CN114668381A - Marmoset monkey nuclear magnetic compatibility orientator - Google Patents

Marmoset monkey nuclear magnetic compatibility orientator Download PDF

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Publication number
CN114668381A
CN114668381A CN202210147817.6A CN202210147817A CN114668381A CN 114668381 A CN114668381 A CN 114668381A CN 202210147817 A CN202210147817 A CN 202210147817A CN 114668381 A CN114668381 A CN 114668381A
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CN
China
Prior art keywords
rod
eye
adjusting device
sliding block
marmoset
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Pending
Application number
CN202210147817.6A
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Chinese (zh)
Inventor
王立平
坤曼特迪
王志杰
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Shenzhen Institute of Advanced Technology of CAS
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Shenzhen Institute of Advanced Technology of CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Institute of Advanced Technology of CAS filed Critical Shenzhen Institute of Advanced Technology of CAS
Priority to CN202210147817.6A priority Critical patent/CN114668381A/en
Publication of CN114668381A publication Critical patent/CN114668381A/en
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/70Means for positioning the patient in relation to the detecting, measuring or recording means
    • A61B5/702Posture restraints
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61DVETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00Appliances for supporting or fettering animals for operative purposes

Abstract

The invention relates to a marmoset nuclear magnetic compatibility orientator, which comprises a bottom plate, wherein three adjusting devices are arranged on the bottom plate, ear bars are arranged in sliding block grooves on a first adjusting device and a second adjusting device, the ear bars can move in the sliding block grooves, when the ear bars move to proper positions, fixing screws are used for fixing the ear bars; a horizontal rod is arranged in a sliding block groove on the third adjusting device, the horizontal rod can move in the sliding block groove, and when the horizontal rod moves to a proper position, a fixing screw is used for fixing the horizontal rod; the end part of the horizontal rod is vertically provided with a through hole, the moving rod penetrates through the through hole and can move up and down along the through hole, the end part of the horizontal rod is horizontally provided with a nozzle rod fixing screw, and when the moving rod moves to a proper position, the nozzle rod fixing screw is used for fixing the moving rod on the horizontal rod; the bottom of the movable rod is connected with a filter tip; two eye rods are arranged at the upper part of the movable rod. The present invention can strictly fix the head of the marmoset during operation and MRI imaging, and the marmoset can keep stable gas anesthesia.

Description

Marmoset nuclear magnetic compatibility orientator
Technical Field
The invention relates to a marmoset nuclear magnetic compatibility locator.
Background
Marmoset is a small-sized primate, and the volume of the marmoset is slightly larger than that of a rat. However, unlike the conventional rodent experimental animals, there are significant individual differences in body size, skull shape, and nucleus location among different marmosets. Considering that the deep brain nuclei of marmosets are themselves small, accurate localization of deep brain nuclei of marmosets (e.g. for virus or drug injection surgery) must be combined with MRI imaging methods.
In the in-vivo skull surgery and MRI imaging of the marmosets, the heads of the marmosets are required to be ensured to be completely free from movement in the surgery and imaging processes so as to realize accurate positioning. This requires a suitable marmoset orientation apparatus to achieve accurate fixation of the marmoset head during surgery and imaging. This positioning apparatus needs to satisfy the following requirements: (1) the head of the marmoset monkey can be strictly fixed, and the fixation can bear the pressure caused by surgical operation and autonomous movement of animals (because of unstable anesthesia); (2) the fixation of the locator can be adjusted correspondingly along with the change of the body type of the marmoset; (3) nuclear magnetic compatibility, and the locator is small enough to be placed in an MRI instrument; (4) the locator can be well linked and matched with a gas anesthesia system.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention provides the marmoset nuclear magnetic compatibility orientator, which can strictly fix the heads of the marmosets in operations and MRI imaging and can keep stable gas anesthesia.
The technical scheme for solving the problems is as follows: a marmoset nuclear magnetic compatibility orientator is characterized in that:
the device comprises a bottom plate, wherein three adjusting devices are arranged on the bottom plate, have the same structure and are divided into a first adjusting device, a second adjusting device and a third adjusting device;
the first adjusting device and the second adjusting device are oppositely arranged and are respectively positioned on two sides of the bottom plate; the third adjusting device is positioned at the front end of the bottom plate;
the adjusting device comprises a vertical column and a U-shaped sliding block which are vertically arranged, a slide way is vertically arranged on one side of the vertical column, a baffle plate is arranged at the upper end of the vertical column, a screw rod is connected onto the baffle plate through threads, the lower end of the screw rod extends into the slide way, and the upper end of the screw rod is connected with a knob; one side wing of the U-shaped sliding block extends into the slideway and is in threaded connection with the screw rod, and the screw rod can drive the U-shaped sliding block to move up and down along the slideway; the other side wing of the U-shaped sliding block is provided with a fixing screw; the middle part of the U-shaped sliding block is provided with a sliding block groove;
Ear rods are arranged in the sliding block grooves on the first adjusting device and the second adjusting device, the ear rods can move in the sliding block grooves, and when the ear rods move to proper positions, the fixing screws are used for fixing the ear rods;
a horizontal rod is arranged in a sliding block groove on the third adjusting device, the horizontal rod can move in the sliding block groove, and when the horizontal rod moves to a proper position, a fixing screw is used for fixing the horizontal rod; the end part of the horizontal rod is vertically provided with a through hole, the moving rod penetrates through the through hole and can move up and down along the through hole, the end part of the horizontal rod is horizontally provided with a nozzle rod fixing screw, and when the moving rod moves to a proper position, the nozzle rod fixing screw is used for fixing the moving rod on the horizontal rod;
the bottom of the movable rod is connected with a filter tip; two eye rods are arranged at the upper part of the movable rod.
Preferably, the upper part of the moving rod is provided with an eye stick base plate, a through hole is vertically formed in the eye stick base plate, the upper part of the moving rod penetrates through the through hole of the eye stick base plate, the eye stick base plate can move up and down along the moving rod, an eye stick base plate fixing screw is horizontally arranged on the eye stick base plate, and when the eye stick base plate moves to a proper position, the eye stick base plate fixing screw is used for fixing the eye stick base plate on the moving rod; the two eye rods are respectively positioned at two sides of the through hole on the upper surface of the eye rod base plate, the eye rods are fixed on the eye rod base plate through the eye rod fixing screws, and the eye rods can rotate around the eye rod fixing screws in the horizontal direction.
Preferably, the axis of the set screw of the adjustment device is at 45 ° to the vertical.
Preferably, the ear rod includes canned paragraph and work end, and the work end setting is in the one end of canned paragraph, the canned paragraph is cuboid or square structure, and the work end is the cone.
Preferably, the baffle plate of the adjusting device is fixed at the upper end of the upright post through a screw.
Preferably, the mouth rod comprises an insertion part and a tooth hook, one end of the insertion part is fixedly connected with the moving rod, the other end of the insertion part is connected with the tooth hook, and the tooth hook is used for hooking the teeth of the animal.
Preferably, the mouth bar is provided with an anaesthetic mask, the anaesthetic mask is provided with a through hole, and the insertion part of the mouth bar penetrates through the through hole.
Preferably, the upright post of the adjusting device is provided with scale marks, and the U-shaped sliding block is provided with a reference line.
Preferably, the bottom plate is a rectangular flat plate.
Preferably, the adjusting device is made of organic materials.
The invention has the advantages that:
1) the horizontal distance between the eye stick/mouth stick and the ear stick can be adjusted by adjusting the clamping position of the horizontal rod on the upright post so as to adapt to the sizes of different animals, the adjusting mode is simple and effective, and the eye stick/mouth stick can be ensured to be always positioned on a horizontal middle line before and after adjustment and be perpendicular to a longitudinal connecting line between the two ear sticks, so that the orientation accuracy of the head of the animal is ensured;
2) In the invention, one eye stick backing plate and a corresponding eye stick backing plate fixing screw are used for adjusting the relative vertical distance between the eye stick and the filter tip, so that the method is simple and effective, and the adjustable range is large;
3) to adapt to different sizes of animals, the vertical heights of ear rods and horizontal rods (with eye rods and mouth rods at the tail ends) are required to be adjusted. In the scheme, the height adjustment of the ear rod and the horizontal rod is realized by using a single upright column to match with the slide block, the screw rod and the knob, so that the adjustment is simple and effective, and the design can reduce the overall height of the marmoset monkey orientator as much as possible, so that the marmoset monkey orientator can be placed into an imaging cavity of medical images such as MRI, CT, PET and the like;
4) the whole design of the scheme inherits the principle of simplicity, effectiveness and stability, all parts can be processed and manufactured by organic materials, and any metal part is not needed completely. The marmoset monkey positioning instrument can achieve nuclear magnetic compatibility.
Drawings
FIG. 1 is a diagram showing an overall structure of a marmoset nuclear magnetic compatibility locator according to the present invention;
FIG. 2 is a diagram showing the positional relationship between three vertical columns and a bottom plate in the marmoset nuclear magnetic compatibility orientator of the present invention;
FIG. 3 is a block diagram of the column of FIG. 1;
FIG. 4 is a block diagram of the horizontal bar of FIG. 1;
FIG. 5 is a diagram of the present invention showing the use of the marmoset nuclear magnetic compatibility locator;
fig. 6 is a structural assembly view of eye and mouth fixing parts of the third adjusting device.
Wherein: 1-base plate, 2-first adjusting device, 3-second adjusting device, 4-third adjusting device, 5-upright post, 6-U-shaped slide block, 7-baffle plate, 8-screw rod, 9-knob, 10-ear rod, 11-fixing screw, 12-horizontal rod, 13-moving rod, 14-mouth rod fixing screw, 15-mouth rod, 16-eye rod, 17-eye rod backing plate, 18-fixing section, 19-working end, 20-inserting part, 21-tooth hook, 22-eye rod backing plate fixing screw and 23-anaesthetic mask.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments of the present invention, belong to the protection scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.
Referring to fig. 1 and 2, a marmoset nuclear magnetic compatibility orientator includes bottom plate 1, is equipped with three adjusting device on bottom plate 1, and three adjusting device structures are the same, divide into first adjusting device 2, second adjusting device 3 and third adjusting device 4. The first adjusting device 2 and the second adjusting device 3 are oppositely arranged and are respectively positioned on two sides of the bottom plate 1; the third adjusting device 4 is located at the front end of the soleplate 1.
Referring to fig. 3, the adjusting device comprises a vertical column 5 and a U-shaped sliding block 6 which are vertically arranged, a slide way is vertically arranged on one side of the vertical column 5, a baffle 7 is arranged at the upper end of the vertical column 5, a screw 8 is connected to the baffle 7 through threads, the lower end of the screw 8 extends into the slide way, and the upper end of the screw 8 is connected with a knob 9; one side wing of the U-shaped sliding block 6 extends into the slideway and is in threaded connection with the screw 8, and the screw 8 can drive the U-shaped sliding block 6 to move up and down along the slideway; the other side wing of the U-shaped sliding block 6 is provided with a fixing screw 11; the middle part of the U-shaped sliding block 6 is a sliding block groove.
The ear rod 10 is arranged in the slide block groove on the first adjusting device 2 and the second adjusting device 3, the ear rod 10 can move in the slide block groove, the ear rod 10 is moved to a proper position, and the fixing screw 11 is used for fixing the ear rod 10. A horizontal rod 12 is arranged in a sliding block groove on the third adjusting device 4, the horizontal rod 12 can move in the sliding block groove, and when the horizontal rod 12 moves to a proper position, a fixing screw 11 is used for fixing the horizontal rod 12; the end part of the horizontal rod 12 is vertically provided with a square through hole, a moving rod 13 penetrates through the square through hole, the moving rod 13 can move up and down along the square through hole, a nozzle rod fixing screw 14 is arranged in the horizontal direction of the end part of the horizontal rod 12, and when the moving rod 13 moves to a proper position, the nozzle rod fixing screw 14 is used for fixing the moving rod 13 on the horizontal rod 12. The bottom of the movable rod 13 is connected with a filter tip 15; two eye rods 16 are provided on the upper portion of the moving rod 13.
Preferably, the axis of the set screw 11 of the adjustment device is arranged at 45 ° to the vertical, so that it effectively limits the ear rod or horizontal rod to move vertically and horizontally. The baffle 7 of the adjusting device is fixed at the upper end of the upright post 5 through a screw, and the baffle 7 is used for limiting the highest displacement of the U-shaped sliding block 6 and fixing the screw rod 8.
As a preferred embodiment of the present invention, referring to fig. 4 and 6, the upper portion of the moving rod 13 is provided with an eye stick pad 17, the eye stick pad 17 is vertically provided with a through hole, the upper portion of the moving rod 13 passes through the through hole of the eye stick pad 17, the eye stick pad 17 can move up and down along the moving rod 13, the eye stick pad 17 is horizontally provided with an eye stick pad fixing screw 22, and when the eye stick pad 17 moves to a proper position, the eye stick pad fixing screw 22 is used for fixing the eye stick pad 17 on the moving rod 13; the two eye rods 16 are respectively positioned at two sides of the through hole on the upper surface of the eye rod backing plate 17, the eye rods 16 are fixed on the eye rod backing plate 17 through eye rod fixing screws, and the eye rods 16 can rotate around the eye rod fixing screws in the horizontal direction. Referring to fig. 6, in assembling, a horizontal rod 12 of the marmoset monkey positioning instrument is clamped on the U-shaped sliding block 6 of the upright post 5 of the third adjusting device 4; a moving rod 13 is inserted into the square through hole and is fixed by a filter rod fixing screw 14; an eye stick backing plate 17 is additionally arranged on the vertical tail rod of the movable rod 13 and is fixed by a corresponding eye stick backing plate fixing screw 22; two eye rods 16 are attached to the eye rod pad 17 and fixed by eye rod fixing screws. Therefore, the eye and mouth fixing part structure of the marmoset monkey positioning instrument has the advantages that all parts are simple and convenient to process and assemble, and the relative distance between the eye rod and the mouth rod is simple and convenient to adjust. These parts can be conveniently machined from organic materials to achieve nuclear magnetic compatibility.
As a preferred embodiment of the present invention, referring to FIG. 1, the ear stick 10 comprises a fixing section 18 and a working end 19, the working end 19 is disposed at one end of the fixing section 18, the fixing section 18 has a rectangular or square structure, and the working end 19 has a conical head.
Referring to fig. 4, the mouth stick 15 according to a preferred embodiment of the present invention includes an insertion portion 20 and a tooth hook 21, wherein one end of the insertion portion 20 is fixedly connected to the moving rod 13, and the other end is connected to the tooth hook 21, and the tooth hook 21 is used for hooking the teeth of the animal.
In a preferred embodiment of the present invention, the mouth rod 15 is provided with an anesthetic mask 23, the anesthetic mask 23 is provided with a through hole, and the insertion portion 20 of the mouth rod 15 passes through the through hole. The anaesthetic mask is made of silica gel material and is provided with a gas inlet and a gas outlet.
Referring to fig. 3, as a preferred embodiment of the present invention, the upright post 5 of the adjusting device is provided with scale marks, and the U-shaped sliding block 6 is provided with a reference line, so as to determine the vertical adjustment distance of the U-shaped sliding block 6.
As a preferred embodiment of the present invention, referring to fig. 1, the base plate 1 is a rectangular flat plate. All components of the invention are made of organic materials and meet the standards for entry into MRI scanners.
Referring to fig. 5, the working principle of the present invention is:
the marmoset monkey is placed on bottom plate 1, adjusts first adjusting device 2, second adjusting device 3, specifically, and the height of ear stick can be adjusted to rotatory knob 9, and after the altitude mixture control was good, remove fixed section 18 and make the working end 19 of both sides ear stick 10 tip support the earhole, then screw up set screw 11, fixed with ear stick 10.
Adjusting the third adjustment means 4, in particular, rotating the knob 9, can adjust the height of the horizontal rod 12, move the horizontal rod 12 to extend the mouth rod 15 into the marmoset mouth and hook the teeth with the tooth hooks 21, at which time the height of the eyestick pad 17 is adjusted, rotate the angle of the eyestick 16 to bring the eyestick 16 against the lower edge of the orbit, tighten the eyestick pad fixing screw 22, and tighten the eyestick fixing screw that fixes the eyestick 16. At this time, the localization of the marmoset heads was completed.
The marmoset nuclear magnetic compatibility locator can be used for fixing and accurately positioning animal surgery and can also be used for MRI imaging.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent structures or equivalent flow transformations made by using the contents of the specification and the drawings, or applied directly or indirectly to other related systems, are included in the scope of the present invention.

Claims (10)

1. A marmoset nuclear magnetism compatible locater is characterized in that:
the device comprises a bottom plate (1), wherein three adjusting devices are arranged on the bottom plate (1), have the same structure and are divided into a first adjusting device (2), a second adjusting device (3) and a third adjusting device (4);
the first adjusting device (2) and the second adjusting device (3) are oppositely arranged and are respectively positioned on two sides of the bottom plate (1); the third adjusting device (4) is positioned at the front end of the bottom plate (1);
the adjusting device comprises a vertical column (5) and a U-shaped sliding block (6) which are vertically arranged, a slide way is vertically arranged on one side of the vertical column (5), a baffle (7) is arranged at the upper end of the vertical column (5), the baffle (7) is connected with a screw rod (8) through threads, the lower end of the screw rod (8) extends into the slide way, and the upper end of the screw rod (8) is connected with a knob (9); one side wing of the U-shaped sliding block (6) extends into the slideway and is in threaded connection with the screw rod (8), and the screw rod (8) can drive the U-shaped sliding block (6) to move up and down along the slideway; the other side wing of the U-shaped sliding block (6) is provided with a fixing screw (11); the middle part of the U-shaped sliding block (6) is provided with a sliding block groove;
ear rods (10) are arranged in the sliding block grooves on the first adjusting device (2) and the second adjusting device (3), the ear rods (10) can move in the sliding block grooves, and when the ear rods (10) move to proper positions, the fixing screws (11) are used for fixing the ear rods (10);
A horizontal rod (12) is arranged in a sliding block groove on the third adjusting device (4), the horizontal rod (12) can move in the sliding block groove, and when the horizontal rod (12) moves to a proper position, a fixing screw (11) is used for fixing the horizontal rod (12); a through hole is vertically formed in the end part of the horizontal rod (12), a moving rod (13) penetrates through the through hole, the moving rod (13) can move up and down along the through hole, a nozzle rod fixing screw (14) is arranged in the horizontal direction of the end part of the horizontal rod (12), and when the moving rod (13) moves to a proper position, the nozzle rod fixing screw (14) is used for fixing the moving rod (13) on the horizontal rod (12);
the bottom of the movable rod (13) is connected with a filter tip (15); two eye rods (16) are arranged at the upper part of the movable rod (13).
2. The marmoset nuclear magnetic compatibility locator according to claim 1, wherein:
an eye stick base plate (17) is arranged at the upper part of the moving rod (13), a through hole is vertically formed in the eye stick base plate (17), the upper part of the moving rod (13) penetrates through the through hole of the eye stick base plate (17), the eye stick base plate (17) can move up and down along the moving rod (13), an eye stick base plate fixing screw (22) is arranged in the horizontal direction of the eye stick base plate (17), and when the eye stick base plate (17) moves to a proper position, the eye stick base plate fixing screw (22) is used for fixing the eye stick base plate (17) on the moving rod (13); the two eye rods (16) are respectively positioned at two sides of the through hole on the upper surface of the eye rod base plate (17), the eye rods (16) are fixed on the eye rod base plate (17) through eye rod fixing screws, and the eye rods (16) can rotate around the eye rod fixing screws in the horizontal direction.
3. The marmoset nuclear magnetic compatibility locator according to claim 1, wherein:
the axis of the fixing screw (11) of the adjusting device is 45 degrees to the vertical direction.
4. The marmoset nuclear magnetic compatibility locator according to claim 2, wherein:
ear stick (10) are including canned paragraph (18) and work end (19), and work end (19) set up the one end at canned paragraph (18), canned paragraph (18) are cuboid or square structure, and work end (19) are the cone head.
5. The marmoset nuclear magnetic compatibility locator according to claim 4, wherein:
the baffle (7) of the adjusting device is fixed at the upper end of the upright post (5) through a screw.
6. The marmoset nuclear magnetic compatibility locator according to claim 5, wherein:
the mouth rod (15) comprises an insertion part (20) and a tooth hook (21), one end of the insertion part (20) is fixedly connected with the moving rod (13), the other end of the insertion part is connected with the tooth hook (21), and the tooth hook (21) is used for hooking the teeth of the animal.
7. The marmoset nuclear magnetic compatibility locator according to claim 6, wherein:
the mouth rod (15) is provided with an anaesthetic mask (23), the anaesthetic mask (23) is provided with a through hole, and the insertion part (20) of the mouth rod (15) passes through the through hole.
8. The marmoset nuclear magnetic compatibility locator according to any one of claims 1 to 7, wherein:
the adjusting device is characterized in that a column (5) of the adjusting device is provided with scale marks, and a U-shaped sliding block (6) is provided with a datum line.
9. The marmoset nuclear magnetic compatibility locator according to claim 8, wherein:
the bottom plate (1) is a rectangular flat plate.
10. The marmoset nuclear magnetic compatibility locator according to claim 8, wherein:
the adjusting device is made of organic materials.
CN202210147817.6A 2022-02-17 2022-02-17 Marmoset monkey nuclear magnetic compatibility orientator Pending CN114668381A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210147817.6A CN114668381A (en) 2022-02-17 2022-02-17 Marmoset monkey nuclear magnetic compatibility orientator

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210147817.6A CN114668381A (en) 2022-02-17 2022-02-17 Marmoset monkey nuclear magnetic compatibility orientator

Publications (1)

Publication Number Publication Date
CN114668381A true CN114668381A (en) 2022-06-28

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Application Number Title Priority Date Filing Date
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Country Status (1)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115399749A (en) * 2022-07-25 2022-11-29 中国人民解放军总医院第一医学中心 Fixing device and magnetic resonance inspection device of rodent experimental animals

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115399749A (en) * 2022-07-25 2022-11-29 中国人民解放军总医院第一医学中心 Fixing device and magnetic resonance inspection device of rodent experimental animals

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