CN111494275B - Eye-irritation-free washing product suitable for infants and preparation method thereof - Google Patents

Abstract

The invention relates to a washing article suitable for infants without eye irritation, which mainly comprises the following components: PEG-80 sorbitan laurate, trideceth sodium sulfate, cocamidopropyl betaine, PEG-40 glyceryl cocoate (and) sodium cocoeth sulfate, sodium cocoamphohydroxypropyl sulfonate, isomalt, a cationic surfactant, a thickening agent, a polyhydric alcohol humectant, a chelating agent, an acid-base regulator, a preservative, essence, an auxiliary material and deionized water. The components and the formula are reasonably regulated and controlled, and the components are mutually synergistic, so that the shampoo disclosed by the invention has better foamability, dispersibility and stability, and meanwhile, has no stimulation and low residue on eyes.

Description

Eye-irritation-free washing product suitable for infants and preparation method thereof

Technical Field

The invention relates to the field of cosmetics, in particular to a cleaning product which is suitable for infants and has no irritation to eyes and a preparation method thereof.

Background

The shampoo without stimulating eyes of infants is developed and researched based on the characteristics of skin and physiological development of infants, the eyes and lacrimal glands of the infants are not developed completely, sufficient lacrimal water cannot be secreted, and the blinking action is less, so that the eyes have poor self-protection capability to external stimulation and are often easily injured. Therefore, there is a need for a cleaning product which is suitable for infants and has no irritation to eyes.

Tween 28, INCI is PEG-80 sorbitan laurate, a yellow to amber liquid, a mild and low-irritation nonionic surfactant and a solubilizer, and can obviously reduce irritation of anionic surfactants such as SLES and SLS. Is compatible with many lipophilic substances (such as mineral oil, wax, essential oil, etc.), and has good emulsifying property. And the raw material can be judged to be nonirritant through an acute eye irritation/corrosion test, and micro-irritation is between nonirritant and light irritation. It is generally accepted that surfactants with lower CMC values mostly have good foaming ability, rather than ionic surfactants, which generally have poor foaming properties despite having lower CMC values.

Tridecyl alcohol polyether sodium sulfate, an anionic surfactant, 65% active matter, yellow viscous liquid, the acrimony is far lower than the traditional surface activity such as AES, etc., can compare favorably with amino acid surface activity; low residue, quick foaming, loose foam, quick defoaming, easy dispersion and good stability.

Cocoamidopropyl betaine, an amphoteric surfactant, has good foaming capacity, fine and stable foam, and has thickening effect in coordination with sulfate surface activity.

Disclosure of Invention

The invention aims to provide a washing article which is suitable for infants and has no irritation to eyes so as to solve the problems in the prior art.

A washing product suitable for infants without eye irritation mainly comprises the following components in percentage by weight:

the PEG-80 sorbitan laurate can be judged to be non-irritant through an acute eye irritation/corrosion test, and is micro-irritant between the non-irritant and the light irritant.

PEG-40 glyceryl cocoate (and) sodium coco-alcohol polyether sulfate and sodium cocoyl amphoteric hydroxypropyl sulfonate can be judged as non-irritating at certain concentration.

Preferably, the composition also comprises 0.50-3.00% of isomalt, 0.05-3.00% of lily extract, 0.05-3.00% of cherry extract and 0.05-3.00% of chamomile extract.

Preferably, the polyol humectant comprises 1.00% to 5.00% glycerin.

Preferably, the cationic surfactant is polyquaternium-10.

Preferably, the thickener comprises 1.00-3.00% of PEG-150 distearate.

Preferably, the pH is in the range of 5.2 to 5.8.

Preferably, the eye-friendly washing product suitable for infants comprises shampoo and shower gel.

Preferably, the composition mainly comprises the following components in percentage by weight:

preferably, the method mainly comprises the following steps:

(1) Adjusting the stirring speed to 50r/min, mixing and stirring uniformly polyquaternium-10, part of cocamidopropyl betaine and deionized water, and heating to 45 ℃ to fully dissolve various raw materials;

(2) Heating glycerol, PEG-150 distearate, partial PEG-80 sorbitan laurate, sodium trideceth sulfate, sodium cocoamphohydroxypropyl sulfonate, PEG-40 glyceryl cocoate (and) sodium cocoeth sulfate, and the remaining cocamidopropyl betaine to 80 deg.C to fully dissolve the raw materials;

(3) Adding acid-base regulator and chelating agent to dissolve the materials completely, and vacuumizing to-0.02;

(4) Adjusting the stirring speed to 30r/min, and cooling to 45 ℃;

(5) Adding the rest PEG-80 sorbitan laurate, isomalt, bulbus Lilii extract, cherry blossom extract, flos Matricariae Chamomillae extract, essence, and antiseptic to dissolve the above materials.

Compared with the prior art, the reasonable regulation and control components and formula of the shampoo disclosed by the invention have the advantages that through the mutual synergistic effect of PEG-80 sorbitan laurate, tridecyl alcohol polyether sodium sulfate, cocamidopropyl betaine, PEG-40 glyceryl cocoate (and) sodium cocoyl alcohol polyether sulfate, cocoyl amphoteric hydroxypropyl sodium sulfonate and isomaltose, the shampoo disclosed by the invention has better foamability, dispersibility, stability and transparency, is soft to skin, good in dry and wet combing performance, can play a role in protecting the head, and is non-irritant to eyes and low in residue. The invention selects the main surface active PEG-80 sorbitan laurate and the tridecyl alcohol polyether sodium sulfate to be coordinated and matched, and the PEG-80 sorbitan laurate can reduce the irritation of the tridecyl alcohol polyether sodium sulfate and make the mild tridecyl alcohol polyether sodium sulfate milder. The tridecyl alcohol polyether sodium sulfate has high foam volume and air-feeling foam, can improve the weak foaming capacity and small foam of PEG-80 sorbitan laurate, and is matched with cocamidopropyl betaine to promote the generation of bubbles and convert the foam from a loose structure into finer foam, so that the foam is fine and rich. Meanwhile, the two components can play a certain thickening role in coordination. The sodium cocoyl amphohydroxypropyl sulfonate has good foaming power, can generate rich, fine and cream foam, can soften and moisten skin after cleaning, can prevent excessive degreasing of the skin and hair, can be used as an auxiliary surfactant to supplement the content of active substances, and can supplement and enhance the foaming capacity of a formula system. The introduction of isomaltose can reduce the irritation caused by impurities or excessive free radicals of the sodium trideceth sulfate. PEG-40 glyceryl cocoate (and) sodium coco-alcohol polyether sulfate, sodium cocoamphohydroxypropylsulfonate can further reduce irritation caused by the primary surfactant. And PEG-40 glyceryl cocoate (and sodium coco-alcohol polyether sulfate) has the characteristic of enabling the foams to be fine by virtue of an amino acid surfactant, and the sodium cocoglucoside hydroxypropyl sulfonate can be used for improving the foaming force by virtue of cooperation with other surfactants. The shampoo of the invention has no stimulation to eyes due to the compound collocation of a plurality of surfactants.

Drawings

FIG. 1 is a report of the acute eye irritation/corrosivity test for an infant-compatible, non-eye-irritating cleaning article of example 1;

fig. 2 is a report of the acute eye irritation/corrosivity test for the infant and baby-adapted, non-eye-irritating cleaning article of example 6.

Detailed Description

To make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in further detail with reference to the accompanying drawings.

Examples 1 to 2

TABLE 1 compositions and weight percentages of non-irritating ophthalmic cleaning products of examples 1-2 for infants and young children

The method for preparing the infant eye-friendly cleansing product of examples 1-2 above, which is suitable for infants, mainly comprises the following steps:

(1) Weighing the raw materials according to the proportion of the ingredients, and performing pre-preparation.

(2) Starting a reaction kettle, adding deionized water, polyquaternium-10 and cocamidopropyl betaine, adjusting the stirring speed to 50r/min, quickly stirring for 10min, and heating to 45 ℃.

(3) Sequentially adding glycerol, PEG-150 distearate, tridecyl polyether sodium sulfate, PEG-80 sorbitan laurate and cocamidopropyl betaine, heating to 80 ℃, stopping heating, adjusting the rotation speed to 30r/min, starting a vacuum pump, vacuumizing to the vacuum degree of-0.02, preserving heat, stirring until the materials are completely dissolved, and adding EDTA-2Na.

(4) And (3) boiling cooling water, starting a vacuum pump again, keeping the vacuum degree at-0.02 in the cooling process, cooling to 45 ℃, cooling for 65min, keeping the rotating speed at 30r/min, sequentially adding the components (PEG-80 sorbitan laurate and essence premix) of the lily extract, the cherry extract, the chamomile extract, the preservative, the PEG-80 sorbitan laurate and the essence, stirring until the components are completely dissolved, sampling, detecting, adjusting to be qualified and discharging.

The infant eye-non-irritating shampoo of examples 1-2 measured a pH of 5.5.

Effect evaluation and assessment

Glycerin, also known as glycerol, is not only a simple moisture absorbent for moisturizing, but also a unique property that other multi-component humectants do not possess. Glycerol plasticizes and softens the SCs, maintains the readily soluble nature of the lamellar lipid layer, and thus promotes enzyme-mediated hydrolysis of corneal desmosomes in the extracellular matrix. This finding indicates that glycerol is a true desmosomal hydrolyzed component of the cornea and is effective in increasing desquamation and improving dry cracked skin. In the formula of the invention, the additive is added to enhance the anti-jelly capability of the formula by utilizing the characteristic of low freezing point. In the pure mixed solution of deionized water and glycerol, 10% of glycerol can make the freezing point of the mixed solution reach-1.6 ℃.

Cold stability test, examples 1 and 2 were placed in an environment at 0 ℃ for 48 hours and then taken out. The results show that example 1 with the addition of glycerin still had fluidity, and example 2 without the addition of glycerin had a jelly-like shape.

Example 1 was selected for acute eye irritation/corrosivity to third parties. The results of the test are shown in FIG. 1 for microstimulation. The experimental results show that the acute eye irritation/erosion of example 1 still does not meet the requirement of no irritation.

Examples 3 to 4

Table 2 components and weight percentages of non-irritating cleaning products for infants and young children in examples 3-4

The method for preparing the cleaning product suitable for infants without stimulating eyes in the embodiments 3 to 4 mainly comprises the following steps:

(1) Weighing the raw materials according to the proportion of the ingredients, and performing pre-preparation.

(2) Starting a reaction kettle, adding deionized water, polyquaternium-10 and cocamidopropyl betaine, adjusting the stirring speed to 50r/min, quickly stirring for 10min, and heating to 45 ℃.

(3) Sequentially adding glycerol, PEG-150 distearate, tridecyl polyether sodium sulfate, PEG-80 sorbitan laurate and cocamidopropyl betaine, heating to 80 ℃, stopping heating, adjusting the rotation speed to 30r/min, starting a vacuum pump, vacuumizing to the vacuum degree of-0.02, preserving heat, stirring until the materials are completely dissolved, and adding EDTA-2Na.

(4) And (3) boiling cooling water, starting a vacuum pump again, keeping the vacuum degree at-0.02 in the cooling process, cooling to 45 ℃, cooling for 65min, keeping the rotating speed at 30r/min, sequentially adding the components (PEG-80 sorbitan laurate and essence premix) of the lily extract, the cherry extract, the chamomile extract, the preservative, the PEG-80 sorbitan laurate, the essence and the isomaltose, stirring until the components are completely dissolved, sampling, detecting, adjusting to be qualified and discharging.

The non-irritating cleaning article of examples 3-4 suitable for infants and young children measured a pH of 5.5.

ISOMALT, also known as barrier sugar (ISOMALT), chemical composition: a mixture of α -D-glucopyranosyl-1, 6-D-sorbitol [ GPS ] and α -D-glucopyranosyl-1, 1-D-mannitol in a ratio of 1. The chemical properties are very stable. Is stable to heat, acid and alkali, and does not cause decomposition or discoloration. The isomaltose can eliminate the free radical activity of hair, protect hair cuticle damage, activate fiber bud cells and well prevent and protect skin damage caused by the surfactant; has protective effect on hair.

Effect evaluation and assessment

The ocular irritation test was performed for example 1, examples 3-4, and example 1 was used as a comparative reference.

Subject: 30 subjects with age distribution of 18-28 years were selected and randomized into 3 groups for testing

And (4) testing method. A non-irritating eye-wash product suitable for infants, examples 1, 3 and 4, was diluted 10 times, the eyes of the test subjects were closed, the diluted solution was applied to the entire eyelid including the eye circumference, the eyes were opened again, the irritation was felt, the number of applications was recorded, and the product was immediately rinsed with clear water once the irritation was felt. And (4) judging the standard: the pain feeling is felt by the smearing times. The test results are shown in table 3.

Table 3 results of eye irritation test on infant or young child-compatible cleaning products without eye irritation in examples 1, 3 and 4

Subject number	Example 1	Subject number	Example 3	Subject number	Example 4
						1	1	11	1	21	2
2	1	12	2	22	1
						3	1	13	1	23	2
4	2	14	2	24	3
						5	1	15	2	25	1
6	1	16	1	26	1
						7	2	17	3	27	1
8	1	18	2	28	2
						9	1	19	1	29	1
10	1	20	2	30	2

As can be seen from the table:

in the eye irritation test of example 1, 8 subjects experienced a tingling sensation upon the first application and 2 subjects experienced a tingling sensation upon the second application.

In the eye irritation test of example 3, 4 subjects experienced a tingling sensation upon the first application and 5 subjects experienced a tingling sensation upon the second application. The third application of 1 subject felt the tingling sensation.

In the eye irritation test of example 4, 5 subjects experienced a tingling sensation upon the first application and 4 subjects experienced a tingling sensation upon the second application. The third application of 1 subject felt a tingling sensation.

The results show that, on the premise of considering individual differences of the testees, after 1% or 2% of the isomalt is added, the number of the testees who feel stabbing pain for the first time is reduced by half, and the irritation of the isomalt in the washing article which is suitable for infants and does not stimulate eyes can be reduced. Although isomalt effectively reduced irritation, 2-3 subjects experienced a tingling sensation upon the first application, judged that they were still in a micro-irritant formulation, concluded that the irritation potential of the co-surfactant itself was still greater, and in particular that cocamidopropyl betaine, sodium trideceth sulfate was milder than conventional amino acid surfactants, but still somewhat irritating, and further explored and tested for modifying the co-surfactant.

Examples 5 to 10

TABLE 4 non-irritating cleaning composition for infants and young children in examples 5-10 and weight percent thereof

The method for preparing the cleaning product suitable for infants without stimulating eyes in the embodiments 5 to 10 mainly comprises the following steps:

(1) Weighing the raw materials according to the proportion of the ingredients, and performing pre-preparation.

(2) Starting a reaction kettle, adding deionized water, polyquaternium-10 and cocamidopropyl betaine, adjusting the stirring speed to 50r/min, quickly stirring for 10min, and heating to 45 ℃.

(3) Sequentially adding glycerol, PEG-150 distearate, tridecyl polyether sodium sulfate, PEG-80 sorbitan laurate, sodium cocoyl amphohydroxypropyl sulfonate, PEG-40 glyceryl cocoate (and) sodium cocoyl polyether sulfate and cocamidopropyl betaine, heating to 80 ℃, stopping heating, adjusting the rotation speed to 30r/min, starting a vacuum pump, vacuumizing to-0.02 vacuum degree, preserving heat, stirring until complete dissolution, and adding citric acid and EDTA-2Na.

(4) And (3) boiling cooling water, starting a vacuum pump again, keeping the vacuum degree at-0.02 in the cooling process, cooling to 45 ℃, cooling for 65min, keeping the rotating speed at 30r/min, sequentially adding the components (PEG-80 sorbitan laurate, isomaltose, lily extract, oriental cherry extract, chamomile extract, preservative and essence) into the mixture, stirring until the components are completely dissolved, sampling, detecting, adjusting to be qualified and discharging. (pH adjustment with citric acid)

PEG-40 glyceryl cocoate (and sodium coco-alcohol polyether sulfate), a particularly mild amino acid surfactant, was prepared by extracting the alcohol ether sulfate from esters and coconut meat as the major ingredient. Is suitable for cleaning formula based on skin and mucosa tolerance, and has excellent tolerance to eyes and skin.

Sodium cocoyl amphohydroxypropyl sulfonate, a super mild anionic surfactant, is derived from the green plants corn and coconut and is based on a renewable resource of alkyl polysaccharide derivatives. The preparation is very mild and can achieve no irritation at a certain concentration; no toxicity and no dioxane; the foaming power is good, and rich, fine and cream-like foam can be generated; the skin is soft and moist after cleaning, and excessive degreasing of the skin and hair is prevented; good stability in a wide pH range.

Effect evaluation and assessment

Eye irritation tests were performed on examples 5-10 and compared to example 1.

Subject: 60 subjects with an age distribution of 18-28 years were selected and randomized into 6 groups for testing.

The test method comprises the following steps: a non-irritating cleaning article suitable for infants and young children, examples 5-10, was diluted 10 times separately, the eyes of the subjects were closed, the diluted solution was applied in large amounts over the entire eyelids including the eye circumference, the eyes were opened again, stinging was experienced, the number of applications was recorded, and once the stinging was experienced, the subjects were immediately rinsed with clear water.

And (4) judging the standard: the pain feeling is felt by the smearing times.

Table 5 results of testing eye irritation of the non-irritating cleaning articles of examples 5-10 suitable for infants and young children

From the table it can be seen that:

in the eye irritation test of example 5, 0 subjects experienced a tingling sensation upon the first application, 8 subjects experienced a tingling sensation upon the second application, and 2 subjects experienced a tingling sensation upon the third application.

In the eye irritation test of example 6, 1 subject experienced a tingling sensation upon the second application and 3 subjects experienced a tingling sensation upon the third application. The 6 subjects felt a tingling sensation only with the fourth application.

In the eye irritation test of example 7, 1 subject experienced a tingling sensation upon the second application, and 4 subjects experienced no tingling sensation upon the third application. The tingling was felt by 5 subjects on the fourth application.

In the eye irritation test of example 8, 0 subjects experienced a tingling sensation upon the first application, 6 subjects experienced a tingling sensation upon the second application, and 4 subjects experienced a tingling sensation upon the third application.

In the eye irritation test of example 9, 0 subjects felt a tingling sensation upon the first application, 7 subjects felt a tingling sensation upon the second application, and 3 subjects felt a tingling sensation upon the third application.

In the eye irritation test of example 10, 0 subjects felt a tingling sensation upon the first application, 4 subjects felt a tingling sensation upon the second application, 4 subjects felt a tingling sensation upon the third application, and 2 subjects felt a tingling sensation upon the fourth application.

In summary, in examples 5-10, compared to example 1, the mild surfactants PEG-40 glyceryl cocoate (and) sodium cocoeth sulfate, sodium cocoglucoside hydroxypropyl sulfonate were added to reduce the level of the original co-surfactant, and no stinging sensation was experienced by the subjects during the first application.

The introduction of two surfactants can reduce stimulus and supplement active matter content to reach standard. PEG-40 glyceryl cocoate (and sodium coco-alcohol polyether sulfate) has the characteristic of enabling foams to be fine and smooth by virtue of an amino acid surfactant, and the sodium cocoglucoside hydroxypropyl sulfonate can be used for improving the foaming force by virtue of cooperation with other surfactants. Compared with the subject in example 1, the eye irritation smearing times of the subjects in examples 6 and 7 are greatly improved, and the irritation is remarkably reduced.

Considering cost constraints, example 6 is preferred to be sent to a third party for acute eye irritation/corrosivity. The test results were non-irritating, as shown in figure 2.

The results of measuring the sensory and index physicochemical properties of example 6 are shown in table 6.

TABLE 6 measurement results of sensory and index physicochemical Properties of example 6

The above results show that: a washing product suitable for infants without irritation to eyes and its preparation method are safe, mild and non-irritant to infants.

The above examples of the present invention are intended to be illustrative only, and are not intended to be limiting of the embodiments of the present invention, and those skilled in the art will be able to make equivalent changes and modifications within the scope of the appended claims.

Claims (3)

1. A washing article suitable for infants without eye irritation is characterized by mainly comprising the following components in percentage by weight:

polyquaternary ammonium salt-10.05%

PEG-150 distearate 2.00%

PEG-80 sorbitan laurate 7.00%

Tridecanol polyether sodium sulfate 4.00%

Cocoamidopropyl betaine 4.00%

PEG-40 Glycerol cocoate (and) sodium coco-alcohol polyether sulfate 3.00%

Coconut acyl amphoteric hydroxypropyl sodium sulfonate 2.00%

1.00 percent of isomaltose

2.00 percent of glycerin

0.10% of lily extract

Oriental cherry flower extract 0.10%

Chamomile extract 0.10%

Chelating agent 0.01% -1.00%

0.01-1.00% of acid-base regulator

0.01 to 1.00 percent of preservative

0.01% -1.00% of essence

0.10-10.00% of auxiliary materials

Deionized water is added to 100%;

the pH range is 5.2 to 5.8.

2. The infant eye-friendly washing product according to claim 1, wherein the infant eye-friendly washing product comprises shampoo and shower gel.

3. The method of making an eye-friendly cleaning article according to claim 1, consisting essentially of the steps of:

(1) Adjusting the stirring speed to 50r/min, mixing and stirring uniformly polyquaternium-10, part of cocamidopropyl betaine and deionized water, and heating to 45 ℃ to fully dissolve various raw materials;

(2) Heating glycerol, PEG-150 distearate, partial PEG-80 sorbitan laurate, sodium trideceth sulfate, sodium cocoamphohydroxypropyl sulfonate, PEG-40 glyceryl cocoate (and) sodium cocoeth sulfate, and the remaining cocamidopropyl betaine to 80 deg.C to fully dissolve the raw materials;

(3) Adding acid-base regulator and chelating agent to dissolve the materials completely, and vacuumizing to-0.02;

(4) Adjusting the stirring speed to 30r/min, and cooling to 45 ℃;

(5) Adding the rest PEG-80 sorbitan laurate, isomalt, bulbus Lilii extract, cherry blossom extract, flos Matricariae Chamomillae extract, essence, and antiseptic to dissolve the above materials.

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