CN85108766A - Suture of amniotic membrane and preparation method thereof - Google Patents
Suture of amniotic membrane and preparation method thereof Download PDFInfo
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- CN85108766A CN85108766A CN 85108766 CN85108766A CN85108766A CN 85108766 A CN85108766 A CN 85108766A CN 85108766 CN85108766 CN 85108766 CN 85108766 A CN85108766 A CN 85108766A CN 85108766 A CN85108766 A CN 85108766A
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- amniotic membrane
- suture
- membrane
- soaking
- fat
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Abstract
Suture of amniotic membrane is the new suture material of a kind of surgical operation.Be the rete layer of personnel selection fetal membrane, slough the fat, albumen on surface after, form through the chrome tanning system of soaking.The clinical observation of example proves this suture of amniotic membrane surplus 920, has nature and absorbs, need not take out stitches, not have the characteristics that immunological rejection, postoperative do not have pain, no clear scar.Be applicable to various operation stitching usefulness, the particularly operation stitching of face amount surgery, plastic surgery, ophthalmology and various internal organs, remarkable with this line effect.
Description
Suture of amniotic membrane is the new suture material of a kind of surgery.
The stitching thread that present surgical stapling art is generally used has: catgut, silk thread, nylon wire, metal wire etc.Use these stitching thread, postoperative can not absorb, need take out stitches, have pain naturally, clear scar be arranged after more.Though catgut need not be taken out stitches when internal organs are sewed up, soak time is very long, often sees catgut because of not being organized absorption in clinical practice, finally the phenomenon of being ostracised out in the body.Just be absorbed entirely through about 20 days and the amniotic membrane line is the longest.
The objective of the invention is to, provide a kind of and absorb naturally, need not take out stitches, not have immunological rejection, postoperative not to have the novel stitching thread of pain, no clear scar.
The present invention realizes like this, with the rete layer of the fresh fetal membrane of people's term labor, through clean knifing, weigh, slough the film surface fat, clean knifing again, weigh, slough membrane surface protein again, cut bar, soak chrome tanning system, sterilize, twist thread, operation such as sterilization is made again.It is in proper order:
1, cleans knifing:, after cleaning with clear water, scrape off lip-deep moisture content and impurity with the fresh amnion that separates.
2, weigh: will clean the amniotic membrane of scraping, and weigh one by one with balance.
3, slough the film surface fat: the amniotic membrane after will weighing, soak a period of time with 10 times of sodium hydroxide solutions of 1% to amniotic membrane weight, slough the fat on film surface.
4, clean knifing again: clean amniotic membrane with clear water, scrape off the fat and the mucus impurity on amniotic membrane surface then.
5, weigh again:, weigh one by one again with balance with the amniotic membrane of scraping fat.
6, slough the albumen on film surface: weigh for sodium chloride solution immersion amniotic membrane a period of time of 1% with 10 times to film, slough the amniotic membrane proteins on surfaces.
7, cut bar: will slough fat and proteic amniotic membrane, clean with clear water, according to the thin and thick of amniotic membrane, vary in size, be slit into the amniotic membrane bar of all size of width from 0.33 to 33mm.
8, soak chrome tanning system: the amniotic membrane bar that will cut, carried out tanning with 10 times in 24 hours to the heavy chromic oxide solution soaking of amniotic membrane bar.
In the chrome tanning system of soaking process, in order to increase the tension intensity of amniotic membrane line, the active ingredient in the solution is fully entered in the amnion tissue, soak after 12 hours, add 0.05 times of heavy sodium bicarbonate of bar and continue to soak 12 hours.Difference according to required line makes pH value reach 5～7.
Internal organs and ophthalmic amniotic membrane line, soaking chromium concn is 1%, pH value is 5.Seam skin amniotic membrane line, soaking chromium concn is 0.1%, pH value is 7.
9, sterilization: the amniotic membrane bar of handling through the chrome tanning system of soaking, after cleaning with clear water, be placed in 0.1% the bromo geramine solution and soaked 30 minutes, twist thread then.
1. before twisting thread, indoor elder generation carries out 20 minutes air sterillization with ultraviolet, makes indoorly to carry out twisting process after aseptic.
2. operator brushed hands earlier before twisting thread, and began to palm, the back of the hand, brushed arm to elbow joint at last from finger tip.
3. steeped hands 3～5 minutes with 0.1% bromo geramine solution.
10, packaged sterile again: be placed in the disinfectant solution and soaked 6 hours twisting with the fingers the line that twines, carry out sterilization once more, then encapsulation.
Effect of the present invention is, observe through animal experiment earlier, done the clinical observation experiment of example surplus in the of 920 again, these experiments comprise: facial trauma is sewed up, limb trauma is sewed up, eye conjunctiva, cornea stitching, powder tumor resection stitching, cesarean, uterus pick entirely, resection of uterine leiomyoma, perineal laceration, vaginal laceration, perineum side cutting stitching, ranular, interior outer lip sebaceous cyst, chapped lip stitching, thyroidectomy stitching, intestinal anastomosis stitching, hepatorrhexis stitching etc.Through clinical observation, prove that this line has nature and absorbs, and the absorption phase is short, seam skin absorbed about 7 days, and cornea absorbed about 17 days, and each organ of internal organs absorbed about 20 days.Postoperative need not taken out stitches, tie lines comes off naturally, no immunological rejection, postoperative do not have characteristics such as pain, NIP, the reaction of no tie lines, no cicatrix.
Be the sutural most preferred embodiment that the present invention makes internal organs and ophthalmic below.
Amniotic membrane with the fresh fetal membrane internal layer of people's term labor, clean and scrape off the moisture content and the impurity on surface with clear water, weigh 1% sodium hydroxide solution with 10 times to film and soak a period of time, scrape off the fat on film surface, 10 times of reuse weigh 1% sodium chloride solution to film and soak a period of time, scrape off the protein on film surface, cut out the wide amniotic membrane bar of 1mm after cleaning with clear water.
The amniotic membrane bar that cuts be placed on 10 times to bar weigh soak 12 hours in 1% the chromic oxide solution after, adds 0.05 times of heavy sodium bicarbonate of bar and continues immersion 12 hours, make pH value reach 5.After the amniotic membrane bar that will soak chrome tanning system is cleaned with clear water, be placed in 0.1% the bromo geramine solution sterilization 30 minutes, then the amniotic membrane bar twisted with the fingers into line, after the drying, the amniotic membrane line of No. 5/0 internal organs and ophthalmic just has been made into.
Claims (4)
1, suture of amniotic membrane is the new suture material of a kind of surgical operation, it is characterized in that, it is internal layer--the amniotic membrane of personnel selection fetal membrane, forms through the chrome tanning system of soaking.
2, suture of amniotic membrane as claimed in claim 1 is characterized in that, what adopted is the rete layer of the fresh fetal membrane of people's term labor.
As claim 1,2 described suture of amniotic membrane, it is characterized in that 3, amniotic membrane is handled through fat and the albumen of sloughing the surface earlier.
4, suture of amniotic membrane as claimed in claim 3 is characterized in that, amniotic membrane is through soaking chrome tanning system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN85108766A CN85108766B (en) | 1985-11-22 | 1985-11-22 | Suture of amniotic membrane and its mfg process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN85108766A CN85108766B (en) | 1985-11-22 | 1985-11-22 | Suture of amniotic membrane and its mfg process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85108766A true CN85108766A (en) | 1986-07-23 |
| CN85108766B CN85108766B (en) | 1988-02-17 |
Family
ID=4796135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN85108766A Expired CN85108766B (en) | 1985-11-22 | 1985-11-22 | Suture of amniotic membrane and its mfg process |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN85108766B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100379466C (en) * | 2006-05-26 | 2008-04-09 | 肖忠渊 | Surgical sewing wire for medical use |
| WO2018039294A1 (en) * | 2016-08-24 | 2018-03-01 | Arthrex, Inc. | Tissue use for repair of injury |
| CN111905140A (en) * | 2020-05-26 | 2020-11-10 | 山东省科学院新材料研究所 | Multifunctional absorbable collagen medical suture and preparation method thereof |
| US11511017B2 (en) | 2019-03-12 | 2022-11-29 | Arthrex, Inc. | Ligament reconstruction |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420488C (en) * | 2003-06-03 | 2008-09-24 | 天津市久康生物工程开发有限公司 | Absorbable medical chitin suture lines and their production |
-
1985
- 1985-11-22 CN CN85108766A patent/CN85108766B/en not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100379466C (en) * | 2006-05-26 | 2008-04-09 | 肖忠渊 | Surgical sewing wire for medical use |
| WO2018039294A1 (en) * | 2016-08-24 | 2018-03-01 | Arthrex, Inc. | Tissue use for repair of injury |
| CN109641078A (en) * | 2016-08-24 | 2019-04-16 | 阿瑟雷克斯股份有限公司 | For repairing the tissue of damage |
| AU2017316682B2 (en) * | 2016-08-24 | 2020-10-15 | Arthrex, Inc. | Tissue use for repair of injury |
| US10987209B2 (en) | 2016-08-24 | 2021-04-27 | Arthrex, Inc. | Tissue use for repair of injury |
| IL264536B1 (en) * | 2016-08-24 | 2023-05-01 | Arthrex Inc | Tissue use for repair of injury |
| IL264536B2 (en) * | 2016-08-24 | 2023-09-01 | Arthrex Inc | Tissue use for repair of injury |
| US11918453B2 (en) | 2016-08-24 | 2024-03-05 | Arthrex, Inc. | Tissue use for repair of injury |
| US11511017B2 (en) | 2019-03-12 | 2022-11-29 | Arthrex, Inc. | Ligament reconstruction |
| CN111905140A (en) * | 2020-05-26 | 2020-11-10 | 山东省科学院新材料研究所 | Multifunctional absorbable collagen medical suture and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN85108766B (en) | 1988-02-17 |
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