CN114761376A - 一种含胺转染试剂和制备方法及转染复合物 - Google Patents

一种含胺转染试剂和制备方法及转染复合物 Download PDF

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Publication number
CN114761376A
CN114761376A CN201980102539.9A CN201980102539A CN114761376A CN 114761376 A CN114761376 A CN 114761376A CN 201980102539 A CN201980102539 A CN 201980102539A CN 114761376 A CN114761376 A CN 114761376A
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transfection
amine
group
present disclosure
nucleotide
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CN201980102539.9A
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Inventor
张鸿雁
杨志伟
黄金宇
王秀莲
吴林玉
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Suzhou Ruibo Biotechnology Co ltd
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Suzhou Ruibo Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/30—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

本公开涉及一种含胺转染试剂和其制备方法以及包含该含胺转染试剂的转染复合物。该含胺转染试剂为式(I)所示化合物或其药学上可接受的盐，含有该含胺转染试剂的转染复合物具有较佳的生物活性和出人意料的低毒性

Description

PCT国内申请，说明书已公开。

Claims (18)

  1. PCT国内申请，权利要求书已公开。
CN201980102539.9A 2019-12-13 2019-12-13 一种含胺转染试剂和制备方法及转染复合物 Pending CN114761376A (zh)

Applications Claiming Priority (1)

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PCT/CN2019/125165 WO2021114227A1 (zh) 2019-12-13 2019-12-13 一种含胺转染试剂和制备方法及转染复合物

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CN114761376A true CN114761376A (zh) 2022-07-15

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CN201980102539.9A Pending CN114761376A (zh) 2019-12-13 2019-12-13 一种含胺转染试剂和制备方法及转染复合物

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CN (1) CN114761376A (zh)
WO (1) WO2021114227A1 (zh)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103380113A (zh) * 2010-11-15 2013-10-30 生命科技公司 含胺的转染试剂及其制备和使用方法
WO2014152678A1 (en) * 2013-03-15 2014-09-25 University Of Massachusetts Compositions and methods for delivering agents to the central nervous system
CN108220293A (zh) * 2016-12-21 2018-06-29 苏州瑞博生物技术有限公司 一种小干扰核酸和药物组合物及其用途
CN108239644A (zh) * 2016-12-23 2018-07-03 苏州瑞博生物技术有限公司 一种小干扰核酸和药物组合物及其用途
CN108265052A (zh) * 2016-12-30 2018-07-10 苏州瑞博生物技术有限公司 一种小干扰核酸和药物组合物及其用途

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103380113A (zh) * 2010-11-15 2013-10-30 生命科技公司 含胺的转染试剂及其制备和使用方法
WO2014152678A1 (en) * 2013-03-15 2014-09-25 University Of Massachusetts Compositions and methods for delivering agents to the central nervous system
CN108220293A (zh) * 2016-12-21 2018-06-29 苏州瑞博生物技术有限公司 一种小干扰核酸和药物组合物及其用途
CN108239644A (zh) * 2016-12-23 2018-07-03 苏州瑞博生物技术有限公司 一种小干扰核酸和药物组合物及其用途
CN108265052A (zh) * 2016-12-30 2018-07-10 苏州瑞博生物技术有限公司 一种小干扰核酸和药物组合物及其用途

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