CN1146446C - Absorbent stitch of tail tendon of cynogale and its preparing process - Google Patents

Abstract

The present invention relates to an absorbent suture thread from tail tendons of a mampalon and a preparation method thereof, which belongs to the technical field of a medical suture thread. The absorbent suture thread is prepared by the steps: drawing a plurality of fiber collagen tail tendons from the bundles of tail tendons of the tail of a mampalon, wherein the basic structure unit of each fiber collagen tail tendon is three strands of spiral procollagen rod substances, and the three peptide chains all have helical conformation; tanning the drawn tail tendons in unsaturated fatty acid oil to obtain unsaturated fatty acid, wherein at least two double-bonds form a bond with the tail tendon collagen so as to form the absorbent suture thread. The absorbent suture thread of the present invention has no irritation, or pain or residual scars on human bodies, and can fall automatically without folding threads; a sutured part can heal smoothly and flatly.

Description

Absorbent stitch of tail tendon of cynogale and manufacture method thereof

The invention belongs to the suture technical field, relate to a kind of absorbent stitch of tail tendon of cynogale and manufacture method thereof.

The main at present gutstring that adopts beaters' skin to manufacture of suture, this gutstring keeps the tension force time in tissue for prolonging gutstring in manufacturing process, the most normal employing ' chromising " method; the chromium ion in the gutstring can between collagen fiber, form ' key ", digested and assimilated the delayed absorption process but can make it difficult, tissue reaction's time is long, sometimes even cause wound suppuration, and heavy metal chromium has been the carcinogenic danger material by generally acknowledging, and it is always disadvantageous to human body to contain chromium in gutstring.

The objective of the invention is to provide a kind of without any chemical treatment, can be absorbed by animal tissue, human body there is not any negative interaction, between its tension period with absorb during synchronously, sew up nonirritant when using, do not have pain, no impression, do not cut tissue, let the acupuncture needle remain at a certain point and the line eye, need not take out stitches, sew up mouth heal smooth, a slick absorbent stitch of tail tendon of cynogale and a manufacture method thereof.

The objective of the invention is to realize with the following methods.

Absorbent stitch of tail tendon of cynogale is that the tail muscle of bunchy extracts one by one one-tenth viscose protocercal tail muscle from the mampalon tail, its basic structural unit is the procollagen of triple helix, procollagen is the shaft that is about 3000A diameter 15A, wherein three peptide chains all have helical conformation, the tail muscle of taking-up obtain after with the unsaturated fatty acid oil tanning unsaturated fatty acid have at least two two keys and the formation of tail muscle collagen ' key ".The otter lithium is a kind of Herbivore, is easy to the artificial breeding, and reproductive capacity is strong, carried out a large amount of artificial breedings in China some areas, as a kind of economic animal, its economic worth is mainly on its fur and meat, the mampalon tail mainly as edible, is not developed other purposes yet.The present invention extracts the tail muscle from tail after the mampalon tail is cut off from first coccygeal vertebra, and the tail muscle on the tail is a fasciculation, and each root tail has 4-5 Beam End muscle, and every tail can extract 40-50 bar tail muscle, every length 20-40cm.

The manufacture method of absorbent stitch of tail tendon of cynogale of the present invention is:

1, mampalon is put to death: with the mampalon mouth immerse one with consistent mouthful of cylinder of mouth size in, Sheng ethanol is choked to death it in it, the advantage of this kind processing method is that the tail muscle is easy to extraction and does not rupture.

2, adopt the method for sterile working that the mampalon tail is cut off from the mampalon first coccygeal vertebra, afterbody disinfects in alcohol, places sterile trays, covers antiseptic gauze, send sterilizing room to extract the tail muscle.

3, under aseptic operating condition, extract one one tail muscle from the tail end of mampalon tail, clean with aseptic ionized water then, scrape off surface fat and impurity.

4, oil tanning: with unsaturated fatty acid tanning tail muscle: relative humidity 90%-100%, oil mass is tail muscle weight 8-12%, guarantee sufficient oxygen, machinery is rubbed the operation of tanning with the hands under warm air, used unsaturated fatty acid is vegetable oil such as Oleum Camelliae, vegetable oil etc. or fish oil, cod-liver oil etc., and the warm air temperature is 28-30 ℃.

5, after tanning is finished, clean tail muscle stitching thread goods several times with 30-40 ℃ of hot water, dry then, or be kept in the normal saline.

6, divide grade packaged stitching thread, divide grade packagedly by suture diameters size and length,, become spendable product, can preserve 3 years through sterilizing;

The absorbent stitch of tail tendon of cynogale that the present invention produces, earlier after rabbit and dog experimental observation obtain satisfied effect, done clinical trial through hospitals such as attached two hospitals of Hunan Medical University, People's Hospital, Hunan Prov., result of the test proves, sutural stitching of the present invention to the human body nonirritant, do not have pain, no cicatrix, do not cut tissue, let the acupuncture needle remain at a certain point and the line eye, need not take out stitches, can come off voluntarily, it is smooth, smooth to sew up mouthful healing.

Be the embodiment that do not limit of the present invention below:

With the mampalon mouth immerse one with the consistent mouth of mouth size cylinder in, contain 96% ethanol in it, it is choked to death, adopts the method for sterile working, cut off from the mampalon first coccygeal vertebra, afterbody is placed in the sterile trays with 75% alcohol disinfecting, cover antiseptic gauze, send sterilizing room to extract the tail muscle, under aseptic operating condition, extract the tail muscle from tail end, clean with aseptic ionized water then, scrape off surface fat and impurity.The tail muscle of cleaning placed on the aseptic balance weigh, use unsaturated fatty acid afterwards, as fish oil, the vegetable oil consumption is that 10% pair of tail muscle of tail muscle weight carries out oil tanning, making humidity during oil tanning is 90%-100%, guarantee sufficient oxygen, after tanning is finished under 28-30 ℃ the warm air, clean several times with 40 ℃ of hot water, dry then or preserve in the normal saline, tail muscle stitching thread is divided grade packaged, divide grade packaged by sutural diameter of tail muscle and length, get final product through the laser sterilization again, the absorbent stitch of tail tendon of cynogale of made has the quality softness, careful, good permeability, water-fast, dry indeformable.Tail muscle of the present invention absorbs sutural collagen and not decomposed by general hydrolysising protease, only decompose for collagenase, in human body under the neutral pH value, extracellular collagen can be by degraded by collagenase, degradation time 10-14 days, consistent with the time that stitching back organization healing needs, wound tissue's healing and stitching thread are absorbed synchronously.That sutural single fracture strength 30um is thick is 650g, and the suture length of making is generally 20-40cm, and thickness 20-900um has all reached the intensity and the length of surgical operation requirement.

Claims (5)

1, a kind of absorbent stitch of tail tendon of cynogale, it is characterized in that this stitching thread is that the tail muscle of bunchy extracts one by one one-tenth viscose protocercal tail muscle from the mampalon tail, its basic structural unit is the procollagen of triple helix, procollagen is the shaft that is about 3000A diameter 15A, wherein three peptide chains all have helical conformation, the tail muscle of taking-up obtain after with unsaturated lipid acid-proof oil tanning unsaturated fatty acid have at least two two keys form with tail muscle collagen ' key " tail muscle absorption stitching thread.

2, the manufacture method of the described absorbent stitch of tail tendon of cynogale of claim 1 is characterized by:

A, mampalon is put to death,

B, the mampalon tail is cut off from the mampalon first coccygeal vertebra, afterbody disinfects in alcohol,

C, the tail end from the mampalon tail under aseptic operating condition extract the tail muscle, clean the tail muscle with aseptic ionized water then, scrape off surface fat and impurity,

D, oil tanning: with unsaturated fatty acid tanning tail muscle,

After e, tanning are finished, clean tail muscle stitching thread goods several times with hot water, dry then, or be kept in the normal saline,

F, divide grade packaged tail muscle stitching thread, divide grade packagedly by suture diameters size and length, sterilize.

3, the manufacture method of absorbent stitch of tail tendon of cynogale according to claim 2, the method that it is characterized in that putting to death mampalon be with the mampalon mouth immerse one with of the same size mouthful of cylinder of mouth in, contain ethanol in it, it is choked to death.

4, the manufacture method of absorbent stitch of tail tendon of cynogale according to claim 2 is characterized in that used unsaturated fatty acid is fish oil or vegetable oil.

5, the manufacture method of absorbent stitch of tail tendon of cynogale according to claim 2, it is characterized in that in relative humidity 90-100%, unsaturated fatty acid oil mass being the 8-12% of tail muscle stitching thread weight, the temperature that guarantees sufficient oxygen, warm air is under the 28-30 ℃ of condition tail muscle stitching thread to be rubbed with the hands to tan.