CN114729001A - 一种齐墩果烷苯丙烯酰胺衍生物及其制备方法和用途 - Google Patents
一种齐墩果烷苯丙烯酰胺衍生物及其制备方法和用途 Download PDFInfo
- Publication number
- CN114729001A CN114729001A CN202080079360.9A CN202080079360A CN114729001A CN 114729001 A CN114729001 A CN 114729001A CN 202080079360 A CN202080079360 A CN 202080079360A CN 114729001 A CN114729001 A CN 114729001A
- Authority
- CN
- China
- Prior art keywords
- cyano
- cancer
- compound
- dioxooleanane
- dien
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Abstract
涉及药物化学领域和药物治疗学领域，具体涉及一类2‑氰基‑3,12‑二氧代齐墩果烷‑1,9(11)‑二烯‑17‑苯丙烯酰胺衍生物及其制备方法；还涉及该类新化合物在制备抗癌药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (12)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019111829675 | 2019-11-27 | ||
| CN201911182967 | 2019-11-27 | ||
| PCT/CN2020/131887 WO2021104391A1 (zh) | 2019-11-27 | 2020-11-26 | 一种齐墩果烷苯丙烯酰胺衍生物及其制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114729001A true CN114729001A (zh) | 2022-07-08 |
Family
ID=76130022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080079360.9A Pending CN114729001A (zh) | 2019-11-27 | 2020-11-26 | 一种齐墩果烷苯丙烯酰胺衍生物及其制备方法和用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230023332A1 (zh) |
| EP (1) | EP4067367A4 (zh) |
| JP (1) | JP2023504428A (zh) |
| KR (1) | KR20220104734A (zh) |
| CN (1) | CN114729001A (zh) |
| WO (1) | WO2021104391A1 (zh) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009146216A2 (en) * | 2008-04-18 | 2009-12-03 | Reata Pharmaceuticals. Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| EA019263B1 (ru) * | 2008-04-18 | 2014-02-28 | Ритэ Фамэсутикл, Инк. | Антиоксидативные модуляторы воспаления: производные олеанолевой кислоты с аминовыми и другими модификациями на с-17 |
| BR112016003454B1 (pt) * | 2013-08-23 | 2023-02-14 | Reata Pharmaceuticals, Inc. | Uso de composto de metil bardoxolona |
| MX2019005401A (es) * | 2016-11-08 | 2019-08-05 | Reata Pharmaceuticals Inc | Metodos para tratar el sindrome de alport con bardoxolona metilo o analogos de la misma. |
| CN106632576A (zh) * | 2016-12-16 | 2017-05-10 | 中国药科大学 | 2－氰基－3，12－二氧代齐墩果烷－1，9（11）－二烯－28－羧酸的合成方法改进 |
-
2020
- 2020-11-26 JP JP2022531563A patent/JP2023504428A/ja active Pending
- 2020-11-26 WO PCT/CN2020/131887 patent/WO2021104391A1/zh unknown
- 2020-11-26 US US17/779,165 patent/US20230023332A1/en active Pending
- 2020-11-26 KR KR1020227018564A patent/KR20220104734A/ko unknown
- 2020-11-26 EP EP20894763.0A patent/EP4067367A4/en active Pending
- 2020-11-26 CN CN202080079360.9A patent/CN114729001A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230023332A1 (en) | 2023-01-26 |
| WO2021104391A1 (zh) | 2021-06-03 |
| JP2023504428A (ja) | 2023-02-03 |
| EP4067367A1 (en) | 2022-10-05 |
| KR20220104734A (ko) | 2022-07-26 |
| EP4067367A4 (en) | 2024-04-10 |
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