CN114869816A - Purslane extract composition - Google Patents
Purslane extract composition Download PDFInfo
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- CN114869816A CN114869816A CN202210497839.5A CN202210497839A CN114869816A CN 114869816 A CN114869816 A CN 114869816A CN 202210497839 A CN202210497839 A CN 202210497839A CN 114869816 A CN114869816 A CN 114869816A
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- purslane
- oily
- asparagus
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- 229940064064 purslane extract Drugs 0.000 title claims abstract description 29
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 239000000284 extract Substances 0.000 claims abstract description 31
- 235000005340 Asparagus officinalis Nutrition 0.000 claims abstract description 28
- 230000037317 transdermal delivery Effects 0.000 claims abstract description 11
- 241000234427 Asparagus Species 0.000 claims description 26
- 238000000605 extraction Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 3
- 239000002904 solvent Substances 0.000 claims description 2
- 230000001476 alcoholic effect Effects 0.000 claims 2
- 239000012675 alcoholic extract Substances 0.000 claims 1
- 239000006286 aqueous extract Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 244000003416 Asparagus officinalis Species 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 23
- 235000001855 Portulaca oleracea Nutrition 0.000 description 18
- 241000219304 Portulacaceae Species 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
- 238000009792 diffusion process Methods 0.000 description 6
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 5
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 5
- 239000012530 fluid Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 239000003208 petroleum Substances 0.000 description 4
- YLLIGHVCTUPGEH-UHFFFAOYSA-M potassium;ethanol;hydroxide Chemical compound [OH-].[K+].CCO YLLIGHVCTUPGEH-UHFFFAOYSA-M 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 2
- 244000234609 Portulaca oleracea Species 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000010779 crude oil Substances 0.000 description 2
- 239000002612 dispersion medium Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 235000020665 omega-6 fatty acid Nutrition 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- UCTWMZQNUQWSLP-UHFFFAOYSA-N Adrenaline Natural products CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000234280 Liliaceae Species 0.000 description 1
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical class CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 229940102884 adrenalin Drugs 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 229940097217 cardiac glycoside Drugs 0.000 description 1
- 239000002368 cardiac glycoside Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000008588 hemolysis Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- -1 saponin compounds Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229930002534 steroid glycoside Natural products 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention relates to a composition containing an oily purslane extract, which is applied to the field of percutaneous absorption medicines or cosmetics, and the transdermal delivery property of the oily purslane extract is effectively improved by adding asparagus extract components.
Description
Technical Field
The invention relates to a composition containing purslane extract, which is applied to the field of percutaneous absorption medicines or cosmetics, and the effective component has higher transdermal delivery.
Background
Purslane (Portulaca oleracea L), which is a Portulacaceae plant, is a traditional Chinese medicine in China, has the effects of dissipating blood, reducing swelling, clearing heat and removing toxicity, and is one of 78 wild plants with homology of medicine and food specified by Ministry of health in China. The whole herb of purslane contains rich adrenalin, flavone, cardiac glycoside and other substances, and research results show that: the seeds and leaves of the purslane contain rich unsaturated fatty acids, such as omega-3 and 6 fatty acids, the omega-3 and 6 fatty acids can effectively reduce the production of arachidonic acid, and the unsaturated fatty acids are important anti-inflammatory components in human bodies, particularly skins.
In recent years, skin care products mainly comprising natural ingredients and plant ingredients are gradually noticed and favored, and new skin care products comprising natural ingredients are continuously developed to achieve better skin care effects, so that the skin care products become an important research subject in the field at present. The use of skin care products is not limited to the field of simple skin care at present, but also extends to the field of adjuvant therapy of certain skin diseases.
For skin care products and medicines, the percutaneous absorption rate of active ingredients is an important product index, unsaturated fatty acids such as omega-3 fatty acid and the like contained in purslane are fat-soluble oily substances which are generally difficult to transport transdermally and are easy to wash away after remaining on the surface of the skin after use. Thus, there is a need to enhance the effect of transdermal delivery of oily purslane extracts.
Asparagus (Asparagus officinalis linn), academic name Asparagus, bamboo shoot, etc., is a perennial herb plant of Asparagus of Liliaceae. The asparagus is a health-care vegetable with excellent quality and rich nutrition, contains amino acids, mineral substances and other various nutrient elements which are indispensable to human bodies, and also contains various active ingredients such as saponin compounds, flavonoids and the like. The asparagus extract has various pharmacological activities such as hemolysis, cholesterol reduction, anti-inflammation and tumor inhibition, and researches show that the asparagus extract has anticancer and antibacterial effects.
Disclosure of Invention
The invention discovers that the asparagus extract can obviously improve the transdermal delivery rate of the oily purslane extract containing the unsaturated fatty acid active ingredient, thereby improving the application prospect and value of the oily purslane extract in the fields of cosmetics and medicines by percutaneous absorption.
The invention provides a method for improving transdermal delivery rate of an oily purslane extract, which is characterized in that the oily purslane extract is mixed with an asparagus extract or a solution containing the asparagus extract.
The invention further provides a composition containing the purslane extract, which is characterized by comprising the oily purslane extract and the asparagus extract, and the composition has an improved transdermal delivery rate of the oily purslane extract.
The oily purslane extract is prepared by lipophilic solvents such as: diethyl ether, ethyl acetate, propane, butane fluids and supercritical CO 2 Fluid extraction is carried out.
The asparagus extract is alcohol or water or alcohol/water extract.
The asparagus extract is present in the form of a solution.
The concentration of the asparagus extract solution is 10-20 mg/ml.
The present invention advantageously and surprisingly eliminates or reduces the disadvantages of poor transdermal delivery of existing oily purslane extracts. In particular, an alcohol or water or alcohol/water extract of asparagus is used as a dispersion medium to enhance transdermal delivery of the oily purslane extract and to enhance transdermal delivery of a composition comprising a dispersion of the oily purslane extract. The dispersion medium of the present invention is formed of natural products and can even be edible.
Detailed Description
The invention is further illustrated by the following examples, which are not intended to limit the scope of the invention. The experimental methods without specifying specific conditions in the following examples were selected according to the conventional methods and conditions, or according to the commercial instructions.
Example 1
Preparation method of oily herba Portulacae extract containing unsaturated fatty acid
Fresh purslane and drinking water are used as main raw materials, the fresh purslane is selected, cleaned and cut up, water is added according to the weight ratio of 1:3 for soaking for 12 hours, the purslane is decocted for 6 hours at 80 ℃, and filtration is carried out to obtain purslane residues.
Extracting purslane residues by using a subcritical isobutane extraction technology, extracting an oily purslane extract: the subcritical fluid extraction process is set under the conditions that the extraction pressure is 0.8MPa, the extraction temperature is 40 ℃, extraction is carried out for 150min, purslane oil-immersed paste is obtained, after three times of extraction, the purslane oil-immersed paste obtained each time is combined, and the crude oil purslane extract is prepared after centrifugation at 4000r/min for 15min and filtration.
Mixing the crude oil purslane extract with 0.5mol/L KOH-ethanol solution according to the weight ratio of 1: 20, mixing, then placing in a water bath at 75 ℃, stirring and refluxing for 120min to obtain a saponified solution; adding ice distilled water equivalent to 0.5mol/L KOH-ethanol solution for quick cooling, extracting saponified substance with petroleum ether equivalent to 0.5mol/L KOH-ethanol solution for multiple times, taking a water layer, adding water for dilution twice, slowly adding 10% HCl, adjusting pH to 2-3, and immediately extracting mixed fatty acid with petroleum ether equivalent to 0.5mol/L KOH-ethanol solution for multiple times to obtain a petroleum ether layer through a separating funnel; washing the petroleum ether layer with 5% NaCl solution to neutral, drying with anhydrous sodium sulfate, filtering, and rotary evaporating to obtain purified oily herba Portulacae extract with light yellow color.
Example 2
Preparation method of Germinatus Phragmitis extract
(1) Drying and pulverizing Germinatus Phragmitis, sieving with 10-40 mesh sieve, adding 70% ethanol at solid/liquid ratio of 1: 5-1: 20(W/V), and ultrasonic treating at power of 20-800W/cm 2 Extracting at 20-60 deg.C for 40 min, performing liquid-solid separation to obtain extractive solution of Germinatus Phragmitis, and distilling the extractive solution under reduced pressure to recover ethanol;
(2) adding water saturated n-butanol into the concentrated solution obtained in the step (1) according to the volume ratio of 1: 0.5 for extraction, repeating the extraction process for 2-3 times according to the same method, combining the extraction solutions, and recovering the extractant under reduced pressure to obtain a purified asparagus extract;
(3) preparing the extract obtained in the step (2) into aqueous solution according to the concentration of 10mg/ml, 15mg/ml and 20mg/ml respectively.
Examples 3 to 6
Preparation of purslane essential oil composition
Mixing the components according to the proportion shown in the table 1 according to the weight percentage, heating to 60-70 ℃, and uniformly mixing to obtain the purslane essential oil composition:
table 1: purslane essential oil composition with different components
| Components | Example 3 | Example 4 | Example 5 | Example 6 |
| Oily purslane extract | 7.0 | 7.0 | 7.0 | 7.0 |
| Water (W) | 93.0 | 0 | 0 | 0 |
| 10mg/ml asparagus extract solution | 0 | 93.0 | 0 | 0 |
| 15mg/ml asparagus extract solution | 0 | 0 | 93.0 | 0 |
| 20mg/ml asparagus extract solution | 0 | 0 | 0 | 93.0 |
Example 7
Transdermal delivery assay
Calculating the diffusion rate of different oily purslane extract solutions through a diffusion cell simulating human skin, and specifically comprises the following steps:
testing in an in vitro Franz diffusion cell with healthy male Wistar rat dorsal skin as a permeation barrier;
fixing the skin between the receiving tank and the supply tank (the inner layer of the skin faces the receiving tank) to ensure that no air bubbles exist between the skin and the receiving liquid;
diffusion cell parameters: effective diffusion area of about 3.14cm 2 The volume of the receiving tank was about 8.5mL, the magnetic stirring speed was 600rpm, and the temperature of the receiving solution was 37.0. + -. 0.1 ℃.
Filling a receiving pool with 1% SDS-10% ethanol-physiological saline as a release medium, removing bubbles, starting stirring, keeping the temperature to (37.0 +/-0.1) DEG C, uniformly coating about 1g of sample on the surface of skin, sucking 0.5mL of receiving solution after 1, 2, 4, 6, 8, 10 and 12 hours, and immediately adding the release medium with the same volume and temperature after sampling. The concentration of purslane extract in the receiving solution filtered through a 0.22 μm filter was determined by HPLC. And calculating the cumulative permeation amount of the medicaments at different times.
The cumulative transdermal quantity per unit area of the purslane extract is calculated according to the following formula:
in the above formula: q: accumulating transdermal volume; s: an effective diffusion area; v: receiving the volume of the normal saline in the pool; c i : the concentration of the drug in the receiving solution from the 1 st to the last sampling; c n : the concentration of the drug in the receiving fluid during the sub-sampling; m is 0 : theoretically weighing the sample; m: the sample is actually weighed.
The test results are shown in table 2.
Table 2: skin cumulative penetration of Portulaca oleracea extract of various examples (12h)
From the experimental results shown in table 2, the transdermal permeation amount of the essential oil of the purslane extract in example 3 is small, and the transdermal permeation amount of the purslane extract is remarkably increased by using the asparagus extract solution as a dispersing agent in examples 4-5, and the increase amount is in positive correlation with the concentration of the asparagus extract solution.
Claims (6)
1. A composition of purslane extract, comprising an oily purslane extract and an asparagus extract.
2. The composition of claim 1, wherein the oily purslane extract is obtained by extraction with a lipophilic solvent.
3. The composition of claim 1, wherein the asparagus extract is an alcoholic or aqueous or alcoholic/aqueous extract.
4. The composition of claim 1, wherein the asparagus extract is present as a solution.
5. The composition of claim 4, wherein the concentration of the asparagus extract solution is 10-20 mg/ml.
6. A method for improving the transdermal delivery rate of an oily purslane extract is characterized in that the oily purslane extract is mixed with an asparagus extract or a solution containing the asparagus extract.
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