CN114681340A - 一种含有脂质包裹稳定技术的脂质屏障修复护肤品及其制备方法 - Google Patents
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Abstract
本发明公开了一种含有脂质包裹稳定技术的脂质屏障修复护肤品,涉及护肤品技术领域,由如下原料制成:保湿剂、卵磷脂、防腐剂、润肤剂、神经酰胺、乳木果油、角鲨烷、氢化磷脂酰胆碱,余量为水。本发明涉及一种脂质包裹技术,可以稳定神经酰胺,安全性高、溶解性好、配伍性好,吸收效果好,生物利用率高,通过脂质包裹技术稳定神经酰胺,通过仿生皮脂配比,通过科学合理搭配,各组分产生协同增效作用,对皮肤由于脂质屏障受损,以最佳摩尔比模拟皮脂膜结构通过磷脂包裹技术稳定神经酰胺、植物甾醇以及植物脂肪酸,配方极简,精简护肤,革新转化技术,手心搓揉,化水为霜,将面霜保湿力和爽肤水的吸收力结合在一起,带给消费者不一样的体验感受。
Description
技术领域
本发明属于护肤品技术领域,具体涉及一种含有脂质包裹稳定技术的脂质屏障修复护肤品及其制备方法。
背景技术
神经酰胺是由神经鞘氨醇长链碱基和脂肪酸组成神经鞘氨脂质的一种,神经酰胺是角质层的主要脂质成分,约占40~50%,其具有很强的缔和水分子能力,在保持角质层水分和维持皮肤屏障功能上起着重要作用,可以改善皮肤干燥、脱屑、粗糙状况。同时能增强皮肤弹性,延缓皮肤衰老,神经酰胺稳定性差,成品易结晶析出,水溶性差,具有高度亲脂性,不易配方,不易吸收,生物利用度低。
发明内容
本发明的目的是针对现有的问题,提供了一种含有脂质包裹稳定技术的脂质屏障修复护肤品及其制备方法。
本发明是通过以下技术方案实现的:
一种含有脂质包裹稳定技术的脂质屏障修复护肤品,由如下重量百分比的原料制成:
保湿剂1~30%、卵磷脂0.1~2%、防腐剂0.5~3%、润肤剂5~15%、神经酰胺0.1~1%、乳木果油1~10%、角鲨烷0.5~8%、氢化磷脂酰胆碱1~5%,余量为水。
进一步优选的,所述的保湿剂包括甘油、丁二醇、二丙二醇、甲基丙二醇、丙二醇和1.3丙二醇。
进一步优选的,所述的卵磷脂包括大豆卵磷脂、溶血卵磷脂,所述的防腐剂包括己二醇、戊二醇、苯氧乙醇。
进一步优选的,所述的润肤剂包括辛酸/癸酸甘油三酯、甘油三(乙基己酸)酯、辛基十二醇。
进一步优选的,所述的神经酰胺包括神经酰胺EOP、神经酰胺EOP、神经酰胺NS/神经酰胺NG、神经酰胺NP、神经酰胺AS、神经酰胺AP。
一种含有脂质包裹稳定技术的脂质屏障修复护肤品的制备方法,包括如下步骤:
(1)按对应重量百分比称取下列原料备用:保湿剂1~30%、卵磷脂0.1~2%、防腐剂0.5~3%、润肤剂5~15%、神经酰胺0.1~1%、乳木果油1~10%、角鲨烷0.5~8%、氢化磷脂酰胆碱1~5%,余量为水;
(2)将保湿剂、卵磷脂以及防腐剂,在80~90℃的加热条件下,将卵磷脂分散成均一体,备用;
(3)将神经酰胺和润肤剂在90℃以上加热溶解均匀后,加入氢化磷脂酰胆碱、乳木果油、角鲨烷分散均匀,备用;
(3)将(1)和(2)的产物混合均匀备用。
(4)将水加热到80~90℃,将(3)加入到水中,开启均质,均质速度3000~6000rpm,乳化均质3~10min;
(5)将(4)加入到高压均质机,压力为1000~2000Ba,均质2遍。
本发明相比现有技术具有以下优点:
1、本发明涉及一种脂质包裹技术,可以稳定神经酰胺,安全性高、溶解性好、配伍性好,吸收效果好,生物利用率高。
2、本发明提供的组合物含有10种活性物,通过科学合理搭配,各组分产生协同增效作用,有助于修复改善脂质屏障受损。
3、本发明通过脂质包裹技术稳定神经酰胺,通过仿生皮脂配比,以最佳摩尔比模拟皮脂膜结构通过磷脂包裹技术稳定神经酰胺、植物甾醇(乳木果油)以及植物脂肪酸,配方极简,精简护肤,革新转化技术,手心搓揉,化水为霜,如水版清润如霜滋养,将面霜保湿力和爽肤水的吸收力结合在一起,带给消费者不一样的体验感受。
具体实施方式
下面通过具体实施方式来进一步说明本大发明的技术方案。
一种含有脂质包裹稳定技术的脂质屏障修复护肤品的制备方法,包括如下步骤:
(1)按对应重量百分比称取下列原料备用:保湿剂、卵磷脂、防腐剂、润肤剂、神经酰胺、乳木果油、角鲨烷、氢化磷脂酰胆碱,余量为水;
(2)将保湿剂、卵磷脂以及防腐剂,在85℃的加热条件下,将卵磷脂分散成均一体,备用;
(3)将神经酰胺和润肤剂在90℃以上加热溶解均匀后,加入氢化磷脂酰胆碱、乳木果油、角鲨烷分散均匀,备用;
(3)将(1)和(2)的产物混合均匀备用。
(4)将水加热到85℃,将(3)加入到水中,开启均质,均质速度4500rpm,乳化均质6.5min;
(5)将(4)加入到高压均质机,压力为1500Ba,均质2遍。
上述含有脂质包裹稳定技术的脂质屏障修复护肤品的组分及重量份如表1所示。
表1
实施例2
制备方法与上述实施例1相同,各组分及其含量如下表1所示
实施例3
制备方法与上述实施例1相同,各组分及其含量如下表1所示。
对比例1
制备方法与上述实施例1相同,各组分及其含量如下表1所示。
对比例2
制备方法与上述实施例1相同,各组分及其含量如下表1所示。
对比例3
制备方法与上述实施例1相同,各组分及其含量如下表1所示。
利用上述各组方法制备的含有脂质包裹稳定技术的脂质屏障修复护肤品的修复效果如下表2所示:
表2
由上表2可以看出,本申请方法制备的含有脂质包裹稳定技术的脂质屏障修复护肤品,含有10种活性物,通过科学合理搭配,各组分产生协同增效作用,有助于修复改善脂质屏障受损。
Claims (6)
1.一种含有脂质包裹稳定技术的脂质屏障修复护肤品,其特征在于,由如下重量百分比的原料制成:
保湿剂1~30%、卵磷脂0.1~2%、防腐剂0.5~3%、润肤剂5~15%、神经酰胺0.1~1%、乳木果油1~10%、角鲨烷0.5~8%、氢化磷脂酰胆碱1~5%,余量为水。
2.根据权利要求1所述一种含有脂质包裹稳定技术的脂质屏障修复护肤品,其特征在于,所述的保湿剂包括甘油、丁二醇、二丙二醇、甲基丙二醇、丙二醇和1.3丙二醇。
3.根据权利要求1所述一种含有脂质包裹稳定技术的脂质屏障修复护肤品,其特征在于,所述的卵磷脂包括大豆卵磷脂、溶血卵磷脂,所述的防腐剂包括己二醇、戊二醇、苯氧乙醇。
4.根据权利要求1所述一种含有脂质包裹稳定技术的脂质屏障修复护肤品,其特征在于,所述的润肤剂包括辛酸/癸酸甘油三酯、甘油三(乙基己酸)酯、辛基十二醇。
5.根据权利要求1所述一种含有脂质包裹稳定技术的脂质屏障修复护肤品,其特征在于,所述的神经酰胺包括神经酰胺EOP、神经酰胺EOP、神经酰胺NS/神经酰胺NG、神经酰胺NP、神经酰胺AS、神经酰胺AP。
6.一种如权利要求1~5中任意一项所述的含有脂质包裹稳定技术的脂质屏障修复护肤品的制备方法,其特征在于,包括如下步骤:
(1)按对应重量百分比称取下列原料备用:保湿剂1~30%、卵磷脂0.1~2%、防腐剂0.5~3%、润肤剂5~15%、神经酰胺0.1~1%、乳木果油1~10%、角鲨烷0.5~8%、氢化磷脂酰胆碱1~5%,余量为水;
(2)将保湿剂、卵磷脂以及防腐剂,在80~90℃的加热条件下,将卵磷脂分散成均一体,备用;
(3)将神经酰胺和润肤剂在90℃以上加热溶解均匀后,加入氢化磷脂酰胆碱、乳木果油、角鲨烷分散均匀,备用;
(3)将(1)和(2)的产物混合均匀备用。
(4)将水加热到80~90℃,将(3)加入到水中,开启均质,均质速度3000~6000rpm,乳化均质3~10min;
(5)将(4)加入到高压均质机,压力为1000~2000Ba,均质2遍。
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US20200276106A1 (en) * | 2016-12-06 | 2020-09-03 | Topical Innovations B.V. | Topical phenytoin for use in the treatment of peripheral neuropathic pain |
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WO2020123407A1 (en) * | 2018-12-11 | 2020-06-18 | Disruption Labs Inc. | Compositions for the delivery of therapeutic agents and methods of use and making thereof |
CN110917067A (zh) * | 2019-12-04 | 2020-03-27 | 九牧厨卫股份有限公司 | 一种具有高保湿功效的浴用润肤膏及其制备方法 |
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