CN114761027A - 用于免疫细胞扩增的Cbl抑制剂和组合物 - Google Patents

用于免疫细胞扩增的Cbl抑制剂和组合物 Download PDF

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CN114761027A
CN114761027A CN202080081556.1A CN202080081556A CN114761027A CN 114761027 A CN114761027 A CN 114761027A CN 202080081556 A CN202080081556 A CN 202080081556A CN 114761027 A CN114761027 A CN 114761027A
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cells
days
cbl
cell
certain embodiments
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Chinese (zh)
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A·T·桑德斯
J·高斯灵
S·A·韦兰
M·洛策
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Nulex Therapeutics
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Nulex Therapeutics
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
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CN202080081556.1A 2019-09-24 2020-09-23 用于免疫细胞扩增的Cbl抑制剂和组合物 Pending CN114761027A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962905124P 2019-09-24 2019-09-24
US62/905124 2019-09-24
US201962954323P 2019-12-27 2019-12-27
US62/954323 2019-12-27
US202062961596P 2020-01-15 2020-01-15
US62/961596 2020-01-15
US202062978254P 2020-02-18 2020-02-18
US62/978254 2020-02-18
US202063032462P 2020-05-29 2020-05-29
US63/032462 2020-05-29
PCT/US2020/052335 WO2021061870A1 (en) 2019-09-24 2020-09-23 Cbl inhibitors and compositions for expansion of immune cells

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CN114761027A true CN114761027A (zh) 2022-07-15

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CN202080081556.1A Pending CN114761027A (zh) 2019-09-24 2020-09-23 用于免疫细胞扩增的Cbl抑制剂和组合物
CN202080081550.4A Pending CN114786687A (zh) 2019-09-24 2020-09-23 用于过继细胞疗法的Cbl抑制剂和组合物

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US (2) US12121540B2 (enExample)
EP (2) EP4034140A1 (enExample)
JP (2) JP2022549303A (enExample)
KR (2) KR20220068227A (enExample)
CN (2) CN114761027A (enExample)
AU (2) AU2020353015A1 (enExample)
CA (2) CA3152293A1 (enExample)
IL (2) IL291577A (enExample)
WO (2) WO2021061870A1 (enExample)

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MX2021004191A (es) 2018-10-15 2021-05-27 Nurix Therapeutics Inc Compuestos bifuncionales para degradar la tirosina cinasa de bruton (btk) mediante la trayectoria de ubiquitina proteosoma.
US12582722B2 (en) 2019-02-13 2026-03-24 Nurix Therapeutics, Inc. Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
CA3136348A1 (en) 2019-04-09 2020-10-15 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
AU2020278592B2 (en) 2019-05-17 2024-10-10 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for Cbl-b inhibition and uses thereof
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
EP4034140A1 (en) 2019-09-24 2022-08-03 Nurix Therapeutics, Inc. Cbl inhibitors and compositions for use in adoptive cell therapy
WO2021113557A1 (en) 2019-12-04 2021-06-10 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
WO2022217123A2 (en) 2021-04-08 2022-10-13 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds
CA3236073A1 (en) 2021-10-26 2023-05-04 Robert J. Brown Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk
AU2022379959A1 (en) * 2021-11-05 2024-05-09 Genentech, Inc. Lactams as cbl-b inhibitors selective over c-cbl
TW202342013A (zh) * 2022-02-10 2023-11-01 英屬開曼群島商百濟神州有限公司 雜環化合物、其組成物及用其進行治療之方法
WO2023217067A1 (zh) * 2022-05-09 2023-11-16 上海先博生物科技有限公司 工程化免疫效应细胞及其与CBL-b抑制剂联用的应用
US20230414598A1 (en) * 2022-06-22 2023-12-28 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds and antiemetic agents
KR20250050018A (ko) 2022-08-16 2025-04-14 그렌마크 파머수티칼스 엘티디. Cbl-b 저해제로서의 치환된 피리디논 화합물
WO2024062363A1 (en) * 2022-09-21 2024-03-28 Glenmark Pharmaceuticals Ltd Bicyclic heterocyclic compounds as cbl-b inhibitors

Citations (5)

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