CN114761435A - 一种分离的结合抗原axl的蛋白及其用途 - Google Patents

一种分离的结合抗原axl的蛋白及其用途 Download PDF

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CN114761435A
CN114761435A CN202080082297.4A CN202080082297A CN114761435A CN 114761435 A CN114761435 A CN 114761435A CN 202080082297 A CN202080082297 A CN 202080082297A CN 114761435 A CN114761435 A CN 114761435A
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antigen binding
binding protein
isolated antigen
seq
amino acid
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吕明
丁晓然
缪仕伟
谈彬
王学恭
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Hangzhou Sumgen Biotech Co Ltd
Sumgen MAb Beijing Biotech Co Ltd
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Hangzhou Sumgen Biotech Co Ltd
Sumgen MAb Beijing Biotech Co Ltd
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Abstract

提供一种分离的抗原结合蛋白，其包含氨基酸序列如SEQ ID NO:1或SEQ ID NO:46所示的VH中的至少一个CDR；且包含氨基酸序列如SEQ ID NO:2所示的VL中的至少一个CDR。还提供包含所述分离的抗原结合蛋白的免疫缀合物、编码所述分离的抗原结合蛋白的核酸、包含所述分离的抗原结合蛋白的载体、包含所述核酸或所述载体的细胞、制备所述分离的抗原结合蛋白的方法以及所述分离的抗原结合蛋白的用途。

Description

PCT国内申请，说明书已公开。

Claims (68)

  1. PCT国内申请，权利要求书已公开。
CN202080082297.4A 2019-11-28 2020-11-27 一种分离的结合抗原axl的蛋白及其用途 Pending CN114761435A (zh)

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PCT/CN2020/132456 WO2021104496A1 (zh) 2019-11-28 2020-11-27 一种分离的结合抗原axl的蛋白及其用途

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US3896111A (en) 1973-02-20 1975-07-22 Research Corp Ansa macrolides
AR097648A1 (es) 2013-09-13 2016-04-06 Amgen Inc Combinación de factores epigenéticos y compuestos biespecíficos que tienen como diana cd33 y cd3 en el tratamiento de leucemia mieloide
CN110642952B (zh) * 2014-08-14 2021-05-25 上海生物制品研究所有限责任公司 抗her3抗体、其制法及其应用
EP3229836B1 (en) * 2014-12-09 2019-11-13 Institut National de la Sante et de la Recherche Medicale (INSERM) Human monoclonal antibodies against axl
JP6857138B2 (ja) * 2015-05-18 2021-04-14 アジェンシス，インコーポレイテッド Ａｘｌタンパク質に結合する抗体
EP3458482A4 (en) * 2016-05-20 2020-01-15 Agency for Science, Technology and Research ANTI-AXL TYROSINE KINASEPEPTOR ANTIBODIES AND USES THEREOF
CN111263770A (zh) * 2017-09-13 2020-06-09 加拿大国家研究委员会 Axl-特异性抗体及其用途
CN110483639A (zh) * 2018-05-15 2019-11-22 复旦大学 靶向axl的抗体及抗体-药物偶联物及其制备方法和用途
CN110540592B (zh) * 2018-05-29 2022-08-09 杭州尚健生物技术有限公司 结合axl蛋白的抗体及其应用
CN110003338B (zh) * 2019-04-16 2021-04-23 北京免疫方舟医药科技有限公司 抗ox40抗体及其应用

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