CN114870737A - Method for extracting medicament by metering any volume - Google Patents
Method for extracting medicament by metering any volume Download PDFInfo
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- CN114870737A CN114870737A CN202210538434.1A CN202210538434A CN114870737A CN 114870737 A CN114870737 A CN 114870737A CN 202210538434 A CN202210538434 A CN 202210538434A CN 114870737 A CN114870737 A CN 114870737A
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- 239000003814 drug Substances 0.000 title claims abstract description 125
- 238000000034 method Methods 0.000 title claims abstract description 30
- 238000003860 storage Methods 0.000 claims abstract description 99
- 239000007788 liquid Substances 0.000 claims abstract description 59
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 38
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 21
- 239000000284 extract Substances 0.000 claims abstract description 3
- 238000000605 extraction Methods 0.000 claims description 17
- 238000001514 detection method Methods 0.000 claims description 15
- 238000004140 cleaning Methods 0.000 claims description 14
- 239000011521 glass Substances 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 7
- 238000012864 cross contamination Methods 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 27
- 229940079593 drug Drugs 0.000 description 13
- 230000008569 process Effects 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000009471 action Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000005086 pumping Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000010009 beating Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 238000003889 chemical engineering Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000013062 quality control Sample Substances 0.000 description 1
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Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/7176—Feed mechanisms characterised by the means for feeding the components to the mixer using pumps
- B01F35/717611—Peristaltic pumps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
- B01F35/211—Measuring of the operational parameters
- B01F35/2112—Level of material in a container or the position or shape of the upper surface of the material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
- G01F22/00—Methods or apparatus for measuring volume of fluids or fluent solid material, not otherwise provided for
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Fluid Mechanics (AREA)
- General Physics & Mathematics (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention relates to a method for metering and extracting any volume of a medicament, which uses a system for metering and extracting any volume of the medicament, wherein the system for metering and extracting any volume of the medicament comprises a controller, a peristaltic pump, a temporary storage device, a multi-channel electromagnetic valve group and a liquid discharge valve, the control end and the feedback end of the peristaltic pump, the temporary storage device, the multi-channel electromagnetic valve group and the control end and the feedback end of the liquid discharge valve are all connected with the controller and are controlled by the controller, a plurality of medicaments are connected with the temporary storage device through the multi-channel electromagnetic valve group, the peristaltic pump is connected with a negative pressure air hole of the temporary storage device and is used for extracting the medicaments, the temporary storage device is also connected with the liquid discharge valve, and the other end of the liquid discharge valve is a medicament output port, wherein the controller respectively meters and extracts each reagent in response to a user request and sends out the reagent through the liquid discharge valve. This application requires lowly to the pump line, and the cost is with low costs, and the measurement volume is controllable, can realize the switching measurement of multichannel, and the cross contamination between the medicament is little simultaneously, the operation of being convenient for.
Description
Technical Field
The invention relates to the technical field of chemistry and chemical engineering, in particular to a method for metering and extracting any volume of a medicament.
Background
In the process of preparing and processing chemical agents, the operations of transferring, diluting, mixing and the like are required to be carried out on the agents, but the agents are relatively troublesome to extract, and the traditional equipment for extracting the agents mainly comprises a plunger pump and a peristaltic pump, and the two equipment have advantages and disadvantages respectively. For example, the stroke of a piston of the plunger pump is in a direct proportion relation with the metering volume, but the metering can be accurately carried out only after the pipeline is filled in advance, so that the plunger pump is not suitable for multi-channel switching, a sample enters the interior of a pump body, and a pump made of special materials is needed for metering highly corrosive liquid; the rotation angle of the peristaltic pump is in direct proportion to the metering volume, but the resilience performance of the pump pipe can be gradually reduced along with the use duration, the pump pipe is required to be calibrated and adjusted frequently, and in addition, the pump pipe made of special materials is also required for metering highly corrosive liquid. In conclusion, the existing medicament extraction equipment is not only troublesome in quantitative extraction, but also needs to be cleaned for multiple times after extraction, so that the mutual pollution among different medicaments is prevented, the operation is complex, the time is wasted, and the controllability of the medicament quantity during extraction is poor, and a large error is usually caused with the required value.
Disclosure of Invention
The invention aims to provide a method for metering and extracting any volume of a medicament, which has low requirement on a pump pipe, low manufacturing cost, controllable metering volume, capability of realizing multi-channel switching metering, small cross contamination among medicaments and convenience in operation.
In order to achieve the purpose, the invention adopts the technical scheme that:
the invention provides a method for metering and extracting any volume of a medicament, which uses a system for metering and extracting any volume of the medicament, wherein the system for metering and extracting any volume of the medicament comprises a controller, a peristaltic pump, a temporary storage device, a multi-channel electromagnetic valve group and a liquid discharge valve, the control end and the feedback end of the peristaltic pump, the temporary storage device, the multi-channel electromagnetic valve group and the control end and the feedback end of the liquid discharge valve are all connected into the controller and controlled by the controller, a plurality of medicaments are connected into the temporary storage device through the multi-channel electromagnetic valve group, the peristaltic pump is connected with a negative pressure air hole of the temporary storage device and used for extracting the medicaments, the temporary storage device is also connected with the liquid discharge valve, and the other end of the liquid discharge valve is a medicament output port, wherein the controller responds to a user request to respectively meter and extract each reagent and sends out the reagent through the liquid discharge valve.
For the above technical solution, the applicant has further optimization measures.
Optionally, the temporary storage device comprises a temporary storage tube, a motor, a screw sliding table and a photoelectric detector, the temporary storage pipe is connected with the multi-channel electromagnetic valve group through a main passage pipe and is also connected with the drain valve, the negative pressure air hole of the temporary storage tube is connected with the peristaltic pump, the screw rod sliding table is arranged in parallel with the length direction of the temporary storage tube, the photoelectric detector is fixed on the screw rod sliding table, the detection end of the photoelectric detector is arranged corresponding to the inner cavity of the temporary storage tube, the photoelectric detector is used for sensing and detecting the liquid level of the medicament in the temporary storage tube, the motor drives the screw rod sliding table to act and drives the photoelectric detector to translate along the length direction of the temporary storage tube, the photoelectric detector adjusts the position of the photoelectric detector according to an input instruction, and different positions of the photoelectric detector along the temporary storage tube correspond to different volumes of medicine extraction.
Further, the lead screw slip table includes lead screw and drive block, the lead screw is on a parallel with the length direction setting of pipe of keeping in, be provided with in the drive block with lead screw complex revolute pair, the outside end of lead screw with the motor links to each other, photoelectric detector fixes on the drive block.
Furthermore, the upper limit position and the lower limit position are respectively arranged on the upper part and the lower part of the screw rod, and an upper limit position switch and a lower limit position switch are respectively arranged at the upper limit position and the lower limit position.
Optionally, the photoelectric detector adopts a U-groove type photoelectric sensor having a U-shaped detection head, the temporary storage tube is clamped between the U-shaped detection heads of the photoelectric detector, and the photoelectric detector detects the medicament liquid level in the temporary storage tube by beating.
Further, the temporary storage tube is vertically arranged and is a transparent glass tube.
Optionally, a tee joint is connected to the main passage pipe, two ports of the tee joint are connected to the main passage pipe, and a bypass outlet is connected to the drain valve through a bypass branch pipe.
Further, an upper limit position and a lower limit position are respectively arranged on the upper portion and the lower portion of the screw rod, the volume of the medicament corresponding to the lower limit position in the controller is configured to be the sum of the volume in the temporary storage tube corresponding to the lower limit position in the tube and the volume in the temporary storage tube and the three-way connecting tube, and correspondingly, the volume of the medicament corresponding to the upper limit position in the controller is configured to be the sum of the volume in the temporary storage tube corresponding to the upper limit position in the tube and the volume in the temporary storage tube and the three-way connecting tube.
Optionally, the multi-channel solenoid valve set includes a plurality of sample valves respectively connected to the main channel pipe, a liquid inlet of each sample valve is connected to a reagent source, a control end of each reagent valve is connected to the controller, and the corresponding reagent valve is opened according to a configuration input at the controller to extract the reagent.
Optionally, the tail end of the main passage pipe is connected with a cleaning liquid valve.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:
the application discloses method is extracted to arbitrary volume measurement of medicament, it adopts peristaltic pump cooperation temporary storage device to carry out the extraction of medicament, send out again after the medicament ration is extracted, perhaps accomplish the ratio in the temporary storage device again and mix or dilute, the peristaltic pump only makes and has the negative pressure cavity in the temporary storage device with the pumped air at this in-process, thereby absorb the sample medicament, the peristaltic pump does not contact with sample medicament direct contact at this in-process, therefore even corrosive medicament also need not too high to the pump line requirement of peristaltic pump, make the overall arrangement lower to the material requirement of pump line.
Furthermore, the control of the volume of the medicament is realized by arranging a temporary storage device for monitoring the liquid level of a glass intelligent temporary storage tube, adjusting the position of a photoelectric detector in advance according to the set medicament amount, and then extracting the medicament until reaching the detection position of the photoelectric detector to finish quantitative extraction of the medicament, namely the metered volume of the medicament is determined by the absolute position of the photoelectric detector and is unrelated to the performance of a pump tube, so that the accuracy of medicament extraction is improved.
In addition, the multichannel electromagnetism valves that designs can satisfy the switching measurement of many sample passageways, also can satisfy the mixture or the dilution of different volume medicaments, and the sample is convenient, and operating efficiency is high, and can effectively avoid the pollution between the medicament.
Drawings
Some specific embodiments of the invention will be described in detail hereinafter, by way of illustration and not limitation, with reference to the accompanying drawings. The same reference numbers in the drawings identify the same or similar elements or components. Those skilled in the art will appreciate that the drawings are not necessarily drawn to scale. In the drawings:
FIG. 1 is a schematic diagram of the apparatus configuration for a method of arbitrary volumetric metered withdrawal of a medicament according to one embodiment of the present invention;
FIG. 2 is a schematic diagram of a temporary storage device according to the method of extracting a medicament by any volume measurement shown in FIG. 1;
FIG. 3 is a schematic diagram of an arrangement of photodetectors and buffer tubes in a buffer device according to an embodiment of the present invention;
FIG. 4 is a schematic view of an arrangement structure of a photodetector and a buffer tube in a buffer device according to another embodiment of the invention.
The reference numbers are as follows:
1. a peristaltic pump;
2. the temporary storage device comprises a temporary storage device 21, a temporary storage tube 22, a motor 23, a lead screw sliding table 231, a lead screw 232, a driving block 233, an upper limit position 234, a lower limit position 24, a photoelectric detector 241 and a detection head;
3. a multi-channel electromagnetic valve bank;
4. a main passage pipe;
5. a tee joint;
6. a bypass branch pipe;
a. b, c and d are sample valves, e is a cleaning solution valve, f and a drain valve.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
The embodiment describes a method for metering and extracting any volume of a medicament, and uses a system for metering and extracting any volume of a medicament, as shown in fig. 1, the system for metering and extracting any volume of a medicament comprises a controller, a peristaltic pump 1, a temporary storage device 2, a multi-channel electromagnetic valve group 3 and a liquid discharge valve f, control ends and feedback ends of the peristaltic pump 1, the temporary storage device 2, the multi-channel electromagnetic valve group 3 and the liquid discharge valve f are all connected to and controlled by the controller, the controller is an external control device, and is in electric control connection with the peristaltic pump 1, the temporary storage device 2, the multi-channel electromagnetic valve group 3 and the liquid discharge valve f, which is not shown in fig. 1. The multi-drug is connected to the temporary storage device 2 through the multi-channel electromagnetic valve group 3, the peristaltic pump 1 is connected with a negative pressure air hole of the temporary storage device 2 and used for pumping drugs, the temporary storage device 2 is further connected with a liquid discharge valve f, the other end of the liquid discharge valve f is a drug output port, and the controller responds to user requests to respectively meter and pump each reagent and sends out the reagent through the liquid discharge valve f.
It can be understood that, in the method, the peristaltic pump 1 is matched with the temporary storage device 2 to extract the medicament, the medicament is quantitatively extracted and then sent out, or the temporary storage device 2 is used for completing proportioning mixing or dilution, in the process, the peristaltic pump 1 only uses pumped air to enable a negative pressure cavity to exist in the temporary storage device 2, so that the sample medicament is absorbed, in the process, the peristaltic pump 1 is not in direct contact with the sample medicament, therefore, even corrosive medicament does not need to have too high requirement on a pump pipe of the peristaltic pump 1, and the requirement on the material of the pump pipe by the whole device is lower.
Specifically speaking, the temporary storage device 2 includes a temporary storage tube 21, a motor 22, a lead screw sliding table 23 and a photoelectric detector 24, the temporary storage tube 21 is vertically arranged, just the temporary storage tube 21 is a transparent glass tube, the bottom liquid inlet and outlet of the temporary storage tube 21 is connected with the multichannel electromagnetic valve group 3 through a main passage tube 4, the temporary storage tube 21 is further connected with a drain valve f, the top of the temporary storage tube 21 is provided with a through hole as a negative pressure air hole, the negative pressure air hole is connected with the peristaltic pump 1 through a gas tube, the lead screw sliding table 23 is parallel to the length direction of the temporary storage tube 21, the photoelectric detector 24 is fixed on the lead screw sliding table 23, the detection end of the photoelectric detector 24 corresponds to the inner cavity of the temporary storage tube 21, the photoelectric detector 24 is used for sensing and detecting the liquid level of the medicament in the temporary storage tube 21, the motor 22 drives the lead screw sliding table 23 to act, The photoelectric detector 24 is driven to translate along the length direction of the temporary storage tube 21, the position of the photoelectric detector 24 is adjusted by the photoelectric detector 24 according to an input instruction, and different positions of the photoelectric detector 24 along the temporary storage tube 21 correspond to the extraction of the medicaments with different volumes.
Lead screw slip table 23 includes lead screw 231 and drive block 232, lead screw 231 is on a parallel with the length direction setting of the pipe 21 of keeping in, be provided with in the drive block 232 with lead screw 231 complex revolute pair, the revolute pair is fixed in the drive block 232, lead screw 231 passes the revolute pair, the outside end of lead screw 231 with motor 22 links to each other, and lead screw 231 rotates under the drive of outside motor 22 to drive block 232 rectilinear movement, photodetector 24 fixes on the drive block 232. The motor 22 is a stepping motor 22 or a servo motor 22 which can precisely move.
For the control of medicament volume, the temporary storage device 2 is provided with a glass temporary storage tube 21 for liquid level monitoring, the position of a photoelectric detector 24 is adjusted in advance according to the set medicament amount, then the medicament is extracted until the medicament reaches the detection position of the photoelectric detector 24, and the quantitative extraction of the medicament can be completed, namely the metering volume of the medicament is determined by the absolute position of photoelectric detection and is unrelated to the performance of a pump tube, and the accuracy of medicament extraction is improved.
The upper limit 233 and the lower limit 234 are respectively arranged above and below the screw rod 231, and the upper limit 233 and the lower limit 234 are respectively provided with an upper limit 233 position switch and a lower limit 234 position switch. The setting of the upper limit 234 and the lower limit 234 can realize the control of the safety and the stability of the detection process, and the accuracy of the medicine taking and metering is ensured while the device is prevented from being damaged.
In the process of extracting the medicament, the medicament amount in the main passage pipe 4 and the bypass branch pipe 6 is often neglected, which causes deviation, usually more, in the taking of the medicament, because the extracted medicament is discharged, the medicament in the connecting pipe between the temporary storage pipe 21 and the liquid discharge valve f is inevitably discharged together, which causes the error of the medicament amount, which also affects the final test or the inaccurate production result, and therefore the medicament amount of the part needs to be considered therein.
The upper limit 233 and the lower limit 234 are respectively arranged on the upper part and the lower part of the screw rod 231, and the volume of the medicament corresponding to the lower limit 234 in the controller is configured to be the tube volume V corresponding to the lower limit 234 in the temporary storage tube 21 Pipe min And the inner volume V of the connection pipe between the temporary storage pipe 21 and the liquid discharge valve f Redundancy In addition, the volume of the medicament corresponding to the upper limit 233 in the controller is configured to be the tube internal volume V corresponding to the upper limit 233 in the temporary storage tube 21 Pipe max And the inner volume V of the connection pipe between the temporary storage pipe 21 and the liquid discharge valve f Redundancy And (4) summing.
The main passage pipe 4 is connected with a tee joint 5, two ports of the tee joint 5 are connected with the main passage pipe 4, and a bypass outlet is connected with the liquid discharge valve f through a bypass branch pipe 6. The inner volume V of the connection pipe between the temporary storage pipe 21 and the liquid discharge valve f Redundancy The main volume is the amount of the medicament in the main passage pipe 4 from the liquid inlet and outlet at the bottom of the temporary storage pipe 21 to the tee joint 5. The dosage of the medicine can be calculated by early debugging of the device, and the value V is calculated Redundancy And the controller is loaded with calculation to ensure the accuracy of the extracted medicament quantity. In practice, the solution of the method is applied relatively speaking to the medicament in the bypass branch 6 between the three-way valve 5 and the drain valve fThe amount is relatively small because during the drawing of the medicament the pressure in the bypass branch 6 does not change, i.e. there is very little medicament entering the bypass branch, and the amount of this part of the medicament is normally ignored, and can be set in the controller, irrespective of the metered volume, as the case may be, and considered by the user's requirements, or the amount of the minor amount of medicament in the bypass branch 6 between the three-way 5 and the discharge valve f.
The algorithm configured in the controller will V Redundancy Calculated within, the medicine which can be measured is (V) Pipe min +V Redundancy ) To (V) Pipe max +V Redundancy ) Any volume in between. The buffer tube 21 is arranged parallel to the lead screw 231, and the upper limit 233 and the lower limit 234 of the lead screw 231 are arranged corresponding to the buffer tube 21, that is, the upper limit 233 and the lower limit 234 of the lead screw 231 do not exceed the height of the bottom surface and the top surface of the buffer tube 21, which is understandable in order to ensure the normal operation of the device. The temporary storage tube 21 in the device is a regular cylindrical tube with a constant cross-sectional area S, so that the final volume of the extracted medicament can be adjusted by adjusting the position of the driving block 232, i.e. the height of the photodetector 24. As shown in fig. 2, the photo detector 24 is located at a height H from the bottom of the buffer tube 21, when the medicine is pumped to the position of the photo detector 24, the pumping is stopped, and then the medicine is discharged, so that the volume of the discharged medicine is (S × H + V) Redundancy ). From this relationship, it can be understood that the cross-sectional area S of the temporary storage tube 21 is constant, and the inner volume V of the connection pipe between the temporary storage tube 21 and the tee 5 is constant Redundancy It is also certain that the linear change of the height H of the photo detector 24 can be converted into the control of the volume of the extracted medicament, and the precise adjustment of the medicament amount can be realized by adjusting the height H of the photo detector 24, and the position adjustment of the photo detector 24 is performed by the motor 22 capable of precisely controlling the linear stroke, the photo detector 24 takes the following limit 234 as the initial position at each measurement, the motor 22 adjusts the height H of the photo detector 24 according to the controller command and algorithm, and the formula of the height H is:
H=（V’-V redundancy ) and/S, wherein V' is the volume of the medicament to be extracted.
If the vertical height from the lower limit 234 of the lead screw 231 to the bottom surface of the temporary storage tube 21 is H, the controller controls the stroke L of the motor 22 to be L = H-H.
In a preferred embodiment, the photo detector 24 is a U-shaped slot type photo sensor, and has a U-shaped detection head 241, the buffer tube 21 is clamped between the U-shaped detection heads 241 of the photo detector 24, and the photo detector 24 detects the liquid level of the medicine in the buffer tube 21.
Two ways are provided for the position between the U-groove type photoelectric sensor and the temporary storage tube 21.
Firstly as shown in fig. 3, the light path on the detecting head 241 is perpendicular to the central axis of the glass tube, and the light path is deviated from the central axis to a certain position, the liquid in the temporary storage tube 21 can deflect the light to receive the light, and the light received by the groove-shaped photoelectric detector 24 is greatly weakened, indicating that the temporary storage tube 21 contains liquid. When liquid is detected, the U-groove type photoelectric sensor sends a control instruction to stop the positive pumping action of the peristaltic pump 1.
In addition, as shown in fig. 4, the light path on the detection head 241 is perpendicular to the central axis of the glass tube, and the light path passes through the central axis, that is, the light path passes through the central line of the temporary storage tube 21, and the refraction of the liquid in the temporary storage tube 21 to the light can focus on the received light. When the light received by the groove-type photodetector 24 is greatly increased, it indicates that there is liquid in the glass tube. When liquid is detected, the U-groove type photoelectric sensor sends a control instruction to stop the positive pumping action of the peristaltic pump 1.
Optionally, the multi-channel solenoid valve set 3 includes a plurality of sample valves respectively connected to the main channel pipe 4, a liquid inlet of each sample valve is connected to a reagent source, a control end of each reagent valve is connected to the controller, and the corresponding reagent valve is opened according to the configuration input at the controller to extract the reagent. The multichannel electromagnetism valves 3 that design can satisfy the switching measurement of many sample passageways, also can satisfy the mixture or the dilution of different volume medicaments, and the sample is convenient, and operating efficiency is high, and can effectively avoid the pollution between the medicament.
In addition, the tail end of the main channel pipe 4 can be connected with a cleaning liquid valve e. The cleaning liquid valve e is arranged to discharge the chemicals from the three-way pipe 5 to the main passage pipe 4 of the cleaning liquid valve e after the chemicals are quantitatively discharged, and even to suck water or cleaning liquid to clean the main passage pipe 4 and even the interior of the temporary storage pipe 21 and discharge the chemicals from the cleaning liquid valve e.
Taking the structure shown in fig. 1 as an example, a, b, c, d, e, and f are all electromagnetic valves that can be controlled electromagnetically, wherein, regarding to the function, a, b, c, and d are sample valves for controlling the type of sample drug to be inhaled, and an inlet of each sample valve is connected with a drug, a cleaning solution, or water, respectively, it should be noted that, according to the user requirement, the multi-channel electromagnetic valve set 3 can add channels according to the specific use requirement, that is, add reagent valves for providing more channels that can be controlled to open and close; e is a cleaning liquid valve for discharging the remaining liquid in the main passage pipe 4 after the extraction and discharge of the chemical; f is a drain valve for extracting a predetermined amount of the drug and then discharging the drug from an outlet of the drain valve f.
When the metering and extracting device is started, initial calibration is firstly carried out, the motor 22 operates to drive the screw rod 231 to rotate so as to move the driving block 232 to the lower limit position 234 to wait, and a, b, c, d, e and f are all in a closed state. The type B and volume V' of the medicine to be extracted are input to the controller through an input device such as a peripheral control panel or a touch display, and after the controller receives an instruction, the controller controls the motor 22 to act, the position of the photoelectric detector 24 is controlled through stroke control of the motor 22, and the driving block 232 drives the photoelectric detector 24 to reach a preset position under the driving of the screw rod 231. Then, the controller only opens the sample valve B corresponding to the drug type B, the peristaltic pump 1 acts, the peristaltic pump 1 rotates clockwise slowly, negative pressure is generated in the temporary storage tube 21, the drug B enters the temporary storage tube 21 from the sample valve B, but light rays change when the liquid level of the drug B passes through the light path of the photoelectric detector 24, the photoelectric detector 24 sends a feedback instruction to the controller, and the controller stops the action of the peristaltic pump 1 and closes the sample valve B. Then, the metered medicament B starts to be sent out, the drain valve f is opened, the peristaltic pump 1 rotates anticlockwise, the metered medicament B is discharged from the outlet of the drain valve f and transferred to an output sample tube until no medicament is discharged completely, and the operation of the peristaltic pump 1 is stopped. As can be seen from FIG. 1, the total amount of the transferred medicine B is the medicine in the temporary storage tube 21, the medicine in the main passage tube 4 between the liquid inlet and outlet at the bottom of the temporary storage tube 21 and the tee joint 5, and the medicine in the bypass branch tube 6 between the tee joint 5 and the liquid discharge valve. After the discharge of the chemical B is completed, the drain valve f is closed, and only the cleaning solution valve e is opened, so that the peristaltic pump 1 rotates counterclockwise, and all the remaining chemical in the main channel tube 4 is discharged. If necessary, the sample valve corresponding to the cleaning liquid or water may be opened to extract and discharge the cleaning liquid or water by the reciprocating action of the peristaltic pump 1, thereby completing the cleaning process for the main passage tube 4, the bypass branch tube 6, and even the buffer tube 21.
In addition, in order to prevent the extracted drug remaining at its sample valve from affecting the main access tube 4, after each drug extraction is completed, the sample valve for metered extraction may also be opened, the peristaltic pump 1 rotated counterclockwise so that the drug is slightly pressed back through the sample valve, and then the peristaltic pump 1 is stopped and the sample valve closed.
Based on the above medicament extraction, the medicament can be automatically extracted, automatically diluted, the labeled sample medicament is recycled and mixed, and the quality control sample can be automatically configured.
The above embodiments are merely illustrative of the technical concept and features of the present invention, and the purpose thereof is to enable those skilled in the art to understand the content of the present invention and implement the invention, and not to limit the scope of the invention, and all equivalent changes or modifications made according to the spirit of the present invention should be covered by the scope of the present invention.
Claims (10)
1. The method is characterized in that a system for metering and extracting the arbitrary volume of the medicament is used, the system for metering and extracting the arbitrary volume of the medicament comprises a controller, a peristaltic pump, a temporary storage device, a multi-channel electromagnetic valve set and a liquid discharge valve, the control end and the feedback end of the peristaltic pump, the temporary storage device, the multi-channel electromagnetic valve set and the liquid discharge valve are all connected to the controller and controlled by the controller, a plurality of medicaments are connected to the temporary storage device through the multi-channel electromagnetic valve set, the peristaltic pump is connected with a negative pressure air hole of the temporary storage device and used for extracting the medicaments, the temporary storage device is further connected with the liquid discharge valve, and the other end of the liquid discharge valve is a medicament output port, wherein the controller responds to a user request to respectively meter and extract each reagent and sends out the reagent through the liquid discharge valve.
2. The method according to claim 1, wherein the temporary storage device comprises a temporary storage tube, a motor, a lead screw sliding table and a photoelectric detector, the temporary storage tube is connected with the multi-channel electromagnetic valve set through a main passage tube, the temporary storage tube is further connected with the drain valve, a negative pressure air hole of the temporary storage tube is connected with the peristaltic pump, the lead screw sliding table is arranged in parallel with the length direction of the temporary storage tube, the photoelectric detector is fixed on the lead screw sliding table, the detection end of the photoelectric detector is arranged corresponding to the inner cavity of the temporary storage tube, the photoelectric detector is used for sensing and detecting the liquid level of the medicament in the temporary storage tube, the motor drives the lead screw sliding table to move and drive the photoelectric detector to translate along the length direction of the temporary storage tube, and the photoelectric detector adjusts the position of the photoelectric detector according to an input instruction, the different positions of the photoelectric detector along the temporary storage tube correspond to different volumes of medicament extraction.
3. A method as claimed in claim 2, wherein the lead screw sliding table includes a lead screw and a driving block, the lead screw is disposed parallel to the length direction of the temporary storage tube, a rotating pair engaged with the lead screw is disposed in the driving block, the outer end of the lead screw is connected to the motor, and the photodetector is fixed on the driving block.
4. A method according to claim 3, wherein the screw rod is provided with an upper limit position and a lower limit position at the upper and lower ends thereof, and an upper limit position switch and a lower limit position switch are provided at the upper limit position and the lower limit position, respectively.
5. A method as claimed in claim 2, wherein the photo detector is a U-shaped photo sensor having U-shaped detection heads, the buffer tube is clamped between the U-shaped detection heads of the photo detector, and the photo detector detects the level of the medicament in the buffer tube.
6. A method of any volume metered dose withdrawal of a medicament as claimed in any one of claims 2 to 5, wherein the buffer tube is arranged vertically and is a transparent glass tube.
7. A method as claimed in claim 6, wherein the main conduit is connected to a tee, two ports of the tee are connected to the main conduit, and the bypass outlet is connected to the drain valve via a bypass branch.
8. The method for extracting any volume of medicament by metering according to claim 7, wherein an upper limit position and a lower limit position are respectively arranged on the upper part and the lower part of a screw rod of the screw rod sliding table, the medicament volume corresponding to the lower limit position in the controller is configured to be the sum of the inner volume corresponding to the lower limit position in the temporary storage tube and the inner volume of the temporary storage tube and the connecting pipe between the three ways, and correspondingly, the medicament volume corresponding to the upper limit position in the controller is configured to be the sum of the inner volume corresponding to the upper limit position in the temporary storage tube and the inner volume of the temporary storage tube and the connecting pipe between the three ways.
9. A method according to claim 1, wherein the multi-channel solenoid valve set comprises a plurality of sample valves connected to the main channel pipe, a liquid inlet of each sample valve is connected to a reagent source, a control end of each reagent valve is connected to the controller, and the reagent valve is opened according to the configuration inputted by the controller for reagent extraction.
10. A method of any volume metered dose withdrawal of a medicament as claimed in claim 2 wherein the trailing end of the main pathway tube is connected to a cleaning fluid valve.
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| CN202210538434.1A CN114870737A (en) | 2022-05-18 | 2022-05-18 | Method for extracting medicament by metering any volume |
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| CN202210538434.1A CN114870737A (en) | 2022-05-18 | 2022-05-18 | Method for extracting medicament by metering any volume |
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Application publication date: 20220809 |