CN114729049B - 抗原结合蛋白 - Google Patents

抗原结合蛋白 Download PDF

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Publication number
CN114729049B
CN114729049B CN202080080763.5A CN202080080763A CN114729049B CN 114729049 B CN114729049 B CN 114729049B CN 202080080763 A CN202080080763 A CN 202080080763A CN 114729049 B CN114729049 B CN 114729049B
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Prior art keywords
seq
acid sequence
binding protein
amino acid
cancer
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Chinese (zh)
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CN114729049A (zh
Inventor
Y.Y.德根哈特
J.关
K.W.汉斯
P.J.莫利
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GlaxoSmithKline Intellectual Property Development Ltd
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GlaxoSmithKline Intellectual Property Development Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN202080080763.5A 2019-09-27 2020-09-25 抗原结合蛋白 Active CN114729049B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411387665.2A CN119431581A (zh) 2019-09-27 2020-09-25 抗原结合蛋白

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962906876P 2019-09-27 2019-09-27
US62/906,876 2019-09-27
US202063057508P 2020-07-28 2020-07-28
US63/057,508 2020-07-28
PCT/EP2020/076834 WO2021058711A2 (en) 2019-09-27 2020-09-25 Antigen binding proteins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202411387665.2A Division CN119431581A (zh) 2019-09-27 2020-09-25 抗原结合蛋白

Publications (2)

Publication Number Publication Date
CN114729049A CN114729049A (zh) 2022-07-08
CN114729049B true CN114729049B (zh) 2024-10-25

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CN202080080763.5A Active CN114729049B (zh) 2019-09-27 2020-09-25 抗原结合蛋白
CN202411387665.2A Pending CN119431581A (zh) 2019-09-27 2020-09-25 抗原结合蛋白

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US (2) US11479607B2 (https=)
EP (1) EP4034562B1 (https=)
JP (3) JP7280387B2 (https=)
KR (1) KR20220070011A (https=)
CN (2) CN114729049B (https=)
AU (1) AU2020355614B2 (https=)
BR (1) BR112022005787A2 (https=)
CA (1) CA3155173A1 (https=)
CO (1) CO2022003053A2 (https=)
ES (1) ES3053994T3 (https=)
IL (1) IL291364A (https=)
MX (1) MX2022003523A (https=)
MY (1) MY207830A (https=)
PH (1) PH12022550671A1 (https=)
TW (1) TWI865617B (https=)
WO (1) WO2021058711A2 (https=)

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WO2021058711A2 (en) 2019-09-27 2021-04-01 Glaxosmithkline Intellectual Property Development Limited Antigen binding proteins
EP4540284A2 (en) 2022-06-17 2025-04-23 Apogee Therapeutics, Inc. Antibodies that bind interleukin 13 and methods of use

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CN107708741A (zh) * 2015-06-12 2018-02-16 免疫医疗公司 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法

Also Published As

Publication number Publication date
JP2023103352A (ja) 2023-07-26
CN119431581A (zh) 2025-02-14
IL291364A (en) 2022-05-01
JP7546723B2 (ja) 2024-09-06
JP7280387B2 (ja) 2023-05-23
TWI865617B (zh) 2024-12-11
AU2020355614A1 (en) 2022-04-14
MY207830A (en) 2025-03-21
US12528864B2 (en) 2026-01-20
JP2024167261A (ja) 2024-12-03
CN114729049A (zh) 2022-07-08
BR112022005787A2 (pt) 2022-06-21
US20230279106A1 (en) 2023-09-07
AU2020355614B2 (en) 2024-12-05
WO2021058711A2 (en) 2021-04-01
PH12022550671A1 (en) 2023-05-29
EP4034562A2 (en) 2022-08-03
KR20220070011A (ko) 2022-05-27
EP4034562C0 (en) 2025-10-29
CO2022003053A2 (es) 2022-04-19
CA3155173A1 (en) 2021-04-01
US20220089728A1 (en) 2022-03-24
US11479607B2 (en) 2022-10-25
WO2021058711A3 (en) 2021-06-03
MX2022003523A (es) 2022-04-25
ES3053994T3 (en) 2026-01-28
TW202128755A (zh) 2021-08-01
EP4034562B1 (en) 2025-10-29
JP2022535034A (ja) 2022-08-04

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