CN114796007B - Antioxidant composition and preparation method and application thereof - Google Patents
Antioxidant composition and preparation method and application thereof Download PDFInfo
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- CN114796007B CN114796007B CN202210479960.5A CN202210479960A CN114796007B CN 114796007 B CN114796007 B CN 114796007B CN 202210479960 A CN202210479960 A CN 202210479960A CN 114796007 B CN114796007 B CN 114796007B
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- 230000003078 antioxidant effect Effects 0.000 title claims abstract description 94
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 86
- 239000000203 mixture Substances 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title abstract description 10
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 claims abstract description 41
- 230000002195 synergetic effect Effects 0.000 claims abstract description 36
- 239000003961 penetration enhancing agent Substances 0.000 claims abstract description 32
- 239000002537 cosmetic Substances 0.000 claims abstract description 13
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical group CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 12
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims description 10
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical group OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 10
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 10
- 229940101267 panthenol Drugs 0.000 claims description 10
- 235000020957 pantothenol Nutrition 0.000 claims description 10
- 239000011619 pantothenol Substances 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 8
- 239000000787 lecithin Substances 0.000 claims description 8
- 229940067606 lecithin Drugs 0.000 claims description 8
- 235000010445 lecithin Nutrition 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 5
- 235000019161 pantothenic acid Nutrition 0.000 claims description 5
- 239000011713 pantothenic acid Substances 0.000 claims description 5
- 229940055726 pantothenic acid Drugs 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035515 penetration Effects 0.000 abstract description 3
- 238000013329 compounding Methods 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 20
- 239000000243 solution Substances 0.000 description 18
- 230000003064 anti-oxidating effect Effects 0.000 description 16
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 8
- 238000005562 fading Methods 0.000 description 7
- 238000002845 discoloration Methods 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 239000002516 radical scavenger Substances 0.000 description 3
- 239000012488 sample solution Substances 0.000 description 3
- 229940123457 Free radical scavenger Drugs 0.000 description 2
- 230000002292 Radical scavenging effect Effects 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- MGJZITXUQXWAKY-UHFFFAOYSA-N diphenyl-(2,4,6-trinitrophenyl)iminoazanium Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1N=[N+](C=1C=CC=CC=1)C1=CC=CC=C1 MGJZITXUQXWAKY-UHFFFAOYSA-N 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- MRAMPOPITCOOIN-VIFPVBQESA-N (2r)-n-(3-ethoxypropyl)-2,4-dihydroxy-3,3-dimethylbutanamide Chemical compound CCOCCCNC(=O)[C@H](O)C(C)(C)CO MRAMPOPITCOOIN-VIFPVBQESA-N 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000003915 air pollution Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 239000003574 free electron Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses an antioxidant composition, a preparation method and application thereof, and belongs to the field of cosmetics, wherein the antioxidant composition comprises the following components in parts by weight: 0.1-30 parts of 3-O-ethyl-L-ascorbic acid, 0.1-30 parts of synergistic antioxidant and 0.1-12.5 parts of penetration enhancer. According to the invention, the antioxidant effect of the 3-O-ethyl-L-ascorbic acid in cosmetics is improved by compounding the synergistic antioxidant, and meanwhile, the penetration enhancer is compounded, so that the penetration rate of the antioxidant composition is improved, the antioxidant composition enters deep skin, and the antioxidant effect is further exerted.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to an antioxidant composition, and a preparation method and application thereof.
Background
The human skin is the largest organ of the body and is the first barrier for human contact with the outside. However, the living environment, air pollution, sunlight irradiation and the like can generate a large amount of free radicals in our bodies, the free radicals can attack normal cells in the bodies, promote the aging of the cells, further destroy the structures of tissues and cells, and cause various skin problems such as aging, color spots, darkness, dryness, sensitivity and the like.
Cosmetics mainly use various high-efficiency antioxidant components, such as free radical trapping or eliminating. 3-O-ethyl-L-ascorbic acid is one of the antioxidant components, and when the 3-O-ethyl-L-ascorbic acid is applied to skin, the 3-O-ethyl-L-ascorbic acid has strong polarity and lower penetration efficiency into the skin, so that the antioxidant and whitening effects are reduced.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides an antioxidant composition, and a preparation method and application thereof.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
in a first aspect, an antioxidant composition comprises the following components in parts by weight: 0.1-30 parts of 3-O-ethyl-L-ascorbic acid, 0.1-30 parts of synergistic antioxidant and 0.1-12.5 parts of penetration enhancer.
According to the invention, the antioxidant effect of the 3-O-ethyl-L-ascorbic acid in cosmetics is improved by compounding the synergistic antioxidant, and meanwhile, the penetration enhancer is compounded, so that the penetration rate of the antioxidant composition is improved, the antioxidant composition enters deep skin, and the antioxidant effect is further exerted.
Preferably, the synergistic antioxidant is panthenol and/or panthenol ethyl ether.
Preferably, the permeation enhancer is lecithin and/or hydrogenated lecithin.
According to the invention, panthenol and/or pantothenic acid alcohol ethyl ether are used as synergistic antioxidants, so that the antioxidation effect of the antioxidation composition is improved, and meanwhile, lecithin and/or hydrogenated lecithin are used as permeation promoters to wrap the mixture of 3-O-ethyl-L-ascorbic acid, panthenol and/or pantothenic acid alcohol ethyl ether, so that the permeation rate of the antioxidation composition is improved, 3-O-ethyl-L-ascorbic acid is helped to enter the deep layer of skin better, and the antioxidation effect is exerted, so that the antioxidation effect of the antioxidation composition is improved.
Preferably, the mass ratio of the 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant and the penetration enhancer is 3-O-ethyl-L-ascorbic acid: synergistic antioxidants: permeation enhancer = 15-70:15-70:1.
The inventor finds that the prepared antioxidant composition has better antioxidant effect under the proportion.
Preferably, the mass ratio of the 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant and the penetration enhancer is 3-O-ethyl-L-ascorbic acid: synergistic antioxidants: permeation enhancer = 20-70:20-70:1.
The inventor finds that the prepared antioxidant composition has better antioxidant effect under the proportion.
Preferably, the mass ratio of the 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant and the penetration enhancer is 3-O-ethyl-L-ascorbic acid: synergistic antioxidants: permeation enhancer = 30-70:30-70:1.
The inventors found that the antioxidant effect of the prepared antioxidant composition is best at the above ratio.
In a second aspect, there is provided a method of preparing an antioxidant composition comprising the steps of:
(1) Adding a penetration enhancer, 3-O-ethyl-L-ascorbic acid and a synergistic antioxidant into water, and stirring at 80 ℃ to form a uniform mixture;
(2) Homogenizing the mixture obtained in the step (1) at the same temperature as in the step (1), and then cooling to room temperature;
(3) And (3) uniformly stirring the mixture obtained in the step (2), regulating the pH to 4.0-8.0, filtering, and cooling to obtain the antioxidant composition.
Since the antioxidant composition needs to be used in cosmetics, it is necessary to control the pH of the antioxidant composition to ensure that it meets the acceptable pH range for human skin.
In a third aspect, there is provided a cosmetic comprising said antioxidant composition.
The above cosmetics include, but are not limited to, lotions, essences, skin care lotions, skin care creams, facial cleansers, facial masks, and the like.
Preferably, the content of the antioxidant composition is 0.1% -30% of the total mass of the cosmetic.
The cosmetic also contains other auxiliary materials, and the content of the antioxidant composition needs to be controlled to ensure that the antioxidant composition can play an antioxidant role.
Compared with the prior art, the invention has the beneficial effects that:
According to the invention, panthenol and/or pantothenic acid alcohol ethyl ether are used as synergistic antioxidants, so that the antioxidation effect of the antioxidation composition is improved, and meanwhile, lecithin and/or hydrogenated lecithin are used as permeation promoters to wrap the mixture of 3-O-ethyl-L-ascorbic acid, panthenol and/or pantothenic acid alcohol ethyl ether, so that the permeation rate of the antioxidation composition is improved, 3-O-ethyl-L-ascorbic acid is helped to enter the deep layer of skin better, and the antioxidation effect is exerted, so that the antioxidation effect of the antioxidation composition is improved.
Drawings
FIG. 1 is a graph showing the state of discoloration of an iodophor solution at 0min for effect example 1;
FIG. 2 is a graph showing the state of discoloration of an iodophor solution at 44min for effect example 1;
FIG. 3 is a graph showing the state of discoloration of an iodophor solution at 72min for effect example 1;
FIG. 4 is a graph showing the state of discoloration of an iodophor solution at 80min for effect example 1;
FIG. 5 is a graph showing the state of discoloration of an iodophor solution at 96min for effect example 1;
FIG. 6 is a graph showing the state of discoloration of an iodophor solution at 103min in effect example 1.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples and the accompanying drawings.
Examples 1 to 4
The composition components of the antioxidant compositions of examples 1 to 4 of the present invention are shown in Table 1 below.
The preparation method of the antioxidant composition of the embodiments 1-4 comprises the following steps:
(1) Adding a penetration enhancer, 3-O-ethyl-L-ascorbic acid and a synergistic antioxidant into water, and stirring at 80 ℃ to form a uniform mixture;
(2) Homogenizing the mixture obtained in the step (1) at 80 ℃ at a rotating speed of 5000r/min for 4min, and then cooling to room temperature;
(3) And (3) uniformly stirring the mixture obtained in the step (2), then adjusting the pH to 4.0-8.0, filtering, and cooling to obtain the antioxidant composition.
The antioxidant compositions obtained in examples 1 to 4 were tested for antioxidant effect by the following test methods: preparing 2% iodophor solution, respectively taking 4 split charging bottles, respectively filling 29g of 2% iodophor solution into the bottle mouth, and sealing the bottle mouth with 3M synthetic skin. Meanwhile, 0.3g of the stock solutions of examples 1-4 are respectively dripped on 3M synthetic skin in split-charging bottles, and the fading condition of 2% iodophor solution in the split-charging bottles is respectively observed along with the time change. The test results are shown in Table 1.
TABLE 1
As can be seen from Table 1, the antioxidant composition of the present application has a good antioxidant effect.
Effect example 1
Effect example the effect of different components on the oxidation resistance of the oxidation resistant composition was tested, and control group 1-6, control group 4-1 and control group 6-1 were set, and the composition components of control group 1-6, control group 4-1 and control group 6-1 are shown in table 2 below, and the oxidation resistant compositions of control group 1-5 and control group 6-1 were prepared according to the preparation method of example 1-4.
The only difference between the control group 4-1 and the control group 4 is the preparation method difference, and the only difference between the control group 6 and the control group 6-1 is the preparation method difference; the preparation method of the control group 4-1 and the control group 6 comprises the following steps:
(1) Adding a penetration enhancer into water, and stirring at 80 ℃ to form a uniform mixture;
(2) Homogenizing the mixture obtained in the step (1) at 80 ℃ at a rotating speed of 5000r/min for 4min, and then cooling to room temperature;
(3) Adding the 3-O-ethyl-L-ascorbic acid and the synergistic antioxidant into the mixture obtained in the step (2), uniformly stirring, then adjusting the pH value to 6.0, filtering, and cooling to obtain the antioxidant composition.
The antioxidant properties of the antioxidant compositions of the control group 1-6, the control group 4-1 and the control group 6-1 were tested by the following methods:
(1) Preparing 2% iodophor solution, respectively taking 8 split charging bottles, respectively filling 29g of 2% iodophor solution into the bottle mouth, and sealing the bottle mouth with 3M synthetic skin. Meanwhile, 0.3g of the stock solutions of examples 1-4 are respectively dripped on 3M synthetic skin in split-charging bottles, and the fading condition of 2% iodophor solution in the split-charging bottles is respectively observed along with the time change.
(2) DPPH radical scavenging rate
DPPH is a stable nitrogen-centered radical with a maximum absorbance at 517 nm. The DPPH assay is a simple method for screening radical scavengers and evaluating antioxidant activity. When the free radical scavenger exists, the absorption of the DPPH liquid gradually disappears due to the pairing of the free radical scavenger and electrons in the DPPH, and the fading degree of the DPPH liquid and the paired electron number form a stoichiometric relation, so that the quantitative analysis can be performed by a spectrophotometry.
The test steps are as follows:
taking the antioxidant compositions of the control group 1-6, the control group 4-1 and the control group 6-1 as sample solutions, accurately sucking 1mL of the sample solution, adding 5mL of DPPH solution with the concentration of 0.1mmol/L, uniformly mixing, standing for 30min at room temperature (25 ℃) in a dark place, measuring the absorbance at 517nm, and calculating the clearance rate, wherein the formula of the clearance rate of DPPH free radicals is as follows: DPPH clearance= [1- (a 1-A2)/A0 ]. 100%;
wherein, the absorbance of A 0 -1 mL of 95% ethanol+3 mLDPPH solution;
A 1 -1 mL absorbance of sample solution + mLDPPH solution;
Absorbance of A 2 -1 mL95% absolute ethanol+3 mLDPPH solution (error in color between different samples was eliminated).
The test results are shown in table 2, fig. 1, fig. 2, fig. 3, fig. 4, fig. 5, and fig. 6.
TABLE 2
From table 1 and fig. 1-6 the following conclusions can be drawn:
1. as can be seen from the data of control group 1, control group 2 and control group 5, 3-O-ethyl-L-ascorbic acid has an antioxidant effect, whereas panthenol and lecithin have no antioxidant effect;
2. As can be seen from the experimental data of the control group 1 and the control group 3, the time for completely fading the control group 1 is 80min, the time for completely fading the control group 3 is 103min, which indicates that only the addition of panthenol reduces the antioxidation effect of the 3-O-ethyl-L-ascorbic acid;
3. As can be seen from the experimental data of the control group 1, the control group 4 and the control group 4-1, the fading time of the control group 4-1 and the control group 6 is 96min and 103min respectively, which indicates that lecithin is added into the antioxidant composition, but the active ingredients are not wrapped, so that the antioxidant effect of the antioxidant composition can be reduced, and the 3-O-ethyl-L-ascorbic acid is wrapped by the lecithin in the control group 4, so that the antioxidant effect of the antioxidant composition can be improved;
4. The experimental data of the control group 4 and the control group 6-1 show that the addition of the panthenol can further reduce the fading time of the iodophor solution and improve the antioxidation effect of the antioxidation composition, which shows that the 3-O-ethyl-L-ascorbic acid, lecithin and panthenol have mutual synergistic effect and play a role in antioxidation of synergistic effect.
Effect example 2
In this effect example, the influence of the mass ratio of 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant and the permeation enhancer on the performance of the antioxidant composition was examined, test groups 1 to 7 were set, the antioxidant compositions of test groups 1 to 7 were prepared in the same manner as in example 1 except that the mass ratio of 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant and the permeation enhancer in test groups 1 to 7 were different, the antioxidant properties of the antioxidant compositions of test groups 1 to 7 were tested in the manner of DPPH radical scavenging rate in effect example 1, and the mass ratio of 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant and the permeation enhancer in the antioxidant compositions of test groups 1 to 7 and the test results were shown in Table 3.
TABLE 3 Table 3
As can be seen from table 2, when the total mass of the 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant, and the permeation enhancer in the antioxidant composition is the same, the mass ratio of the 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant, and the permeation enhancer is 3-O-ethyl-L-ascorbic acid: synergistic antioxidants: the antioxidant composition has better antioxidant effect when the penetration enhancer=15-70:15-70:1, wherein when the mass ratio of 3-O-ethyl-L-ascorbic acid, the synergistic antioxidant and the penetration enhancer is 3-O-ethyl-L-ascorbic acid: synergistic antioxidants: penetration enhancer = 70:70:1, the antioxidant effect of the antioxidant composition is optimal.
Finally, it should be noted that the above-mentioned embodiments illustrate rather than limit the scope of the invention, and that those skilled in the art will understand that the technical scheme of the invention may be modified or equally substituted without departing from the spirit and scope of the technical scheme of the invention.
Claims (8)
1. An antioxidant composition is characterized by comprising the following components in parts by weight: 0.1-30 parts of 3-O-ethyl-L-ascorbic acid, 0.1-30 parts of synergistic antioxidant and 0.1-12.5 parts of penetration enhancer; the synergistic antioxidant is panthenol and/or pantothenic acid alcohol ethyl ether; the permeation enhancer is lecithin and/or hydrogenated lecithin; the permeation enhancer encapsulates the 3-O-ethyl-L-ascorbic acid and the synergistic antioxidant.
2. The antioxidant composition of claim 1, wherein the mass ratio of 3-O-ethyl-L-ascorbic acid, synergistic antioxidant, permeation enhancer is 3-O-ethyl-L-ascorbic acid: synergistic antioxidants: permeation enhancer = 15-70:15-70:1.
3. The antioxidant composition of claim 1, wherein the mass ratio of 3-O-ethyl-L-ascorbic acid, synergistic antioxidant, permeation enhancer is 3-O-ethyl-L-ascorbic acid: synergistic antioxidants: permeation enhancer = 20-70:20-70:1.
4. The antioxidant composition of claim 1, wherein the mass ratio of 3-O-ethyl-L-ascorbic acid, synergistic antioxidant, permeation enhancer is 3-O-ethyl-L-ascorbic acid: synergistic antioxidants: permeation enhancer = 30-70:30-70:1.
5. A process for preparing an antioxidant composition as claimed in any one of claims 1 to 4, comprising the steps of:
(1) Adding a penetration enhancer, 3-O-ethyl-L-ascorbic acid and a synergistic antioxidant into water, and stirring at 40-80 ℃ to form a uniform mixture;
(2) Homogenizing the mixture obtained in the step (1) at the same temperature as in the step (1), and then cooling to room temperature;
(3) And (3) uniformly stirring the mixture obtained in the step (2), regulating the pH, filtering, and cooling to obtain the antioxidant composition.
6. The process according to claim 5, wherein the pH in the step (3) is 4.0 to 8.0.
7. A cosmetic comprising the antioxidant composition of any one of claims 1 to 4.
8. The cosmetic according to claim 7, wherein the content of the antioxidant composition is 0.1% to 30% of the total mass of the cosmetic.
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| CN113101236A (en) * | 2021-04-30 | 2021-07-13 | 上海其然生物科技有限公司 | Instant mixed and used whitening essence with multiple antioxidation effects and preparation method thereof |
| CN113208945A (en) * | 2021-05-18 | 2021-08-06 | 华熙生物科技股份有限公司 | Antioxidant composition, preparation method and application thereof in cosmetic composition |
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| CN108653037A (en) * | 2018-07-27 | 2018-10-16 | 北京斯利安药业有限公司 | Skin conditioning agent composition, its application and whitening mask |
| JP2019137695A (en) * | 2019-05-14 | 2019-08-22 | 株式会社クラレ | Method for permeation of skin active ingredient |
| CN113101236A (en) * | 2021-04-30 | 2021-07-13 | 上海其然生物科技有限公司 | Instant mixed and used whitening essence with multiple antioxidation effects and preparation method thereof |
| CN113208945A (en) * | 2021-05-18 | 2021-08-06 | 华熙生物科技股份有限公司 | Antioxidant composition, preparation method and application thereof in cosmetic composition |
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