CN114787353A - 调节共济蛋白表达和治疗弗里德赖希共济失调的方法和组合物 - Google Patents
调节共济蛋白表达和治疗弗里德赖希共济失调的方法和组合物 Download PDFInfo
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- CN114787353A CN114787353A CN202080078749.1A CN202080078749A CN114787353A CN 114787353 A CN114787353 A CN 114787353A CN 202080078749 A CN202080078749 A CN 202080078749A CN 114787353 A CN114787353 A CN 114787353A
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C12N2310/10—Type of nucleic acid
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962904391P | 2019-09-23 | 2019-09-23 | |
US62/904,391 | 2019-09-23 | ||
PCT/US2020/052101 WO2021061698A1 (en) | 2019-09-23 | 2020-09-23 | Methods and compositions for modulating frataxin expression and treating friedrich's ataxia |
Publications (1)
Publication Number | Publication Date |
---|---|
CN114787353A true CN114787353A (zh) | 2022-07-22 |
Family
ID=75166421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202080078749.1A Pending CN114787353A (zh) | 2019-09-23 | 2020-09-23 | 调节共济蛋白表达和治疗弗里德赖希共济失调的方法和组合物 |
Country Status (7)
Country | Link |
---|---|
US (1) | US20220348893A1 (ja) |
EP (1) | EP4034660A4 (ja) |
JP (1) | JP2022548800A (ja) |
CN (1) | CN114787353A (ja) |
AU (1) | AU2020352984A1 (ja) |
CA (1) | CA3155417A1 (ja) |
WO (1) | WO2021061698A1 (ja) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2022548399A (ja) | 2019-09-23 | 2022-11-18 | オメガ セラピューティクス, インコーポレイテッド | 肝細胞核因子4-アルファ(HNF4α)遺伝子発現をモジュレートするための組成物および方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102043422B1 (ko) * | 2011-06-09 | 2019-11-11 | 큐알엔에이, 인크. | 프라탁신 (fxn)에 대한 자연 안티센스 전사체의 저해에 의한 프라탁신 (fxn) 관련된 질환의 치료 |
WO2013071440A1 (en) * | 2011-11-18 | 2013-05-23 | UNIVERSITé LAVAL | Methods and products for increasing frataxin levels and uses thereof |
US10323073B2 (en) * | 2014-03-20 | 2019-06-18 | UNIVERSITé LAVAL | CRISPR-based methods and products for increasing frataxin levels and uses thereof |
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2020
- 2020-09-23 JP JP2022543368A patent/JP2022548800A/ja active Pending
- 2020-09-23 CA CA3155417A patent/CA3155417A1/en active Pending
- 2020-09-23 CN CN202080078749.1A patent/CN114787353A/zh active Pending
- 2020-09-23 AU AU2020352984A patent/AU2020352984A1/en active Pending
- 2020-09-23 US US17/754,051 patent/US20220348893A1/en active Pending
- 2020-09-23 WO PCT/US2020/052101 patent/WO2021061698A1/en unknown
- 2020-09-23 EP EP20870270.4A patent/EP4034660A4/en active Pending
Also Published As
Publication number | Publication date |
---|---|
CA3155417A1 (en) | 2021-04-01 |
JP2022548800A (ja) | 2022-11-21 |
EP4034660A1 (en) | 2022-08-03 |
EP4034660A4 (en) | 2023-10-11 |
WO2021061698A1 (en) | 2021-04-01 |
AU2020352984A1 (en) | 2022-03-31 |
US20220348893A1 (en) | 2022-11-03 |
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