CN114686536A - Preparation method of cocoyl surfactant, cocoyl cleansing mousse and preparation method - Google Patents

Preparation method of cocoyl surfactant, cocoyl cleansing mousse and preparation method Download PDF

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CN114686536A
CN114686536A CN202210324778.2A CN202210324778A CN114686536A CN 114686536 A CN114686536 A CN 114686536A CN 202210324778 A CN202210324778 A CN 202210324778A CN 114686536 A CN114686536 A CN 114686536A
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cocoyl
surfactant
oil
preparation
acid
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陈旻
魏娟
庞颖
潘莎
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Hangzhou Formulator Technology Co ltd
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/04Alpha- or beta- amino acids
    • C12P13/14Glutamic acid; Glutamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

Abstract

The invention discloses a preparation method of a cocoyl surfactant, a cocoyl cleansing mousse and a preparation method, wherein the cocoyl surfactant is prepared by mixing cocoyl chloride and amino acid in water, carrying out lipase catalytic reaction, neutralizing with alkali, adjusting the pH value, and filtering to obtain the cocoyl surfactant; the cocoyl cleansing mousse comprises the following components in percentage by mass: 3-16% of cocoyl surfactant, 3-13% of humectant, 2-13% of auxiliary surfactant, 1-3% of pH regulator, 1-3% of skin conditioner, 1-3% of emollient, 0-1% of chelating agent, 0-1% of aromatic and the balance of water, the cocoyl surfactant prepared by a lipase catalysis mode has few residual impurities, the yield of the cocoyl surfactant is high, the preparation method is simple and convenient, and the cleansing mousse containing the cocoyl surfactant is relatively mild.

Description

Preparation method of cocoyl surfactant, cocoyl cleansing mousse and preparation method
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to a preparation method of a cocoyl surfactant, a cocoyl cleansing mousse and a preparation method of the cocoyl cleansing mousse.
Background
A cleansing mousse product appeared in the chinese cosmetic market in the mid 90 s. It is a novel skin cleanser special for washing face or removing makeup. The face mousse has good convenience, extensibility and permeability. When the face washing cream is used for washing the face, sweat stain, oil dirt, foundation make-up, scurf and the like on the face can be removed, and when the face washing cream is used for removing makeup, oil paint, fat powder, lipstick, eyebrow handwriting and the like can be thoroughly washed away. The face-cleaning mousse can be used under the anhydrous condition, and can make the face skin tender, smooth and clean after being used. Because the cleansing mousse has excellent skin cleansing effect and incomparable advantages with the perfumed soap, the perfumed soap is very popular with consumers.
The coconut oil acyl cleansing mousse contains the coconut oil acyl surfactant, the preparation of the coconut oil acyl surfactant requires that coconut oil acyl chloride and various amino acids are subjected to a one-to-one chemical catalytic reaction to obtain various surfactants, and the various surfactants are mixed and compounded to obtain the coconut oil acyl surfactant, so that the preparation of the coconut oil acyl surfactant is complicated. The cocoyl surfactant prepared by adopting a chemical catalysis mode has the following defects: the residual ingredients in the cocoyl surfactant such as cocoyl chloride are more, so that the cocoyl surfactant is strong in irritation, and the cocoyl cleansing mousse has certain irritation to skin; the yield of surfactant is low.
Disclosure of Invention
The invention aims to solve the problems in the background art and provides a preparation method of a cocoyl surfactant, a cocoyl cleansing mousse and a preparation method.
In order to achieve the above object, the present invention provides a method for preparing a cocoyl surfactant, comprising: mixing cocoyl chloride and amino acid in water, adding lipase for catalytic reaction at the temperature of 30-50 ℃, neutralizing with alkali, adjusting the pH to 5-6, and filtering to obtain the cocoyl surfactant, wherein the amino acid comprises at least one of hydrolyzed oat protein, methyl taurine, glutamic acid, isethionate, aminopropionic acid, malic amino acid, alanine, glycine, aminopropionic acid, taurine, sarcosine, threonine, wheat amino acid, aspartic acid, serine, valine, proline, threonine, isoleucine, histidine and phenylalanine.
Preferably, the molar ratio of the cocoyl chloride to the amino acid is 1: 1-2.
Preferably, the lipase comprises at least one of pseudomonas fluorescens, rhizomucor miehei, penicillium expansum, candida cylindracea, pseudomonas cepacia, thermomyces lanuginosus and candida antarctica, and the catalytic reaction time is 5-10 h.
Preferably, the alkali comprises at least one of sodium hydroxide, potassium hydroxide and triethanolamine, and the neutralization is carried out at the temperature of 50-70 ℃ by using the alkali.
Preferably, the mass ratio of the cocoyl chloride to the water to the lipase is 1: 80-100: 0.0001-0.005.
The present invention also proposes a cocoyl facial mousse comprising a cocoyl surfactant obtained by the above method of preparation.
Preferably, the cocoyl cleansing mousse comprises the following components in mass percent: 3-16% of cocoyl surfactant, 3-13% of humectant, 2-13% of auxiliary surfactant, 1-3% of pH regulator, 1-3% of skin conditioner, 1-3% of emollient, 0-1% of chelating agent, 0-1% of aromatic and the balance of water.
Preferably, the emollient comprises glyceryl laurate, glyceryl caprylate, coco acid, dimethicone, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiable, isononyl isononanoate, cyclopentadimethicone, cyclohexasiloxane, PPG-17/IPDI/DMPA copolymer, PEG/PPG-10/30 copolymer, caprylic/capric triglyceride, cocoa butter and petrolatum, the skin conditioner comprises at least one of olive leaf extract, inulin, p-hydroxyacetophenone, dipotassium glycyrrhizinate, turmeric root extract, lactobacillus fermentation product, madecassoside, sodium PCA, sodium lactate, the moisturizer comprises at least one of polyethylene glycol-32, glyceryl polyether-26, allantoin, octylhydroxamic acid, phytosphingosine, panthenyl ethyl ether, panthenol ethyl ether, sodium oleate, sodium lactate, the moisturizer comprises at least one of glyceryl laurate, glyceryl caprylate, caprylyl hydroxamate, caprylyl alcohol, kollium, kohlo-O, and petrolatum, and kohlo-O, and kohlo-O, or kohlo-O, with at least one, or kohlo-O, or kohlo-O, with at least one, or kohlo-O, or kohlo, or ko, At least one of glycerin, butanediol, 1, 2-hexanediol, 1, 2-pentanediol, 1, 3-propanediol, 1, 4-butanediol, 1, 5-pentanediol, 1, 6-hexanediol, 1, 9-nonanediol, 2, 3-butanediol, propylene glycol, hexanediol, C20-22 alcohol, polyethylene glycol-8, sorbitol, pyrrolidone carboxylic acid.
Preferably, the chelating agent comprises at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA, calcium disodium EDTA, tripotassium EDTA and dipotassium EDTA, the pH adjusting agent comprises at least one of citric acid, sodium citrate, sodium glycolate, potassium chloride, arginine and sodium chloride, the fragrance comprises at least one of damascena flower oil, thuja oil, passion fruit oil, rosa canina essential oil, sugarcane leaf oil, lavender oil, grapefruit oil, melaleuca oil and sweet orange extract, and the auxiliary surfactant comprises at least one of lauryl hydroxysulfobetaine, PEG-80 sorbitan laurate, olive oil PEG-7 esters, PEG-40 stearate, PEG-40 glyceryl cocoate and PEG-7 sodium olive oil carboxylate.
The invention also provides a preparation method of the coconut oil acyl cleansing mousse, which comprises the following steps:
mixing the cocoyl surfactant, the humectant, the chelating agent and water in proportion, heating to 75-85 ℃, and uniformly stirring;
adding auxiliary surfactant, and stirring uniformly;
cooling to 58-62 ℃, adding a pH regulator, and uniformly stirring;
and cooling to 43-48 ℃, adding a skin conditioner, an emollient and an aromatic, uniformly stirring, and filtering to obtain the coconut oil acyl cleansing mousse.
The invention has the beneficial effects that: according to the invention, a lipase catalysis mode is adopted, and a proper catalytic reaction temperature and a proper pH value are selected according to comprehensive consideration of reaction yield and enzyme activity, so that the cocoyl chloride can synchronously react with various amino acids, the preparation steps of the cocoyl surfactant can be simplified, the preparation efficiency is improved, and the prepared cocoyl surfactant has less residual impurities and high yield; the leave-on impurities in the cocoyl surfactant are low, making the cleansing mousse containing cocoyl surfactant relatively mild.
The features and advantages of the present invention will be described in detail by embodiments in conjunction with the accompanying drawings.
Drawings
Fig. 1 is a comparative graphical representation of cocoyl chloride residue ratios for examples of the present invention.
Fig. 2 is a graphical representation of the cocoyl surfactant yield comparison of an embodiment of the present invention.
Detailed Description
The invention provides a preparation method of a cocoyl surfactant, which comprises the following steps: mixing cocoyl chloride and amino acid in water, adding lipase for catalytic reaction at the temperature of 30-50 ℃, neutralizing with alkali, adjusting the pH to 5-6, and filtering to obtain the cocoyl surfactant, wherein the amino acid comprises at least one of hydrolyzed oat protein, methyl taurine, glutamic acid, isethionate, aminopropionic acid, malic amino acid, alanine, glycine, aminopropionic acid, taurine, sarcosine, threonine, wheat amino acid, aspartic acid, serine, valine, proline, threonine, isoleucine, histidine and phenylalanine.
The molar ratio of the cocoyl chloride to the amino acid is 1: 1-2, so that the cocoyl chloride and the amino acid are fully reacted, and the yield of the cocoyl surfactant and the reaction completeness of the cocoyl chloride are guaranteed.
The lipase comprises at least one of pseudomonas fluorescens, rhizomucor miehei, penicillium expansum, candida cylindracea, pseudomonas cepacia, thermomyces lanuginosus and candida antarctica, the catalytic reaction time is 5-10 h, the lipase has a good catalytic effect on the reaction of cocoyl chloride and amino acid, the catalytic reaction time is sufficient, the completeness of the reaction is guaranteed, and the yield of the surfactant is guaranteed.
The alkali comprises at least one of sodium hydroxide, potassium hydroxide and triethanolamine, and is neutralized at 50-70 ℃ by the alkali, so that no harmful substances are generated.
The mass ratio of the cocoyl chloride to the water to the lipase is 1: 80-100: 0.0001-0.005, so that the cocoyl chloride and the amino acid are fully reacted, and the yield of the cocoyl surfactant and the reaction completeness of the cocoyl chloride are guaranteed.
The invention also provides a coconut acyl cleansing mousse which comprises the following components in percentage by mass: 3-16% of cocoyl surfactant, 3-13% of humectant, 2-13% of auxiliary surfactant, 1-3% of pH regulator, 1-3% of skin conditioner, 1-3% of emollient, 0-1% of chelating agent, 0-1% of aromatic and the balance of water, and the cocoyl cleansing mousse is mild due to the fact that the cocoyl surfactant obtained by the preparation method is included.
The emollient comprises glyceryl laurate, glyceryl caprylate, coconic acid, dimethicone, hydrogenated ethylhexyl olive oleate, hydrogenated olive oil unsaponifiable matter, isononyl isononanoate, cyclopentadimethicone, cyclohexasiloxane, PPG-17/IPDI/DMPA copolymer, PEG/PPG-10/30 copolymer, caprylic/capric triglyceride, cocoa butter and petrolatum, the skin conditioning agent comprises at least one of olive leaf extract, inulin, p-hydroxyacetophenone, dipotassium glycyrrhizinate, turmeric root extract, lactobacillus fermentation product, madecassoside, sodium PCA, sodium lactate, and the humectant comprises polyethylene glycol-32, glyceryl polyether-26, allantoin, octylhydroxamic acid, phytosphingosine, panthenyl ethyl ether, glycerin, butylene glycol, 1, 2-butylene glycol, sodium PCA, sodium lactate, At least one of 1, 2-hexanediol, 1, 2-pentanediol, 1, 3-propanediol, 1, 4-butanediol, 1, 5-pentanediol, 1, 6-hexanediol, 1, 9-nonanediol, 2, 3-butanediol, propylene glycol, hexanediol, C20-22 alcohol, polyethylene glycol-8, sorbitol, pyrrolidone carboxylic acid.
The chelating agent comprises at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA, disodium calcium EDTA, tripotassium EDTA and dipotassium EDTA, the pH regulator comprises at least one of citric acid, sodium citrate, sodium glycolate, potassium chloride, arginine and sodium chloride, the aromatic comprises at least one of damascena flower oil, beimeiyuan cypress oil, ovum gallus domesticus flavus seed oil, Rosa canina essential oil, sugarcane leaf oil, lavender oil, grapefruit oil, cajeput oil and sweet orange extract, and the auxiliary surfactant comprises at least one of lauryl hydroxy sulfobetaine, PEG-80 sorbitan laurate, olive oil PEG-7 esters, PEG-40 stearate, PEG-40 glyceryl cocoate and PEG-7 sodium olive oil carboxylate.
The invention also provides a preparation method of the cocoyl cleansing mousse, which comprises the following steps:
mixing the cocoyl surfactant, the humectant, the chelating agent and water in proportion, heating to 75-85 ℃, and uniformly stirring;
adding an auxiliary surfactant, and uniformly stirring;
cooling to 58-62 ℃, adding a pH regulator, and uniformly stirring;
and cooling to 43-48 ℃, adding a skin conditioner, an emollient and an aromatic, uniformly stirring, and filtering to obtain the coconut oil acyl cleansing mousse.
The invention is further illustrated by the following specific examples, which are intended to be illustrative only and not limiting:
example 1
This example provides a method of making a cocoyl surfactant: mixing cocoyl chloride, hydrolyzed oat protein and glutamic acid in water, adding pseudomonas fluorescens to perform catalytic reaction for 5 hours at the temperature of 50 ℃, neutralizing with sodium hydroxide at the temperature of 70 ℃, adjusting the pH value to 6, and filtering to obtain the cocoyl surfactant, wherein the mass ratio of the cocoyl chloride to the water to the pseudomonas fluorescens is 1:100:0.005, and the molar ratio of the cocoyl chloride to the mixture of the hydrolyzed oat protein and the glutamic acid is 1: 2.
In this example, the cocoyl cleansing mousse comprised the following ingredients in mass percent: 16% of cocoyl surfactant, 813% of polyethylene glycol, 13% of lauryl hydroxy sulfobetaine, 1% of disodium EDTA, 3% of citric acid, 3% of olive leaf extract, 3% of glyceryl laurate, 1% of rosa damascena flower oil and 47% of water.
In this example, a method of preparing a cocoyl facial mousse includes the steps of:
s01, mixing cocoyl surfactant, polyethylene glycol-8, EDTA disodium and water in proportion, heating to 85 ℃, and uniformly stirring;
s02, adding lauryl hydroxy sulfobetaine at the temperature, and uniformly stirring;
s03, cooling to 60 ℃, adding citric acid, and uniformly stirring;
s04, cooling to 45 ℃, adding the olive leaf extract, the glyceryl laurate and the rosa damascena flower oil, uniformly stirring, and filtering to obtain the coconut oil acyl cleansing mousse.
Example 2
This example provides a method of making a cocoyl surfactant: mixing cocoyl chloride, wheat amino acid, aminopropionic acid, glutamic acid and malic amino acid in water, adding Rhizomucor miehei, carrying out catalytic reaction for 10 hours at the temperature of 30 ℃, neutralizing with potassium hydroxide at the temperature of 50 ℃, adjusting the pH value to 5, and filtering to obtain the cocoyl surfactant, wherein the mass ratio of the cocoyl chloride to the water to the Rhizomucor miehei is 1:50:0.0001, and the molar ratio of the cocoyl chloride to the mixture of the wheat amino acid, the aminopropionic acid, the glutamic acid and the malic amino acid is 1:1.
In this example, the cocoyl cleansing mousse comprised the following ingredients in mass percent: cocoyl surfactant 3%, sorbitol 3%, PEG-80 sorbitan laurate 2%, arginine 1%, madecassoside 1%, glyceryl caprylate 1%, and water 89%.
In this example, a method of preparing a cocoyl facial mousse includes the steps of:
s01, mixing cocoyl surfactant, sorbitol and water in proportion, heating to 85 ℃, and uniformly stirring;
s02, adding PEG-80 sorbitan laurate at the temperature, and uniformly stirring;
s03, cooling to 60 ℃, adding arginine, and uniformly stirring;
s04, cooling to 45 ℃, adding madecassoside and glyceryl caprylate, uniformly stirring, and filtering to obtain the cocoyl cleansing mousse.
Example 3
This example provides a method of making a cocoyl surfactant: mixing cocoyl chloride, methyl taurine, alanine and malic amino acid in water, adding penicillium expansum, carrying out catalytic reaction for 7.5h at the temperature of 40 ℃, neutralizing with triethanolamine at the temperature of 60 ℃, adjusting the pH value to 5, and filtering to obtain the cocoyl surfactant, wherein the mass ratio of the cocoyl chloride to the water to the penicillium expansum is 1:75:0.0025, and the molar ratio of the cocoyl chloride to the mixture of the methyl taurine, the alanine and the malic amino acid is 1: 1.5.
In this example, the cocoyl cleansing mousse comprises the following components in mass percent: 9.5% of cocoyl surfactant, 8% of glycerol, 0.5% of dipotassium EDTA, 7.5% of olive oil PEG-7 esters, 2% of sodium citrate, 2% of coconut oil acid, 0.5% of sweet orange extract, 2% of inulin and 68% of water.
In this example, a method of preparing a cocoyl facial mousse includes the steps of:
s01, mixing cocoyl surfactant, glycerol, EDTA dipotassium and water in proportion, heating to 80 ℃, and uniformly stirring;
s02, adding olive oil PEG-7 esters at the temperature, and uniformly stirring;
s03, cooling to 60 ℃, adding sodium citrate, and uniformly stirring;
s04, cooling to 45 ℃, adding inulin, coconut oil acid and sweet orange extract, uniformly stirring, and filtering to obtain the coconut oil acyl cleansing mousse.
Example 4
This example provides a method of making a cocoyl surfactant: mixing cocoyl chloride and alanine in water, adding pseudomonas fluorescens to perform catalytic reaction for 5 hours at the temperature of 50 ℃, neutralizing with sodium hydroxide at the temperature of 70 ℃, adjusting the pH value to 6, and filtering to obtain the cocoyl surfactant, wherein the mass ratio of the cocoyl chloride to the pseudomonas fluorescens is 1:75:0.0025, the molar ratio of the cocoyl chloride to the alanine is 1:1.5, and the cocoyl surfactant is disodium cocoyl glutamate.
In this example, the cocoyl cleansing mousse comprises the following components in mass percent: 9.5% of cocoyl surfactant, 8% of glycerol, 0.5% of dipotassium EDTA, 7.5% of olive oil PEG-7 esters, 2% of sodium citrate, 2% of coconut oil acid, 0.5% of sweet orange extract, 2% of inulin and 68% of water.
In this example, a method of preparing a cocoyl facial mousse includes the steps of:
s01, mixing cocoyl surfactant, glycerol, EDTA dipotassium and water in proportion, heating to 80 ℃, and uniformly stirring;
s02, adding olive oil PEG-7 esters at the temperature, and uniformly stirring;
s03, cooling to 60 ℃, adding sodium citrate, and uniformly stirring;
s04, cooling to 45 ℃, adding inulin, coconut oil acid and sweet orange extract, uniformly stirring, and filtering to obtain the coconut oil acyl cleansing mousse.
Comparative example 1
In this comparative example, the cocoyl surfactant was prepared by the following method: adding cocoyl chloride and alanine into an acetone solution according to the molar ratio of 1:1.5, adding sodium hydroxide to perform catalytic reaction for 6 hours at the temperature of 120 ℃, neutralizing with the sodium hydroxide at the temperature of 70 ℃, adjusting the pH value to 6, and filtering to obtain the cocoyl surfactant, wherein the mass ratio of the cocoyl chloride to the acetone solution to pseudomonas fluorescens is 1:75:0.0025, and the cocoyl surfactant is disodium cocoyl glutamate.
In this comparative example, the formulation of a cocoyl cleansing mousse and method of preparation is the same as in example 4 except that cocoyl surfactant is obtained using a different cocoyl surfactant preparation method.
Experiments on the influence of lipase on the residue rate of cocoyl chloride in the preparation of cocoyl surfactant:
the same amount of cocoyl surfactant (disodium cocoyl glutamate) prepared by the preparation method of cocoyl surfactant in comparative example 1 and example 4 was taken and recorded as product a and product B, and the cocoyl chloride residue rates in product a and product B were measured by the same measurement method, and the specific measurement results are shown in fig. 1.
As can be seen from fig. 1, the cocoyl chloride residual rate of product a is significantly higher than that of product B, which indicates that the cocoyl chloride residual rate in the preparation of cocoyl surfactant is relatively lower by adopting a lipase catalysis mode compared with the cocoyl chloride residual rate in the cocoyl surfactant prepared by the traditional chemical catalysis mode, and the irritation of cocoyl surfactant to skin is effectively reduced.
Second, experiments on the effect of lipase on the yield of cocoyl surfactant in the preparation of cocoyl surfactant:
taking appropriate amount of cocoyl chloride and alanine, equally dividing into two groups, respectively marking as an experimental group and a control group, respectively preparing the cocoyl surfactant (disodium cocoyl glutamate) according to the preparation methods of the cocoyl surfactant in the embodiment 4 and the comparative example 1 by the experimental group and the control group, keeping the environment and the content of the added substances in each stage in the experimental group and the control group the same, and finally detecting the yield of the cocoyl surfactant (disodium cocoyl glutamate) in the experimental group and the control group according to the same detection method, wherein the specific detection result is shown in fig. 2.
As can be seen from fig. 2, the yield of the cocoyl surfactant in the experimental group is significantly higher than that of the cocoyl surfactant in the control group, which indicates that the yield of the cocoyl surfactant is higher when the cocoyl surfactant is prepared by a lipase catalysis method compared with the yield of the cocoyl surfactant prepared by a traditional chemical catalysis method.
Third, regarding the reaction experiment of coconut oil acyl cleansing mousse to human skin
Selecting 99 testers without obvious skin function defects, fully cleaning the back skins of the testers before the experiment, cleaning the skin by using a paper towel, dividing the 99 testers into three groups which are respectively marked as an experiment group 1, a control group 1 and a control group 2, respectively pasting the three groups of testers on the back by using the same spot tester according to corresponding operation steps to carry out a spot pasting test, using the coconut oil acyl clean surface mousse of example 4 diluted to 1% by using deionized water as an allergen in the first group, using the coconut oil acyl clean surface mousse of comparative example 1 diluted to 1% by using the deionized water as the allergen in the second group, using the deionized water as the allergen in the third group, using the same addition amount of the allergens in the three groups, observing the skin reaction conditions of the testees respectively within 0.5h, 24h and 48h, and dividing and counting the skin reaction degree of the test part of each testee according to the same rating rule (the rating rule is shown in the following table 2), specific statistical results are shown in table 1 below.
TABLE 1 statistical table of different skin reactions in patch test
Figure BDA0003571372940000111
TABLE 2 skin reaction grading Table
Figure BDA0003571372940000112
Combining tables 1 and 2, the number of people with adverse skin reactions in experimental group 1 was significantly lower than the number of people with adverse skin reactions in control group 1, indicating that the cocoyl cleansing mousse containing the cocoyl surfactant prepared using the present cocoyl surfactant preparation method was milder and less irritating than the cocoyl cleansing mousse containing the cocoyl surfactant prepared using the conventional cocoyl surfactant preparation process.
The above embodiments are illustrative of the present invention, and are not intended to limit the present invention, and any simple modifications of the present invention are within the scope of the present invention.

Claims (10)

1. A preparation method of a cocoyl surfactant is characterized by comprising the following steps: mixing cocoyl chloride and amino acid in water, adding lipase for catalytic reaction at the temperature of 30-50 ℃, neutralizing with alkali, adjusting the pH to 5-6, and filtering to obtain the cocoyl surfactant, wherein the amino acid comprises at least one of hydrolyzed oat protein, methyl taurine, glutamic acid, isethionate, aminopropionic acid, malic amino acid, alanine, glycine, aminopropionic acid, taurine, sarcosine, threonine, wheat amino acid, aspartic acid, serine, valine, proline, threonine, isoleucine, histidine and phenylalanine.
2. A process for the preparation of cocoyl surfactant according to claim 1, characterized in that: the molar ratio of the cocoyl chloride to the amino acid is 1: 1-2.
3. A process for the preparation of cocoyl surfactant according to claim 1, characterized in that: the lipase comprises at least one of pseudomonas fluorescens, rhizomucor miehei, penicillium expansum, candida cylindracea, pseudomonas cepacia, thermomyces lanuginosus and candida antarctica, and the catalytic reaction time is 5-10 h.
4. A process for the preparation of cocoyl surfactant according to claim 1, characterized in that: the alkali comprises at least one of sodium hydroxide, potassium hydroxide and triethanolamine, and is neutralized by the alkali at the temperature of 50-70 ℃.
5. A process for the preparation of cocoyl surfactant according to claim 1, characterized in that: the mass ratio of the cocoyl chloride to the water to the lipase is 1: 80-100: 0.0001-0.005.
6. A cocoyl cleansing mousse characterized by: the cocoyl facial mousse comprising a cocoyl surfactant obtained according to the method of making of any of claims 1 to 5.
7. A cocoyl facial mousse according to claim 6, wherein: the cocoyl cleansing mousse comprises the following components in percentage by mass: 3-16% of cocoyl surfactant, 3-13% of humectant, 2-13% of auxiliary surfactant, 0-1% of chelating agent, 1-3% of pH regulator, 1-3% of skin conditioner, 1-3% of emollient, 0-1% of aromatic and the balance of water.
8. A cocoyl facial mousse according to claim 7, wherein: the emollient comprises at least one of laurin, caprylic acid, cocoanut acid, dimethicone, ethylhexyl hydrogenated olive oleate, unsaponifiable hydrogenated olive oil, isononyl isononanoate, cyclopentyldimethicone, cyclohexasiloxane, PPG-17/IPDI/DMPA copolymer, PEG/PPG-10/30 copolymer, caprylic/capric triglyceride, cocoa butter and petrolatum, the skin conditioner comprises at least one of olive leaf extract, inulin, p-hydroxyacetophenone, dipotassium glycyrrhizinate, turmeric root extract, lactobacillus fermentation product, madecassoside, sodium PCA, sodium lactate, and the moisturizer comprises at least one of polyethylene glycol-32, glyceryl polyether-26, allantoin, octylhydroxamic acid, phytosphingosine, panthenyl ethyl ether, glycerin, butylene glycol, caprylic acid, caprylyl hydroxamate, phytosphingosine, panthenyl ethyl ether, glycerin, butylene glycol, hydrogenated olive oil unsaponifiable, isononyl isononanoate, cyclopentyldimethyl silicone, cycloheximide, and petrolatum, 1, 2-butanediol, 1, 2-hexanediol, 1, 2-pentanediol, 1, 3-propanediol, 1, 4-butanediol, 1, 5-pentanediol, 1, 6-hexanediol, 1, 9-nonanediol, 2, 3-butanediol, propylene glycol, hexanediol, C20-22 alcohol, polyethylene glycol-8, sorbitol, pyrrolidone carboxylic acid.
9. A cocoyl facial mousse according to claim 7, wherein: the chelating agent comprises at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA, calcium disodium EDTA, tripotassium EDTA and dipotassium EDTA, the pH regulator comprises at least one of citric acid, sodium citrate, sodium glycolate, potassium chloride, arginine and sodium chloride, the aromatic comprises at least one of damascena flower oil, thuja oil, egg-berry seed oil, rosa canina essential oil, sugarcane leaf oil, lavender oil, grapefruit oil, melaleuca oil and sweet orange extract, and the auxiliary surfactant comprises at least one of lauryl hydroxy sulfobetaine, PEG-80 sorbitan laurate, olive oil PEG-7 esters, PEG-40 stearate, PEG-40 glyceryl cocoate and PEG-7 sodium olive oil carboxylate.
10. A method of preparing a cocoyl facial mousse according to claim 7, wherein: the method comprises the following steps:
mixing the cocoyl surfactant, the humectant, the chelating agent and water in proportion, heating to 75-85 ℃, and uniformly stirring;
adding auxiliary surfactant, and stirring uniformly;
cooling to 58-62 ℃, adding a pH regulator, and uniformly stirring;
and cooling to 43-48 ℃, adding a skin conditioner, an emollient and an aromatic, uniformly stirring, and filtering to obtain the coconut oil acyl cleansing mousse.
CN202210324778.2A 2022-03-29 2022-03-29 Preparation method of cocoyl surfactant, cocoyl cleansing mousse and preparation method Withdrawn CN114686536A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115057793A (en) * 2022-07-28 2022-09-16 湖州欧利生物科技有限公司 Production process of N-fatty acyl disodium glutamate
CN115109664A (en) * 2022-07-25 2022-09-27 张俊杰 Amino acid cleansing soap flakes and preparation method thereof
CN115721592A (en) * 2022-12-12 2023-03-03 深圳市理然化妆品有限公司 Soapberry face-cleaning mousse and preparation method thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115109664A (en) * 2022-07-25 2022-09-27 张俊杰 Amino acid cleansing soap flakes and preparation method thereof
CN115109664B (en) * 2022-07-25 2023-10-20 张俊杰 Amino acid cleansing soap flake and preparation method thereof
CN115057793A (en) * 2022-07-28 2022-09-16 湖州欧利生物科技有限公司 Production process of N-fatty acyl disodium glutamate
CN115057793B (en) * 2022-07-28 2024-04-16 湖州欧利生物科技有限公司 Production process of N-fatty acyl disodium glutamate
CN115721592A (en) * 2022-12-12 2023-03-03 深圳市理然化妆品有限公司 Soapberry face-cleaning mousse and preparation method thereof

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