CN114728005A - Bi853520在癌症治疗中的用途 - Google Patents
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- CN114728005A CN114728005A CN202080080643.5A CN202080080643A CN114728005A CN 114728005 A CN114728005 A CN 114728005A CN 202080080643 A CN202080080643 A CN 202080080643A CN 114728005 A CN114728005 A CN 114728005A
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Abstract
涉及一种治疗发生KRAS突变的肿瘤的方法，所述方法使用化合物2‑氟‑5‑甲氧基‑4‑[(4‑(2‑甲基‑3‑氧代‑2,3‑二氢‑1H‑异吲哚‑4‑氧基)‑5‑三氟甲基‑嘧啶‑2‑基)氨基]‑N‑(1‑甲基‑哌啶‑4‑基)苯甲酰胺或其药学上可接受的盐，其可以单独给药，或者与KRAS抑制剂和/或MEK抑制剂联用。
Description
PCT国内申请，说明书已公开。
Claims (48)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
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| CN201911191139 | 2019-11-28 | ||
| CN202011287049 | 2020-11-17 | ||
| CN2020112870491 | 2020-11-17 | ||
| PCT/CN2020/132244 WO2021104454A1 (zh) | 2019-11-28 | 2020-11-27 | Bi853520在癌症治疗中的用途 |
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| WO2021104454A1 (zh) * | 2019-11-28 | 2021-06-03 | 应世生物科技(南京)有限公司 | Bi853520在癌症治疗中的用途 |
| CN116096713A (zh) * | 2020-08-03 | 2023-05-09 | 应世生物科技(南京)有限公司 | 化合物的固体形式 |
| WO2023003417A1 (ko) * | 2021-07-22 | 2023-01-26 | 국립암센터 | Kras 돌연변이 특이적 저해제 및 이를 포함하는 암 예방 또는 치료용 조성물 |
| WO2023246869A1 (zh) | 2022-06-24 | 2023-12-28 | 应世生物科技(南京)有限公司 | 治疗肿瘤的药物组合及用途 |
| WO2024051679A1 (zh) * | 2022-09-05 | 2024-03-14 | 应世生物科技(南京)有限公司 | Fak抑制剂及egfr-tki的药物组合及用途 |
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| CN104478865A (zh) * | 2008-11-24 | 2015-04-01 | 贝林格尔·英格海姆国际有限公司 | 用于治疗例如癌症的疾病的取代的嘧啶 |
| CN105530937A (zh) * | 2013-03-13 | 2016-04-27 | 昂克希尔迪克斯有限公司 | 使用7-苄基-10-(2-甲基苄基)-2,6,7,8,9,10-六氢咪唑并[1,2-a]吡啶并[4,3-d]嘧啶-5(3h)-酮的联合疗法 |
| CN108289892A (zh) * | 2015-06-29 | 2018-07-17 | 维瑞斯特姆股份有限公司 | 治疗组合物、组合和使用方法 |
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| CA2786696C (en) | 2010-01-12 | 2021-05-25 | Jill Detmer | Oligonucleotides and methods for detecting pik3ca mutations |
| SG11201707127VA (en) | 2015-03-06 | 2017-09-28 | Beyondspring Pharmaceuticals Inc | Method of treating cancer associated with a ras mutation |
| WO2020202005A1 (en) * | 2019-04-02 | 2020-10-08 | Inxmed (Shanghai) Co., Ltd. | Combination of a fak kinase inhibitor and an agent targeting t-cell co-stimulatory receptors |
| JP2023503897A (ja) * | 2019-11-18 | 2023-02-01 | ▲應▼世生物科技（南京）有限公司 | Ｎｒａｓ変異を有する腫瘍を治療するための医薬品の調製におけるｆａｋ阻害剤の使用 |
| WO2021104454A1 (zh) * | 2019-11-28 | 2021-06-03 | 应世生物科技(南京)有限公司 | Bi853520在癌症治疗中的用途 |
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| BR112022010319A2 (pt) | 2022-08-16 |
| TW202133852A (zh) | 2021-09-16 |
| KR20220107229A (ko) | 2022-08-02 |
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| US20230000867A1 (en) | 2023-01-05 |
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