CN114668701A - 一种婴儿湿疹用天然富硒植物精华舒缓乳液及其制备方法 - Google Patents
一种婴儿湿疹用天然富硒植物精华舒缓乳液及其制备方法 Download PDFInfo
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- CN114668701A CN114668701A CN202210480027.XA CN202210480027A CN114668701A CN 114668701 A CN114668701 A CN 114668701A CN 202210480027 A CN202210480027 A CN 202210480027A CN 114668701 A CN114668701 A CN 114668701A
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Abstract
本发明公开了一种婴儿湿疹用天然富硒植物精华舒缓乳液，其特征在于，按重量份计，包括如下组分：药蜀葵根提取物0.1‑2份，欧舒敏组合物0.1‑2份，润肤剂5‑15份，保湿剂5‑15份，乳化剂1‑6份，增稠剂1‑6份，抗氧剂0.1‑1份，富硒温泉水53‑88份。与现有技术相比，本发明具有如下优势：乳液选材天然低敏、制备工艺简单温和；对湿疹发病的“风、湿、热”三邪病因有较好的治疗针对性；仿生皮脂膜性能好、对婴儿皮肤友好安全，内在补水舒缓、外在抗炎呵护，具有明显的抗敏舒缓的临床效果，舒缓显效率≥90%。
Description
技术领域
本发明属于日用化学品与皮肤医学领域,具体涉及一种婴儿湿疹用天然富硒植物精华舒缓乳液及其制备方法。
背景技术
婴儿皮肤较薄，角质层发育不完整，皮脂含量低，导致皮肤的保护能力下降，容易受外界元素影响而发生湿疹。婴儿湿疹是由于遗传、气候环境、化学品接触和日晒等因素导致的一种变态反应性皮肤病，多发于数月大的婴儿，发病率为12-25％，成长后逐渐减轻，但偶有反复发作。湿疹主要表现为瘙痒性皮疹，皮损呈多形性对称分布，以红斑、糜烂和渗出为主。传统针对湿疹的治疗多采用激素类药物，虽然见效快，但是停药后易复发，如局部用皮质甾醇类药物会导致皮肤变薄，产生皮肤干燥、萎缩、毛细血管扩张、色素沉着等副作用，更为严重者可能产生下丘脑-垂体-肾上腺轴的抑制，或出现生长阻抑现象。
近年来，具有舒敏修复抗刺激功效的婴幼儿儿化妆品日益受到人们的重视，尤其是基于天然植物源提取物在其中配方中的应用，越来越受到学者和市场的青睐。如欧舒敏组合物，就是把母菊花提取、欧锦葵花提取物、芍药根提取物、欧蒲公英根茎/根提取物、忍冬花提取物、紫花地丁提取物、库拉索芦荟叶汁这几个都有抗炎舒敏效果的原料复配而成。欧舒敏组合物有助表皮内稳性，活化皮肤天然保湿因子，促进丝聚合蛋白的表达，有助保湿和皮脂完整性，增强皮肤对外界刺激的耐受性，增加对TRPV1受体的拮抗能力，增强皮肤的屏障功能，具有对湿疹的预防和修复功效，气味自然，适合亚洲人及婴幼儿肤质。同时研究发现硒元素在人体中可增强免疫功能、保护生物细胞膜、明显促进血液循环、防止皮肤老化、减少和防止瘢痕的增生，温泉水本身也有应用于护肤类化妆品中改善角质层修复的案例，深入的研究发现富含矿物质的温泉水不仅可以消炎，还能促进皮肤屏障的修复，有效降低敏感模型的真皮肥大细胞脱颗粒率，具有很好的舒敏应用潜力。
我国也有很多治疗婴儿湿疹的发明，如中国专利号CN103768193A公开了一种治疗婴儿湿疹的药物及其制备方法，它由防风、金银花、白芷、牛蒡子、野菊花、地肤子、紫荆皮、丹参和桃树胶等加工而成，临床实验证明治疗湿疹具有疗效。中国专利号CN113262188A公开了一种缓解湿疹的植物提取液，其包括甘葛藤、欧蓍草和香橼等提取物，制备的植物提取液组合物，对缓解湿疹的功效显著。中国专利号CN107343868A公开了一种具有祛湿疹功能的组合物及其制备方法，该组合物主要是由金银花、苦参、蛇床子、当归、防风、柿蒂、野菊花和僵蚕等物质，用于湿疹的治疗和防治。中国专利号CN109846777A公开了一种具有缓解婴童湿疹功效的植物提取物组合物，其包括酸橙、茵陈蒿和葛根等植物性有效成分，可从多途径预防和修婴童湿疹皮肤，有效避免外源伤害性物质对婴童皮肤的造成的刺激和致敏作用。但是，目前治疗湿疹的天然植物源提取组合物或中药成分配方中，大多数只是简单萃取，未经过进一步精制纯化，中药气味较为浓厚，容易影响婴幼儿食欲及日常生活，有的配方以油性成分为主，基本上就是在皮肤表面涂一层油，对于一些皮脂腺较旺盛的皮肤类型反而会堵塞毛孔，成为皮肤的负担。
发明内容
本发明的目的是提供一种婴儿湿疹用天然富硒植物精华舒缓乳液及其制备方法，以解决上述技术背景中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种婴儿湿疹用天然富硒植物精华舒缓乳液，按重量份计,原料包括：药蜀葵根提取物0.1-2份，欧舒敏组合物0.1-2份，润肤剂5-15份，保湿剂5-15份，乳化剂1-6份，增稠剂1-6份，抗氧剂0.1-1份，富硒温泉水53-88份。
优选的，所述润肤剂为山茶籽油、辛酸甘油三酯、癸酸甘油三酯、橄榄油、霍霍巴油、角鲨烯和聚二甲基硅烷中的一种或几种。
优选的，所述保湿剂为1,3-丙二醇、甘油、1,2-己二醇、辛酰羟肟酸和聚乙二醇中的一种或几种。
优选的，所述乳化剂为鲸蜡硬脂醇橄榄油酸酯、山梨糖橄榄油酸酯、茶皂素和卵磷脂中的一种或几种。
优选的，所述增稠剂为鲸蜡硬脂醇、白蜂蜡、聚丙烯酸钠、丙烯酰二甲基牛磺酸铵/VP共聚物和玻尿酸中的一种或几种。
优选的，所述抗氧剂为生育酚乙酸酯、对羟基苯乙酮和茶多酚中的一种或几种。
优选的，所述富硒温泉水，其硒元素含量为0.01-0.05mg/L。
所述婴儿湿疹用天然富硒植物精华舒缓乳液，其制备方法为：
(1)在容器a中加入润肤剂、保湿剂和乳化剂，在50-100℃条件下搅拌混合10-30分钟，使其分散均匀，冷却至室温后，加入药蜀葵根提取物、欧舒敏组合物和抗氧剂，搅拌混合30-60分钟，得到溶液a；
(2)在容器b中加入增稠剂和富硒温泉水，在50-100℃条件下搅拌混合30-60分钟，使其溶解完全，冷却至40-50℃，得到溶液b；
(3)将溶液a逐滴搅拌加入溶液b中，搅拌混合60-120分钟，搅拌均匀后，冷却至室温，得到婴儿湿疹用天然富硒植物精华舒缓乳液。
与现有技术相比，本发明的有益效果是：
本发明方法降低了中药气味，更加清新自然，选材天然低敏，对湿疹发病的“风、湿、热”三邪病因有较好的治疗针对性，乳液性能好，对婴儿皮肤友好安全，内在补水舒缓、外在抗炎呵护，具有明显的抗敏舒缓的临床效果，舒缓显效率≥90％，同时本发明工艺简单，具有广阔的使用前景。
附图说明
图1，为本发明的抗敏舒缓功效测试的各实施例样品疗效对比图。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其它实施例，都属于本发明保护的范围。
实施例1
一种婴儿湿疹用天然富硒植物精华舒缓乳液，按重量份计，组分如下：药蜀葵根提取物0.5份，欧舒敏组合物0.5份，山茶籽油10份，1,3-丙二醇10份，鲸蜡硬脂醇橄榄油酸酯3份，鲸蜡硬脂醇3份，生育酚乙酸酯0.3份和硒含量0.03mg/L的富硒温泉水72.7份。
所述的婴儿湿疹用天然富硒植物精华舒缓乳液，其制备步骤为：
(1)在容器中加入山茶籽油、1,3-丙二醇、鲸蜡硬脂醇橄榄油酸酯，在80℃条件下搅拌混合20分钟，使其分散均匀，冷却至室温后，加入药蜀葵根提取物、欧舒敏组合物和生育酚乙酸酯，搅拌混合45分钟；
(2)在容器中加入鲸蜡硬脂醇和富硒温泉水，在80℃条件下搅拌混合45分钟，使其溶解完全，冷却至45℃；
(3)向步骤(2)所得溶液中逐滴搅拌加入步骤(1)溶液，搅拌90分钟，冷却至室温，得到婴儿湿疹用天然富硒植物精华舒缓乳液。
实施例2
一种婴儿湿疹用天然富硒植物精华舒缓乳液，按重量份计，包括如下组分：药蜀葵根提取物0.1份，欧舒敏组合物0.1份，辛酸甘油三酯5份，1,2-己二醇5份，山梨糖橄榄油酸酯1份，白蜂蜡1份，对羟基苯乙酮0.1份和硒含量0.01mg/L的富硒温泉水87.7份。
所述的婴儿湿疹用天然富硒植物精华舒缓乳液，其制备步骤为：
(1)在容器中加入辛酸甘油三酯、甘油、山梨糖橄榄油酸酯，在50℃条件下搅拌混合10分钟，使其分散均匀，冷却至室温后，加入药蜀葵根提取物、欧舒敏组合物和对羟基苯乙酮，搅拌混合30分钟；
(2)在容器中加入白蜂蜡和富硒温泉水，在50℃条件下搅拌混合30分钟，使其溶解完全，冷却至40℃；
(3)向步骤(2)所得溶液中逐滴搅拌加入步骤(1)溶液，搅拌60分钟，冷却至室温，得到所述婴儿湿疹用天然富硒植物精华舒缓乳液。
实施例3
一种婴儿湿疹用天然富硒植物精华舒缓乳液，按重量份计，包括如下组分：药蜀葵根提取物2份，欧舒敏组合物2份，霍霍巴油15份，甘油15份，卵磷脂6份，聚丙烯酸钠6份，茶多酚1份和硒含量0.05mg/L的富硒温泉水53份。
所述的婴儿湿疹用天然富硒植物精华舒缓乳液，其制备步骤为：
(1)在容器中加入霍霍巴油、甘油、卵磷脂，在100℃条件下搅拌混合30分钟，使其分散均匀，冷却至室温后，加入药蜀葵根提取物、欧舒敏组合物和茶多酚，搅拌混合60分钟；
(2)在容器中加入聚丙烯酸钠和富硒温泉水，在100℃条件下搅拌混合60分钟，使其溶解完全，冷却至50℃；
(3)向步骤(2)所得溶液中逐滴搅拌加入步骤(1)溶液，搅拌120分钟，冷却至室温，得到所述婴儿湿疹用天然富硒植物精华舒缓乳液。
对比例1
一种舒缓乳液，按重量份计，包括如下组分：山茶籽油10份，1,3-丙二醇10份，鲸蜡硬脂醇橄榄油酸酯3份，鲸蜡硬脂醇3份，生育酚乙酸酯0.3份和水73.7份。
所述的舒缓乳液，其制备步骤为：
(1)在容器中加入山茶籽油、1,3-丙二醇、鲸蜡硬脂醇橄榄油酸酯，在80℃条件下搅拌混合20分钟，使其分散均匀，冷却至室温后，加入生育酚乙酸酯，搅拌混合45分钟；
(2)在容器中加入鲸蜡硬脂醇和水，在80℃条件下搅拌混合45分钟，使其溶解完全，冷却至45℃；
(3)向步骤(2)所得溶液中逐滴搅拌加入步骤(1)溶液，搅拌90分钟，冷却至室温，得到舒缓乳液。
抗敏舒缓功效测试：
(1)测试对象：100名皮肤过敏受试者，男女各50名，年龄为18-50岁之间，随机分成5组，每组20名受试者，分为空白对照组、实施例1组、实施例2组、实施例3组、对比例1组。
(2)测试方法：按照《化妆品安全技术规范2015年版》，在受试者背部和前臂曲侧部位，进行皮肤封闭型斑贴试验测试。空白对照组不使用乳液，其余各组分别使用相应例的舒缓乳液进行测试。每天早晚各涂抹一次，涂抹前清洁皮肤过敏区。连续使用3天后复诊，评价抗敏舒缓效果。
(3)评价标准：
a显效：皮肤红肿、瘙痒、皮损等过敏现象消失；
b有效：皮肤红肿、瘙痒、皮损等过敏现象减轻；
c无效：皮肤红肿、瘙痒、皮损等过敏现象无明显变化；
d加重：皮肤红肿、瘙痒、皮损等过敏现象恶化。
(4)治疗结果：从表1和图1中的结果可以看出，空白对照组的受试者由于未及时进行有效抗过敏治疗，在研究期间过敏症状有加重趋势。实施例1-3组的结果表明，在本发明配方的特定组分作用下，使得本发明的舒缓乳液具有明显的抗敏舒缓的临床效果，舒缓显效率≥90％。对比例1组的结果表明，除去本发明的部分组分即药蜀葵根提取物、欧舒敏组合物和富硒温泉水，在仅具有保湿剂、乳化剂、增稠剂和抗氧剂这些乳液基本成分的情况下，舒缓乳液仅具有50％的舒缓显效率。
表1：抗敏舒缓作用测试结果
以上所述仅为本发明的实施例，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明技术原理的前提下，可以对这些实施例进行多种变化、修改、替换和变型，这些变化、修改、替换和变型，也应视为本发明的保护范围。
Claims (8)
1.一种婴儿湿疹用天然富硒植物精华舒缓乳液，按重量份计,原料包括：药蜀葵根提取物0.1-2份，欧舒敏组合物0.1-2份，润肤剂5-15份，保湿剂5-15份，乳化剂1-6份，增稠剂1-6份，抗氧剂0.1-1份，富硒温泉水53-88份。
2.根据权利要求1所述的一种婴儿湿疹用天然富硒植物精华舒缓乳液，其特征在于，所述润肤剂为山茶籽油、辛酸甘油三酯、癸酸甘油三酯、橄榄油、霍霍巴油、角鲨烯和聚二甲基硅烷中的一种或几种。
3.根据权利要求1所述的一种婴儿湿疹用天然富硒植物精华舒缓乳液，其特征在于，所述保湿剂为1,3-丙二醇、甘油、1,2-己二醇、辛酰羟肟酸和聚乙二醇中的一种或几种。
4.根据权利要求1所述的一种婴儿湿疹用天然富硒植物精华舒缓乳液，其特征在于，所述乳化剂为鲸蜡硬脂醇橄榄油酸酯、山梨糖橄榄油酸酯、茶皂素和卵磷脂中的一种或几种。
5.根据权利要求1所述的一种婴儿湿疹用天然富硒植物精华舒缓乳液，其特征在于，所述增稠剂为鲸蜡硬脂醇、白蜂蜡、聚丙烯酸钠、丙烯酰二甲基牛磺酸铵/VP共聚物和玻尿酸中的一种或几种。
6.根据权利要求1所述的一种婴儿湿疹用天然富硒植物精华舒缓乳液，其特征在于，所述抗氧剂为生育酚乙酸酯、对羟基苯乙酮和茶多酚中的一种或几种。
7.根据权利要求1所述的一种婴儿湿疹用天然富硒植物精华舒缓乳液，其特征在于，所述富硒温泉水，其硒元素含量为0.01-0.05 mg/L。
8.根据权利要求1-7任一项所述的婴儿湿疹用天然富硒植物精华舒缓乳液，其制备方法为：
（1）在容器a中加入润肤剂、保湿剂和乳化剂，在50-100℃条件下搅拌混合10-30分钟，使其分散均匀，冷却至室温后，加入药蜀葵根提取物、欧舒敏组合物和抗氧剂，搅拌混合30-60分钟，得到溶液a；
（2）在容器b中加入增稠剂和富硒温泉水，在50-100℃条件下搅拌混合30-60分钟，使其溶解完全，冷却至40-50℃，得到溶液b；
（3）将溶液a逐滴搅拌加入溶液b中，搅拌混合60-120分钟，搅拌均匀后，冷却至室温，得到婴儿湿疹用天然富硒植物精华舒缓乳液。
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