CN114767590A - Scar and acne mark removing beauty lotion and preparation method and application thereof - Google Patents
Scar and acne mark removing beauty lotion and preparation method and application thereof Download PDFInfo
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- CN114767590A CN114767590A CN202210420975.4A CN202210420975A CN114767590A CN 114767590 A CN114767590 A CN 114767590A CN 202210420975 A CN202210420975 A CN 202210420975A CN 114767590 A CN114767590 A CN 114767590A
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- acne
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Abstract
The invention belongs to the field of cosmetic preparations, and particularly relates to scar and acne mark removing cosmetic liquid as well as a preparation method and application thereof. The scar-removing acne-mark-removing beauty lotion comprises the following raw materials: centella asiatica extract, honeysuckle flower extract, trumpet creeper flower extract, alanyl glutamine, propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerin, methyl hydroxybenzoate, propyl hydroxybenzoate and deionized water. The scar-removing acne mark-removing beauty lotion provided by the invention can effectively resist inflammation, inhibit acne scar formation and hyperplasia, soften formed old acne marks, repair redness and acne mark pigmentation and have the function of skin water locking.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, and in particular relates to scar and acne mark removing beauty lotion and a preparation method and application thereof.
Background
Acne develops well on the face, chest and back, and is a peritrichotic inflammatory skin disease caused by excessive sebum secretion, follicular sebaceous gland duct blockage and propionibacterium acnes. About 80% to 90% of the population, except children, suffer from the disease or have suffered from acne. Inflammatory healing often leaves scars, mainly pigmented and depressed scars, which are internationally classified as boxcar-type scars, rolling-type scars, and icicle-type scars. Facial acne scars can affect the psychology of people, many people are self-inferior due to the acne scars, many people lose free choice and the right to choose marriage, and thus, the active treatment of the acne scars is particularly important.
The existing Chinese patent medicine for treating acne scars is mainly asiaticoside cream and is widely applied to clinic. The needle roller of the micro needle is very fine, the roller is fully distributed with the fine needles with the diameter of 0.5mm-2mm, and when the needle roller rolls on the skin, the skin is punctured for many times by the micro needle head to generate micropores penetrating the dermis. The wound initiates wound healing and growth factor release in the dermis, allowing collagen production and deposition in the upper layers of the dermis. The micro-needle has definite curative effect on acne pit-type scars, particularly has definite curative effect on boxcar-type scars and rolling scars, can stimulate the regeneration of facial collagen, and has certain whole-face beautifying and lifting effects. Clinically, the asiaticoside ointment is applied to acne by combining with microneedle introduction, but the ointment is thick and greasy in texture and poor in comfort, and the face is easy to have reactions such as redness and swelling and discomfort after the ointment is applied. In addition, the micro-needle has the problems of dry and sensitive skin, even active dry lines, local color deposition, uneven skin color and the like in a period of time after treatment, pain and discomfort in the operation process and the like.
The development of the beautifying liquid which has fresh texture, exact curative effect on removing scars and acne marks, can relieve the burning sensation of pain in the microneedle treatment process and relieve the side effect of microneedle treatment has very important significance.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention aims to provide a scar and acne mark removing cosmetic liquid as well as a preparation method and application thereof.
In order to achieve the above objects and other related objects, the present invention adopts the following technical solutions:
the invention provides a scar and acne mark removing cosmetic liquid which comprises the following raw materials: centella asiatica extract, honeysuckle flower extract, trumpet creeper extract, alanyl glutamine, propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerol, methyl hydroxybenzoate, propyl hydroxybenzoate and deionized water.
In some preferred embodiments, the weight percentages of the raw materials of the components are as follows: 3.5 to 20 percent of centella extract, 1.5 to 10 percent of honeysuckle extract, 1.5 to 10 percent of trumpet creeper extract, 5.0 to 20.0 percent of alanyl glutamine, 15 to 55 percent of propylene diglycerol acrylate/acrylic acid copolymer, 1.0 to 4.0 percent of PVM/MA copolymer, 0.1 to 1.0 percent of glycerol, 0.01 to 0.15 percent of methyl hydroxybenzoate, 0.01 to 0.05 percent of propyl hydroxybenzoate and 35 to 55 percent of deionized water.
In some preferred embodiments, the weight percentages of the raw materials of the components are as follows: 5-15% of centella asiatica extract, 2-5% of honeysuckle extract, 3-5% of Chinese trumpet creeper extract, 8.0-15.0% of alanyl glutamine, 20-30% of propylene diglyceride acrylate/acrylic acid copolymer, 2.0-3.0% of PVM/MA copolymer, 0.1-0.5% of glycerol, 0.02-0.1% of methylparaben, 0.03-0.05% of propyl hydroxybenzoate and 40.0-50.0% of deionized water.
In some preferred embodiments, the weight percentages of the raw materials of the components are as follows: centella asiatica extract 10%, honeysuckle flower extract 3.5%, trumpet creeper flower extract 3.5%, alanyl glutamine 10%, propylene diglycerol acrylate/acrylic acid copolymer 25%, PVM/MA copolymer 2.0%, glycerin 0.5%, methyl hydroxybenzoate 0.05%, propyl hydroxybenzoate 0.03%, and deionized water 45.42%.
The second aspect of the invention provides a preparation method of the scar and acne mark removing cosmetic liquid, which comprises the following steps:
s1, stirring the centella extract, the honeysuckle extract, the trumpetcreeper extract and alanyl glutamine to obtain a first mixture;
s2, stirring propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerol, methyl hydroxybenzoate, propyl hydroxybenzoate and deionized water to obtain a second mixture;
s3, mixing the first mixture obtained in the step S1 and the second mixture obtained in the step S2, stirring, and uniformly mixing to obtain the scar and acne mark removing beauty fluid.
In some preferred embodiments, the stirring speed in step S1 is 60-150 rpm, and the stirring time is 0.5-1 h.
In some preferred embodiments, the stirring speed in step S2 is 100 to 200rpm, and the stirring time is 0.5 to 1 hour;
in some preferred embodiments, the stirring speed in step S3 is 100 to 200rpm, and the stirring time is 0.5 to 1 hour.
In a third aspect of the invention, the scar and acne mark removing cosmetic liquid is provided for use in scar and acne mark removing.
In a fourth aspect of the invention, the invention provides the use of the scar and acne mark removing cosmetic liquid in the preparation of a medical or cosmetic product for scar repair or acne mark removal.
In a fifth aspect of the invention, the use of the scar and acne mark removing cosmetic liquid for preparing a cosmetic product with any one of the following effects is provided: 1) repairing depressed scars of the skin; 2) reduction in acne pigmented pigmentation; 3) cystic acne with detumescence and stagnation eliminating effects; 4) inhibiting acne scar formation and hyperplasia.
The invention also provides an application of the scar and acne mark removing beauty fluid in preparation of the microneedle substrate fluid.
In a seventh aspect of the invention, a scar and acne mark removing cosmetic product is provided, which comprises the cosmetic liquid.
In an eighth aspect of the present invention, there is provided a method for using the cosmetic liquid, comprising the steps of:
(a) disinfecting the face of a patient before use;
(b) selecting sterile needle roller with diameter of 0.5-1.0 mm, staggering and rolling for 3-5 times in each direction of local skin, and applying the cosmetic liquid while rolling until local skin swelling occurs.
The beauty fluid provided by the invention is matched with microneedle therapy, is beneficial to leading in of effective components of the fluid, enhances the effect after use, and has better effect compared with direct coating.
Compared with the prior art, the invention has the following beneficial effects:
1. the scar-removing acne mark-removing beauty fluid provided by the invention has the synergistic effect of all components, can inhibit scar hyperplasia, relieve pigmentation, resist inflammation and pain, has the effects of clearing heat, relieving pain, preserving moisture and locking water, and is suitable for being used as a base liquid for microneedle treatment.
2. The scar and acne mark removing cosmetic liquid provided by the invention has obvious treatment effects on scars and acne marks, can obviously improve the scar depression degree of patients, improves the skin appearance flatness, relieves the acne mark pigmentation, promotes cyst type acne to reduce swelling and eliminate stagnation, and inhibits the formation and proliferation of acne scars, can relieve the side effect of microneedle treatment when used as a microneedle base liquid, has a curative effect superior to that of asiaticoside ointment, and has a good clinical application value.
Drawings
FIG. 1 is a photograph of affected part before treatment in typical case 1.
FIG. 2 is a photograph of the affected part after treatment in typical case 1.
Fig. 3 is a photograph of the affected part left in stock before treatment in typical case 2.
FIG. 4 is a photograph of the affected part after treatment of typical case 2.
Fig. 5 is a photograph of affected part left before treatment in typical case 3.
Fig. 6 is a photograph of the affected part after treatment in typical case 3.
Fig. 7 is a photograph of affected part left in the file before the second treatment in typical case 3.
Fig. 8 is a photograph of the affected part after the second treatment in typical case 3.
Detailed Description
The invention takes the centella extraction solution as the main component of the beauty fluid, the active component of the asiaticoside has the effects of clearing heat, promoting diuresis, detoxifying and eliminating carbuncle, can inhibit scar hyperplasia, relieve pigmentation, is easy to permeate into skin and has fresh texture; meanwhile, the honeysuckle extract and the trumpet creeper extract are added, and are synergistic to diminish inflammation and fade, so that the calming and relieving effects are achieved, and the problem of red swelling and sensitivity of the skin after rolling can be effectively relieved; l-glutamine is generated after oligopeptide-1 and oligopeptide-3 in alanyl glutamine (dipeptide) are hydrolyzed, so that LXR activity in main keratinocytes of a human body and activation of epidermal lipid synthase can be promoted, the hydration of skin is improved, skin aging resistance is facilitated, and a good water locking function is realized; the polyvinyl formal/methyl acrylate copolymer (PVM/MA copolymer) has certain lubrication thickening property, and is combined with the effective components for use, so that the moisture retention of the cosmetic liquid is enhanced, and the cosmetic liquid provided by the invention can effectively relieve the pain and burning sensation in the process when being used as a base liquid for microneedle treatment, and the pain of a patient is relieved.
Propylene diglycerol acrylate/acrylic acid copolymer: commercially available cosmetic raw materials. The cosmetic liquid is used as thickener, viscosity control agent and humectant, and can impart fluidity and transparency to skin, and is mild and non-irritating.
PVM/MA copolymer: commercially available cosmetic raw materials. Can be used as antistatic agent, adhesive and emulsion stabilizer in cosmetics.
Glycerol: the chemical name is glycerol, which is colorless, odorless and sweet viscous liquid, has strong water absorption, and can moisten skin without chapping when being smeared on the skin. The glycerin is quickly absorbed, and is a good moisturizing product for skin peeled in season, pockmarked skin, sensitive skin and the like, so that the skin can be kept soft and elastic, and is not damaged by dust, weather and the like and is dry.
Methyl hydroxybenzene ester: the chemical name is methyl p-hydroxybenzoate, also called methyl p-hydroxybenzoate or methyl p-hydroxybenzoate, is an organic substance with chemical formula C8H8O3White crystalline powder or colorless crystals, with the property of being readily soluble in alcohol, ether and acetone, very slightly soluble in water, boiling point 270-280 ℃. The product is mainly used as a sterilization preservative for organic synthesis, food, cosmetics and medicines, and also used as a feed preservative.
Propyl hydroxybenzoate: the chemical name is propyl p-hydroxybenzoate, also called propylparaben or propylparaben, which is an organic matter and has the chemical formula of C10H12O3White crystalline powder, easily soluble in alcohol, ether and acetone, slightly soluble in water, boiling point 133 ℃. The product is mainly used as a sterilization preservative for organic synthesis, food, cosmetics and medicines, and also used as a feed preservative.
Before the present embodiments are further described, it is to be understood that the scope of the invention is not limited to the particular embodiments described below; it is also to be understood that the terminology used in the examples herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention. Test methods in which specific conditions are not noted in the following examples are generally performed under conventional conditions or conditions recommended by each manufacturer.
When numerical ranges are given in the examples, it is understood that both endpoints of each of the numerical ranges and any number between the two endpoints are optional unless otherwise specified in the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In addition to the specific methods, devices, and materials used in the examples, any methods, devices, and materials similar or equivalent to those described in the examples may be used in the practice of the invention in addition to the specific methods, devices, and materials used in the examples, in keeping with the knowledge of one skilled in the art and with the description of the invention.
Unless otherwise indicated, the experimental methods, detection methods and preparation methods disclosed in the present invention all employ conventional techniques in the art.
Example 1
The scar and acne mark removing beauty lotion comprises the following raw materials in percentage by weight: centella asiatica extract 7.0%, honeysuckle extract 3.0%, Chinese trumpet creeper extract 5.0%, alanyl glutamine 8.0%, propylene diglycerol acrylate/acrylic acid copolymer 20%, PVM/MA copolymer 2.5%, glycerin 0.6%, methyl hydroxybenzoate 0.10%, propyl hydroxybenzoate 0.02%, and deionized water 53.78%.
Example 2
The scar and acne mark removing beauty lotion comprises the following raw materials in percentage by weight: centella asiatica extract 10%, honeysuckle extract 3.5%, Chinese trumpet creeper extract 3.5%, alanyl glutamine 10%, propylene diglycerol acrylate/acrylic acid copolymer 25%, PVM/MA copolymer 2.0%, glycerin 0.5%, methyl hydroxybenzoate 0.05%, propyl hydroxybenzoate 0.03%, and deionized water 45.42%.
Example 3
The scar and acne mark removing beauty lotion comprises the following raw materials in percentage by weight: 15% of centella asiatica extract, 6.0% of honeysuckle extract, 6.5% of trumpet creeper extract, 5% of alanyl glutamine, 15% of propylene diglycerol acrylate/acrylic acid copolymer, 3.0% of PVM/MA copolymer, 0.8% of glycerol, 0.15% of methyl hydroxybenzoate, 0.05% of propyl hydroxybenzoate and 48.5% of deionized water.
Clinical application
Firstly, a research object: shanghai university of transportation medical college affiliated with the southern institute of the ninth people's hospital outpatient department of traditional Chinese medicine beauty treatment, and the diagnosis standard and the inclusion standard are met. 60 patients with acne vulgaris scars were selected. The minimum scar area is 2cm, the maximum scar area is 42cm, wherein the scar area mainly represents 14 ice cone type scars, 27 rolling type scars and 49 boxcar types. Treatment groups 30, 2 of which were male and 28 of which were 28 women, were 21 years of minimum age and 35 years of maximum age. The treatment groups contained 30 cases, wherein 1 case was male, 29 cases were female, the age was 19 years minimum, the age was 34 years maximum, and the comparative difference between the gender and the age in the two groups was not statistically significant (P > 0.05). Exclusion criteria, patients had recent history of taking photosensitizing drugs, history of sun exposure, mental disorder, pregnant women, scar constitutions.
Preparation of beautifying liquid
2.1 major Components manufacturer and product number
Centella extraction solution: shanghai Yttrium Lankan chemical technology Co., Ltd., product No. YH-51512. The solid content is more than 3.5%, and the main effective components are asiaticoside, madecassoside, asiatic acid and madecassic acid. The pharmacological action has inhibiting effect on Staphylococcus aureus, hemolytic streptococcus, various dysentery bacilli and typhoid bacillus, and has influence on activity of scar fibroblast. The traditional Chinese medicine composition is clinically used for promoting wound healing and inhibiting scar hyperplasia. The extraction process comprises the following steps: 1. cleaning centella asiatica, grinding the centella asiatica into 2.1,3 heating and extracting by propylene glycol, 3 filtering (a filter screen with 300 meshes), 4 filtering by cloth, 5 filtering by paper, 6 filtering, heating and concentrating the centella asiatica, 7 concentrating the centella asiatica, 8 freezing the centella asiatica, 9 unfreezing and adjusting the pH value, 10 filtering by thawing, 11 sterilizing the centella asiatica, 12 preserving the centella asiatica, 13 testing the centella asiatica, 14 packaging the centella asiatica and the centella asiatica.
Extracting solution of Chinese trumpet creeper: shanghai Yttrium Lange chemical technology Co., Ltd., product number YH-52868. The solid content is 3.5-10%, and the main active ingredients are triterpenes, flavonoids, anthocyanidins, volatile oil and the like. Has pharmacological effects of improving blood circulation, inhibiting thrombosis, relieving pain, resisting inflammation, and resisting oxidation. The traditional Chinese medicine composition is clinically used for treating skin diseases such as acne and hormone-dependent dermatitis. The extraction process comprises the following steps: 1. cleaning the campsis grandiflora, grinding the campsis grandiflora to 2.1, heating and extracting the campsis grandiflora by 3 propylene glycol, filtering (a filter screen with 300 meshes) the campsis grandiflora, filtering (a filter screen with 4 meshes) the campsis grandiflora, filtering by 5 cloths, filtering by 6 papers, heating and concentrating 7, freezing 8, freezing 9, unfreezing and adjusting (adjusting pH and the like) 10, performing nanofiltration 11, sterilizing 12, performing corrosion prevention 13, performing quality inspection 14 and packaging.
Honeysuckle extract: shanghai Yttrium Lang chemical science and technology, product number YH-51120. The solid content is 3.5-10%, and the main active ingredients are volatile oil, organic acids, flavonoids, iridoid glycosides, triterpenoid saponins and the like. The pharmacological action is to clear away heat and toxic material, cool and disperse wind-heat. The clinical application is: abscess and swelling, sore, throat impediment, erysipelas. The extraction process comprises the following steps: 1. cleaning honeysuckle, grinding 2.1,3 propylene glycol, heating and extracting 3, filtering (a filter screen with 300 meshes) 4, filtering with cloth 5, filtering with paper 6, heating and concentrating 7, performing quality inspection 8, freezing 9, unfreezing and adjusting (adjusting pH and the like) 10, performing nanofiltration 11, sterilizing 12, performing corrosion prevention 13, performing quality inspection 14, and packaging.
Litai essence powder: shanghai Yttrium Lange chemical technology, Inc. Chinese name: alanylglutamine, INCI name ALANYL GLUTAMINE, CAS No. 39537-23-0. The product is white to light yellow powder, is soluble in water, and has stable property at normal temperature. Wherein, the oligopeptide-1 content is 35 wt%, the oligopeptide-3 content is 20 wt%, and the composition has the effects of resisting oxidation, delaying skin aging, promoting tissue repair, preserving moisture and locking water.
2.2 preparation method
The cosmetic liquid is prepared according to the following steps:
mixing the centella extract, the honeysuckle extract, the campsis grandiflora extract and the litide essence powder, and stirring at the speed of 100rpm for 1h to obtain a first mixture;
step two, mixing propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerol, methyl hydroxybenzoate and propyl hydroxybenzoate, adding deionized water, and stirring at 130rpm for 1h to obtain a second mixture;
and step three, mixing the first mixture obtained in the step one and the second mixture obtained in the step two, stirring at 180rpm, and uniformly mixing to obtain the scar and acne mark removing cosmetic liquid.
The beauty lotion prepared by the method comprises the following components in percentage by weight: centella asiatica extract 10%, honeysuckle extract 3.5%, Chinese trumpet creeper extract 3.5%, alanyl glutamine 10%, propylene diglycerol acrylate/acrylic acid copolymer 25%, PVM/MA copolymer 2.0%, glycerin 0.5%, methyl hydroxybenzoate 0.05%, propyl hydroxybenzoate 0.03%, and deionized water 45.42%.
Third, preoperative preparation
Before treatment, medical staff are well communicated with patients fully, treatment methods, intraoperative care matters and emergency prevention methods are introduced to the patients, and psychological stress of the patients is reduced so as to obtain coordination and understanding of the patients. Simultaneously, the face of the patient is cleaned before operation and is photographed and kept under the same light source.
Fourth, the therapeutic method
The facial disinfectant of the treatment group is used for disinfection. The micro-needle treatment selects a sterile needle roller with the thickness of 0.5mm to 1.0mm, holds the prepared beauty solution with the left hand, and performs staggering and rolling for 3 to 5 times in each direction of local skin, and paints the beauty solution while rolling until the local skin swells as a treatment end point. The treatment sites were kept from exposure to raw water for 24 hours after treatment, and were noted for moisture retention and sun protection. The treatment is performed 1-6 times, 2 times per month.
And disinfecting the facial disinfectant of the control group. The micro-needle treatment selects a sterile needle roller with the thickness of 0.5mm to 1.0mm, and the sterile needle roller is staggered and rolled for 3 to 5 times in each direction of local skin until the local skin is swollen to be a treatment end point. After the treatment is finished, the asiaticoside ointment is applied to the scar, the treatment part is prevented from contacting raw water within 24 hours after the application treatment, and the moisture retention and the sun protection are paid attention to. The treatment is performed 1-6 times, 2 times per month.
Fifth, therapeutic results
5.1 therapeutic Standard
(1) And (3) healing: the scar depression repair degree of a patient reaches 90 percent;
(2) the effect is shown: the scar depression repairing degree of a patient reaches over 60 percent, the appearance is smooth, and the uneven color is obviously reduced;
(3) the method has the following advantages: the scar depression repair degree of a patient is 30-59%, the appearance is improved to a certain extent, and uneven color is obviously reduced;
(4) and (4) invalidation: the scar depression degree is restored to be less than 30 percent, and the appearance is not changed or even aggravated.
Total effective rate (number of cure cases + number of significant cases + number of effective cases)/total number of cases × 100%.
5.2 subjective satisfaction survey of patients. According to subjective evaluation of patients on satisfaction degree of treatment effect and treatment experience, indexes are divided into completely satisfactory, satisfactory and unsatisfactory in sequence, and the satisfaction rate is (completely satisfactory + satisfactory)/the number of cases is multiplied by 100%.
5.3 comparing the two groups of adverse reactions. Common adverse reactions are facial infection, skin allergy or sensitization, deep color, others (deep color, new acne, erythema edema).
5.4 statistical analysis
The study data was analyzed using SPSS 22.0,the count data is expressed in percent (%), column x2And (6) checking. P is less than 0.05, which indicates that the difference has statistical significance.
5.5 results
5.5.1 therapeutic effects are shown in Table 1 below:
TABLE 1 comparison of the efficacy of the two groups of patients
Note: chi shape2＝7.341)P<The effective rate of the 0.05 treatment group is higher than that of the control group.
The statistical results in table 1 show that the curative effect of the beautifying fluid provided by the invention on scar depression and acne mark is better than that of the asiaticoside ointment when the beautifying fluid is used together with the rolling needles, and the beautifying fluid provided by the invention has good scar and acne mark removing effects.
5.5.2 Observation of adverse reactions
TABLE 2 adverse reaction comparison of two groups of patients
Note: chi-type food processing machine2＝5.24P<The incidence of adverse reactions was lower in the 0.05 treated group than in the control group.
The statistical results in table 2 show that the adverse reaction rate of the cosmetic liquid provided by the invention in combination with the roller pin for treating scar depression and acne marks is lower than that of the asiaticoside ointment, which indicates that the cosmetic liquid provided by the invention can reduce the side effects of acupuncture treatment.
5.5.3 satisfaction survey
The satisfaction degree of the treatment group patients on the treatment effect is 95.53 percent, which is obviously higher than 76.47 percent of the control group, and the difference has statistical significance (P is less than 0.05). The satisfaction degree of the treatment group patients on the treatment experience is 93.33 percent, which is obviously higher than that of the control group by 66.67 percent, and the difference has statistical significance (P is less than 0.05). Wherein, in the investigation process of the satisfaction degree of treatment experience, the VRS method is adopted to allow patients in a treatment group and patients in a control group to respectively evaluate the burning sensation of pain in the treatment process, the evaluation results of the patients in the treatment group are 19 cases of slight pain and 11 cases of moderate pain, and the evaluation results of the patients in the control group are 5 cases of slight pain, 18 cases of moderate pain and 7 cases of severe pain.
Typical cases
Case 1: aged for 30 years, aged for a certain woman, the member of Shanghai hospital. For repeated acne for three months, the patient can see the acne with a pigmented scar for more than 1 month, and the patient can be treated in his hospital 11 months in 2020, wherein FIG. 1 is a photograph of the treatment site; the scar and acne mark removing cosmetic liquid is adopted to be matched with the needle roller for treatment, and the treatment is carried out once per week for 4 times. Fig. 2 is a photograph of the skin after treatment, which shows that the acne marks on the cheek are obviously pale and partially disappear, and the facial skin is relatively white and tight.
Case 2: somebody in grandson, female, age 27, Shanghai, in white collar. There is a history of acne for many years, and skin roughness with pigmentation is secondary to the topical application of hormone drugs. Treatment in my hospital 11 months in 2020, FIG. 3 is a photograph of a pre-treatment reservation; the scar and acne mark removing cosmetic liquid is used together with the roller pin for treatment, and the treatment is performed once every two weeks for 4 times. FIG. 4 is a photograph of the skin after treatment, which shows that the pits on both cheeks become shallow, the acne marks become pale, and the skin pores are reduced to be finer and more white than before treatment.
Case 3: jin Yi in a certain age, male, 19 years old, Shanghai at school. In the history of acne, 2 years, obvious sunken pockmarks are left locally, cystic acne is left at the lower jaw, the treatment is carried out in our hospital 12 months in 2020, and fig. 5 is a photograph of a treatment previous reservation; the scar and acne mark removing cosmetic liquid disclosed by the invention is matched with roller needle treatment once a week and four times of treatment, a picture 6 is a picture of a left file after treatment, cystic acne is obviously reduced and eliminated, and acne marks disappear, and after three months, as the acne of a patient has new and several acne marks, the acne marks remain, the patient needs to be treated for 2 times according to the initiative requirement of the patient, a picture 7 is a picture 8 is a picture of a left file after two times of treatment, the acne marks can be obviously eliminated, and the skin is smooth and compact compared with the skin.
While the invention has been described with respect to a preferred embodiment, it will be understood by those skilled in the art that the foregoing and other changes, omissions and deviations in the form and detail thereof may be made without departing from the scope of this invention. Those skilled in the art can make various changes, modifications and equivalents to the disclosed technology without departing from the spirit and scope of the present invention, and all such changes, modifications and equivalents are intended to be included therein as equivalents of the present invention; meanwhile, any changes, modifications and variations of the above-described embodiments, which are equivalent to those of the technical spirit of the present invention, are within the scope of the technical solution of the present invention.
Claims (10)
1. The scar and acne mark removing beauty lotion is characterized by comprising the following raw materials: centella asiatica extract, honeysuckle flower extract, trumpet creeper flower extract, alanyl glutamine, propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerin, methyl hydroxybenzoate, propyl hydroxybenzoate and deionized water.
2. The cosmetic liquid as claimed in claim 1, wherein the weight percentage of the raw materials of each component is as follows: 3.5-20% of centella extract, 1.5-10% of honeysuckle extract, 1.5-10% of trumpet creeper extract, 5.0-20.0% of alanyl glutamine, 15-55% of propylene diglycerol acrylate/acrylic acid copolymer, 1.0-4.0% of PVM/MA copolymer, 0.1-1.0% of glycerol, 0.01-0.15% of methyl hydroxybenzoate, 0.01-0.05% of propyl hydroxybenzoate and 35-55% of deionized water.
3. The cosmetic liquid according to claim 1, wherein the weight percentages of the raw materials of the components are as follows: centella asiatica extract 10%, honeysuckle extract 3.5%, Chinese trumpet creeper extract 3.5%, alanyl glutamine 10%, propylene diglycerol acrylate/acrylic acid copolymer 25%, PVM/MA copolymer 2.0%, glycerin 0.5%, methyl hydroxybenzoate 0.05%, propyl hydroxybenzoate 0.03%, and deionized water 45.42%.
4. A method for preparing a cosmetic liquid according to any one of claims 1 to 3, comprising the steps of:
s1, stirring the centella extract, the honeysuckle extract, the campsis grandiflora extract and the alanyl glutamine to obtain a first mixture;
s2, stirring propylene diglycerol acrylate/acrylic acid copolymer, PVM/MA copolymer, glycerol, methyl hydroxybenzoate, propyl hydroxybenzoate and deionized water to obtain a second mixture;
s3, mixing the first mixture obtained in the step S1 and the second mixture obtained in the step S2, stirring, and uniformly mixing to obtain the scar and acne mark removing cosmetic liquid.
5. The method of claim 4, further comprising one or more of the following features:
(1) in the step S1, the stirring speed is 60-150 rpm, and the stirring time is 0.5-1 h;
(2) in the step S2, the stirring speed is 100-200 rpm, and the stirring time is 0.5-1 h;
(3) in the step S3, the stirring speed is 100-200 rpm, and the stirring time is 0.5-1 h.
6. Use of a cosmetic liquid according to any one of claims 1 to 3 for removing scars and acne marks.
7. Use of a cosmetic liquid according to any one of claims 1 to 3 in the manufacture of a medical or cosmetic product for scar repair or acne mark removal.
8. Use of a cosmetic liquid according to any one of claims 1 to 3 for the preparation of a cosmetic product having any one of the following effects: 1) repairing depressed scars of the skin; 2) reduction of acne pigmentation; 3) cystic acne with detumescence and stagnation eliminating effects; 4) inhibiting acne scar formation and hyperplasia.
9. Use of a cosmetic liquid according to any one of claims 1 to 3 for the preparation of a microneedle base fluid.
10. A scar and acne mark removing cosmetic product comprising the cosmetic liquid according to any one of claims 1 to 3.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103002903A (en) * | 2010-06-28 | 2013-03-27 | Ade治疗公司 | Keloid treatment |
| CN109646356A (en) * | 2019-01-30 | 2019-04-19 | 邯郸市丛台区本草汉方贸易有限公司 | Chinese medicine composition, its purposes and facial mask |
| CN111419757A (en) * | 2020-04-30 | 2020-07-17 | 南京苗邦美业企业管理有限公司 | Herbal skin-care essence |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103002903A (en) * | 2010-06-28 | 2013-03-27 | Ade治疗公司 | Keloid treatment |
| CN109646356A (en) * | 2019-01-30 | 2019-04-19 | 邯郸市丛台区本草汉方贸易有限公司 | Chinese medicine composition, its purposes and facial mask |
| CN111419757A (en) * | 2020-04-30 | 2020-07-17 | 南京苗邦美业企业管理有限公司 | Herbal skin-care essence |
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