CN114748542A - 一种用于治疗高血压的内服药酒及其制备方法 - Google Patents
一种用于治疗高血压的内服药酒及其制备方法 Download PDFInfo
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Abstract
本发明涉及中药技术领域，尤其是涉及一种用于治疗高血压的内服药酒及其制备方法，由中药经白酒浸泡去药渣制成，所述中药包括以下重量份数的组分：豨签草2‑10份、牛膝1‑6份、夏枯草1‑6份、桑白皮1‑6份、芹菜根1‑6份、荠菜1‑9份、钩藤1‑6份和野菊1‑7份。本发明所述的用于治疗高血压的内服药酒，其中豨签草、牛膝、夏枯草、桑白皮、芹菜根、荠菜、钩藤和野菊，相互协同、互相配合，共同起到有效降低血压的作用。本发明的药酒能有效治疗患者的高血压，进而消除因高血压产生的头晕等症状，而且无明显副作用，不伤害身体，提高了生活质量。
Description
技术领域
本发明涉及中药技术领域，尤其是涉及一种用于治疗高血压的内服药酒及其制备方法。
背景技术
高血压(hypertension)是指以体循环动脉血压(收缩压和/或舒张压)增高为主要特征(收缩压≥140毫米汞柱，舒张压≥90毫米汞柱)，可伴有心、脑、肾等器官的功能或器质性损害的临床综合征。高血压是最常见的慢性病，也是心脑血管病最主要的危险因素。正常人的血压随内外环境变化在一定范围内波动。在整体人群，血压水平随年龄逐渐升高，以收缩压更为明显，但50岁后舒张压呈现下降趋势，脉压也随之加大。近年来，人们对心血管病多重危险因素的作用以及心、脑、肾靶器官保护的认识不断深入，高血压的诊断标准也在不断调整，目前认为同一血压水平的患者发生心血管病的危险不同，因此有了血压分层的概念，即发生心血管病危险度不同的患者，适宜血压水平应有不同。
目前，高血压病的控制主要依靠药物，西药治疗见效快，但副作用大，长期依靠西药治疗可能会在后期服用较大剂量，从而导致剂量依赖性的不良反应增加，常用的降压药物有五大类：ACEI(血管紧张素转化酶抑制剂)、ARB(血管紧张素受体拮抗剂)、CCB(钙通道阻滞剂)、β受体阻滞剂和利尿剂。但实际上，抗高血压西药的治疗效果并不理想，因此亟需一种疗效确切、安全毒副作用小的治疗药物。
发明内容
本发明的目的在于提供一种用于治疗高血压的内服药酒，此药酒能够有效地降低高血压，效果显著，副作用小。本发明还提供其制备方法。
一种用于治疗高血压的内服药酒，由中药经白酒浸泡去药渣制成，所述中药包括以下重量份数的组分：豨签草2-10份、牛膝1-6份、夏枯草1-6份、桑白皮1-6份、芹菜根1-6份、荠菜1-9份、钩藤1-6份和野菊1-7份。
优选地，所述中药包括以下重量份数的组分：豨签草4份、牛膝3份、夏枯草3份、桑白皮3份、芹菜根3份、荠菜4份、钩藤3份和野菊3份。
优选地，所述中药包括以下重量份数的组分：豨签草6份、牛膝4份、夏枯草4份、桑白皮4份、芹菜根4份、荠菜5份、钩藤4份和野菊4份。
优选地，所述中药与白酒的重量比为(2.8-3.2)：25。
优选地，所述中药与白酒的重量比为3：25。
一种用于治疗高血压的内服药酒的制备方法，包括以下步骤：
S1：将中药按照重量份数进行称重并取出；
S2：将称重好的中药进行粉碎并研磨；
S3：将研磨完毕的中药加入到白酒中进行泡制；
S4：待中药中的组分充分进入到白酒中成为药酒，并将药酒进行过滤去除药渣；
过滤之后的药酒即为成品。
优选地，将研磨好的中药包入纱布中，再将纱布放入白酒中进行泡制。
优选地，步骤S2中所述中药研磨之后的细度为180-200目。
优选地，步骤S3中泡制的时间为14-17天。
优选地，步骤S3中泡制的时间为15天。
本发明中的药物机理如下：
豨莶草：菊科草本植物“豨莶”、“腺梗豨莶”或“毛梗豨莶”的地上部分。味辛、苦，性寒，归肝、肾经。可以祛除风湿、强健筋骨、清热解毒，可用于乳腺炎、风寒泄泻、反胃呕吐等症。
牛膝：为苋科牛膝属植物牛膝(怀牛膝)Achyranthes bidentata BI.和川牛膝属(杯苋属)植物川牛膝(甜牛膝)Cyathula officinalis Kuan的根。具有活血通经，补肝肾，强筋骨，利水通淋，引火(血)下行的功效。主治瘀血阻滞经闭、痛经、经行腹痛、胞衣不下，跌打伤痛，腰膝酸痛，下肢痿软，淋证，水肿，小便不利，头痛，眩晕，齿痛，口舌生疮，吐血，衄血。
夏枯草：为唇形科夏枯草属植物夏枯草Prunella vulgaris L.的干燥果穗。具有清热泻火，明目，散结消肿的功效。主治目赤肿痛，头痛眩晕，目珠夜痛，瘰疬，瘿瘤，乳痈肿痛。
桑白皮：为桑科桑属植物桑Morus alba L.的根皮。具有泻肺平喘，利水消肿的功效。主治肺热咳喘，水肿。
芹菜根：主要是因为芹菜根中含酸性的降压成分，临床上芹菜根对于原发性、妊娠性及更年期高血压均有效。
荠菜：为十字花科荠属植物荠菜Capsella bursapastoris(L.)Medic的全草。具有利水消肿，明目，止血的功效。主治水肿证、肝热目赤，目生翳膜、血热出血、淋证、崩漏等。
钩藤：为茜草科钩藤属植物钩藤Uncaria rhynch0phylla(Miq.)Jacks.、大叶钩藤Uncaria macrophylla Wall.、毛钩藤Uncaria hirsuta Havil.、华钩藤Uncaria sinensis(Oliv.)Havil.或无柄果钩藤Uncaria sessilifructus Roxb.的带钩茎枝。具有清热平肝，息风止痉的功效。主治肝风内动，惊痫抽搐；肝火上攻或肝阳上亢之头痛眩晕等；风热表证之头痛目赤，斑疹透发不畅等。
野菊：为菊科植物野菊Dendranthemaindicum(L.)DesMoul.或岩香菊Dendranthemalavandulifolium(Fisch.exTrautv.)Ling&Shih的根或全草。野菊广布于东北、华北、华东、华中及西南；甘菊分布于吉林、辽宁、河北、山西、陕西、甘肃、青海、新疆、山东、江苏、浙江、江西、湖北、四川、云南等地。具有清热解毒之功效。用于感冒，气管炎，肝炎，高血压病，痢疾，痈肿，疔疮，目赤肿痛，瘰疬，湿疹。
本发明的有益效果：
本发明的药酒能有效治疗患者的高血压，进而消除因高血压产生的头晕等症状，而且无明显副作用，不伤害身体，提高了生活质量；
本发明所述的用于治疗高血压的内服药酒，其中豨签草、牛膝、夏枯草、桑白皮、芹菜根、荠菜、钩藤和野菊，相互协同、互相配合，共同起到有效降低血压的作用。
具体实施方式
应该指出，以下详细说明都是例示性的，旨在对本申请提供进一步的说明。除非另有指明，本文使用的所有技术和科学术语具有与本申请所属技术领域的普通技术人员通常理解的相同含义。
需要注意的是，这里所使用的术语仅是为了描述具体实施方式，而非意图限制根据本申请的示例性实施方式。如在这里所使用的，除非上下文另外明确指出，否则单数形式也包括复数形式，此外，还应当理解的是，当在本说明中使用术语“包含”和/或“包括”时，其指明存在特征、步骤、操作、器件、组件和/或它们的组合。
下面将结合实施例对本发明的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
一种用于治疗高血压的内服药酒，由中药经白酒浸泡去药渣形成，称取中药：豨签草60g、牛膝40g、夏枯草40g、桑白皮40g、芹菜根40g、荠菜50g、钩藤40g和野菊40g。
将上述中药进行粉碎并研磨，研磨之后中药的细度为190目，将研磨好的中药包入纱布中，称取2917g白酒，将包有中药的纱布放入到白酒中进行泡制，泡制15天之后，中药中的组分充分进入到白酒中成为药酒，并将药酒进行过滤去除药渣，过滤之后的药酒即为成品。
实施例2
一种用于治疗高血压的内服药酒，由中药经白酒浸泡去药渣形成，称取中药：豨签草40g、牛膝30g、夏枯草30g、桑白皮30g、芹菜根30g、荠菜40g、钩藤30g和野菊30g。
将上述中药进行粉碎并研磨，研磨之后中药的细度为200目，将研磨好的中药包入纱布中，称取2167g白酒，将包有中药的纱布放入到白酒中进行泡制，泡制15天之后，中药中的组分充分进入到白酒中成为药酒，并将药酒进行过滤去除药渣，过滤之后的药酒即为成品。
实施例3
一种用于治疗高血压的内服药酒，由中药经白酒浸泡去药渣形成，称取中药：豨签草20g、牛膝10g、夏枯草10g、桑白皮10g、芹菜根10g、荠菜10g、钩藤10g和野菊10g。
将上述中药进行粉碎并研磨，研磨之后中药的细度为200目，将研磨好的中药包入纱布中，称取750g白酒，将包有中药的纱布放入到白酒中进行泡制，泡制15天之后，中药中的组分充分进入到白酒中成为药酒，并将药酒进行过滤去除药渣，过滤之后的药酒即为成品。
实施例4
一种用于治疗高血压的内服药酒，由中药经白酒浸泡去药渣形成，称取中药：豨签草100g、牛膝60g、夏枯草60g、桑白皮60g、芹菜根60g、荠菜90g、钩藤60g和野菊70g。
将上述中药进行粉碎并研磨，研磨之后中药的细度为200目，将研磨好的中药包入纱布中，称取4667g白酒，将包有中药的纱布放入到白酒中进行泡制，泡制15天之后，中药中的组分充分进入到白酒中成为药酒，并将药酒进行过滤去除药渣，过滤之后的药酒即为成品。
临床试验总结：
患病情况：选取100例45 65岁的高血压病患者作为研究对象，其中，男性60例，女性40例，纳入标准为患者的舒张压≥90mmHg，收缩压≥140mmHg；属于原发性高血压；符合《中医病证诊断疗效标准》相关要求，将100例患者随机分为两组，每组50人，其中，第一组服用本发明实施例1制备的药酒，第二组服用非洛地平缓释片，各组均按规定按时服药，并避免食用辛辣刺激的食物，不服用其他类药物并保持良好的生活饮食习惯；各组持续用药2个月后，观察各组临床疗效。
本发明所述药酒为内服；
内服用法用量：成年人每天晚上一次，每次服用一两，即50g。未成年人禁止服用本发明所述的药酒。
治疗结果：
第一组患者，提前一天停用药物，停用药物一天后测量血压，评定疗效结果，治愈46例，治愈率92％，显效2例，显效率为4％，无效2例，无效率为4％，总有效率为96％。
第二组患者，正常服用药物期间，进行血压测量，评定疗效结果，治愈40例，治愈率80％，显效3例，显效率为6％，无效7例，无效率为14％，总有效率为86％。提前一天停用药物，停用药物一天后再次测量血压，评定疗效结果，治愈25例，治愈率50％，显效10例，显效率为20％，无效13例，无效率为30％，总有效率为70％。
疗效判断标准：
治愈：患者头痛、头晕等临床症状基本消失，血压下降20mmHg以上；
显效：患者头痛、头晕等临床症状有效改善，血压下降10～20mmHg之间；
无效：患者临床症状变化不明显，血压不下降或者下降10mmHg以下。
可以看出本发明的药酒即使在停用药物一天后，对维持患者血压水平方面也有着更加显著的效果，而且第二组患者在停用药物一天后，血压水平就会产生变化，由此可见，本发明的药酒治疗效果显著，能帮助患者更好的将血压维持在健康水平。
以下列举三个典型病例：
马某，男55岁，收缩压170mmHg、舒张压110mmHg；
每天晚上服用50g，30天后，收缩压130mmHg、舒张压85mmHg。
陈某，男63岁，收缩压160mmHg、舒张压100mmHg；
每天晚上服用50g，20天后，收缩压115mmHg、舒张压80mmHg。
郭某，女56岁，收缩压160mmHg、舒张压100mmHg；
每天晚上服用50g，25天后，收缩压125mmHg、舒张压80mmHg。
最后应说明的是：以上各实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述各实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分或者全部技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的范围。
Claims (10)
1.一种用于治疗高血压的内服药酒，其特征在于，由中药经白酒浸泡去药渣制成，所述中药包括以下重量份数的组分：豨签草2-10份、牛膝1-6份、夏枯草1-6份、桑白皮1-6份、芹菜根1-6份、荠菜1-9份、钩藤1-6份和野菊1-7份。
2.根据权利要求1所述的用于治疗高血压的内服药酒，其特征在于，所述中药包括以下重量份数的组分：豨签草4份、牛膝3份、夏枯草3份、桑白皮3份、芹菜根3份、荠菜4份、钩藤3份和野菊3份。
3.根据权利要求1所述的用于治疗高血压的内服药酒，其特征在于，所述中药包括以下重量份数的组分：豨签草6份、牛膝4份、夏枯草4份、桑白皮4份、芹菜根4份、荠菜5份、钩藤4份和野菊4份。
4.根据权利要求1所述的用于治疗高血压的内服药酒，其特征在于，所述中药与白酒的重量比为(2.8-3.2)：25。
5.根据权利要求1所述的用于治疗高血压的内服药酒，其特征在于，所述中药与白酒的重量比为3：25。
6.一种权利要求1-5任一所述的用于治疗高血压的内服药酒的制备方法，其特征在于，包括以下步骤：
S1：将中药按照重量份数进行称重并取出；
S2：将称重好的中药进行粉碎并研磨；
S3：将研磨完毕的中药加入到白酒中进行泡制；
S4：待中药中的组分充分进入到白酒中成为药酒，并将药酒进行过滤去除药渣；
过滤之后的药酒即为成品。
7.根据权利要求6所述的用于治疗高血压的内服药酒的制备方法，其特征在于，将研磨好的中药包入纱布中，再将纱布放入白酒中进行泡制。
8.根据权利要求6所述的用于治疗高血压的内服药酒的制备方法，其特征在于，步骤S2中所述中药研磨之后的细度为180-200目。
9.根据权利要求6所述的用于治疗高血压的内服药酒的制备方法，其特征在于，步骤S3中泡制的时间为14-17天。
10.根据权利要求6所述的用于治疗高血压的内服药酒的制备方法，其特征在于，步骤S3中泡制的时间为15天。
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