CN114828877A - 多特异性t细胞受体 - Google Patents

多特异性t细胞受体 Download PDF

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Publication number
CN114828877A
CN114828877A CN202080087017.9A CN202080087017A CN114828877A CN 114828877 A CN114828877 A CN 114828877A CN 202080087017 A CN202080087017 A CN 202080087017A CN 114828877 A CN114828877 A CN 114828877A
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mhc
tcr
antigen
sub
epitope
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CN202080087017.9A
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Chinese (zh)
Inventor
克劳斯·弗吕
路易斯·皮克
约纳·萨夏
斯克特·汉森
本杰明·宾贝尔
沙希德·阿卜杜勒哈克
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Oregon Health and Science University
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Oregon Health and Science University
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2740/10011—Retroviridae
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    • C12N2740/15034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN202080087017.9A 2019-12-16 2020-12-15 多特异性t细胞受体 Pending CN114828877A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962948691P 2019-12-16 2019-12-16
US62/948,691 2019-12-16
PCT/US2020/065147 WO2021126872A1 (en) 2019-12-16 2020-12-15 Multi-specific t cell receptors

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Publication Number Publication Date
CN114828877A true CN114828877A (zh) 2022-07-29

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CN202080087017.9A Pending CN114828877A (zh) 2019-12-16 2020-12-15 多特异性t细胞受体

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US (1) US20230272036A1 (https=)
EP (1) EP4076510A4 (https=)
JP (2) JP2023507142A (https=)
KR (1) KR20220116458A (https=)
CN (1) CN114828877A (https=)
AU (1) AU2020404933A1 (https=)
CA (1) CA3161826A1 (https=)
WO (1) WO2021126872A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020127231A1 (en) * 1996-03-28 2002-09-12 Jonathan Schneck Soluble divalent and multivalent heterodimeric analogs of proteins
US20180133321A1 (en) * 2016-10-18 2018-05-17 Oregon Health & Science University Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11384365B2 (en) * 2018-03-19 2022-07-12 Boehringer Ingelheim Vetmedica Gmbh EHV with inactivated UL18 and/or UL8

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020127231A1 (en) * 1996-03-28 2002-09-12 Jonathan Schneck Soluble divalent and multivalent heterodimeric analogs of proteins
US20180133321A1 (en) * 2016-10-18 2018-05-17 Oregon Health & Science University Cytomegalovirus vectors eliciting t cells restricted by major histocompatibility complex e molecules

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANDREW K. SEWELL: "Why must T cells be cross-reactive?", 《NATURE REVIEWS》, 30 September 2012 (2012-09-30), pages 669 - 677 *
CHAO-YING ZHOU等: ""Human CD8+ T cells transduced with an additional receptor bispecific for both Mycobacterium tuberculosis and HIV-1 recognize both epitopes"", 《J. CELL. MOL. MED》, 31 December 2016 (2016-12-31), pages 1984 - 1998 *
SHALYN C. CLUTE等: "Broad Cross-Reactive TCR Repertoires Recognizing Dissimilar Epstein-Barr and In", 《J IMMUNOL》, 1 October 2010 (2010-10-01), pages 6753 - 6764 *

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Publication number Publication date
CA3161826A1 (en) 2021-06-24
EP4076510A4 (en) 2024-01-10
US20230272036A1 (en) 2023-08-31
KR20220116458A (ko) 2022-08-23
JP2023507142A (ja) 2023-02-21
AU2020404933A1 (en) 2022-06-30
JP2026010019A (ja) 2026-01-21
EP4076510A1 (en) 2022-10-26
WO2021126872A1 (en) 2021-06-24

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