parts of beeswax; 80 parts of distilled water; 0.5 part of chitin; 0.01 part of orange oil; and 0.01 part of peppermint oil to prepare a repairing paste F.
Specifically, the sterilization rates of test strains escherichia coli, staphylococcus aureus, mucor, streptococcus and proteus are respectively measured according to a paper diffusion method for the repair pastes A to G.
Table 1 shows the determination of the bactericidal rate of the repairing pastes A to G on Escherichia coli, Staphylococcus aureus, Mucor, Streptococcus and Proteus
Figure BDA0003653519740000041
The bactericidal rate of bacteria which are easy to contact with wounds in life, such as escherichia coli, staphylococcus aureus, mucor, streptococcus, proteus and the like, is determined through the repairing pastes A to G, and the results are shown: the repairing paste A to the repairing paste E can almost completely kill escherichia coli, staphylococcus aureus, mucor, streptococcus and proteus; the bee products or the chitin which are lacked have unsatisfactory sterilization rate on escherichia coli, staphylococcus aureus, mucor, streptococcus and proteus and can not completely kill bacteria.
The repair cream prepared by the formula can effectively kill common bacteria in life and prevent inflammation, and has the effects of relieving pain, quickly repairing skin and the like on small wounds by using the chitin, the bee products, the orange essential oil and the mint essential oil on the basis of preventing inflammation caused by bacterial infection.
The repairing paste disclosed by the invention forms a protective film after being smeared, is attached to a small wound of the skin, prevents bacteria in life from entering the small wound, takes glycerin as a base, preserves moisture and locks water, prevents the protective film from being dried and cracked, is long in protective film aging, takes the beeswax for uniform dispersion, takes the beeswax as one of bee products, adopts natural components, has affinity to the skin, is free from rejection, can quickly form a film, and promotes wound healing.
The above are only typical examples of the present invention, and besides, the present invention may have other embodiments, and all the technical solutions formed by equivalent substitutions or equivalent changes are within the scope of the present invention as claimed.

Claims (6)

1. The antibacterial and anti-inflammatory skin repair cream is characterized in that: the antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5-10 parts of glycerol; 2-5 parts of beeswax; 80-100 parts of distilled water; 0.5-2 parts of chitin; 0.01-0.1 part of orange oil; 0.01-0.1 part of peppermint oil.
2. The antibacterial and anti-inflammatory skin repair cream according to claim 1, characterized in that: the antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5-10 parts of glycerol; 2-5 parts of beeswax; 80-100 parts of distilled water; 2-5 parts of bee products; 0.5-2 parts of chitin; 0.01-0.1 part of orange oil; 0.01-0.1 part of peppermint oil.
3. The antibacterial and anti-inflammatory skin repair cream according to claim 2, characterized in that: the antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 5 parts of glycerol; 2 parts of beeswax; 80 parts of distilled water; 2 parts of bee products; 0.5 part of chitin; 0.01 part of orange oil; and 0.01 part of peppermint oil.
4. The antibacterial and anti-inflammatory skin repair cream according to claim 2, characterized in that: the antibacterial and anti-inflammatory skin repair cream is prepared from 8 parts by weight of glycerol; 4 parts of beeswax; 90 parts of distilled water; 3 parts of bee products; 1 part of chitin; 0.05 part of orange oil; and 0.05 part of mint oil.
5. The antibacterial and anti-inflammatory skin repair cream according to claim 2, characterized in that: the antibacterial and anti-inflammatory skin repair cream is prepared from the following raw materials, by weight, 10 parts of glycerol; 5 parts of beeswax; 100 parts of distilled water; 5 parts of bee products; 2 parts of chitin; 0.1 part of orange oil; and 0.1 part of peppermint oil.
6. The antibacterial and anti-inflammatory skin repair cream according to claim 2, characterized in that: the bee product is one or more of Mel, bee pollen, propolis, and Lac Regis Apis.
CN202210558625.4A 2022-05-20 2022-05-20 Antibacterial and anti-inflammatory skin repair cream Pending CN114886960A (en)

Priority Applications (1)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110141627A (en) * 2019-05-16 2019-08-20 中南苑(深圳)药械研究有限公司 A kind of skin wound care composition, care agent and preparation method
CN114159353A (en) * 2022-01-07 2022-03-11 贵州省畜牧兽医研究所 Honeycomb nose moistening cream for repairing nasal mucosa and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110141627A (en) * 2019-05-16 2019-08-20 中南苑(深圳)药械研究有限公司 A kind of skin wound care composition, care agent and preparation method
CN114159353A (en) * 2022-01-07 2022-03-11 贵州省畜牧兽医研究所 Honeycomb nose moistening cream for repairing nasal mucosa and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
李炳辉 等: "甲壳素麻油蜂蜡膏促进糖尿病足创面愈合的研究进展" *

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