CN114761425A - 用于免疫效应细胞工程化的增强的嵌合抗原受体和其用途 - Google Patents

用于免疫效应细胞工程化的增强的嵌合抗原受体和其用途 Download PDF

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CN114761425A
CN114761425A CN202080082465.XA CN202080082465A CN114761425A CN 114761425 A CN114761425 A CN 114761425A CN 202080082465 A CN202080082465 A CN 202080082465A CN 114761425 A CN114761425 A CN 114761425A
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cell
cells
receptor
derived
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B·瓦拉梅尔
R·比乔戴尔
T·T·李
J·古德里奇
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Fate Therapeutics Inc
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Fate Therapeutics Inc
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CN202080082465.XA 2019-10-07 2020-10-07 用于免疫效应细胞工程化的增强的嵌合抗原受体和其用途 Pending CN114761425A (zh)

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US201962912000P 2019-10-07 2019-10-07
US62/912,000 2019-10-07
US201962916468P 2019-10-17 2019-10-17
US62/916,468 2019-10-17
PCT/US2020/054601 WO2021071962A1 (en) 2019-10-07 2020-10-07 Enhanced chimeric antigen receptor for immune effector cell engineering and use thereof

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US (1) US20240115602A1 (https=)
EP (1) EP4041759A4 (https=)
JP (1) JP2022550899A (https=)
KR (1) KR20220108038A (https=)
CN (1) CN114761425A (https=)
AU (1) AU2020363697A1 (https=)
BR (1) BR112022006440A2 (https=)
CA (1) CA3151781A1 (https=)
IL (1) IL291924A (https=)
MX (1) MX2022004080A (https=)
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CN117285651A (zh) * 2023-09-27 2023-12-26 中国医学科学院北京协和医院 靶向c-MET的嵌合抗原受体、CAR-M及其用途
WO2024140778A1 (zh) * 2022-12-27 2024-07-04 科济生物医药（上海）有限公司 Nkg2d工程化细胞及其组合物
WO2026002201A1 (zh) * 2024-06-28 2026-01-02 上海苹谱医疗科技有限公司 具有增强肿瘤靶向浸润能力的间充质干细胞及其应用
WO2026067758A1 (en) * 2024-09-29 2026-04-02 Nanjing Legend Biotech Co., Ltd. Engineered cells and uses thereof

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US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
KR102774451B1 (ko) 2017-11-14 2025-02-28 앱클론(주) 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체
US11649294B2 (en) 2017-11-14 2023-05-16 GC Cell Corporation Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
AU2022423987A1 (en) * 2021-12-29 2024-07-11 Century Therapeutics, Inc. Genetically engineered cells having anti-cd19 / anti-cd22 chimeric antigen receptors, and uses thereof
US20250222029A1 (en) 2022-04-08 2025-07-10 Fate Therapeutics, Inc. Chimeric antigen receptor for tumor targeting
US20250228943A1 (en) 2022-04-08 2025-07-17 Fate Therapeutics, Inc. Cells having solid tumor targeting backbone and use thereof
WO2023215278A1 (en) * 2022-05-03 2023-11-09 The Broad Institute, Inc. Modified immune cells and methods for use thereof
JP2025516571A (ja) * 2022-05-10 2025-05-30 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫寛容を増強するための組成物及び方法
US20250090582A1 (en) * 2022-06-08 2025-03-20 Century Therapeutics, Inc. Genetically engineered cells having anti-cd133 / anti-egfr chimeric antigen receptors, and uses thereof
JP2025527534A (ja) * 2022-08-17 2025-08-22 アルティバ・バイオセラピューティクス・インコーポレイテッド 抗－ヒト表皮成長因子受容体２（ｈｅｒ２）キメラ抗原受容体（ｃａｒ）を含むナチュラルキラー細胞を投与する方法
EP4655314A2 (en) * 2023-01-29 2025-12-03 Case Western Reserve University Chimeric antigen receptor constructs with optimized intracellular domains for natural killer cells
JP2025059072A (ja) * 2023-09-28 2025-04-09 沛爾生技醫藥股▲分▼有限公司 Ｎｋｐ３０膜貫通ドメインを含む単離核酸分子及びこれを含むキメラ抗原受容体
WO2025097150A1 (en) * 2023-11-03 2025-05-08 The University Of Chicago Bcl-2 inhibition to amplify chimeric antigen receptor therapy
CN118420786B (zh) * 2024-06-12 2025-10-17 浙江大学医学院附属第一医院(浙江省第一医院) 一种靶向her2和hla-g的双特异性嵌合抗原受体及其应用

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