CN103110615A - Preparation method of microelement zinc-iron raw injection for pig - Google Patents
Preparation method of microelement zinc-iron raw injection for pig Download PDFInfo
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- CN103110615A CN103110615A CN2013100290527A CN201310029052A CN103110615A CN 103110615 A CN103110615 A CN 103110615A CN 2013100290527 A CN2013100290527 A CN 2013100290527A CN 201310029052 A CN201310029052 A CN 201310029052A CN 103110615 A CN103110615 A CN 103110615A
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Abstract
Aiming at the current situations of pig industries in China, the invention provides a preparation method of a microelement zinc-iron raw injection for a pig. Double distilled water is added to water-soluble zinc and iron compounds to prepare the zinc-iron raw injection. The zinc-iron raw injection is characterized by further comprising a certain amount of sorbitol, wherein preferably, the water-soluble zinc and iron compounds are zinc gluconate and ferric citrate; preferably, the zinc-iron raw injection contains 2.75g of water-soluble zinc gluconate, 6.0g of ferric citrate, 150g of sorbitol and 500ml of double distilled water; and preferably, the preparation method comprises the steps of weighing zinc gluconate according to the weight, adding double distilled water, raising the temperature, fully stirring for dissolving, adding ferric citrate and sorbitol, raising the temperature, fully stirring for dissolving, regulating a pH value, fixing the volume, filtering to remove impurities, packaging, sterilizing and inspecting by a sterilizing lamp and acquiring a finished product. Compared with the prior art, the preparation method has the beneficial effects that the reasonable matching of organic microelements is adopted; the category of the elements is reduced; the production process is simplified; and the effects of promoting the growth and increasing the immunity are obvious.
Description
Technical field
The invention belongs to the veterinary drug technical field, relate to a kind of preparation method that promotes the injection of boar and market pig growth and enhancing immunity, specifically a boar trace element zinc ferrum is given birth to the preparation method of injection.
Background technology
Trace element is that animal body is depended on for existence, the important substance of healthy growth basic.Wherein zinc, ferrum main function in body has: participate in the activation of enzyme, promote lymphopoiesis and mobility, enhancing development, enhancing immunity etc.Must keep certain amount in animal body, too low or shortage can affect its normal growth, reduces immunity, trace element deficiency even occurs.
China's floor space is large, and the Regional Distribution of mineral is different, depends merely on the needs that forage grass and drinking-water are difficult to satisfy animal body, and the rise of scale stable breeding has in addition limited the animal free choice feeding, has more reduced the absorption of trace element.Therefore, the poultry in the most areas of China all lack trace element, the different poor growth of degree and hypoimmunity occur.Though contain trace mineral supplement in feedstuff, search for food every day and easily cause trace element to exceed standard, cause trace element poisoning, affect growth promoter.
Summary of the invention
For above-mentioned problems of the prior art and defective, the object of the invention is to the pig industry present situation for China, provide a boar trace element zinc ferrum to give birth to the preparation method of injection.
One boar trace element zinc ferrum is given birth to the preparation method of injection, by zinc, the water-soluble compound of ferrum, adds distilled water formulated, it is characterized in that: also contain a certain amount of sorbitol.
As preferably, the soluble compound of zinc, ferrum is zinc gluconate and ferric citrate.
As preferably, water-soluble compound zinc gluconate 2.75g, ferric citrate 6.0g, sorbitol 150g, distilled water 500ml.
As preferably, take by weight ferric citrate → the add distilled water → abundant stirring and dissolving of heating → add zinc gluconate and the sorbitol → abundant stirring and dissolving → adjustment pH value → standardize solution → filtering and impurity removing → packing → sterilization lamp inspection → finished product of heating.
The specific embodiment:
Embodiment, its preparation method is:
A, take ferric citrate (C
6H
5FeO
75H
2O) 6.0g adds the 300ml distilled water, the abundant stirring and dissolving of heating.
B, add zinc gluconate (C again
12H
22O
14Zn) 2.75g, sorbitol 150g, the abundant stirring and dissolving of heating.
C, use sodium hydroxide solution (0.1mol/L) adjust pH to 4.5～5.5 are settled to 500mL.
D, filtration are packed as 2mL, 5mL or 10mL.
E, sterilization, lamp inspection.
Compared with prior art, beneficial effect of the present invention is:
1. use the reasonably combined of organic trace element;
2. the element kind reduces;
3. production technology is simplified;
4. promote growth and enhancing immunity successful.
Clinical trial and curative effect thereof:
Test 1:
A, method
1,35 20 of age in days Du Luoke piglets are divided into test group and matched group at random, 10 every group.Test group piglet branch intramuscular injection " zinc-iron is given birth to injection " 0.3ml/kg body weight, matched group injecting normal saline 0.3ml/kg body weight is injected 1 time altogether.After administration, every 15d adopts anticoagulation 1 time, observes E garland quantity, and blood sampling is observed 4 times continuously.
2, anticoagulation is carried out the lymphocyte proliferation experiment, according to the lymphocyte transformation degree, can reflect the immunity of organism level.
3,10d, 20d weigh in respectively once before piglets and after test, carry out weight increment test.
B, result
1, after the piggy injection zinc-iron was given birth to injection, the E rosettes rate test group that the different number of days piglet forms all was significantly higher than matched group.Concrete outcome sees Table 1.
Table 1 E rosettes rate (%)
2, after the injection zinc-iron was given birth to injection, on the impact of piglet lymphocyte proliferation when the different blood sampling time, SI represented with stimulation index.After medication, the T lymphocyte transformation of test group increment SI value is significantly higher than matched group, and concrete outcome sees Table 2.
Table 2 lymphocyte transformation increment test SI value
3, after the piggy injection zinc-iron was given birth to injection, in experimental period, test group and matched group pig were extremely remarkable at 65 ages in days and 95 age in days body weight differences, see table 3 for details.
Table 3 weight gain of piglets result of the test
C, brief summary
Can find out from table 1, table 2, E rosettes rate and lymphocyte transformation increment test SI value all are significantly improved than matched group, after giving birth to injection namely for the piggy injection zinc-iron, can significantly improve its cellular immune function.Table 3 can be found out, matched group and experimental group initial weight zero difference, but along with the increase of age in days, the weightening finish difference of test group and matched group is remarkable gradually, and as can be known, zinc-iron is given birth to the growth that injection can significantly promote piglet.
Test 2:
A, method
1,20 of 75 age in days Duroc finishing swines are divided into test group and matched group at random, 10 every group.Test group piglet branch intramuscular injection " zinc-iron is given birth to injection " 0.2ml/kg body weight, matched group injecting normal saline 0.2ml/kg body weight is injected 1 time altogether.After administration, every 10d adopts anticoagulation 1 time, observes E garland quantity, and blood sampling is observed 4 times continuously.
2, test front and test and weighed in respectively once in rear 1 month, 2 months, carrying out weight increment test.
B, result
1, after growth pig injection zinc-iron was given birth to injection, the E rosettes rate test group that the pig of different number of days forms was all higher than matched group.Concrete outcome sees Table 4.
Table 4 E rosettes rate (%)
2, after growth pig injection zinc-iron was given birth to injection, in experimental period, test group and matched group pig were extremely remarkable at 105 ages in days and 135 age in days body weight differences, see table 5 for details.
Table 5 growth pig weight increment test result
C, brief summary
As can be seen from Table 4, E rosettes rate is improved than matched group, after giving birth to injection namely for growth pig injection zinc-iron, can improve its cellular immune function.Table 5 can be found out, matched group and the basic zero difference of experimental group initial weight, but along with the increase of age in days, and the daily gain significant difference of test group and matched group illustrates that zinc-iron gives birth to injection can significantly promote the to grow growth of pig.
Test 3:
A, method
20 adult broad sows are divided into test group and matched group at random, 10 every group.Test group pig branch intramuscular injection " zinc-iron is given birth to injection " 0.2ml/kg body weight, matched group injecting normal saline 0.2ml/kg body weight is injected 1 time altogether.15d adopts respectively anticoagulation 1 time before administration and after administration, observes E rosettes quantity; Simultaneously its appetite, skin are observed by hair, the mental status etc.
B, result
1, grow up after boar injection zinc-iron gives birth to injection, before administration and the E rosettes rate test group that after administration, 15d forms all higher than matched group.Concrete outcome sees Table 6.
The E rosettes rate (%) of broad sow after table 6 uses zinc-iron to give birth to
2, grow up after broad sow injection zinc-iron gives birth to injection, in experimental period test group pig appetite, skin by hair, the mental status etc. significantly better than matched group.Concrete outcome sees Table 7.
Broad sow cosmetic variation situation after table 7 uses zinc-iron to give birth to
C, brief summary
Give birth to the broad sow of preparation by the injection zinc-iron, appetite increases, and the mental status is clearly better than matched group, and is ruddy shinny, and is neatly glossy by hair.E rosettes rate is improved than matched group, after namely giving birth to injection to broad sow injection zinc-iron, can improve its hematid immunity function.Illustrate that this preparation can strengthen the immunity of boar, enhance metabolism, improve swinery health level.
Claims (4)
1. a boar trace element zinc ferrum is given birth to the preparation method of injection, it is characterized in that: by zinc, the water-soluble compound of ferrum, add distilled water formulated, it is characterized in that: also contain a certain amount of sorbitol.
2. a boar trace element zinc ferrum according to claim 1 is given birth to the preparation method of injection, and it is characterized in that: the soluble compound of zinc, ferrum is zinc gluconate and ferric citrate.
3. a boar trace element zinc ferrum according to claim 1 is given birth to the preparation method of injection, it is characterized in that: take by weight ferric citrate → the add distilled water → abundant stirring and dissolving of heating → add zinc gluconate and the sorbitol → abundant stirring and dissolving → adjustment pH value → standardize solution → filtering and impurity removing → packing → sterilization lamp inspection → finished product of heating.
4. a boar trace element zinc ferrum according to claim 3 is given birth to the preparation method of injection, it is characterized in that: water-soluble compound zinc gluconate 2.75g, ferric citrate 6.0g, sorbitol 150g, distilled water 500ml.
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| CN2013100290527A CN103110615A (en) | 2013-01-15 | 2013-01-15 | Preparation method of microelement zinc-iron raw injection for pig |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948624A (en) * | 2014-03-24 | 2014-07-30 | 甘孜藏族自治州畜牧业科学研究所 | Yak disease-resistance, growth-promoting and fat-growing agent and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380065A (en) * | 2002-04-27 | 2002-11-20 | 叶玉辉 | Trace element preparation for livestock and fowl and its preparation method |
| CN1517085A (en) * | 2003-01-15 | 2004-08-04 | 华瑞制药有限公司 | Multi-microelement injecta and its preparation method and application |
-
2013
- 2013-01-15 CN CN2013100290527A patent/CN103110615A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1380065A (en) * | 2002-04-27 | 2002-11-20 | 叶玉辉 | Trace element preparation for livestock and fowl and its preparation method |
| CN1517085A (en) * | 2003-01-15 | 2004-08-04 | 华瑞制药有限公司 | Multi-microelement injecta and its preparation method and application |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948624A (en) * | 2014-03-24 | 2014-07-30 | 甘孜藏族自治州畜牧业科学研究所 | Yak disease-resistance, growth-promoting and fat-growing agent and preparation method thereof |
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Application publication date: 20130522 |