CN1148195C

CN1148195C - Trace element preparation for livestock and fowl and its preparation method

Info

Publication number: CN1148195C
Application number: CNB021136637A
Authority: CN
Inventors: 叶玉辉
Original assignee: Individual
Current assignee: Individual
Priority date: 2002-04-27
Filing date: 2002-04-27
Publication date: 2004-05-05
Anticipated expiration: 2022-04-27
Also published as: CN1380065A

Abstract

The present invention provides a trace element preparation for livestock and fowl and a preparation method thereof, which relates to the technical field of veterinary drugs. The trace element preparation is prepared from water-soluble compounds containing Se, Co , Cu, Zn, Fe, Mn, Mg and Cr by adding a given amount of injection water. The preparation method comprises the following steps: weighing the compounds according to required weights, adding the injection water, stirring, heating, filtering, packaging, sterilizing and checking. The trace element preparation can effectively necessary trace elements for the livestock and the fowl, and has the obvious effects of disease resistance, weight gain, fattening, grain saving, low consumption and haleness.

Description

A kind of Rare Elements Preparations that is used for poultry and preparation method thereof

Technical field:

The present invention is a kind of Rare Elements Preparations that is used for poultry and preparation method thereof, relates to the veterinary drug technical field.

Background technology:

In the prior art, the patent No. by applicant's invention is that CN90105866l discloses " poultry are used trace mineral supplement and preparation method thereof ", said preparation contains selenium, cobalt, copper, zinc, iron microelement, but also lack necessary other part trace element of poultry body, and the formula proportion of various elements is also reasonable inadequately, thereby has influenced action function and the result of use of said preparation to the poultry body.

The purpose of this invention is to provide that a kind of trace element formula kind is more comprehensive, formula proportion is more reasonable, can satisfy substantially the poultry body to the demand of necessary various trace element, improve Rare Elements Preparations of its action function and result of use and preparation method thereof.

Summary of the invention:

Purpose of the present invention can realize by following technical measures:

A kind of Rare Elements Preparations that is used for poultry, it is with sodium selenite 0.0001-0.01g, cobaltous sulfate 0.06-2.0g, copper sulfate 0.2-3.0g, zinc sulfate 0.4-5.0g, ferric citrate 1.0-15g, manganese sulfate 0.08-2.0g, magnesium sulfate 0.08-2.0g, Neutral potassium chromate 0.0001-0.01g, and adding 100ml water for injection obtains.

The optimum formula ratio that is used for the Rare Elements Preparations of poultry is: be with sodium selenite 0.001g, cobaltous sulfate 0.6g, copper sulfate 2.0g, zinc sulfate 4.0g, ferric citrate 10.0g, manganese sulfate 0.8g, magnesium sulfate 0.8g, Neutral potassium chromate 0.001g, adding 100ml water for injection obtains.

Above-mentioned various water-soluble chemical compound, than calculating, the element ratio that is contained is with weight %: sodium selenite contains selenium 44.2%, sulphuric acid and bores and contain cobalt 24.8%, copper sulfate cupric 25.5%, zinc sulfate and contain zinc 22.7%, ferric citrate iron content 18.5%, manganese sulfate and contain that manganese 32.5%, magnesium sulfate contain magnesium 16.17%, Neutral potassium chromate contains chromium 26.18%.

The preparation method of this preparation is: by required weight in the prescription take by weighing that sodium selenite, cobaltous sulfate, copper sulfate, zinc sulfate, ferric citrate, sulphuric acid are violent, magnesium sulfate, Neutral potassium chromate, add in a certain amount of water for injection, fully stir heating for dissolving; Filter, remove impurity; Packing, sealing ampoule; Sterilization and carry out the product quality inspection production process is prepared into the ejection preparation of different size, kind.

The present invention compared with prior art, the remarkable advantage that is had is:

Trace element is that poultry and other biological body are depended on, ensured body health for existence, promote normal growth to grow institute indispensable nutrient substance basis, it participates in the metabolism of animal body life process, has the kinase system, the effect of human body immunity improving function, therefore, claimed work " biological element " material.Element must be kept certain value volume and range of product in vivo for animal, and quantity too much may cause poisoning; Crossing low or lacking then influences its normal growth, reduces immunologic function, even some trace element deficiency occurs, common as cobalamin deficiency, zinc deficiency, selenium deficiency etc.The kind of element is also very important, must replenish the trace elements necessary kind that is difficult to obtain by other approach.Reasonably prescription can make the effect of playing coordinated balance between some elements, reduces consumption, avoids occurring untoward reaction.

China has a vast territory; various places distribution mineral situation is not quite similar; some geographic area is originally with regard to some mineral of natural shortage; it almost is impossible that animal bodies such as poultry are attempted to obtain necessary whole trace element from feedstuff, forage grass or natural environment; in addition along with the rise of commodity market economy; the stable breeding poultry of scale will substitute nature and put in a suitable place to breed; thereby limited the additional approach that poultry searched for food, obtained trace unit naturally; therefore then be generally to lack trace element for the most geographic poultry of China, comprise kind and quantity.

This preparation at China's animal and fowl fodder present situation, feeding manner and to the situations such as demand of trace element, proposes and has improved the prescription of preparation: on the basis of original selenium, cobalt, copper, ferrum, zinc microelement, increased manganese, magnesium, chromium trace element just; Reduce the proportion of copper and zinc element, improved the proportion of selenium and cobalt element, made its various trace element more can satisfy the actual needs of living organism, therefore obtained satisfied result of use:

1, treatment domestic animal anemia disease.Treatment anemia sheep 14 examples, it is pale to show as conjunctiva before the treatment, and hydrosarca is withered thick random, unglazed by hair shaft, and the blood sampling chemical examination: blood is rare as water, and is rose pink, do not coagulate hemoglobin 2.0 ± 0.2g, erythrocyte 200 ± 0.4 ten thousand/cubic millimeter.Utilize this preparation injection in every month 1-2 time, after 3-4 month, Anemia disappears, and erythrocyte increases to 1,000 ten thousand/cubic millimeter, and hemoglobin is raised to 10g, and it is normal that growth promoter recovers.

2, growing and fattening is obvious.Utilizing this preparation to carry out controlled trial to draught animals such as pig, cattle, sheep shows, shows good growing and fattening effect:

Pig is fattened test:

A, material and method

Material is No. 1 2ml dress of this preparation.

Experimental animal and grouping: in raising the family, selecting 21 families, amounting to 100, body weight first-filial generation piglet between 20-50kg is subjects.Each household is according to great little matched group and the test group of being divided at random of pig support body, and each group is respectively 50.Body weight did not have significant difference between checked two groups by statistics.

Test: weigh on an empty stomach to the pig Zhi Jinhang that participates in the experiment first day morning of test, finishes the back and the next morning it is weighed on an empty stomach; By test group pig Zhi Daxiao respectively cervical region inject this preparation, the above injection of body weight 20kg 6ml, the above injection of 30kg 8ml, the above injection of 50kg 10ml, contrast is not injected; 60 days experimental periods; According to feeding method is constant separately at ordinary times, contrast identical with the test group feeding method, not special raising feedstuff and trophic level.

B, result of the test

Table 1 test pig is propped up cosmetic variation

The behavior of group appetite skin hair color changes

Test group increases red tender glossy hypokinesia, agree eat, agree sleep

Matched group no change true qualities thick disorderly active, doss few

Table 2 test weightening finish and food consumption

It is flat that group test test starting weight end heavily has a net increase of the flat every weightening finish 1kg head of the flat clean consumption grain head of accent

The weightening finish of a couple of days number weightening finish total amount feed consumption feed consumption

Test group 50 60 1928.3 3108.4 1180.1 23.602 3074.2 61.484 2.6 0.393

Matched group 50 60 1952.9 2704.0 751.1 15.022 3073.3 61.466 4.2 0.250

Credit is analysed by statistics, and the test group head increases weight the utmost point on ordinary days significantly than the big 0.143kg of matched group (P＜0.01).The every weightening finish of test group 1kg, the feed consumption utmost point lack 1.6kg (P＜0.01) than matched group significantly.

C, brief summary

As can be seen from Table 1, by injecting this preparation, Corii Sus domestica skin gain color after 10 days, turn over tender, the hair color light, lubricated, activity reduces, and agree eat and agree sleep, and does not have to turn over the circle phenomenon and take place.

As can be seen from Table 2, the projection flat weightening finish of pig of injecting this preparation reaches 23.60kg, props up the weightening finish 8.58kg of Duoing than the pig of not injecting, though the flat consumption of head grain does not have much difference, but the pig that every weightening finish 1kg material consumpting ratio is not injected props up few 1.6kg, has the effect of short fertilizer, joint grain, low consumption.

Cattle is fattened test

Subjects is 27 of pastoral area consumption cattle that live in about 3000 meters of height above sea level, age 2.5-4 year, be divided into matched group and three test group at random, and test is 110 days under identical natural grazing condition, and the result is a table 1.

The gaining effect of this preparation of table 1 consumption beef injection is observed

A group number experimental period injected dose head increases weight on ordinary days than matched group weightening finish %

(my god) (ml/ head) (g)

Matched group 6 110 0 148-

Test 1 group 5 109 16 663.7 348.4

Test 2 group 8 106 20 787.0 431.8

Test 3 group 8 110 24 737.0 398.0

Can find out that from table 1 the injection group is than the high 348.4-431.8% of daily gain of matched group, average out to 392.7%, difference is (P＜0.01) very significantly.

Sheep is fattened test

Subjects is that the sand at 2 monthly ages can milk sheep 12, is divided into 6 of 6 of matched groups and test group at random, result such as table 1.

Table 1 sheep is injected the fattening effect of this preparation and observes

Variety test flat starting weight (kg) injected dose head increase weight on ordinary days (g) compare matched group

Natural law matched group test group (ml/ head) matched group test group weightening finish %

Husky energy milk sheep 110 15.13 15.00 6 100 140 40

As seen from Table 1, the test injection group is higher by 40% than the flat weightening finish of matched group day, and fattening effect is (P＜0.01) extremely significantly.

3, strengthen resistance against diseases.Injecting this preparation compares with the domestic animal of not injecting this preparation, show as that good bloom, color of the leather are ruddy, honey stomach, anti-thick, joint material, be difficult for catching a cold and other respiratory tract digestive tract disease, injection is then not opposite, especially more outstanding to the performance of domestic animals such as stable breeding pig, cattle, sheep.

4, prevention and treatment endemicity trace element deficiency.The distribution of mineral has region, some local natural lack or lack fully certain or some animal body trace elements necessary, so that influenced animal body trace element deficiency has been appearred in the acquisition of trace element, common as cobalamin deficiency, zinc deficiency, selenium deficiency, iron deficiency anemia etc.Utilize this preparation that all kinds of domestic animals are regularly injected, low dose can play preventive effect; Heavy dose can play therapeutical effect.

5, meet national meat standard.The back of the body longue of getting respectively behind cattle, pig test group, the matched group slaughtering animal carries out the quality test, and the result is as follows:

Sample/project moisture (g%) protein (g/100g)

No. 1 (test group) 76.57 19.94 of cattle

No. 2 (matched groups) 76.75 20.41 of cattle

No. 1 (test group) 73.34 20.31 of pig

No. 2 (matched groups) 74.17 20.80 of pig

The meat of test group and matched group does not have significant difference (P＞0.01).

Test group cattle, Carnis Sus domestica product color aquatic foods, delicious, do not measure hormone and antibiotic remains, heavy metal does not exceed standard, and meets national regulation meat standard.

The specific embodiment:

Below will be to this preparation embodiment that offers the best:

Embodiment 1

Pharmaceutical formulation is formed

Get sodium selenite 0.001g, cobaltous sulfate 0.6g, copper sulfate 2.0g, zinc sulfate 4.0g, ferric citrate 10.0g, manganese sulfate 0.8g, magnesium sulfate 0.8g, Neutral potassium chromate 0.001g, add in the 100ml water for injection.

Preparation method is: get sodium selenite 1.0g, cobaltous sulfate 600g, copper sulfate 2000g, zinc sulfate 4000 ferric citrate 10000g, manganese sulfate 800g, magnesium sulfate 800g, Neutral potassium chromate 1.0g, add in the 100000m water for injection; Fully stir heating for dissolving; Impurity screening; Last machine packing and sealing ampoule; Sterilization and product quality inspection production process are prepared into every ampoule the 2ml injection formulation are housed.Every contains the above-claimed cpd gross weight is 0.364g.Be called for short No. 1 preparation.

Embodiment 2

Prescription is formed

Get sodium selenite 0.0005g, cobaltous sulfate 0.3g, copper sulfate 1.0g, zinc sulfate 2.0g, ferric citrate 5.0g, manganese sulfate 0.4g, magnesium sulfate 0.4g, Neutral potassium chromate 0.0005g, add in the 100ml water for injection.

Get sodium selenite 0.5g, cobaltous sulfate 300g, copper sulfate 1000g, zinc sulfate 2000g, ferric citrate 5000g, manganese sulfate 400g, magnesium sulfate 400g, Neutral potassium chromate 0.5g, add in the 100000ml water for injection; Fully stir heating for dissolving; Following production craft step is identical with embodiment 1, will not repeat.Make every ampoule packing 2ml injection, every contains the chemical compound gross weight is 0.182g.Be called for short No. 2 preparation.

Embodiment 3

Prescription is formed

Get sodium selenite 0.005g, cobaltous sulfate 1.0g, copper sulfate 2.5g, zinc sulfate 4.5g, ferric citrate 13.0g, manganese sulfate 1.0g, magnesium sulfate 1.0g, Neutral potassium chromate 0.005g, add in the 100ml water for injection.

Get sodium selenite 5g, cobaltous sulfate 1000g, copper sulfate 2500g, zinc sulfate 4500g, ferric citrate 13000g, manganese sulfate 1000g, magnesium sulfate 1000g, Neutral potassium chromate 5g, add in the 100000ml water for injection; Fully stir heating for dissolving; Following production craft step is identical with embodiment 1, will not repeat.Make every ampoule branch injection 2ml is housed.Every contains the chemical compound gross weight is 0.460g.Be called for short No. 3 preparation.

The using dosage of preparation and method:, determine the milliliter number of its preparation using dosage according to the body weight kilogram number in animal growth and development stage.All adopt intramuscular injection.Concrete using dosage is as follows:

Pig: 2ml was injected in 10-15 days in piglet birth back;

Deliver pig 10-15kg for sale, injection 10ml; 30-40kg, injection 12-14ml;

Breeding boar injection 12-16ml can inject at twice;

Broad sow injection 12-16ml can inject at twice;

Sheep: 15-20kg, injection 10ml; 40-60kg injects 12-14ml

Plant more than the sheep 40-50kg injection 12-14ml.

Cattle: young cattle 30kg, injection 10-12ml; Adult cattle 150-300kg, injection 24-28ml..

Rabbit: 0.5-1.0kg, injection 2ml.

Dog: 6-15kg, injection 4-6ml; 20-40kg, injection 6-10ml.

Goose: 0.5-1.0kg, injection 2ml.

Above injection is the dosage of No. 1 preparation, if use No. 2 preparations, consumption should strengthen as one sees fit; If use No. 3 preparations, consumption should reduce as one sees fit.The content of every injection chemical compound: No. 2 preparation is equivalent to 50% of No. 1 preparation; No. 3 preparation is equivalent to 126% of No. 1 preparation.

Claims

1, a kind of Rare Elements Preparations that is used for poultry, it is characterized in that: it is with sodium selenite 0.0001-0.01g, cobaltous sulfate 0.06-2.0g, copper sulfate 0.2-3.0g, zinc sulfate 0.4-5.0g, ferric citrate 1.0-15g, manganese sulfate 0.08-2.0g, magnesium sulfate 0.08-2.0g, Neutral potassium chromate 0.0001-0.01g, and adding 100ml water for injection obtains.

2, the Rare Elements Preparations that is used for poultry according to claim 1, it is characterized in that: it is with sodium selenite 0.001g, cobaltous sulfate 0.6g, copper sulfate 2.0g, zinc sulfate 4.0g, ferric citrate 10.0g, manganese sulfate 0.8g, magnesium sulfate 0.8g, Neutral potassium chromate 0.001g, and adding 100ml water for injection obtains.

3, according to claim 2 or the 3 described Rare Elements Preparations that are used for poultry, it is characterized in that: % is than calculating by weight, and sodium selenite contains selenium 44.2%, cobaltous sulfate and contains cobalt 24.8%, copper sulfate cupric 25.5%, zinc sulfate and contain zinc 22.7%, ferric citrate iron content 18.5%, manganese sulfate and contain that manganese 32.5%, magnesium sulfate contain magnesium 16.17%, Neutral potassium chromate contains chromium 26.18%.

4, according to any one described preparation method that is used for the Rare Elements Preparations of poultry of claim 1-3, it is characterized in that: by required weight take by weighing that sodium selenite, cobaltous sulfate, copper sulfate, zinc sulfate, ferric citrate, sulphuric acid are violent, magnesium sulfate, Neutral potassium chromate, add in a certain amount of water for injection, fully stir heating for dissolving; Filter, remove impurity; Packing, sealing ampoule; Sterilization, carry out product quality inspection, be prepared into the ejection preparation of different size, kind.