CN114786479A - 一种il-15人源化小鼠模型及其用途 - Google Patents
一种il-15人源化小鼠模型及其用途 Download PDFInfo
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
Abstract
提供了一种小鼠及其功能活性部分，其包含人源化的IL‑15基因，其中所述人源化的IL‑15基因包含人IL‑15基因区段和小鼠IL‑15基因区段，其中所述人IL‑15基因区段包含人IL‑15基因的外显子4、外显子5、外显子6、外显子7，以及外显子8的至少一部分，其中所述小鼠IL‑15基因区段包含小鼠IL‑15基因的外显子1，外显子2和外显子3。还提供了所述小鼠的制备方法及用途。
Description
PCT国内申请，说明书已公开。
Claims (47)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019113606239 | 2019-12-25 | ||
| CN201911360623 | 2019-12-25 | ||
| PCT/CN2020/139153 WO2021129766A1 (zh) | 2019-12-25 | 2020-12-24 | 一种il-15人源化小鼠模型及其用途 |
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| CN114786479A true CN114786479A (zh) | 2022-07-22 |
| CN114786479B CN114786479B (zh) | 2023-12-15 |
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| Country | Link |
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| US (1) | US20220354097A1 (zh) |
| CN (1) | CN114786479B (zh) |
| WO (1) | WO2021129766A1 (zh) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025539A (en) * | 1996-04-09 | 2000-02-15 | Mayo Foundation For Medical Education And Research | IL-5 transgenic mouse |
| CN1780856A (zh) * | 2003-02-26 | 2006-05-31 | 根马布股份公司 | 白介素15(il－15)的特异性人抗体 |
| CN105308184A (zh) * | 2013-04-16 | 2016-02-03 | 瑞泽恩制药公司 | 大鼠基因组的靶向修饰 |
| CN105744829A (zh) * | 2013-10-15 | 2016-07-06 | 瑞泽恩制药公司 | 人源化的il-15动物 |
| CN106470545A (zh) * | 2014-05-07 | 2017-03-01 | 瑞泽恩制药公司 | 人源化IL‑4和IL‑4Rα动物 |
| CN107896479A (zh) * | 2015-04-13 | 2018-04-10 | 再生元制药公司 | 人源化SIRPα‑IL15敲入小鼠及其使用方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109266656B (zh) * | 2018-10-10 | 2021-02-19 | 江苏集萃药康生物科技股份有限公司 | 一种PD1人源化BALB/c小鼠模型的构建方法及其应用 |
-
2020
- 2020-12-24 US US17/764,791 patent/US20220354097A1/en active Pending
- 2020-12-24 WO PCT/CN2020/139153 patent/WO2021129766A1/zh active Application Filing
- 2020-12-24 CN CN202080063249.0A patent/CN114786479B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6025539A (en) * | 1996-04-09 | 2000-02-15 | Mayo Foundation For Medical Education And Research | IL-5 transgenic mouse |
| CN1780856A (zh) * | 2003-02-26 | 2006-05-31 | 根马布股份公司 | 白介素15(il－15)的特异性人抗体 |
| CN105308184A (zh) * | 2013-04-16 | 2016-02-03 | 瑞泽恩制药公司 | 大鼠基因组的靶向修饰 |
| CN105744829A (zh) * | 2013-10-15 | 2016-07-06 | 瑞泽恩制药公司 | 人源化的il-15动物 |
| CN106470545A (zh) * | 2014-05-07 | 2017-03-01 | 瑞泽恩制药公司 | 人源化IL‑4和IL‑4Rα动物 |
| CN107896479A (zh) * | 2015-04-13 | 2018-04-10 | 再生元制药公司 | 人源化SIRPα‑IL15敲入小鼠及其使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114786479B (zh) | 2023-12-15 |
| WO2021129766A1 (zh) | 2021-07-01 |
| US20220354097A1 (en) | 2022-11-10 |
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