CN114848564A

CN114848564A - Washing-free disinfectant with sun-screening and skin-care functions and preparation and application thereof

Info

Publication number: CN114848564A
Application number: CN202210319508.2A
Authority: CN
Inventors: 杨方强; 丁超; 杨友强; 魏金刚; 李振华; 张龙飞
Original assignee: Guangdong Kingfa Science and Technology Co Ltd
Current assignee: Guangdong Kingfa Science and Technology Co Ltd
Priority date: 2022-03-29
Filing date: 2022-03-29
Publication date: 2022-08-05

Abstract

The invention provides a no-clean disinfectant with sunscreen and skin care functions, and preparation and application thereof. The disinfectant formula comprises the following components in percentage by mass: 60-85% of an alcohol antibacterial agent, 0.05-0.4% of a non-alcohol antibacterial agent, 1-4% of a sun-screening skin care agent, 0.2-1.5% of a thickening agent, 0.3-0.9% of a skin softening agent, 2.0-5.2% of a humectant, 0.2-0.5% of an antioxidant, 1.5-4.0% of an emulsifier, 0.03-0.9% of a preservative, 0.05-0.3% of a nutrient, 0.5-1.3% of a surfactant, 0.05-0.7% of a pH regulator, 0-0.2% of an essence, and the balance of deionized water; the disinfectant can effectively inhibit or kill pathogenic microorganisms and realize skin care and sunscreen effects by adding a specific sunscreen skin care agent.

Description

Washing-free disinfectant with sun-screening and skin-care functions and preparation and application thereof

Technical Field

The invention belongs to the technical field of disinfectants, and particularly relates to a no-clean disinfectant with sun-screening and skin-care functions, and preparation and application thereof.

Background

The hand-washing-free disinfectant can effectively inhibit or kill pathogenic microorganisms and protect human health, and among numerous existing disinfection products, alcohol disinfectants such as ethanol or isopropanol which are the most commonly used disinfectants are widely applied to daily life, particularly in the medical industry. The ethanol or the isopropanol can be used for disinfection because the ethanol or the isopropanol can absorb the moisture of bacterial protein, so that the bacterial protein is dehydrated, denatured and solidified, thereby achieving the aim of killing bacteria. Meanwhile, the strength of the sterilization and disinfection capacity of ethanol or isopropanol as an effective sterilization component has a direct relation with the concentration, and the ethanol or isopropanol is too high or too low, if the concentration is too high, the ethanol or isopropanol volatilizes to take away moisture on the skin, and the high-concentration alcohol also decomposes sebum of the skin, so that the skin is directly exposed to the sun and is attacked by ultraviolet rays, and the skin is degreased, dried and loses luster after being frequently used.

Therefore, there is a need to develop a non-washing disinfectant with sunscreen and skin care functions, so that the disinfectant can effectively inhibit or kill pathogenic microorganisms and can also achieve the effects of skin care and sunscreen.

Disclosure of Invention

Aiming at the defects in the prior art, the invention aims to provide a no-clean disinfectant with sun-screening and skin-care functions, which can effectively inhibit or kill pathogenic microorganisms such as staphylococcus aureus, escherichia coli and candida albicans and can realize the effects of sun-screening, moisturizing and skin-care.

The invention aims to provide a no-clean disinfectant with sun-screening and skin-care functions.

The invention also aims to provide a preparation method of the no-clean disinfectant.

Another object of the present invention is to provide the use of the above-mentioned leave-on disinfectant in the preparation of a disinfecting product.

The above object of the present invention is achieved by the following technical solutions:

the invention provides a no-clean disinfectant with sun-screening and skin-care functions, which comprises the following components in percentage by mass: 60-85% of an alcohol antibacterial agent, 0.05-0.4% of a non-alcohol antibacterial agent, 1-4% of a sun-screening skin care agent, 0.2-1.5% of a thickening agent, 0.3-0.9% of a skin softening agent, 2.0-5.2% of a humectant, 0.2-0.5% of an antioxidant, 1.5-4.0% of an emulsifier, 0.03-0.9% of a preservative, 0.05-0.3% of a nutrient, 0.5-1.3% of a surfactant, 0.05-0.7% of a pH regulator, 0-0.2% of an essence, and the balance of deionized water;

the sunscreen skin care agent consists of bacillus/soybean fermentation product extracting solution, shea butter and oat alkaloid.

In the non-washing disinfectant, the sunscreen skin care agent which is composed of the bacillus/soybean fermentation product extracting solution, the shea butter and the oat alkaloid is added, wherein the bacillus/soybean fermentation product extracting solution reduces the release of mast cell and leucocyte histamine, has good functions of preventing and repairing allergy, and has certain effects on ultraviolet ray damage resistance, wrinkle removal, aging resistance, moisture preservation and the like. The shea butter is an effective natural moisturizing product, has the effects of promoting cell regeneration and repairing skin water films, can resist ultraviolet rays, fully moistens skin, and has excellent repairing and anti-inflammatory functions. The avenanthramides have skin soothing and antiallergic biological activities, can effectively relieve skin itch caused by dryness, diminish inflammation and have the effect of relieving skin erythema.

The three components in the sunscreen skin care agent have synergistic effect, the sunscreen skin care effect of the whole disinfectant is remarkably improved, and adverse reactions and damages of hand skin degreasing, drying and gloss loss after multiple uses are avoided. The sun-screening and skin-protecting cream has the functions of sun screening, skin care, moisture retention and skin protection while effectively inhibiting or killing pathogenic microorganisms.

Preferably, the mass ratio of the bacillus/soybean fermentation product extracting solution, the shea butter and the oat alkaloid in the sunscreen skin care agent is (2-25): (1-9): (0.2-9).

Further preferably, the mass ratio of the bacillus/soybean fermentation product extracting solution to the shea butter to the avenanthramides is (2.3-18): (1.1-7): (0.25-6).

Most preferably, the mass ratio of the bacillus/soybean fermentation product extracting solution to the shea butter to the avenanthramides is 2.5: 1.2: 0.3.

preferably, the alcohol antibacterial agent comprises one or both of ethanol and isopropanol.

Preferably, the non-alcoholic antibacterial agent comprises one or more of benzalkonium chloride, benzalkonium bromide, benzethonium chloride, didodecyldimethylammonium chloride, and trichlorohydroxydiphenyl ether.

Preferably, the thickening agent comprises one or more of carbomer, hydroxyethyl cellulose, acrylic acid and acrylate.

Preferably, the skin softening agent comprises one or more of aloe extract, PEG/PPG-14/7 dimethyl ether, and C12-15 alcohol benzoate.

Preferably, the humectant comprises one or more of glycerin, shea butter and propylene glycol.

When the moisture in the epidermis is reduced, the self-protection capability of the skin is reduced, various harmful factors damage the skin, so that the skin is dry, wrinkled, glossy and cracked in severe cases, and therefore, the self-protection capability of the skin can be enhanced by adding the moisturizing agent, and the resistance of the skin to various irritants is further enhanced.

Further preferably, the humectant comprises glycerin and shea butter.

Preferably, the antioxidant comprises one or more of p-hydroxyacetophenone, butylated hydroxyanisole and propyl gallate.

Preferably, the emulsifier comprises one or more of PEG-7 glyceryl cocoate, polyoxyethylene monostearate, and polyoxyethylene sorbitan monopalmitate.

Preferably, the preservative comprises one or more of cetylpyridinium chloride, polychloropropyl biguanide, chlorphenesin, benzoic acid, phenoxyethanol, methyl paraben and chamomile extract.

Preferably, the nutrient comprises one or more of vitamin E acetate, vitamin A and phytol.

Preferably, the surfactant comprises one or more of decyl glucoside, polysorbate 20, cocamidopropyl betaine.

Preferably, the pH regulator comprises one or more of triethanolamine, sodium metaphosphate and potassium chloride.

Preferably, the essence comprises one or more of lemon essence, eugenol and cinnamyl alcohol.

As a preferred embodiment, the method for preparing the no-clean disinfectant comprises the following steps:

s1, uniformly mixing a thickening agent, a pH regulator and a proper amount of deionized water, and stirring for 3-5 minutes to form a regulating solution;

s2, mixing an alcohol antibacterial agent, a non-alcohol antibacterial agent, a skin softening agent, a humectant, an antioxidant, an emulsifier, a preservative, a nutrient, a surfactant, essence and a proper amount of deionized water, and stirring in a sealed manner for 8-15 minutes to obtain a first mixed material;

s3, adding the sunscreen skin care agent into the first mixed material, mixing, and stirring in a sealed mode for 5-10 minutes to obtain a second mixed material;

and S4, mixing the regulating solution with the second mixed material, supplementing water, and stirring in a sealed manner for 5-10 minutes to obtain the non-washing disinfectant with the sun-screening and skin-care functions.

Preferably, the stirring speed in the step S1 is 2000-3000 r/min; step S2, the stirring speed is 60-100 r/min; step S3, the stirring speed is 60-100 r/min; and step S4, the stirring speed is 100-140 r/min.

In addition, the invention also claims the application of the no-clean disinfectant in the preparation of disinfection products, wherein the products comprise but are not limited to disinfection wet tissues, disinfection nursing tissues, disinfection sprays, disinfection washing liquids and disinfection liquids.

Compared with the prior art, the invention has the following beneficial effects:

according to the invention, the sunscreen skin care agent composed of the bacillus/soybean fermentation product extracting solution, the shea butter and the oat alkaloid is added into the disinfectant, and the synergistic sunscreen effect of the humectant and the sunscreen skin care agent is utilized, so that the no-wash disinfectant disclosed by the invention has the effects of sunscreen, skin care and moisture retention while effectively inhibiting or killing pathogenic microorganisms, and can be used for preparing various disinfection products.

Detailed Description

The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated.

Sunscreen skin care agent-1: the bacillus/soybean fermentation product extracting solution adopts a product with Guangzhou cypress biotechnological number BY-ZJ2020120935, and is of cosmetic grade;

sunscreen skin care agent-2: the shea butter is refined by adopting a product of number RY-JLA81 of Guangzhou daily oil science and technology Limited company;

sunscreen skin care agent-3: the oat alkaloid adopts a product with a serial number of RZ-2020092302 of Xianrong coconut Biotechnology Limited, and the purity is 80 percent;

alcohol antibacterial agent-1: ethanol, adopting a product with the number of C0691510226 of Nanjing chemical reagent limited company, and the purity is 99.9%;

alcohol antibacterial agent-2: isopropanol, adopting a product with the number of C0690546005 of Nanjing chemical reagent Limited, and the purity of the isopropanol is 99.9 percent;

non-alcoholic antibacterial agent-1: the didecyl dimethyl ammonium chloride adopts a product of a Hubei Yuancheng science and technology company No. 7173-51-5, and the purity is 70 percent;

non-alcoholic antibacterial agent-2: trichloro-hydroxy diphenyl ether, adopting the product of the Hubei Ferry chemical company No. 3380-34-5, the purity is 99 percent;

thickener-1: carbomer, a product from Shanghai Ji to Biochemical technology, Inc. No. carbomer 940, USP grade;

thickener-2: hydroxyethyl cellulose, adopting a product of a Guangdong Jiang chemical reagent company Limited with a number PA09326, and being 1000-1500 mpa.s grade;

thickener-3: acrylic acid, adopting a product with the number of A103526 of Shanghai Aladdin Biotechnology, Inc., and the purity AR is more than 99% (GC);

skin softening agent-1: the aloe extract adopts a product of Wuhanfeng shin chemical products Limited company No. 7986, and the purity is more than 98 percent;

skin softening agent-2: c12-15 alcohol benzoate, which adopts a product of serial number 68411-27-8 of Xian kang Nuo chemical Co., Ltd, and has the purity of 98%;

humectant-1: glycerol, which is a product with the number GB190 of Beijing Soilebao science and technology Limited, and the purity is more than or equal to 99.0 percent;

humectant-2: avocado oil, a product of Shanghai Dingfen chemical technology Limited with the number P34025, grade BR;

antioxidant: p-hydroxyacetophenone, commercially available;

emulsifier: PEG-7 glyceryl cocoate, commercially available;

preservative: flos Matricariae Chamomillae extract, cetylpyridinium chloride, phenoxyethanol, and is commercially available;

a nutrient agent: vitamin E acetate, commercially available;

surfactant (b): decyl glucoside, cocamidopropyl betaine, commercially available;

pH regulator: triethanolamine, commercially available;

essence: lemon essence, commercially available.

It should be noted that, for the commercial products, the following examples and comparative examples are from the same source as the same raw materials used in the parallel experiments.

Examples 1-7 No-clean disinfectants with sunscreen and skin care functions and their preparation

1. Table 1 provides the formulations of 7 leave-on disinfectants

TABLE 1

2. The preparation method of the no-clean disinfectant comprises the following steps:

(1) preparing raw materials of the disinfectants in the table 1 according to the weight percentage;

(2) under the condition of normal temperature, adding a thickening agent, a pH regulator and a proper amount of deionized water into a homogenizing dissolving pot, and stirring for 3-5 minutes at the speed of 2500 revolutions per minute to form a regulating solution for later use;

(3) putting an alcohol antibacterial agent, a non-alcohol antibacterial agent, a skin softening agent, a humectant, an antioxidant, an emulsifier, a preservative, a nutritional agent, a surfactant, essence and a proper amount of deionized water into a homogenizing and dissolving pot, and hermetically stirring at the speed of 80 revolutions per minute for 10 minutes to obtain a first mixed material;

(4) adding the sun-screening skin care agent into a homogenizing dissolving pot to be mixed with the first mixed material, and hermetically stirring at the speed of 80 revolutions per minute for 10 minutes to obtain a second mixed material;

(5) and adding the standby regulating solution into a homogenizing dissolving pot to be mixed with the second mixed material, supplementing water, and hermetically stirring at the speed of 120 revolutions per minute for 8 minutes to obtain the hand-free disinfectant with the sun-screening and skin-care functions.

Example 8

The difference from the example 2 is that in the formula, the mass ratio of the bacillus/soybean fermentation product extracting solution to the shea butter to the oat alkaloid is 25: 1: 0.2 (the total mass of the sunscreen skincare agent is unchanged).

Example 9

The method is the same as example 2, except that in the formula, the mass ratio of the bacillus/soybean fermentation product extracting solution to the shea butter to the oat alkaloid is 2: 9: 0.2 (the total mass of the sunscreen skincare agent is unchanged).

Example 10

The difference from the example 2 lies in that in the formula, the mass ratio of the bacillus/soybean fermentation product extracting solution, the shea butter and the oat alkaloid is 2: 1: 9 (total mass of sunscreen skin care agent is unchanged).

Example 11

The difference from the example 2 lies in that in the formula, the mass ratio of the bacillus/soybean fermentation product extracting solution, the shea butter and the oat alkaloid is 2.3: 1.1: 6 (the total mass of sunscreen skincare agent is unchanged).

Example 12

The difference from the example 2 lies in that in the formula, the mass ratio of the bacillus/soybean fermentation product extracting solution, the shea butter and the oat alkaloid is 2.3: 7: 0.25 (the total mass of sunscreen skincare agent is unchanged).

Example 13

The difference from the example 2 lies in that in the formula, the mass ratio of the bacillus/soybean fermentation product extracting solution, the shea butter and the oat alkaloid is 18: 1.1: 0.25 (the total mass of sunscreen skincare agent is unchanged).

Comparative example 1

The difference from the example 2 is that the mass percentage of the ethanol in the formula is 50%.

Comparative example 2

The difference from example 3 is that the alcohol antibacterial agent accounts for 90% by mass (15% isopropanol and 75% ethanol).

Comparative example 3

The difference from the example 2 is that in the formula, the sunscreen skin care agent does not contain oat alkaloid, and the mass ratio of the bacillus/soybean fermentation product extracting solution to the shea butter is 2.5: 1.2 (the total mass of sunscreen skincare agent is unchanged).

Comparative example 4

The same as example 2, except that the sunscreen skin care agent in the formula does not contain shea butter, and the mass ratio of the bacillus/soybean fermentation product extracting solution to the oat alkaloid is 2.5: 0.3 (the total mass of the sunscreen skincare agent is unchanged).

Comparative example 5

The sunscreen skin care agent is similar to the sunscreen skin care agent in example 2, except that the sunscreen skin care agent does not contain a bacillus/soybean fermentation product extracting solution, and the mass ratio of the shea butter to the oat alkaloid is 1.2: 0.3 (the total mass of the sunscreen skincare agent is unchanged).

Comparative example 6

The difference is that the sun-screening skin care agent is not contained in the formula as in example 2.

Comparative example 7

The difference is that in the formula, the sunscreen skin care agent accounts for 6% by mass (the mass ratio of the bacillus/soybean fermentation product extracting solution, the shea butter and the oat alkaloid is unchanged) like in the example 2.

Comparative example 8

The difference from the example 2 is that the weight percentage of the sunscreen skin care agent in the formula is 0.5% (the weight ratio of the bacillus/soybean fermentation product extract, the shea butter and the oat alkaloid is unchanged).

Comparative example 9

The difference from example 2 is that no humectant was added to the formulation.

Comparative example 10

The difference is that in the formula, the humectant accounts for 1% by mass (the mass ratio of the glycerin to the avocado oil is unchanged) as in example 2.

Comparative example 11

The difference is that in the formula, the humectant accounts for 6% by mass (the mass ratio of the glycerin to the avocado oil is unchanged) as in example 2.

Experimental example 1 skin irritation experiment

1. Experimental methods

The leave-on disinfectants prepared in examples 1 to 13 and comparative examples 1 to 11 were subjected to skin irritation tests according to the disinfection specifications.

Detecting the environment: general grade animal house, laboratory animal use license number: SYXK (Yue) 2018-; the room temperature is 21-23 ℃, and the relative humidity is 47-49%.

Experimental animals: common-grade New Zealand white rabbit, Guangdong province medical experimental animal center (Sanshui base) (experimental animal production license number: SCXK 2019-. The weight of the experimental animal is 2.2-2.4kg, and the qualification number of the experimental animal is as follows: no. 44411600007696. Number/sex of experimental animals used for each sample of leave-on disinfectant: 4/female; the dosage of the skin smearing no-clean disinfectant is as follows: 0.5 ml.

And (3) observing time points: the skin reaction of the site given the test substance was observed at 1 hour, 24 hours, and 48 hours after the removal of the test substance.

The specific test procedure for each leave-on disinfectant sample:

(1) 4 healthy adult New Zealand rabbits were selected. 24h before the test, the two sides of the spine of the experimental animal were cut off, and 2 depilated areas (about 3 cm. times.3 cm for each depilated area) were prepared.

(2) A0.5 ml sample was applied to the skin of the left depilatory area of the experimental animal, covered with a patch, and secured with a non-irritating adhesive tape and bandage. A patch was wetted with normal saline and applied to the skin of the right depilatory area of the experimental animal as a control. After being applied for 4h, the residual test substance is removed by warm water. The skin reactions at the sites given the test substances were observed at 1 hour, 24 hours and 48 hours after the removal of the test substances, and the skin reactions at each observation time point were recorded.

2. Results of the experiment

(1) Example 1 results of the skin irritation test of the leave-on disinfectant on rabbits are shown in table 2.

TABLE 2

As can be seen from Table 2, the no-wash disinfectant of example 1 is non-irritating to rabbit skin.

(2) The results of the tests of examples 2-13, which were conducted in the same manner as in example 1, are shown in Table 3.

TABLE 3

(3) The results of the tests of comparative examples 1 to 11, which were conducted in the same manner as in example 1, are shown in Table 4.

TABLE 4

Comparative example	1	2	3	4	5	6	7	8	9	10	11
												Skin irritation	Is free of	Is provided with	Is free of	Is free of	Is free of	Is provided with	Is free of	Is free of	Is provided with	Is free of	Is free of

In conclusion, the hand-washing-free disinfectants prepared in the embodiments 1-13 of the invention have no irritation to the skin and high safety; the no-clean disinfectant prepared in comparative example 2 causes slight pain to the skin due to the excessive alcohol content, and chapped skin in severe cases; in comparative examples 6 and 9, the skin was slightly painful due to the absence of sunscreen moisturizer or moisturizer.

Experimental example 2 skin moisture Retention test

1. Experimental methods

240 volunteers were randomly selected and divided into 24 groups of 10 groups, the proportion of dry skin, neutral skin and mixed skin in each group was about the same, each group was applied with the no-clean disinfectants prepared in examples 1-13 and comparative examples 1-11, and the skin moisture tester was used to test the moisture change of the hands of the volunteers before and after applying the disinfectant hand sanitizer.

2. Results of the experiment

TABLE 5

As can be seen from the results of table 5, the moisture content of the skin was significantly increased and the skin was excellent in moisturizing effect using the disinfectants prepared in examples 1 to 13. After the disinfectants prepared according to various proportions are used, the skin moisture content increase rate of a subject is obviously reduced, and the long-acting moisturizing effect on the skin cannot be realized.

Experimental example 3 sunscreen test

1. Experimental methods

240 volunteers were randomly selected and divided into 24 groups of 10, each group having the same ratio of dry skin, neutral skin and mixed skin, each group was applied with the leave-on disinfectants prepared in examples 1 to 13 and comparative examples 1 to 11, and the minimum erythema dose before use and the minimum erythema dose after use were measured by the SPF-290S sun protection factor analyzer according to the test method specified in the cosmetic safety specification, and the SPF value was outputted.

2. Results of the experiment

TABLE 6

As can be seen from the results in Table 6, the disinfectants prepared in examples 1-13 have an SPF factor of 4-9.7 and excellent sun protection effect; comparative examples 3 to 8, in which sunscreen skin care agents of different compositions were used, the SPF coefficient of the obtained disinfectant was significantly reduced, indicating that excellent sunscreen performance can be achieved by adding a specific sunscreen skin care agent; the SPF of comparative examples 9-11, which were used in too much or too little amounts (even without the addition), showed a significant reduction in the amount of humectant used in the disinfectant of the present invention, which was found to be synergistic with sunscreen benefit agents.

Experimental example 4 Sterilization Effect test

The leave-on disinfectants of examples 1-13 and comparative examples 1-11 were tested for bactericidal effect. The test is carried out according to the requirement of 2002 edition 'Disinfection technical Specification' of Ministry of health, and the sterilization test is respectively carried out on staphylococcus aureus, escherichia coli and candida albicans. The results are shown in tables 7, 8 and 9.

TABLE 7 Effect on killing Staphylococcus aureus

TABLE 8 Effect on Escherichia coli

TABLE 9 killing effect on Candida albicans

As can be seen from the results in tables 7 to 9, the leave-on disinfectants prepared in examples 1 to 13 and comparative examples 2 to 11 were effective for 1min, had killing log values of > 5.0 for Staphylococcus aureus, > 5.0 for Escherichia coli, and > 4.0 for Candida albicans, and met the requirements of the Disinfection Specification (2002 edition). The sterilization effect of the no-clean disinfectant of the comparative example 1 is weakened, and the sterilization effectiveness of the disinfectant on harmful bacteria cannot be ensured.

The results show that the no-clean disinfectant prepared by the invention is safe to use, mild and non-irritant. Can effectively inhibit or kill pathogenic microorganisms such as staphylococcus aureus, escherichia coli and candida albicans, and can realize the effects of moisturizing, protecting skin and preventing sun.

The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.

Claims

1. A no-clean disinfectant with sunscreen and skin care functions is characterized by comprising the following components in percentage by mass: 60-85% of an alcohol antibacterial agent, 0.05-0.4% of a non-alcohol antibacterial agent, 1-4% of a sun-screening skin care agent, 0.2-1.5% of a thickening agent, 0.3-0.9% of a skin softening agent, 2.0-5.2% of a humectant, 0.2-0.5% of an antioxidant, 1.5-4.0% of an emulsifier, 0.03-0.9% of a preservative, 0.05-0.3% of a nutrient, 0.5-1.3% of a surfactant, 0.05-0.7% of a pH regulator, 0-0.2% of an essence, and the balance of deionized water;

2. The no-clean disinfectant as claimed in claim 1, wherein the mass ratio of bacillus/soybean fermentation product extract, shea butter and oat alkaloid in the sunscreen skin care agent is (2-25): (1-9): (0.2-9).

3. The leave-on disinfectant according to claim 1, wherein said alcohol based antimicrobial agent comprises one or both of ethanol and isopropanol.

4. The leave-on disinfectant according to claim 1, wherein said non-alcoholic antimicrobial agent comprises one or more of benzalkonium chloride, benzalkonium bromide, benzethonium chloride, didodecyldimethylammonium chloride, trichlorohydroxydiphenyl ether.

5. The no-clean disinfectant as recited in claim 1, wherein said thickening agent comprises one or more of carbomer, hydroxyethyl cellulose, acrylic acid, and acrylates.

6. The leave-on disinfectant according to claim 1, wherein the skin softening agent comprises one or more of aloe vera extract, PEG/PPG-14/7 dimethyl ether, C12-15 alcohol benzoate.

7. The no-clean disinfectant as recited in claim 1, wherein said humectant includes one or more of glycerin, shea butter, and propylene glycol.

8. A method of preparing a leave-in disinfectant as claimed in any of claims 1 to 7, comprising the steps of:

9. The method according to claim 8, wherein the stirring speed of step S1 is 2000-3000 r/min; step S2, the stirring speed is 60-100 r/min; step S3, the stirring speed is 60-100 r/min; and step S4, wherein the stirring speed is 100-140 r/min.

10. Use of a leave-on disinfectant according to any one of claims 1 to 7 for the preparation of a disinfectant product, wherein said product comprises a moist disinfectant wipe, a disinfectant care wipe, a disinfectant spray, a disinfectant lotion.