CN114668148A - Health-care composition with nerve calming and sleep aiding effects and preparation method, health-care product and application thereof - Google Patents
Health-care composition with nerve calming and sleep aiding effects and preparation method, health-care product and application thereof Download PDFInfo
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- CN114668148A CN114668148A CN202210340555.5A CN202210340555A CN114668148A CN 114668148 A CN114668148 A CN 114668148A CN 202210340555 A CN202210340555 A CN 202210340555A CN 114668148 A CN114668148 A CN 114668148A
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Abstract
The invention provides a health-care composition with the effects of soothing nerves and helping sleep, a preparation method thereof, a health-care product and application, and relates to the technical field of health-care products. The health-care composition is mainly prepared from peanut stem and leaf extract, aminobutyric acid, theanine, cordyceps militaris extract and other raw materials in a specific ratio, has a good effect on sleep tranquilization through the synergistic cooperation effect of the raw materials, and has great practical significance on improving sleep, relieving fatigue and improving life quality of people. The invention also provides a preparation method of the health-care composition, and the method has the advantages of simple process, convenience in operation and suitability for industrial large-scale production.
Description
Technical Field
The invention relates to the technical field of health products, in particular to a health composition with nerve calming and sleep aiding effects, a preparation method thereof, a health product and application thereof.
Background
In recent years, the country has been increasingly supporting the major health industry, and the nutritional health food industry has been gaining social importance as an important support for the major health industry. With the rise of the concept of 'big health', the increase of the dominant income of all nationwide residents, the upgrading of consumption and the aging of population, the sudden epidemic situation is superposed, and the health concept of the nationwide is continuously changed and deepened, so that the huge health market demand is derived, and the future growth space of the nutritional health-care food industry prospect and the subdivision field is available.
With the accelerated pace of life, higher working pressure and continuous decline of sleep quality of people, people in sub-health have increased year by year, the sleep deficiency is more and more younger, and the people have great harm to the body and spirit. Therefore, how to improve insomnia and improve sleep quality is an urgent problem to be solved.
In view of the above, the present invention is particularly proposed.
Disclosure of Invention
The first purpose of the invention is to provide a health-care composition with the effects of soothing nerves and helping sleep.
The second purpose of the invention is to provide a preparation method of the health-care composition with the effects of soothing nerves and helping sleep.
The third purpose of the invention is to provide a health care product which comprises the health care composition with the effects of soothing nerves and helping sleep.
The fourth purpose of the invention is to provide the application of the health-care composition or the health-care product with the effects of soothing nerves and helping sleep.
In order to achieve the purpose, the invention has the following technical scheme:
the invention provides a health-care composition with functions of calming nerves and helping sleep, which comprises the following raw materials in parts by weight:
65-85 parts of peanut stem and leaf extract, 6-12 parts of aminobutyric acid, 5-10 parts of theanine and 5-10 parts of cordyceps militaris extract.
Further, on the basis of the technical scheme, the health-care composition comprises the following raw materials in parts by weight:
68-80 parts of peanut stem and leaf extract, 8-11 parts of aminobutyric acid, 6.5-10 parts of theanine and 5.5-9 parts of cordyceps militaris extract.
Further, on the basis of the technical scheme of the invention, the preparation method of the peanut stem and leaf extract comprises the following steps:
extracting stems and leaves of peanut with water to obtain an extracting solution, concentrating and drying to obtain a crude product of the extract of the stems and leaves of the peanut;
and (4) crushing and purifying the crude product of the peanut stem and leaf extract to obtain the peanut stem and leaf extract.
Further, on the basis of the technical scheme, in the preparation method of the peanut stem and leaf extract, peanut stem and leaf are extracted by water for 1-3 times;
preferably, the temperature of each extraction is 90-95 ℃ independently, and the time of each extraction is 1-2h independently.
Preferably, the feed-liquid ratio of each extraction is 1: (5-10).
Further, on the basis of the technical scheme of the invention, in the preparation method of the peanut stem and leaf extract, the extracting solution is concentrated to the specific gravity of 1.1-1.2;
preferably, the drying is spray drying;
preferably, the temperature of the spray drying is 190-210 ℃;
preferably, the pulverized particle size is 80-100 mesh.
The invention also provides a preparation method of the health-care composition with the effects of soothing nerves and helping sleep, which comprises the following steps:
mixing the raw materials to obtain the health-care composition with the effects of soothing nerves and helping sleep.
The invention also provides a health-care product which comprises the health-care composition with the functions of soothing nerves and helping sleep and auxiliary materials.
Further, on the basis of the technical scheme, the auxiliary materials comprise any one or a combination of at least two of a matrix, a suspending agent, a sweetening agent, a filling agent, a disintegrating agent, a lubricating agent or a preservative.
Further, on the basis of the technical scheme, the dosage form of the health care product comprises any one of capsules, tablets, pills, granules or oral liquid.
The invention also provides application of the health-care composition or the health-care product with the effects of soothing nerves and aiding sleep in the fields of improving sleep and soothing nerves.
Compared with the prior art, the invention has the following technical effects:
(1) the invention provides a health-care composition with functions of calming nerves and helping sleep, which is mainly prepared from peanut stem leaf extract, aminobutyric acid, theanine, cordyceps militaris extract and other raw materials in a specific ratio, has a good sleep-calming effect through the synergistic cooperation effect of the raw materials, and has great practical significance for improving sleep, relieving fatigue and improving life quality of people.
(2) The invention provides a preparation method of the health-care composition with the effects of soothing nerves and helping sleep, and the method is simple in process, convenient to operate and suitable for industrial large-scale production.
(3) The invention provides a health-care product which comprises the health-care composition with the effects of soothing nerves and helping sleep. In view of the advantages of the health-care composition with the effects of soothing nerves and helping sleep, the health-care product prepared from the health-care composition has the same advantages.
(4) The invention provides the application of the health-care composition or the health-care product with the effects of calming nerves and helping sleep, and the health-care composition or the health-care product has good application in the fields of improving sleep and calming nerves due to the effects of the health-care composition or the health-care product.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
Fig. 1 is a flow chart of a preparation process of a peanut stem and leaf extract in an embodiment of the invention.
Detailed Description
Embodiments of the present invention will be described in detail below with reference to embodiments and examples, but those skilled in the art will understand that the following embodiments and examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. Those who do not specify the conditions are performed according to the conventional conditions or the conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
According to the first aspect of the invention, the health care composition with the effects of soothing nerves and helping sleep is provided, and comprises the following raw materials in parts by weight:
65-85 parts of peanut stem leaf extract, 6-12 parts of aminobutyric acid, 5-10 parts of theanine and 5-10 parts of cordyceps militaris extract.
The peanut stem and leaf extract is mainly prepared by extracting peanut stem and leaf. Although the peanut stems and leaves are not traditional Chinese medicines, the peanut stems and leaves are more applied in China folks. The linalool, ferulic acid, naringenin-4, 7-dimethyl ether, 2' -0-methyl isoliquiritigenin and other components in peanut stem and leaf have good and reliable effects on sleep and tranquilization. The peanuts are planted in a large area in China, the resources of peanut stems and leaves are rich, and the guarantee is provided for obtaining peanut stem and leaf extracts.
The amount of the peanut stem and leaf extract is also limited, and the typical but non-limiting weight parts of the peanut stem and leaf extract are 65 parts, 66 parts, 68 parts, 70 parts, 72 parts, 74 parts, 75 parts, 76 parts, 78 parts, 80 parts, 82 parts, 84 parts or 85 parts.
Aminobutyric acid is a substance having a certain therapeutic effect on the human body. The amino butyric acid is an important inhibitory neurotransmitter in the central nervous system of the human body, has the main effects of calming the heart, soothing the nerves, strengthening the brain and improving intelligence for the human body, so the proper use of the amino butyric acid can effectively promote sleep and improve the condition of insomnia and dreaminess. For women, aminobutyric acid also has certain beautifying and face nourishing effects. Meanwhile, the traditional Chinese medicine composition has a good blood pressure reducing effect for patients with hypertension. In addition, the composition has certain improving and protecting effects on the liver and the kidney of a human body.
Typical but non-limiting parts by weight of aminobutyric acid are 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, 10.5 parts, 11 parts, 11.5 parts, or 12 parts.
Theanine is a unique free amino acid in tea, has sweet taste, and is a main ingredient for promoting the secretion of saliva or body fluid and moistening sweet in tea. Theanine can affect central nerve, and can promote release of dopamine in brain central nerve to improve physiological activity of dopamine in brain. The common anti-fatigue effect of drinking tea comes from the effect to a certain extent. Theanine can effectively reduce hypertension. To some extent, theanine exhibits a hypotensive effect which is a calming effect which undoubtedly contributes to the recovery from physical and mental fatigue. Theanine can improve memory and learning by activating central neurotransmitters. Meanwhile, the tea has the function of relieving central hyperexcitability caused by caffeine, so that people can enjoy the sensation of relaxed and pleasant mind and body which is not provided by coffee and cocoa when drinking tea.
Typical but non-limiting parts by weight of theanine are 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, or 10 parts.
The extract (cordyceps militaris extract) of the cordyceps militaris can effectively tonify kidney yang, and is mainly used for treating impotence, spermatorrhea and soreness and pain of waist and knees caused by kidney deficiency; the traditional Chinese medicine composition can also effectively treat patients with weakness after illness, and has a certain relieving effect on senile chronic bronchitis and pulmonary heart disease; can effectively tonify lung and relieve asthma, and has certain relieving effect on patients with cough, such as pulmonary tuberculosis; can be used for preventing and treating cerebral thrombosis and cerebral hemorrhage. Typical but non-limiting parts by weight of the cordyceps militaris extract are 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts or 10 parts.
It should be noted that the ratio of the above raw materials should be controlled within the range of the numerical value defined by the present invention, that is, (65-85): (6-12): (5-10): (5-10), if the value is beyond the range, the nerve soothing and sleep aiding effects of the health care composition are obviously reduced.
In the invention, the theory of 'monarch, minister, assistant and guide' in traditional Chinese medicine is taken as guidance, the branches and leaves of peanuts are taken to have the characteristic of 'opening day and closing night', the principle can follow the rules of yin and yang growth and elimination in nature, and the principle is synchronous with the 'sleep in night and the rule in day' of human sleep, and has the effects of calming the liver, suppressing yang, soothing the nerves and strengthening the brain, and the effect of entering the liver, the heart and the lung meridians is sweet and light in nature and taste, slightly bitter and astringent. And the aminobutyric acid and the theanine are taken as assistants to achieve the effect of soothing the nerves during sleep.
The health-care composition with the effects of soothing the nerves and helping sleep is mainly prepared from the raw materials of peanut stem and leaf extract, aminobutyric acid, theanine, cordyceps militaris extract and the like in a specific ratio, wherein the peanut stem and leaf extract mainly solves the problem of insomnia and dreaminess, is matched with the effects of soothing the nerves and calming of the aminobutyric acid and the theanine, and has a good effect of soothing the nerves for sleep through the synergistic cooperation effect of the raw materials, so that the health-care composition has important practical significance for improving sleep, relieving fatigue and improving life quality of people.
It is to be noted that "comprising", "made mainly of … …" in the present invention means that it may include other materials in addition to the materials, which impart different properties to the health care composition. In addition, the terms "comprising," "made primarily of … …," and "made of … …," as used herein, are intended to be interchangeable.
As an optional embodiment of the invention, the health-care composition comprises the following raw materials in parts by weight:
68-80 parts of peanut stem and leaf extract, 8-11 parts of aminobutyric acid, 6.5-10 parts of theanine and 5.5-9 parts of cordyceps militaris extract.
The sleep-aiding and nerve-soothing effects of the health-care composition are more remarkable by further optimizing the dosage of each raw material of the health-care composition.
The health composition is not limited in the source of peanut stem and leaf extract, and can be obtained commercially or by itself.
As an alternative embodiment of the present invention, the preparation method of the peanut stem and leaf extract comprises the following steps:
extracting stems and leaves of peanut with water to obtain an extracting solution, concentrating and drying to obtain a crude product of the extract of the stems and leaves of the peanut;
and (4) crushing and purifying the crude product of the peanut stem and leaf extract to obtain the peanut stem and leaf extract.
The preparation method has simple process and convenient operation, and can realize sufficient extraction of effective components (such as linalool, ferulic acid, naringenin-4, 7-dimethyl ether, 2' -0-methyl isoliquiritigenin, etc.) in peanut stem and leaf, so that the content of effective components in the peanut stem and leaf extract is high.
In an alternative embodiment of the present invention, the method for preparing the peanut stem and leaf extract comprises extracting the peanut stem and leaf with water for 1-3 times.
As an optional embodiment of the invention, the temperature of each extraction is respectively and independently 90-95 ℃, and the time of each extraction is respectively and independently 1-2 h.
Typical but non-limiting extraction temperatures are 90 deg.C, 91 deg.C, 92 deg.C, 93 deg.C, 94 deg.C or 95 deg.C. Typical but non-limiting extraction times are 1h, 1.5h or 2 h.
As an optional implementation mode of the invention, the ratio of material to liquid extracted each time is 1: (5-10). The material-liquid ratio refers to the weight ratio of peanut stems and leaves to water of 1:5, 1:6, 1:7, 1:8, 1:9 or 1: 10.
Through the limitation of each process parameter in the extraction process, the effective components in the stems and leaves of the peanuts enter the extracting solution as much as possible.
As an optional embodiment of the invention, in the preparation method of the peanut stem and leaf extract, the extracting solution is concentrated to the specific gravity of 1.1-1.2;
as an alternative embodiment of the present invention, the drying is spray drying, preferably, the temperature of spray drying is 190-.
Typical but non-limiting temperatures for spray drying are 190 ℃, 195 ℃, 200 ℃, 205 ℃ or 210 ℃.
As an alternative embodiment of the invention, the size of the ground particles is 80-100 mesh. Typical but non-limiting grind sizes are 80 mesh, 90 mesh, or 100 mesh.
As a preferred embodiment of the present invention, the preparation method of the peanut stem and leaf extract comprises the following steps, as shown in fig. 1:
(a) adding clean water into peanut stem and leaf in an extraction tank according to a weight ratio (material-liquid ratio) of 1:5, heating to 90-95 ℃, soaking twice, soaking for 2 hours for the first time, filtering to collect water extract, adding water into raw materials, soaking for 1 hour for the second time at 90-95 ℃, then combining the two extracting solutions, filtering, centrifuging, evaporating and concentrating in multiple stages to obtain peanut stem and leaf concentrated solution with the specific gravity of 1.1-1.2, and spray-drying at 190-210 ℃ to obtain crude peanut stem and leaf extract;
(b) and (3) crushing the crude peanut stem and leaf extract in a 10 ten thousand grade clean area, and sieving by using a 80-mesh sieve to remove impurities and purify to obtain the peanut stem and leaf extract.
According to a second aspect of the present invention, there is also provided a preparation method of the above health composition with effects of soothing nerves and aiding sleep, comprising the following steps:
mixing the raw materials to obtain the health-care composition with the effects of soothing nerves and helping sleep.
The preparation method has simple process and convenient operation, and is suitable for large-scale industrial production.
According to a third aspect of the invention, the invention also provides a health care product, which comprises the health care composition with the functions of soothing the nerves and helping sleep and auxiliary materials.
In view of the advantages of the health-care composition with the effects of soothing the nerves and aiding sleep, the health-care product prepared from the composition has the same advantages.
The specific type of the auxiliary materials is not limited, and those commonly used in the art can be used.
As an alternative embodiment of the invention, the auxiliary material comprises any one or a combination of at least two of a base, a suspending agent, a sweetener or a disintegrant.
The matrix can be used to solubilize a nutraceutical composition, including but not limited to vegetable oils. Examples of the vegetable oil include corn oil, sesame oil, palm oil, sunflower oil, peanut oil, walnut oil, olive oil, soybean oil, and rapeseed oil.
There are many types of suspending agents, including but not limited to beeswax.
The sweetener may be selected from the group of substances commonly used in the art, including but not limited to erythritol, maltitol, xylitol, stevia, sucrose, white sugar, fructose, brown sugar or maltose.
Disintegrants include, but are not limited to, gelatin.
The health-care composition with the functions of soothing the nerves and helping sleep is matched with auxiliary materials and can be prepared into health-care products of different formulations.
As an alternative embodiment of the present invention, the formulation of the health product includes any one of capsules, tablets, pills, granules or oral liquid.
As a preferred embodiment of the present invention, the health product is a soft capsule health product, comprising a health composition and an auxiliary material;
the auxiliary material is peanut oil, and the mass of the health-care composition accounts for 10-40% of the total mass of the health-care composition and the auxiliary material.
The proportion of the mass of the nutraceutical composition to the total mass of the nutraceutical composition and the auxiliary material is typically, but not limited to, 10%, 12%, 14%, 15%, 18%, 20%, 22%, 24%, 25%, 28%, 30%, 32%, 34%, 35%, 38% or 40%.
As a preferred embodiment of the present invention, the preparation method of the health product (soft capsule) comprises the following steps:
mixing the health composition with adjuvants, and filtering to obtain content;
and pelleting the content and the glue solution for forming the soft capsule, shaping and drying to obtain the health-care product in the form of the soft capsule.
The gelatin solution for forming soft capsules may be prepared from conventional raw materials in the art, such as purified water, glycerin, gelatin, and the like. In addition, food pigment such as brilliant blue and amaranth can be added into the glue solution.
According to the fourth aspect of the invention, the application of the health-care composition or the health-care product with the effects of soothing the nerves and helping sleep in the fields of improving sleep and soothing the nerves is also provided.
In view of the effects of the health-care composition or the health-care product with the effects of soothing nerves and helping sleep, the health-care composition or the health-care product has good application in the fields of improving sleep and soothing nerves.
The technical solution provided by the present invention is further described below with reference to examples and comparative examples.
Example 1
The embodiment provides a health-care composition with the effects of soothing nerves and helping sleep, which is prepared from the following raw materials in parts by weight:
70 parts of peanut stem leaf extract, 6 parts of aminobutyric acid, 5 parts of theanine and 6 parts of cordyceps militaris extract.
The preparation method of the peanut stem and leaf extract comprises the following steps:
(a) adding clean water into peanut stem leaves in an extraction tank according to the weight ratio (material-liquid ratio) of 1:5, heating to 92 ℃, soaking for two times, soaking for 2 hours for the first time, filtering and collecting water extract, adding water into raw materials, soaking for 1 hour for the second time at 92 ℃, then combining the two extracting solutions, filtering, centrifuging and evaporating in multiple stages to obtain peanut stem leaf concentrated solution with the specific gravity of 1.1-1.2, and performing spray drying at 200 ℃ to obtain a crude product of peanut stem leaf extract;
(b) and (3) crushing the crude peanut stem and leaf extract in a 10 ten thousand grade clean area, and sieving with a 80-mesh sieve to remove impurities and purify to obtain the peanut stem and leaf extract.
Example 2
The embodiment provides a health-care composition with the effects of soothing nerves and helping sleep, which is prepared from the following raw materials in parts by weight:
70 parts of peanut stem leaf extract, 11 parts of aminobutyric acid, 10 parts of theanine and 9 parts of cordyceps militaris extract.
The preparation method of the peanut stem and leaf extract is the same as that of example 1.
Example 3
The embodiment provides a health-care composition with the effects of soothing nerves and helping sleep, which is prepared from the following raw materials in parts by weight:
65 parts of peanut stem leaf extract, 12 parts of aminobutyric acid, 5 parts of theanine and 10 parts of cordyceps militaris extract.
The preparation method of the peanut stem and leaf extract is the same as that of example 1.
Example 4
The embodiment provides a health-care composition with the effects of soothing nerves and helping sleep, which is prepared from the following raw materials in parts by weight:
85 parts of peanut stem leaf extract, 6 parts of aminobutyric acid, 8 parts of theanine and 5 parts of cordyceps militaris extract.
The preparation method of the peanut stem and leaf extract is the same as that of example 1.
Examples 1 to 4 are processes for preparing a health composition with tranquilizing and sleep-aiding effects, which includes the following steps:
mixing the raw materials to obtain the health-care composition with the effects of soothing nerves and helping sleep.
Comparative example 1
The comparative example provides a health-care composition which is prepared from the following raw materials in parts by weight:
50 parts of peanut stem leaf extract, 20 parts of aminobutyric acid, 18 parts of theanine and 12 parts of cordyceps militaris extract.
Comparative example 2
The comparative example provides a health-care composition which is prepared from the following raw materials in parts by weight:
90 parts of peanut stem leaf extract, 3 parts of aminobutyric acid, 3 parts of theanine and 4 parts of cordyceps militaris extract.
Comparative example 3
This comparative example provides a health composition, except that aminobutyric acid was not added to the raw material of example 1, and the kinds and amounts of the raw materials were the same as those of example 1.
Comparative example 4
This comparative example provides a health composition, except that theanine was not added to the raw materials of example 1, and the kinds and amounts of the other raw materials were the same as those of example 1.
Comparative example 5
The comparative example provides a health-care composition, except that the cordyceps militaris extract is not added in the raw materials of the example 1, and the types and the use amounts of the other raw materials are the same as those of the example 1.
Comparative example 6
This comparative example provides a health composition, except that no peanut stem and leaf extract was added to the raw materials of example 1, and the types and amounts of the other raw materials were the same as those of example 1.
Comparative example 7
This comparative example provides a health composition, except that the peanut stem and leaf extract and aminobutyric acid were not added to the raw materials of example 1, and the kinds and amounts of the other raw materials were the same as those of example 1.
Comparative example 8
The comparative example provides a health care composition, the raw materials of which only comprise peanut stem and leaf extract, and the preparation method of the peanut stem and leaf extract is the same as that of the example 1.
Comparative example 9
The comparative example provides a nutraceutical composition with only aminobutyric acid as a raw material.
Comparative example 10
The comparative example provides a health composition comprising theanine as the only raw material.
Comparative example 11
The comparative example provides a health-care composition, and the raw materials only comprise cordyceps militaris extract.
Comparative example 12
The comparative example provides a health care composition, which comprises the following raw materials:
60 parts of peanut stem and leaf extract, 20 parts of spina date seed extract and 3 parts of mulberry extract.
Comparative examples 1-12 provide nutraceutical compositions prepared in the same manner as in examples 1-4.
Example 5-example 8
Examples 5 to 8 respectively provide a health product (soft capsule) comprising the health composition and the adjuvant provided in examples 1 to 4;
the auxiliary material is peanut oil, and the mass of the health-care composition accounts for 40% of the total mass of the health-care composition and the auxiliary material.
Examples 5 to 8 provide a method for preparing a health product (soft capsule), comprising the steps of:
mixing the health composition with adjuvants, and filtering to obtain content;
and pelleting the content and the glue solution for forming the soft capsule, shaping and drying to obtain the health-care product in the form of the soft capsule.
Comparative examples 13 to 24
Comparative examples 13 to 24 each provide a health product (soft capsule) comprising the health composition and the adjuvant provided in comparative examples 1 to 12, respectively, and the amount of the health composition, the kind and amount of the adjuvant, and the preparation method of the health product used in the preparation are the same as those in examples 5 to 8, and are not described herein again.
In order to compare the technical effects of the respective examples and comparative examples, the following experimental examples were specifically set.
Examples of the experiments
1. Test article
Test article 1 (comparative example 12), content: 600g/kg of peanut stem and leaf extract, 200g/kg of spina date seed extract and 30g/kg of mulberry extract; specification: 200 mg/granule;
sample 2 (example 1), content: 700g/kg of peanut stem and leaf extract, 60g/kg of aminobutyric acid, 50g/kg of theanine and 60g/kg of cordyceps militaris extract; specification: 200 mg/granule;
test article 3 (comparative example 1), content: 500g/kg of peanut stem and leaf extract, 200g/kg of aminobutyric acid, 180g/kg of theanine and 120g/kg of cordyceps militaris extract; specification: 200 mg/granule.
2. Reagent
Sodium pentobarbital, lot No. 202018010925100, specification: 25 g/bottle, molecular weight: 248.25, manufacturer: merck, Germany.
Barbiturate sodium, lot No. MY4025, specification: 25 g/bottle, molecular weight: 206.17, manufacturer: jiuding chemical (Shanghai) science and technology, Inc.
3. Test animal and breeding environment
40 SPF-grade KM mice, male, were used for the test weighing 18-22g, provided by Jinan Pengyue test animal breeders Co., Ltd, production license number: SCXK (lu) 20190003, test animal quality certification number: no. 370726211101161563. Breeding mice in ten thousand-level barrier environment, trying for 20-25 ℃, ensuring that the daily temperature difference is less than or equal to 3 ℃, ventilating times are 10-20 times/h, the humidity is 40-70%, the pressure gradient is 20-50Pa, and the light and shade alternation time of day and night is 12h/12 h; the test animal uses the license number: SCXK (lu) 20180031.
4. Dosage design and basis
The human dose of the test samples 1, 2 and 3 was 400 mg/day, calculated as 70kg of adult human body weight, 5.71mg/kg of human body dose, and 57.1mg/kg of human body dose, which is 10 times of the recommended dose, was administered to mice. The intragastric administration volume of the mice of the three test sample groups is 20mL/kg, the administration is carried out once a day, the negative control group is provided with pure water with the same volume, and each index is detected after the three test samples are continuously administered for 30/33 d.
5. Pharmaceutical formulation
Test article 1, 2, 3 solution: 0.043g of each of the powders 1, 2 and 3 was weighed out, dissolved in pure water and diluted to 15mL, and the concentration of the solution was 2.87 g/mL.
6. Main instrument equipment
Model LE203E/02 electronic balance, mettler-toledo (shanghai) ltd.
Model AUW-120D electronic balance, shimadzu, japan.
Electronic balance model Uw2200H, shimadzu, japan.
7. Test method
(1) Direct sleep test
And observing whether the animals in the tested group are fed with the test products with different formulas, and whether the animals in the control group are in sleep after the animals in the control group are fed with the solvent with the same volume. The disappearance of the righting reflex is used as an index for sleeping. When the mouse is placed in the dorsal position, it can turn over right immediately. If the patient can not be righted for more than 30-60 seconds, the righting reflex is considered to disappear, and the patient enters sleep. The recovery of the righting reflex is the awakening of the animal, the time from disappearance of the righting reflex to recovery is the sleeping time of the animal, and the number of sleeping animals and the sleeping time of the negative control group and the test sample group are recorded.
(2) Pentobarbital sodium subthreshold dose hypnosis test
A pre-test is carried out before a formal test, and the sub-threshold hypnotic doses of the sodium pentobarbital are respectively determined to be 32mg/kg (administration for 7 days), 34mg/kg (administration for 14 days) and 35mg/kg (administration for 30 days), namely the maximum sub-threshold dose of the sodium pentobarbital of which 80-90% of mice turn over normal reflex does not disappear. 30min after animals are given the test article or pure water last time, the maximum sub-threshold hypnotic dose of the sodium pentobarbital is injected into the abdominal cavity of each group of animals, and the number of the animals falling asleep within 30min is recorded (the animals with the turn-over reflex disappeared for more than 1 min). The test was carried out in a quiet environment at 24-25 ℃.
(3) Test for prolonging sleep time of sodium pentobarbital
The pre-test is carried out before the formal test, the dose of the sodium pentobarbital which enables the animals to fall asleep for 100 percent but does not lead to overlong sleep time is respectively 53mg/kg (7 days and 14 days of administration) and 54mg/kg (30 days of administration), and the formal test is carried out by using the doses. After the animals are fully conscious in the sub-threshold dose hypnosis test of the pentobarbital, the pentobarbital sodium is injected into the abdominal cavity of each group of animals, the disappearance of the righting reflex is taken as an index, and the sleep time of the pentobarbital sodium prolonged by the test sample is observed.
(4) Barbiturate sodium sleep latency test
Before the formal test, a preliminary test is carried out, and the barbiturate sodium dose which enables the animals to fall asleep for 100% but does not lead to excessive sleep time is determined to be 270mg/kg (administration lasts for 33 days), and the formal test is carried out by using the dose. 30min after animals are given test samples with different formulas or pure water at the last time, injecting barbital sodium solution into abdominal cavities of animals of each group, and observing the influence of the test samples on the sleep latency of the barbital sodium by taking the disappearance of the righting reflex as an index.
(5) Statistics of test data
The metrology data was analyzed using one-way analysis of variance (ANOVA) or T-test. If the measured data has uniform variance, adopting single-factor analysis of variance LSD test. If the variance of the metrology data is not uniform, a one-way analysis of variance Dunnett's T3 test is used. The number of sleeping animals is counted by X2And (4) testing, and when the total case number of the four-table is less than 40, or the total case number is equal to or greater than 40 but the theoretical number is equal to or less than 1, applying an exact probability method.
(6) Determination of results
Direct sleep test: and comparing the difference between the number of the animals falling asleep and the sleeping time of the control group and the test group, and if the number of the animals falling asleep or the sleeping time is obviously increased, the test result is positive.
Pentobarbital sodium subthreshold dose hypnosis test: and comparing the difference between the numbers of the animals falling asleep in the control group and the test group, wherein the incidence rate of the animals falling asleep is obviously increased, and the test result is positive.
Test for prolonging sleep time of sodium pentobarbital: and comparing the difference between the test group and the control group in the sleep time extension, wherein the test result is positive if the sleep time extension is significant.
Barbiturate sodium sleep latency test: comparing the difference between the sleep latency of the control group and the sleep latency of the test group, if the sleep latency is obviously shortened, the test result is positive.
The test sample can be judged to have the function of improving the sleep function.
8. Test results
(1) Influence of three formula test samples of peanut stem leaves on direct sleep of mice
Animals in the test group were given 3 formulations of the test article and no direct sleep was observed in the negative control group after the same volume of solvent.
(2) Influence of three formula test samples of peanut stem leaves on number of mice pentobarbital sodium sleeping animals
When the test articles 1, 2 and 3 are administrated for 7 days, the number of animals falling asleep is 3, 4 and 2 respectively; at 14 days of administration, the number of sleeping animals was 2; the number of animals falling asleep at 30 days of administration was 3, 6 and 3, respectively. Through statistical analysis, the number of sleeping animals in each test sample group is increased, but the difference is not statistically significant compared with a negative control group (P > 0.05). Specific results are shown in table 1.
TABLE 1 Effect of test articles on the number of sleeping animals in mice
Note: n10
(3) Influence of three peanut stem leaf samples on prolonging of pentobarbital sodium sleep time of mice
Test article 2 tends to prolong the sleep time of the mice by 7 days when administered as compared with the negative control group (P ═ 0.07); the test products 1, 2 and 3 are administrated for 14 days, and the effect of prolonging the sleep time of the mouse is not found; the test article 1 and the test article 2 can be administrated for 30 days, and the sleep time of the mouse can be obviously prolonged (P is less than 0.05). The specific results are shown in Table 2.
TABLE 2 Effect of test articles on the prolongation of sleep time in mice
Note: n ═ 10, x: p <0.05 compared to the negative control group.
(4) Influence of three test samples of peanut stems and leaves on sleep latency of barbital sodium in mice
Through statistical analysis, the test article 2 can shorten the sleep latency of mice after being administrated for 33 days, and the difference has statistical significance (P is less than 0.05).
TABLE 3 Effect of test samples on sleep latency in mice
Note: n ═ 10, x: p <0.05 compared to negative control group
9. Conclusion of the experiment
After the test article 1, 2 and 3 preparation 30/33d with the dose of 57.1mg/kg is orally administered to the mice, compared with a negative control group, the test article 2 can obviously prolong the sleep time of the pentobarbital sodium mice after being administered for 30 days, the difference has significance (P <0.05), the sleep latency period of the pentobarbital sodium mice can be obviously shortened (P <0.05) after being administered for 33 days, and the direct sleep effect is avoided. From this, it was found that sample 2 had an effect of improving the sleep function of mice.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. A health-care composition with the effects of calming nerves and helping sleep is characterized by comprising the following raw materials in parts by weight:
65-85 parts of peanut stem leaf extract, 6-12 parts of aminobutyric acid, 5-10 parts of theanine and 5-10 parts of cordyceps militaris extract.
2. The health-care composition as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:
68-80 parts of peanut stem and leaf extract, 8-11 parts of aminobutyric acid, 6.5-10 parts of theanine and 5.5-9 parts of cordyceps militaris extract.
3. A health composition as claimed in claim 1 or 2, wherein the preparation method of the peanut stem and leaf extract comprises the steps of:
extracting stems and leaves of peanut with water to obtain an extracting solution, concentrating and drying to obtain a crude product of the extract of the stems and leaves of the peanut;
and (3) crushing and purifying the crude peanut stem and leaf extract to obtain the peanut stem and leaf extract.
4. A health composition as claimed in claim 3, wherein the extract of peanut stem and leaf is prepared by extracting peanut stem and leaf with water for 1-3 times;
preferably, the temperature of each extraction is respectively and independently 90-95 ℃, and the time of each extraction is respectively and independently 1-2 h;
preferably, the feed-liquid ratio of each extraction is 1: (5-10).
5. A health composition as claimed in claim 3, wherein the peanut stem and leaf extract is prepared by concentrating the extractive solution to specific gravity of 1.1-1.2;
preferably, the drying is spray drying;
preferably, the temperature of the spray drying is 190-210 ℃;
preferably, the pulverized particle size is 80-100 mesh.
6. A method for preparing a health composition with tranquilizing and sleep-aiding effects according to any one of claims 1 to 5, comprising the steps of:
mixing the raw materials to obtain the health-care composition with the effects of soothing nerves and helping sleep.
7. A health product, which is characterized by comprising the health composition with the effects of soothing the nerves and aiding sleep of any one of claims 1 to 5 and auxiliary materials.
8. The health product of claim 7, wherein the adjuvant comprises any one or a combination of at least two of a matrix, a suspending agent, a sweetener, or a disintegrant.
9. The health product according to claim 7 or 8, wherein the dosage form of the health product comprises any one of capsules, tablets, pills, granules or oral liquid.
10. Use of the health composition with tranquilizing and sleep-aiding effects of any one of claims 1 to 5 or the health product of any one of claims 7 to 9 in the fields of improving sleep and tranquilizing.
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