CN114728005A - Bi853520在癌症治疗中的用途 - Google Patents
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- CN114728005A CN114728005A CN202080080643.5A CN202080080643A CN114728005A CN 114728005 A CN114728005 A CN 114728005A CN 202080080643 A CN202080080643 A CN 202080080643A CN 114728005 A CN114728005 A CN 114728005A
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Abstract
涉及一种治疗发生KRAS突变的肿瘤的方法，所述方法使用化合物2‑氟‑5‑甲氧基‑4‑[(4‑(2‑甲基‑3‑氧代‑2,3‑二氢‑1H‑异吲哚‑4‑氧基)‑5‑三氟甲基‑嘧啶‑2‑基)氨基]‑N‑(1‑甲基‑哌啶‑4‑基)苯甲酰胺或其药学上可接受的盐，其可以单独给药，或者与KRAS抑制剂和/或MEK抑制剂联用。
Description
PCT国内申请，说明书已公开。
Claims (48)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
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| CN201911191139 | 2019-11-28 | ||
| CN2019111911398 | 2019-11-28 | ||
| CN2020112870491 | 2020-11-17 | ||
| CN202011287049 | 2020-11-17 | ||
| PCT/CN2020/132244 WO2021104454A1 (zh) | 2019-11-28 | 2020-11-27 | Bi853520在癌症治疗中的用途 |
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| AU2020390236A1 (en) * | 2019-11-28 | 2022-07-14 | Inxmed (Nanjing) Co., Ltd. | Use of BI853520 in cancer treatment |
| MX2023001418A (es) * | 2020-08-03 | 2023-04-10 | Inxmed Nanjing Co Ltd | Forma sólida de compuesto. |
| KR20230016158A (ko) * | 2021-07-22 | 2023-02-01 | 국립암센터 | Kras 돌연변이 특이적 저해제 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| WO2023246869A1 (zh) * | 2022-06-24 | 2023-12-28 | 应世生物科技(南京)有限公司 | 治疗肿瘤的药物组合及用途 |
| WO2024051679A1 (zh) * | 2022-09-05 | 2024-03-14 | 应世生物科技(南京)有限公司 | Fak抑制剂及egfr-tki的药物组合及用途 |
Citations (3)
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| CN104478865A (zh) * | 2008-11-24 | 2015-04-01 | 贝林格尔·英格海姆国际有限公司 | 用于治疗例如癌症的疾病的取代的嘧啶 |
| CN105530937A (zh) * | 2013-03-13 | 2016-04-27 | 昂克希尔迪克斯有限公司 | 使用7-苄基-10-(2-甲基苄基)-2,6,7,8,9,10-六氢咪唑并[1,2-a]吡啶并[4,3-d]嘧啶-5(3h)-酮的联合疗法 |
| CN108289892A (zh) * | 2015-06-29 | 2018-07-17 | 维瑞斯特姆股份有限公司 | 治疗组合物、组合和使用方法 |
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| CA2786696C (en) | 2010-01-12 | 2021-05-25 | Jill Detmer | Oligonucleotides and methods for detecting pik3ca mutations |
| MY190034A (en) | 2015-03-06 | 2022-03-22 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
| WO2020202005A1 (en) * | 2019-04-02 | 2020-10-08 | Inxmed (Shanghai) Co., Ltd. | Combination of a fak kinase inhibitor and an agent targeting t-cell co-stimulatory receptors |
| KR20220101677A (ko) * | 2019-11-18 | 2022-07-19 | 인엑스메드 (난징) 컴퍼니 리미티드 | Nras 돌연변이를 갖는 종양을 치료하기 위한 약물의 제조에서의 fak 억제제의 용도 |
| AU2020390236A1 (en) * | 2019-11-28 | 2022-07-14 | Inxmed (Nanjing) Co., Ltd. | Use of BI853520 in cancer treatment |
-
2020
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- 2020-11-27 PE PE2022000861A patent/PE20230180A1/es unknown
- 2020-11-27 TW TW109141718A patent/TW202133852A/zh unknown
- 2020-11-27 WO PCT/CN2020/132244 patent/WO2021104454A1/zh unknown
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2023
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| CN105530937A (zh) * | 2013-03-13 | 2016-04-27 | 昂克希尔迪克斯有限公司 | 使用7-苄基-10-(2-甲基苄基)-2,6,7,8,9,10-六氢咪唑并[1,2-a]吡啶并[4,3-d]嘧啶-5(3h)-酮的联合疗法 |
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| CA3159860A1 (en) | 2021-06-03 |
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| US20230372340A1 (en) | 2023-11-23 |
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| WO2021104454A1 (zh) | 2021-06-03 |
| PE20230180A1 (es) | 2023-02-01 |
| EP4066837A1 (en) | 2022-10-05 |
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