JP2022545083A - パーキンソン病を評価するためのニューロメラニン高感度mri - Google Patents
パーキンソン病を評価するためのニューロメラニン高感度mri Download PDFInfo
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- JP2022545083A JP2022545083A JP2022510980A JP2022510980A JP2022545083A JP 2022545083 A JP2022545083 A JP 2022545083A JP 2022510980 A JP2022510980 A JP 2022510980A JP 2022510980 A JP2022510980 A JP 2022510980A JP 2022545083 A JP2022545083 A JP 2022545083A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4082—Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
- A61B5/4088—Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
- A61B5/4842—Monitoring progression or stage of a disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/70—Means for positioning the patient in relation to the detecting, measuring or recording means
- A61B5/702—Posture restraints
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
- A61B6/03—Computed tomography [CT]
- A61B6/037—Emission tomography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Radiology & Medical Imaging (AREA)
- High Energy & Nuclear Physics (AREA)
- General Physics & Mathematics (AREA)
- Physiology (AREA)
- Developmental Disabilities (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Optics & Photonics (AREA)
- Psychiatry (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025028218A JP2025074118A (ja) | 2019-08-20 | 2025-02-25 | パーキンソン病を評価するためのニューロメラニン高感度mri |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962889300P | 2019-08-20 | 2019-08-20 | |
| US62/889,300 | 2019-08-20 | ||
| PCT/US2020/046686 WO2021034770A1 (en) | 2019-08-20 | 2020-08-17 | Neuromelanin-sensitive mri for assessing parkinson's disease |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025028218A Division JP2025074118A (ja) | 2019-08-20 | 2025-02-25 | パーキンソン病を評価するためのニューロメラニン高感度mri |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022545083A true JP2022545083A (ja) | 2022-10-25 |
| JPWO2021034770A5 JPWO2021034770A5 (https=) | 2023-08-25 |
| JP2022545083A5 JP2022545083A5 (https=) | 2023-08-25 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022510980A Withdrawn JP2022545083A (ja) | 2019-08-20 | 2020-08-17 | パーキンソン病を評価するためのニューロメラニン高感度mri |
| JP2025028218A Pending JP2025074118A (ja) | 2019-08-20 | 2025-02-25 | パーキンソン病を評価するためのニューロメラニン高感度mri |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025028218A Pending JP2025074118A (ja) | 2019-08-20 | 2025-02-25 | パーキンソン病を評価するためのニューロメラニン高感度mri |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20220273184A1 (https=) |
| EP (1) | EP4018202A4 (https=) |
| JP (2) | JP2022545083A (https=) |
| KR (2) | KR20220100851A (https=) |
| CN (1) | CN114787631A (https=) |
| AU (1) | AU2020334980A1 (https=) |
| CA (1) | CA3151632A1 (https=) |
| IL (1) | IL290693A (https=) |
| MX (1) | MX2022002105A (https=) |
| WO (1) | WO2021034770A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025074118A (ja) * | 2019-08-20 | 2025-05-13 | テラン バイオサイエンシズ インコーポレイテッド | パーキンソン病を評価するためのニューロメラニン高感度mri |
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| US10955423B2 (en) | 2015-12-15 | 2021-03-23 | The General Hospital Corporation | Methods of estimating blood glucose and related systems |
| US11293852B2 (en) | 2016-04-07 | 2022-04-05 | The General Hospital Corporation | White blood cell population dynamics |
| TWI781463B (zh) * | 2020-10-15 | 2022-10-21 | 臺北醫學大學 | 腦部多巴胺轉運體檢查系統及其運作方法 |
| JP2024510080A (ja) * | 2021-03-11 | 2024-03-06 | テラン バイオサイエンシズ インコーポレイテッド | バイオマーカーを含む撮像データセットのハーモナイゼーションのためのシステム、デバイス及び方法 |
| EP4312729A4 (en) * | 2021-04-02 | 2025-02-26 | Spintech, Inc. | SYSTEMS AND METHODS FOR TEMPLATE-BASED AUTOMATIC RECOGNITION OF ANATOMICAL STRUCTURES |
| WO2022266654A1 (en) * | 2021-06-16 | 2022-12-22 | The General Hospital Corporation | Methods to characterize functional and dysfunctional acute inflammatory responses to pathologic processes |
| US11911170B2 (en) * | 2021-09-13 | 2024-02-27 | Christopher J. Rourk | Deep brain sensing and stimulation probe |
| TW202333668A (zh) | 2021-12-15 | 2023-09-01 | 美商德利克斯醫療公司 | 經苯氧基及苄氧基取代之精神成形素(psychoplastogen)及其用途 |
| WO2023235766A2 (en) * | 2022-05-31 | 2023-12-07 | University Of Ottawa Institute Of Mental Health Research | Methods for acquiring and analyzing neuromelanin-sensitive mri |
| US12599313B2 (en) * | 2022-06-23 | 2026-04-14 | ViBo Health LLC | Health trackers for autonomous targeting of tissue sampling sites |
| CN114999657A (zh) * | 2022-08-03 | 2022-09-02 | 首都医科大学附属北京友谊医院 | 评估帕金森病患者的神经纤维束与步态障碍的相关性的方法和相关产品 |
| US20260049105A1 (en) * | 2022-08-18 | 2026-02-19 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Selective mc4r ligand for treating obesity and cognitive loss |
| WO2024081800A1 (en) * | 2022-10-12 | 2024-04-18 | Octave Bioscience, Inc. | Measuring brain volumes for modeling neurological disease state |
| CN115735857B (zh) * | 2022-11-24 | 2025-11-18 | 江苏珂玛麒生物科技有限公司 | 一种帕金森病动物模型的构建方法 |
| KR102906269B1 (ko) * | 2023-08-03 | 2026-01-02 | 재단법인대구경북과학기술원 | 파킨슨 환자의 lid 발병 예측을 위한 정보제공방법 |
| CN116740064B (zh) * | 2023-08-14 | 2023-10-20 | 山东奥洛瑞医疗科技有限公司 | 一种核磁共振肿瘤区域提取方法 |
| CN117372437B (zh) * | 2023-12-08 | 2024-02-23 | 安徽农业大学 | 用于面神经麻痹智能化检测与量化方法及其系统 |
| KR102832391B1 (ko) * | 2024-08-13 | 2025-07-14 | 주식회사 휴런 | Mri영상에서 뉴로멜라닌의 탈침착 정량화를 위한 이미지 처리방법 및 그 처리장치 |
| KR102834035B1 (ko) * | 2024-08-16 | 2025-07-21 | 주식회사 휴런 | 3d 멀티 에코 gre를 이용한 뉴로멜라닌과 나이그로좀1의 동시 촬영 및 이미지 처리방법 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150023877A1 (en) * | 2013-07-18 | 2015-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of parkinsons disease diagnosis and monitoring treatment |
| US20150125057A1 (en) * | 2012-05-04 | 2015-05-07 | Emory University | Methods, systems and computer readable storage media storing instructions for imaging and determining information associated with regions of the brain |
| JP2016527942A (ja) * | 2013-07-02 | 2016-09-15 | サージカル インフォメーション サイエンシズ インコーポレイテッドSurgical Information Sciences,Inc. | 脳画像パイプライン及び脳画像領域の位置及び形状予測のための方法並びにシステム |
| JP2017517325A (ja) * | 2014-06-12 | 2017-06-29 | コミッサリア ア レネルジー アトミーク エ オ ゼネルジ ザルタナテイヴ | 拡散強調磁気共鳴イメージングを用いて組織内の鉄の量を定量化するmri方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6288545B1 (en) * | 1999-03-22 | 2001-09-11 | General Electric Company | Method and apparatus for calibration of RF and gradient field time delays |
| EP1332363A4 (en) * | 2000-10-09 | 2007-08-29 | Kay Double | PROOF OF NEURODEGENERATIVE DISEASES |
| US20070275944A1 (en) * | 2006-04-05 | 2007-11-29 | The Board Of Trustees Operating Michigan State University | Antioxidants and methods of their use |
| WO2016154682A1 (en) * | 2015-04-02 | 2016-10-06 | Crc For Mental Health Ltd | Method for predicting risk of cognitive deterioration |
| US11352671B2 (en) * | 2015-05-01 | 2022-06-07 | Vanderbilt University | Predicting therapeutic response in Parkinson's disease |
| WO2017053718A2 (en) * | 2015-09-23 | 2017-03-30 | Boston Medical Center Corporation | Biomarkers for the early detection of parkinson's disease |
| EP3547252B1 (en) * | 2016-12-28 | 2025-10-22 | Shanghai United Imaging Healthcare Co., Ltd. | Multi-modal image processing system and method |
| CN113271985A (zh) * | 2018-08-07 | 2021-08-17 | 悦智有限公司 | 用于诊断多巴胺能和运动障碍的方法 |
| US20220273184A1 (en) * | 2019-08-20 | 2022-09-01 | Terran Biosciences, Inc. | Neuromelanin-sensitive mri for assessing parkinson's disease |
-
2020
- 2020-08-17 US US17/636,018 patent/US20220273184A1/en not_active Abandoned
- 2020-08-17 EP EP20854758.8A patent/EP4018202A4/en active Pending
- 2020-08-17 JP JP2022510980A patent/JP2022545083A/ja not_active Withdrawn
- 2020-08-17 MX MX2022002105A patent/MX2022002105A/es unknown
- 2020-08-17 KR KR1020227009108A patent/KR20220100851A/ko not_active Ceased
- 2020-08-17 CA CA3151632A patent/CA3151632A1/en active Pending
- 2020-08-17 KR KR1020257022022A patent/KR20250110932A/ko active Pending
- 2020-08-17 AU AU2020334980A patent/AU2020334980A1/en not_active Abandoned
- 2020-08-17 WO PCT/US2020/046686 patent/WO2021034770A1/en not_active Ceased
- 2020-08-17 CN CN202080067730.7A patent/CN114787631A/zh active Pending
-
2022
- 2022-02-17 IL IL290693A patent/IL290693A/en unknown
-
2025
- 2025-02-25 JP JP2025028218A patent/JP2025074118A/ja active Pending
- 2025-09-11 US US19/326,321 patent/US20260007323A1/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150125057A1 (en) * | 2012-05-04 | 2015-05-07 | Emory University | Methods, systems and computer readable storage media storing instructions for imaging and determining information associated with regions of the brain |
| JP2016527942A (ja) * | 2013-07-02 | 2016-09-15 | サージカル インフォメーション サイエンシズ インコーポレイテッドSurgical Information Sciences,Inc. | 脳画像パイプライン及び脳画像領域の位置及び形状予測のための方法並びにシステム |
| US20150023877A1 (en) * | 2013-07-18 | 2015-01-22 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of parkinsons disease diagnosis and monitoring treatment |
| JP2017517325A (ja) * | 2014-06-12 | 2017-06-29 | コミッサリア ア レネルジー アトミーク エ オ ゼネルジ ザルタナテイヴ | 拡散強調磁気共鳴イメージングを用いて組織内の鉄の量を定量化するmri方法 |
Non-Patent Citations (2)
| Title |
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| CLIFFORD M CASSIDT, ET.AL.,: "Neuralmelanin-sensitive MRI as a noninvasive proxy measure of dopamine function in the human brain", PNAS, vol. 116,11, JPN7024001305, 12 March 2019 (2019-03-12), US, pages 5108 - 5117, ISSN: 0005293199 * |
| KEITA MATSUURA ET AL.: "A longitudinal study of neuromelanin-sensitive magnetic resonance imaging in Parkinson’s disease", NEUROSCIENCE LETTERS, vol. 633, JPN6024012256, 2016, pages 112 - 117, ISSN: 0005445595 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025074118A (ja) * | 2019-08-20 | 2025-05-13 | テラン バイオサイエンシズ インコーポレイテッド | パーキンソン病を評価するためのニューロメラニン高感度mri |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4018202A1 (en) | 2022-06-29 |
| KR20250110932A (ko) | 2025-07-21 |
| CA3151632A1 (en) | 2021-02-25 |
| WO2021034770A1 (en) | 2021-02-25 |
| AU2020334980A1 (en) | 2022-03-03 |
| EP4018202A4 (en) | 2023-11-01 |
| CN114787631A (zh) | 2022-07-22 |
| JP2025074118A (ja) | 2025-05-13 |
| KR20220100851A (ko) | 2022-07-18 |
| MX2022002105A (es) | 2022-08-04 |
| IL290693A (en) | 2022-04-01 |
| US20220273184A1 (en) | 2022-09-01 |
| US20260007323A1 (en) | 2026-01-08 |
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