CN114667349A - 用于调节腺相关病毒(aav)和aav受体(aavr)之间的相互作用以改变aav生物分布的方法和组合物 - Google Patents

用于调节腺相关病毒(aav)和aav受体(aavr)之间的相互作用以改变aav生物分布的方法和组合物 Download PDF

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CN114667349A
CN114667349A CN202080077968.8A CN202080077968A CN114667349A CN 114667349 A CN114667349 A CN 114667349A CN 202080077968 A CN202080077968 A CN 202080077968A CN 114667349 A CN114667349 A CN 114667349A
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unmodified
modified
raav
capsid protein
aav
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Chinese (zh)
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E.津恩
C.蒂珀
L.H.范登贝格
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University of California San Diego UCSD
Massachusetts Eye and Ear
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Massachusetts Eye and Ear Infirmary
University of California San Diego UCSD
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14145—Special targeting system for viral vectors

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CN202080077968.8A 2019-09-09 2020-09-09 用于调节腺相关病毒(aav)和aav受体(aavr)之间的相互作用以改变aav生物分布的方法和组合物 Pending CN114667349A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962897973P 2019-09-09 2019-09-09
US62/897,973 2019-09-09
US201962934996P 2019-11-13 2019-11-13
US62/934,996 2019-11-13
PCT/US2020/050027 WO2021050614A2 (en) 2019-09-09 2020-09-09 Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav

Publications (1)

Publication Number Publication Date
CN114667349A true CN114667349A (zh) 2022-06-24

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CN202080077968.8A Pending CN114667349A (zh) 2019-09-09 2020-09-09 用于调节腺相关病毒(aav)和aav受体(aavr)之间的相互作用以改变aav生物分布的方法和组合物

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Country Link
US (1) US12570998B2 (https=)
EP (1) EP4028531A2 (https=)
JP (1) JP2022547197A (https=)
KR (1) KR20220054435A (https=)
CN (1) CN114667349A (https=)
AU (1) AU2020347165A1 (https=)
BR (1) BR112022004183A2 (https=)
CA (1) CA3153972A1 (https=)
IL (1) IL291136A (https=)
WO (1) WO2021050614A2 (https=)

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CA3153972A1 (en) 2019-09-09 2021-03-18 Massachusetts Eye And Ear Infirmary Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav
WO2022150634A2 (en) * 2021-01-08 2022-07-14 Massachusetts Eye And Ear Infirmary Methods and compositions for modulating the interaction between adeno-associated virus (aav) and the aav receptor (aavr) for altered bio-distribution of aav
US20240352077A1 (en) * 2021-08-25 2024-10-24 Children's Medical Research Institute Modified aav capsids and vectors
US20240425549A1 (en) * 2021-08-25 2024-12-26 Children's Medical Research Institute Modified aav capsid polypeptides and vectors
KR20240095539A (ko) 2021-10-08 2024-06-25 디노 테라퓨틱스, 인코포레이티드 캡시드 변이체 및 이의 사용 방법
WO2023095034A1 (en) * 2021-11-24 2023-06-01 Novartis Ag Modulators of adeno-associated virus transduction and uses thereof
WO2023106256A1 (ja) * 2021-12-06 2023-06-15 学校法人順天堂 改変型アデノ随伴ウイルスベクター
WO2024238807A2 (en) 2023-05-16 2024-11-21 Affinia Therapeutics Inc. Recombinant aavs with improved tropism and specificity
WO2025179124A1 (en) * 2024-02-23 2025-08-28 The Board Of Regents Of The University Of Texas System Enhanced aav9 capsid protein
WO2025194042A1 (en) 2024-03-14 2025-09-18 Affinia Therapeutics Inc. Plasmid system for production of recombinant adenoassociated virus
WO2025235491A1 (en) 2024-05-07 2025-11-13 Affinia Therapeutics Inc. Recombinant aav for treatment of cardiac diseases

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CA3153972A1 (en) 2021-03-18
IL291136A (en) 2022-05-01
US12570998B2 (en) 2026-03-10
AU2020347165A1 (en) 2022-03-31
WO2021050614A3 (en) 2021-05-20
EP4028531A2 (en) 2022-07-20
KR20220054435A (ko) 2022-05-02
WO2021050614A2 (en) 2021-03-18
US20220411820A1 (en) 2022-12-29
BR112022004183A2 (pt) 2022-05-31
JP2022547197A (ja) 2022-11-10

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