CN114787631A - 用于评估帕金森病的神经黑色素敏感性mri - Google Patents

用于评估帕金森病的神经黑色素敏感性mri Download PDF

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Publication number
CN114787631A
CN114787631A CN202080067730.7A CN202080067730A CN114787631A CN 114787631 A CN114787631 A CN 114787631A CN 202080067730 A CN202080067730 A CN 202080067730A CN 114787631 A CN114787631 A CN 114787631A
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China
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mri
disease
parkinson
neuromelanin
years
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CN202080067730.7A
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Chinese (zh)
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S·克拉克
G·霍尔加赫尔南德茨
C·M·卡西迪
K·温格勒
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Mental Health Research Foundation Co ltd
Human Bioscience Co ltd
Columbia University in the City of New York
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Mental Health Research Foundation Co ltd
Human Bioscience Co ltd
Columbia University in the City of New York
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4082—Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/70—Means for positioning the patient in relation to the detecting, measuring or recording means
    • A61B5/702—Posture restraints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03—Computed tomography [CT]
    • A61B6/037—Emission tomography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Physiology (AREA)
  • Developmental Disabilities (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
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  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Optics & Photonics (AREA)
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CN202080067730.7A 2019-08-20 2020-08-17 用于评估帕金森病的神经黑色素敏感性mri Pending CN114787631A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962889300P 2019-08-20 2019-08-20
US62/889,300 2019-08-20
PCT/US2020/046686 WO2021034770A1 (en) 2019-08-20 2020-08-17 Neuromelanin-sensitive mri for assessing parkinson's disease

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CN114787631A true CN114787631A (zh) 2022-07-22

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US (2) US20220273184A1 (https=)
EP (1) EP4018202A4 (https=)
JP (2) JP2022545083A (https=)
KR (2) KR20220100851A (https=)
CN (1) CN114787631A (https=)
AU (1) AU2020334980A1 (https=)
CA (1) CA3151632A1 (https=)
IL (1) IL290693A (https=)
MX (1) MX2022002105A (https=)
WO (1) WO2021034770A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10955423B2 (en) 2015-12-15 2021-03-23 The General Hospital Corporation Methods of estimating blood glucose and related systems
US11293852B2 (en) 2016-04-07 2022-04-05 The General Hospital Corporation White blood cell population dynamics
US20220273184A1 (en) * 2019-08-20 2022-09-01 Terran Biosciences, Inc. Neuromelanin-sensitive mri for assessing parkinson's disease
TWI781463B (zh) * 2020-10-15 2022-10-21 臺北醫學大學 腦部多巴胺轉運體檢查系統及其運作方法
JP2024510080A (ja) * 2021-03-11 2024-03-06 テラン バイオサイエンシズ インコーポレイテッド バイオマーカーを含む撮像データセットのハーモナイゼーションのためのシステム、デバイス及び方法
EP4312729A4 (en) * 2021-04-02 2025-02-26 Spintech, Inc. SYSTEMS AND METHODS FOR TEMPLATE-BASED AUTOMATIC RECOGNITION OF ANATOMICAL STRUCTURES
WO2022266654A1 (en) * 2021-06-16 2022-12-22 The General Hospital Corporation Methods to characterize functional and dysfunctional acute inflammatory responses to pathologic processes
US11911170B2 (en) * 2021-09-13 2024-02-27 Christopher J. Rourk Deep brain sensing and stimulation probe
TW202333668A (zh) 2021-12-15 2023-09-01 美商德利克斯醫療公司 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途
WO2023235766A2 (en) * 2022-05-31 2023-12-07 University Of Ottawa Institute Of Mental Health Research Methods for acquiring and analyzing neuromelanin-sensitive mri
US12599313B2 (en) * 2022-06-23 2026-04-14 ViBo Health LLC Health trackers for autonomous targeting of tissue sampling sites
CN114999657A (zh) * 2022-08-03 2022-09-02 首都医科大学附属北京友谊医院 评估帕金森病患者的神经纤维束与步态障碍的相关性的方法和相关产品
US20260049105A1 (en) * 2022-08-18 2026-02-19 Arizona Board Of Regents On Behalf Of The University Of Arizona Selective mc4r ligand for treating obesity and cognitive loss
WO2024081800A1 (en) * 2022-10-12 2024-04-18 Octave Bioscience, Inc. Measuring brain volumes for modeling neurological disease state
CN115735857B (zh) * 2022-11-24 2025-11-18 江苏珂玛麒生物科技有限公司 一种帕金森病动物模型的构建方法
KR102906269B1 (ko) * 2023-08-03 2026-01-02 재단법인대구경북과학기술원 파킨슨 환자의 lid 발병 예측을 위한 정보제공방법
CN116740064B (zh) * 2023-08-14 2023-10-20 山东奥洛瑞医疗科技有限公司 一种核磁共振肿瘤区域提取方法
CN117372437B (zh) * 2023-12-08 2024-02-23 安徽农业大学 用于面神经麻痹智能化检测与量化方法及其系统
KR102832391B1 (ko) * 2024-08-13 2025-07-14 주식회사 휴런 Mri영상에서 뉴로멜라닌의 탈침착 정량화를 위한 이미지 처리방법 및 그 처리장치
KR102834035B1 (ko) * 2024-08-16 2025-07-21 주식회사 휴런 3d 멀티 에코 gre를 이용한 뉴로멜라닌과 나이그로좀1의 동시 촬영 및 이미지 처리방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260577A1 (en) * 2000-10-09 2005-11-24 Kay Double Detection of neurodegenerative disorders
US20070275944A1 (en) * 2006-04-05 2007-11-29 The Board Of Trustees Operating Michigan State University Antioxidants and methods of their use
US20150023877A1 (en) * 2013-07-18 2015-01-22 The Board Of Trustees Of The Leland Stanford Junior University Methods of parkinsons disease diagnosis and monitoring treatment
CN105637536A (zh) * 2013-07-02 2016-06-01 外科信息科学股份有限公司 脑图像流水线和脑图像区域位置和形状预测的方法和系统
US20190049466A1 (en) * 2015-09-23 2019-02-14 Boston Medical Center Corporation Biomarkers for the early detection of parkinson's disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288545B1 (en) * 1999-03-22 2001-09-11 General Electric Company Method and apparatus for calibration of RF and gradient field time delays
EP2844143B1 (en) * 2012-05-04 2023-07-19 Emory University Method for imaging and determining information associated with regions of the brain
ES2822201T3 (es) * 2014-06-12 2021-04-29 Commissariat Energie Atomique Método de IRM para cuantificar la cantidad de hierro en tejidos utilizando difusión por imágenes de resonancia magnética
WO2016154682A1 (en) * 2015-04-02 2016-10-06 Crc For Mental Health Ltd Method for predicting risk of cognitive deterioration
US11352671B2 (en) * 2015-05-01 2022-06-07 Vanderbilt University Predicting therapeutic response in Parkinson's disease
EP3547252B1 (en) * 2016-12-28 2025-10-22 Shanghai United Imaging Healthcare Co., Ltd. Multi-modal image processing system and method
CN113271985A (zh) * 2018-08-07 2021-08-17 悦智有限公司 用于诊断多巴胺能和运动障碍的方法
US20220273184A1 (en) * 2019-08-20 2022-09-01 Terran Biosciences, Inc. Neuromelanin-sensitive mri for assessing parkinson's disease

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050260577A1 (en) * 2000-10-09 2005-11-24 Kay Double Detection of neurodegenerative disorders
US20070275944A1 (en) * 2006-04-05 2007-11-29 The Board Of Trustees Operating Michigan State University Antioxidants and methods of their use
CN105637536A (zh) * 2013-07-02 2016-06-01 外科信息科学股份有限公司 脑图像流水线和脑图像区域位置和形状预测的方法和系统
US20150023877A1 (en) * 2013-07-18 2015-01-22 The Board Of Trustees Of The Leland Stanford Junior University Methods of parkinsons disease diagnosis and monitoring treatment
US20190049466A1 (en) * 2015-09-23 2019-02-14 Boston Medical Center Corporation Biomarkers for the early detection of parkinson's disease

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLIFFORD M. CASSIDY 等: ""Neuromelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain"", PNAS, vol. 116, no. 11, 22 February 2019 (2019-02-22), pages 5108 - 5117, XP055652401, DOI: 10.1073/pnas.1807983116 *

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EP4018202A1 (en) 2022-06-29
KR20250110932A (ko) 2025-07-21
CA3151632A1 (en) 2021-02-25
WO2021034770A1 (en) 2021-02-25
AU2020334980A1 (en) 2022-03-03
EP4018202A4 (en) 2023-11-01
JP2025074118A (ja) 2025-05-13
KR20220100851A (ko) 2022-07-18
JP2022545083A (ja) 2022-10-25
MX2022002105A (es) 2022-08-04
IL290693A (en) 2022-04-01
US20220273184A1 (en) 2022-09-01
US20260007323A1 (en) 2026-01-08

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