CN114767590B - Scar-removing acne mark-removing beautifying liquid and preparation method and application thereof - Google Patents

Scar-removing acne mark-removing beautifying liquid and preparation method and application thereof Download PDF

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CN114767590B
CN114767590B CN202210420975.4A CN202210420975A CN114767590B CN 114767590 B CN114767590 B CN 114767590B CN 202210420975 A CN202210420975 A CN 202210420975A CN 114767590 B CN114767590 B CN 114767590B
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acne
scar
extract
percent
cosmetic liquid
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CN114767590A (en
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李琰
蒉纲
万怡
雷海燕
廖明娟
王永灵
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Ninth Peoples Hospital Shanghai Jiaotong University School of Medicine
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Abstract

The invention belongs to the field of cosmetic preparations, and particularly relates to a scar and acne mark removing cosmetic liquid and a preparation method and application thereof. The invention relates to a scar and acne mark removing cosmetic liquid, which comprises the following raw materials in parts by weight: centella asiatica extract, honeysuckle extract, campsis grandiflora extract, alanyl glutamine, propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerin, methylparaben, propylparaben and deionized water. The scar-removing acne mark-removing cosmetic liquid provided by the invention can effectively resist inflammation, inhibit formation and proliferation of acne scars and soften formed old acne marks, can repair red blood streaks and acne mark pigmentation, and has a skin water locking function.

Description

Scar-removing acne mark-removing beautifying liquid and preparation method and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a scar and acne mark removing cosmetic liquid and a preparation method and application thereof.
Background
Acne is well-developed on the face and chest and back, and is a Mao Zhouyan skin disorder due to excessive sebum secretion, obstruction of the pilosebaceous ducts, and Mao Cuochuang propionibacteria. About 80% -90% of people except children suffer from the disease or have suffered from acne. Inflammatory healing tends to leave behind scars, mainly pigmentation and pitting scars, which are classified internationally into boxcar type scars, rolling type scars, ice cone type scars. The facial acne scars can affect the mind of people, so that many people can spell because of the acne scars, and also many people lose the free selection work and select the right of marital, and as such, the positive treatment of the acne scars is particularly important.
The traditional Chinese patent medicine for treating acne scars is mainly asiaticoside cream and is widely applied to clinic. The roller pin of the micro needle is very fine, the roller is fully covered with fine needles with the diameter of 0.5mm-2mm, and when the roller pin rolls on the skin, the micro needle head is utilized to puncture the skin for a plurality of times, so that micropores penetrating through the dermis are generated. Wounds initiate wound healing and growth factor release in the dermis, which allows collagen to be produced and deposited on the upper dermis. The micro needle has definite curative effect on acne sinking type scars, especially on boxcar type scars and rolling type scars, can stimulate the regeneration of facial collagen, and has certain full face beautifying and lifting effects. The asiaticoside ointment combined with the microneedle has been clinically applied to acne, but the ointment is thick and greasy in body, poor in comfort and easy to have reactions such as redness, swelling and discomfort on the face after administration. In addition, the microneedles have the problems of skin dryness sensitivity, even active dry streak, local color deposition, uneven skin color and the like in a period of time after treatment, pain and discomfort in the operation process and the like.
The beauty liquid which has fresh texture, definite curative effect of removing scars and acne marks, can relieve pain and burning sensation in the microneedle treatment process and reduce side effects of microneedle treatment is developed, and has very important significance.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention aims to provide a scar and acne mark removing cosmetic liquid and a preparation method and application thereof.
In order to achieve the above and other related objects, the present invention adopts the following technical scheme:
the invention provides a scar and acne mark removing cosmetic liquid, which comprises the following raw materials in parts by weight: centella asiatica extract, honeysuckle extract, campsis grandiflora extract, alanyl glutamine, propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerin, methylparaben, propylparaben and deionized water.
In some preferred embodiments, the weight percentages of the component raw materials are: 3.5 to 20 percent of centella asiatica extract, 1.5 to 10 percent of honeysuckle extract, 1.5 to 10 percent of campsis grandiflora extract, 5.0 to 20.0 percent of alanyl glutamine, 15 to 55 percent of propylene diglycerol acrylate/acrylic acid copolymer, 1.0 to 4.0 percent of PVM/MA copolymer, 0.1 to 1.0 percent of glycerol, 0.01 to 0.15 percent of methylparaben, 0.01 to 0.05 percent of propylparaben and 35 to 55 percent of deionized water.
In some preferred embodiments, the weight percentages of the component raw materials are: 5-15% of centella asiatica extract, 2-5% of honeysuckle extract, 3-5% of campsis grandiflora extract, 8.0-15.0% of alanyl glutamine, 20-30% of malonyl acrylate/acrylic acid copolymer, 2.0-3.0% of PVM/MA copolymer, 0.1-0.5% of glycerin, 0.02-0.1% of methylparaben, 0.03-0.05% of propylparaben and 40.0-50.0% of deionized water.
In some preferred embodiments, the weight percentages of the component raw materials are: 10% of centella asiatica extract, 3.5% of honeysuckle extract, 3.5% of campsis grandiflora extract, 10% of alanyl glutamine, 25% of propylene diglycerol acrylate/acrylic acid copolymer, 2.0% of PVM/MA copolymer, 0.5% of glycerol, 0.05% of methylparaben, 0.03% of propylparaben and 45.42% of deionized water.
In a second aspect of the present invention, a preparation method of the aforementioned scar-removing acne mark-removing cosmetic liquid is provided, comprising the following steps:
s1, stirring centella asiatica extract, honeysuckle extract, campsis grandiflora extract and alanyl glutamine to obtain a first mixture;
s2, stirring the propylene diglycerol acrylate/acrylic acid copolymer, the PVM/MA copolymer, glycerol, methylparaben, propylparaben and deionized water to obtain a second mixture;
and S3, mixing the first mixture obtained in the step S1 and the second mixture obtained in the step S2, and stirring the mixture uniformly to obtain the scar and acne mark removing cosmetic liquid.
In some preferred embodiments, the stirring speed in step S1 is 60 to 150rpm and the stirring time is 0.5 to 1h.
In some preferred embodiments, the stirring speed in step S2 is 100-200 rpm and the stirring time is 0.5-1 h;
in some preferred embodiments, the stirring speed in step S3 is 100 to 200rpm and the stirring time is 0.5 to 1h.
In a third aspect, the invention provides an application of the scar and acne mark removing cosmetic liquid in scar and acne mark removing.
In a fourth aspect, the invention provides the use of the scar-removing acne mark-removing cosmetic liquid in preparing a medical or cosmetic product for scar repair or acne mark removal.
In a fifth aspect, the present invention provides the use of the aforementioned scar-removing acne mark-removing cosmetic liquid for preparing a cosmetic product having any one of the following effects: 1) Skin pit scar repair; 2) Acne print pigmentation is reduced; 3) Cyst type acne detumescence and stagnation elimination; 4) Inhibit acne scar formation and hyperplasia.
In a sixth aspect, the invention provides an application of the scar and acne mark removing cosmetic liquid in preparing a microneedle base liquid.
In a seventh aspect, the present invention provides a cosmetic product for removing scars and acne marks, comprising the cosmetic liquid.
According to an eighth aspect of the present invention, there is provided a method for using the above-mentioned cosmetic liquid, comprising the steps of:
(a) Sterilizing the face of the patient before use;
(b) Selecting 0.5-1.0 mm sterile roller pin, interleaving and rolling for 3-5 times in all directions of local skin, and applying the cosmetic liquid while rolling until swelling of local skin is finished.
The beautifying liquid provided by the invention is matched with microneedle therapy, is beneficial to the introduction of effective components of the liquid, enhances the effect after use, and has better effect compared with direct coating.
Compared with the prior art, the invention has the following beneficial effects:
1. the scar-removing acne mark-removing cosmetic liquid provided by the invention has the synergistic effect of all the components, can inhibit scar hyperplasia, lighten pigmentation, simultaneously has the effects of resisting inflammation and easing pain, and has the effects of clearing heat and relieving pain, preserving moisture and locking water, and is suitable for being used as a base liquid for microneedle treatment.
2. The scar-removing acne mark-removing cosmetic liquid provided by the invention has obvious treatment effects on scars and acne marks, can obviously improve the scar depression degree of patients, improves the skin appearance flatness, reduces acne mark pigmentation, promotes cyst type acne to reduce swelling and dissipate stagnation, inhibits acne scar formation and hyperplasia, can reduce the side effect of slight needle treatment when used as a microneedle base liquid, has better curative effect than asiaticoside ointment, and has good clinical application value.
Drawings
FIG. 1 is a photograph of a typical case 1 with a file left on the affected area before treatment.
FIG. 2 is a photograph of the affected area after treatment of typical case 1.
FIG. 3 is a photograph of a typical case 2 with a file left on the affected area before treatment.
Fig. 4 is a photograph of the affected part after the treatment of typical case 2.
Fig. 5 is a photograph of a typical case 3 with a file left on the affected part before treatment.
Fig. 6 is a photograph of the affected part after the treatment of typical case 3.
FIG. 7 is a photograph of a typical case 3 with a file left on the affected area before the second treatment.
FIG. 8 is a photograph of the affected area after the secondary treatment of typical case 3.
Detailed Description
The centella asiatica extract is used as the main component of the beauty treatment liquid, and the asiaticoside contained in the centella asiatica extract has the effects of clearing heat, promoting diuresis, removing toxicity and eliminating carbuncles, can inhibit scar hyperplasia, lighten pigmentation, is easy to permeate skin and has fresh and cool texture; meanwhile, the honeysuckle extract and the campsis grandiflora extract are added, and the honeysuckle extract and the campsis grandiflora extract are synergistic in anti-inflammation and reddening, calm and ease, so that the problem of skin redness and swelling sensitivity after rolling can be effectively relieved; the oligopeptide-1 and oligopeptide-3 in alanyl glutamine (lipeptide) are hydrolyzed to generate L-glutamine, which can promote the LXR activity in main keratinocytes of human body and the activation of epidermis lipid synthase, improve the hydration of skin, be beneficial to skin aging and have good water locking function; the polyvinyl formal/methyl acrylate copolymer (PVM/MA copolymer) has certain lubrication thickening property, and is used together with the active ingredients, so that the moisturizing property of the beautifying liquid is enhanced, and the pain and burning sensation in the process can be effectively relieved when the beautifying liquid is used as a base liquid for microneedle treatment, and the pain of a patient is relieved.
Propylene diglycerol acrylate/acrylic acid copolymer: commercially available cosmetic raw materials. Can be used as thickener, viscosity control agent and humectant, and can give fluidity and transparency to skin care liquid, and is mild and has no irritation.
PVM/MA copolymer: commercially available cosmetic raw materials. It is used as antistatic agent, binder and emulsion stabilizer in cosmetics.
Glycerol: the chemical name is glycerol, is colorless, odorless and sweet viscous liquid, has strong water absorption, and can be applied on skin to moisten skin without chapping. The glycerin is absorbed quickly, and the skin peeled by changing seasons, acne scars, sensitive skin and the like are all excellent moisturizing products, so that the skin can be kept soft and elastic, and is not damaged by dust, climate and the like and is dried.
Methylparaben: the chemical name is methyl parahydroxybenzoate, also called methylparaben or methylparaben, is an organic matter, and the chemical formula is C 8 H 8 O 3 White crystalline powder or colorless crystals, which have the property of being easily dissolved in alcohol, ether and acetone, and being very slightly dissolved in water, and the boiling point is 270-280 ℃. The organic antiseptic is mainly used as an antiseptic for organic synthesis, food, cosmetics and medicines, and also used as a feed antiseptic.
Propyl paraben: the chemical name is propyl p-hydroxybenzoate, also known as propyl p-hydroxybenzoate or propyl p-hydroxybenzoate, is an organic matter, and the chemical formula is C 10 H 12 O 3 White crystalline powder, having the property of being easily soluble in alcohols, ethers and acetone, and slightly soluble in water, with a boiling point of 133 ℃. Is mainly used for organic synthesis, food, cosmetics and medicineIs also used as a feed preservative.
Before the embodiments of the invention are explained in further detail, it is to be understood that the invention is not limited in its scope to the particular embodiments described below; it is also to be understood that the terminology used in the examples of the invention is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the invention. The test methods in the following examples, in which specific conditions are not noted, are generally conducted under conventional conditions or under conditions recommended by the respective manufacturers.
Where numerical ranges are provided in the examples, it is understood that unless otherwise stated herein, both endpoints of each numerical range and any number between the two endpoints are significant both in the numerical range. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, materials used in the embodiments, any methods, devices, and materials of the prior art similar or equivalent to those described in the embodiments of the present invention may be used to practice the present invention according to the knowledge of one skilled in the art and the description of the present invention.
Unless otherwise indicated, the experimental methods, detection methods, and preparation methods disclosed in the present invention all employ techniques conventional in the art.
Example 1
The scar and acne mark removing cosmetic liquid comprises the following raw materials in percentage by weight: centella asiatica extract 7.0%, honeysuckle flower extract 3.0%, campsis grandiflora extract 5.0%, alanyl glutamine 8.0%, propylene diglycerol acrylate/acrylic acid copolymer 20%, PVM/MA copolymer 2.5%, glycerin 0.6%, methylparaben 0.10%, propylparaben 0.02% and deionized water 53.78%.
Example 2
The scar and acne mark removing cosmetic liquid comprises the following raw materials in percentage by weight: 10% of centella asiatica extract, 3.5% of honeysuckle extract, 3.5% of campsis grandiflora extract, 10% of alanyl glutamine, 25% of propylene diglycerol acrylate/acrylic acid copolymer, 2.0% of PVM/MA copolymer, 0.5% of glycerol, 0.05% of methylparaben, 0.03% of propylparaben and 45.42% of deionized water.
Example 3
The scar and acne mark removing cosmetic liquid comprises the following raw materials in percentage by weight: 15% of centella asiatica extract, 6.0% of honeysuckle extract, 6.5% of campsis grandiflora extract, 5% of alanyl glutamine, 15% of propylene diglycerol acrylate/acrylic acid copolymer, 3.0% of PVM/MA copolymer, 0.8% of glycerol, 0.15% of methylparaben, 0.05% of propylparaben and 48.5% of deionized water.
Clinical application
1. Study object: the medical college of Shanghai communication is affiliated to the medical department of beauty of traditional Chinese medicine department of south China of the ninth people's hospital, and meets the diagnosis standard and inclusion standard. 60 acne vulgaris scar patients were selected. The scar area is 2cm minimum and 42cm maximum, wherein the scar is mainly 14 cases of ice cone type scars, 27 cases of rolling type scars and 49 cases of box type scars. 30 treatment groups, 2 men and 28 women, were aged 21 years minimum and 35 years maximum. 30 treatment groups, 1 male and 29 female, were aged at least 19 years and at most 34 years, and there was no statistical significance of the difference between the gender and age of the two groups (P > 0.05). Exclusion criteria patients had a recent history of light sensitive drugs, a history of solar insolation, mental abnormalities, pregnant women, and scar constitutions.
2. Cosmetic liquid preparation
2.1 major component manufacturers and product numbers
Centella asiatica extract: YH-51512, a product of Shanghai yttrium Lang chemical technology Co., ltd. The solid content is more than 3.5%, and the main medicinal components are asiaticoside, madecassoside, asiatic acid and madecassic acid. The pharmacological action has inhibiting effect on staphylococcus aureus, hemolytic streptococcus, various dysentery bacillus and typhoid bacillus, and also has influence on scar fibroblast activity. Is clinically used for promoting wound healing and inhibiting scar hyperplasia. The extraction process comprises the following steps: 1. cleaning centella asiatica, crushing 2.1,3 propylene glycol, heating and extracting 3, filtering (300-mesh filter screen) 4, filtering 5, filtering by paper 6, heating and concentrating 7, quality testing 8, freezing 9, thawing and adjusting (PH adjusting and the like) 10, nanofiltration 11, sterilizing 12, preserving 13, quality testing 14 and packaging.
Campsis grandiflora extracting solution: YH-52868 is a product of Shanghai yttrium Lang chemical technology Co. The solid content is 3.5% -10%, and the main medicinal components are triterpenes, flavonoids, anthocyanidins, volatile oil and the like. The pharmacological effects have effects of improving blood circulation, inhibiting thrombosis, relieving pain, relieving inflammation, and resisting oxidation. Clinically used for treating dermatosis such as acne, hormone dependent dermatitis, etc. The extraction process comprises the following steps: 1. cleaning campsis grandiflora, crushing 2.1,3 propylene glycol, heating and extracting 3, filtering (300-mesh filter screen) 4, filtering by cloth 5, filtering by paper 6, heating and concentrating 7, quality testing 8, freezing 9, thawing and adjusting (pH adjusting and the like) 10, nanofiltration 11, sterilizing 12, preserving 13, quality testing 14 and packaging.
Honeysuckle extract: YH-51120, a product of Shanghai yttrium Lang chemical technology Co., ltd. The solid content is 3.5% -10%, and the main medicinal components are volatile oil, organic acids, flavonoids, iridoid glycosides, triterpenoid saponins and the like. Pharmacological actions of clearing heat and detoxicating, cooling and dispelling wind-heat. The clinical application is as follows: carbuncle and swelling can be caused by sore, sore throat, erysipelas. The extraction process comprises the following steps: 1. cleaning honeysuckle, crushing 2.1,3 propylene glycol, heating and extracting 3, filtering (300-mesh filter screen) 4, cloth filtering 5, paper filtering 6, heating and concentrating 7, quality inspection 8, freezing 9, thawing adjustment (pH adjustment and the like) 10, nanofiltration 11, sterilization 12, preservation 13, quality inspection 14 and packaging.
Lipeptide essence powder: yttrium over sea enamel chemical technology limited. Chinese name: alanylglutamine, INCI name ALANYL GLUTAMINE, CAS No.39537-23-0. The product is white to pale yellow powder, is soluble in water, and has stable properties at normal temperature. Wherein the content of oligopeptide-1 is 35wt%, and the content of oligopeptide-3 is 20wt%, and the composition has the effects of resisting oxidation, delaying skin aging, promoting tissue repair, and moisturizing and locking water.
2.2 preparation method
The cosmetic liquid is prepared according to the following steps:
step one, mixing the centella asiatica extract, the honeysuckle extract, the campsis grandiflora extract and the Lipeptide essence powder, and stirring at a speed of 100rpm for 1h to obtain a first mixture;
step two, mixing the propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerol, methylparaben and propylparaben, adding deionized water, and stirring at 130rpm for 1h to obtain a second mixture;
and step three, mixing the first mixture obtained in the step one and the second mixture obtained in the step two, and stirring at 180rpm, and uniformly mixing to obtain the scar and acne mark removing cosmetic liquid.
The beauty lotion prepared by the method comprises the following components in percentage by weight: 10% of centella asiatica extract, 3.5% of honeysuckle extract, 3.5% of campsis grandiflora extract, 10% of alanyl glutamine, 25% of propylene diglycerol acrylate/acrylic acid copolymer, 2.0% of PVM/MA copolymer, 0.5% of glycerol, 0.05% of methylparaben, 0.03% of propylparaben and 45.42% of deionized water.
3. Preoperative preparation
The medical staff before treatment can communicate with the patient fully, introduce the treatment method, the intraoperative notice and the emergency prevention method to the patient, and reduce the psychological pressure of the patient so as to obtain the coordination and understanding of the patient. At the same time, the face of the patient is cleaned before operation and photographed under the same light source for reservation.
4. Therapeutic method
The face disinfectant of the treatment group is disinfected. The microneedle therapy selects a sterile rolling needle with the thickness of 0.5mm to 1.0mm, the prepared cosmetic liquid is held by a left hand, the cosmetic liquid is staggered and rolled for 3 to 5 times in all directions of local skin, and the cosmetic liquid is smeared while rolling until the local skin is swollen as a treatment end point. The treated area was inhibited from contacting raw water for 24 hours after treatment, and care was taken for moisture retention and sun protection. Treatment is carried out for 1-6 times, 2 times per month.
The facial disinfectant of the control group was sterilized. The microneedle therapy selects a sterile roller needle with the thickness of 0.5mm-1.0mm, and the roller needle is staggered and rolled for 3-5 times in all directions of local skin until swelling of the local skin appears as a treatment end point. After the treatment is finished, the asiaticoside ointment is smeared on the scar, and the treated part is forbidden to contact with raw water within 24 hours after the smearing treatment, and the moisture preservation and the sun protection are paid attention to. Treatment is carried out for 1-6 times, 2 times per month.
5. Therapeutic results
5.1 Standard of efficacy
(1) And (3) healing: the repair degree of scar recess of the patient reaches 90%;
(2) The effect is shown: the repairing degree of the scar recess of the patient reaches 60 percent, the appearance is smooth, and the uneven color is obviously reduced;
(3) The method is effective: the repairing degree of scar recess of the patient is 30-59%, the appearance is improved to a certain extent, and uneven color is obviously reduced;
(4) Invalidation: the scar recession degree is repaired to be lower than 30%, and the appearance is not changed or even aggravated.
Total effective rate= (number of recovery cases + number of significant cases + number of effective cases)/total case number x 100%.
5.2 subjective satisfaction surveys of patients. According to subjective evaluation of patients on satisfaction and treatment experience of treatment effect, indexes are divided into very satisfactory, satisfactory and unsatisfactory in sequence, and the satisfaction rate= (very satisfactory+satisfactory)/number of cases is multiplied by 100%.
5.3 comparing the occurrence of the two groups of adverse reactions. Common adverse reactions are facial infection, skin allergy or sensitivity, color sinking, others (color sinking, acne, erythema edema).
5.4 statistical analysis
Study data were analyzed using SPSS 22.0, and count data was expressed as percent (%), row χ 2 And (5) checking. P is less than 0.05, and the prompt difference has statistical significance.
5.5 results
5.5.1 therapeutic effects are shown in Table 1 below:
table 1 comparison of the efficacy of two groups of patients
Note that: x-shaped articles 2 ＝7.34 1) P<The effective rate of the 0.05 treatment group is higher than that of the control group.
As shown by the statistical results in Table 1, the curative effect of the cosmetic liquid provided by the invention for treating scar recess and acne mark by matching with the rolling needle is superior to that of asiaticoside ointment, and the cosmetic liquid provided by the invention has good scar and acne mark removing effect.
5.5.2 adverse reaction observations
Table 2 comparison of adverse effects in two groups of patients
Note that: x-shaped articles 2 ＝5.24P<Adverse events were lower in the 0.05 treatment group than in the control group.
As shown by the statistical results in Table 2, the adverse reaction rate of the cosmetic liquid provided by the invention for treating scar recess and acne mark by matching with the needle roller is lower than that of asiaticoside ointment, which indicates that the cosmetic liquid provided by the invention can reduce the side effect of microneedle treatment.
5.5.3 satisfaction survey
The satisfaction degree of the treatment group patients on the treatment effect is 95.53 percent, which is obviously higher than that of the control group 76.47 percent, and the difference has statistical significance (P is less than 0.05). The satisfaction degree of the treatment group patients on the treatment experience is 93.33%, which is obviously higher than that of the control group 66.67%, and the difference has statistical significance (P is less than 0.05). In the treatment experience satisfaction investigation process, the VRS method is adopted to enable the treatment group patients and the control group patients to evaluate pain and burning sensation in the treatment process respectively, the treatment group patients evaluate 19 cases of mild pain and 11 cases of moderate pain, and the control group patients evaluate 5 cases of mild pain, 18 cases of moderate pain and 7 cases of severe pain.
Typical cases
Case 1: aged somewhere, women, 30 years old, and staff in Shanghai hospitals. For repeated acne for three months, the treatment is carried out in the hospital in the year 2020 at 11 after the pigment scar is left for 1 month, and fig. 1 is a photograph of the treatment before the treatment; the scar and acne mark removing beautifying liquid is matched with the needle roller for treatment, and the treatment is carried out once per week for 4 times. Fig. 2 is a photograph of a post-treatment residue, in which a number of acne marks on the cheek are visibly pale in color, partially disappeared, and fair and firm in facial skin than before.
Case 2: some sun, some woman, 27 years old, shanghai is on duty. For many years, acne was followed by the subsequent rough skin with pigmentation after topical hormonal medications were administered. Treatment in China is 11 months in 2020, and fig. 3 is a photograph of a reservation before treatment; the scar and acne mark removing beautifying liquid is matched with the needle roller for treatment, and the treatment is carried out once every two weeks for 4 times. Fig. 4 is a photograph of a post-treatment residue showing a clear lightening of the pits of both cheeks, a lightening of the pigmentation of the acne marks, a shrinking of the pores of the skin, and a finer and whiter appearance than before the treatment.
Case 3: some gold, men, 19 years old, students in Shanghai. For 2 years of history of acne, obvious concave acne pits are locally reserved, cystic acne is reserved at the lower jaw, the treatment is carried out in the hospital in the year 2020, and fig. 5 is a photograph of a reservation before the treatment; by adopting the scar and acne removing beautifying liquid disclosed by the invention and matching with the needle roller treatment, after four times of treatment, fig. 6 is a photograph of a post-treatment mark, it can be obviously seen that cystic acne is obviously reduced and removed, acne marks disappear, after three months, the acne marks are left for a plurality of new acnes of a patient, the patient is required to actively treat the acne marks for 2 times, fig. 7 and 8 are photographs of the post-treatment mark, and the acne marks are obviously removed, and the skin is smoother and tighter than before.
While the invention has been described with respect to preferred embodiments thereof, it will be understood by those skilled in the art that various modifications and additions may be made without departing from the scope of the invention. Equivalent embodiments of the present invention will be apparent to those skilled in the art having the benefit of the teachings disclosed herein, when considered in the light of the foregoing disclosure, and without departing from the spirit and scope of the invention; meanwhile, any equivalent changes, modifications and evolution of the above embodiments according to the essential technology of the present invention still fall within the scope of the technical solution of the present invention.

Claims (5)

1. The application of the scar and acne mark removing cosmetic liquid in preparing the microneedle base liquid comprises the following component raw materials in percentage by weight: 3.5 to 20 percent of centella asiatica extract, 1.5 to 10 percent of honeysuckle extract, 1.5 to 10 percent of campsis grandiflora extract, 5.0 to 20.0 percent of alanyl glutamine, 15 to 55 percent of glycerate acrylate/acrylic acid copolymer, 1.0 to 4.0 percent of PVM/MA copolymer, 0.1 to 1.0 percent of glycerol, 0.01 to 0.15 percent of methylparaben, 0.01 to 0.05 percent of propylparaben and 35 to 55 percent of deionized water.
2. The use according to claim 1, wherein the cosmetic liquid comprises the following raw materials in percentage by weight: 10% of centella asiatica extract, 3.5% of honeysuckle extract, 3.5% of campsis grandiflora extract, 10% of alanyl glutamine, 25% of glycerol acrylic ester/acrylic acid copolymer, 2.0% of PVM/MA copolymer, 0.5% of glycerol, 0.05% of methylparaben, 0.03% of propylparaben and 45.42% of deionized water.
3. The use according to any one of claims 1 to 2, wherein the preparation method of the cosmetic liquid comprises the steps of:
s1, stirring centella asiatica extract, honeysuckle extract, campsis grandiflora extract and alanyl glutamine to obtain a first mixture;
s2, stirring the glycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerol, methylparaben, propylparaben and deionized water to obtain a second mixture;
and S3, mixing the first mixture obtained in the step S1 and the second mixture obtained in the step S2, and stirring the mixture uniformly to obtain the scar and acne mark removing cosmetic liquid.
4. The use of claim 3, further comprising one or more of the following features:
(1) In the step S1, the stirring speed is 60-150 rpm, and the stirring time is 0.5-1 h;
(2) In the step S2, the stirring speed is 100-200 rpm, and the stirring time is 0.5-1 h;
(3) And in the step S3, the stirring speed is 100-200 rpm, and the stirring time is 0.5-1 h.
5. The use according to any one of claims 1-2, wherein the cosmetic liquid has the following efficacy: 1) Skin pit scar repair; 2) Acne print pigmentation is reduced; 3) Cyst type acne detumescence and stagnation elimination; 4) Inhibit acne scar formation and hyperplasia.
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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103002903A (en) * 2010-06-28 2013-03-27 Ade治疗公司 Keloid treatment
CN109646356A (en) * 2019-01-30 2019-04-19 邯郸市丛台区本草汉方贸易有限公司 Chinese medicine composition, its purposes and facial mask
CN111419757A (en) * 2020-04-30 2020-07-17 南京苗邦美业企业管理有限公司 Herbal skin-care essence

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103002903A (en) * 2010-06-28 2013-03-27 Ade治疗公司 Keloid treatment
CN109646356A (en) * 2019-01-30 2019-04-19 邯郸市丛台区本草汉方贸易有限公司 Chinese medicine composition, its purposes and facial mask
CN111419757A (en) * 2020-04-30 2020-07-17 南京苗邦美业企业管理有限公司 Herbal skin-care essence

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