CN85108766B - Novel surgical suture - Google Patents
Novel surgical suture Download PDFInfo
- Publication number
- CN85108766B CN85108766B CN85108766A CN85108766A CN85108766B CN 85108766 B CN85108766 B CN 85108766B CN 85108766 A CN85108766 A CN 85108766A CN 85108766 A CN85108766 A CN 85108766A CN 85108766 B CN85108766 B CN 85108766B
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- CN
- China
- Prior art keywords
- surgical sutures
- amniotic membrane
- hours
- people
- cicatrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
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- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims abstract description 19
- 210000001691 amnion Anatomy 0.000 claims abstract description 12
- 238000002791 soaking Methods 0.000 claims abstract description 5
- 210000004379 membrane Anatomy 0.000 claims abstract 2
- 239000012528 membrane Substances 0.000 claims abstract 2
- 210000002219 extraembryonic membrane Anatomy 0.000 claims description 8
- 229910052804 chromium Inorganic materials 0.000 claims description 7
- 239000011651 chromium Substances 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 abstract description 10
- 231100000241 scar Toxicity 0.000 abstract description 8
- 238000010521 absorption reaction Methods 0.000 abstract description 5
- 102000004169 proteins and genes Human genes 0.000 abstract description 4
- 108090000623 proteins and genes Proteins 0.000 abstract description 4
- 210000002826 placenta Anatomy 0.000 abstract 1
- 210000000589 cicatrix Anatomy 0.000 description 16
- 208000027418 Wounds and injury Diseases 0.000 description 11
- 206010052428 Wound Diseases 0.000 description 10
- 239000002729 catgut Substances 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 230000002980 postoperative effect Effects 0.000 description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 8
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 125000001246 bromo group Chemical group Br* 0.000 description 4
- 210000004087 cornea Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 230000029663 wound healing Effects 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- WGLPBDUCMAPZCE-UHFFFAOYSA-N Trioxochromium Chemical compound O=[Cr](=O)=O WGLPBDUCMAPZCE-UHFFFAOYSA-N 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 208000034693 Laceration Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 2
- 150000001845 chromium compounds Chemical class 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000004969 inflammatory cell Anatomy 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 2
- 239000001117 sulphuric acid Substances 0.000 description 2
- 235000011149 sulphuric acid Nutrition 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 206010003011 Appendicitis Diseases 0.000 description 1
- 208000031868 Calculus ureteric Diseases 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 206010011732 Cyst Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241000283898 Ovis Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000000014 Ureteral Calculi Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 206010009259 cleft lip Diseases 0.000 description 1
- 210000000795 conjunctiva Anatomy 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000003544 deproteinization Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000002310 elbow joint Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000002682 general surgery Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 210000000537 nasal bone Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 206010034878 phimosis Diseases 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000009146 rhinoscleroma Diseases 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- -1 silk thread Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000009804 total hysterectomy Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 210000003934 vacuole Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The surgical suture is made up by using amniotic membrane of human placenta membrane through the processes of removing fat and protein from its surface and soaking in chrome and tanning. It has the features of natural absorption, no need of removing suture, natural falling of suture knot, no pain after operation and no obvious scar.
Description
The present invention relates to a kind of new surgical sutures, particularly relating to a kind of is not stay cicatrix or slight new surgical stitching thread and its manufacture method of cicatrix behind can absorbing naturally of making of raw material, the wound healing with people's term labor fetal membrane, and application clinically.
The stitching thread that present surgical stapling art is generally used has: catgut, silk thread, nylon wire, metal wire etc.Use these stitching thread, postoperative can not absorb naturally, need take out stitches, have pain, clear scar be arranged after more.Though catgut is used for need not taking out stitches when internal organs are sewed up, soak time is longer, often can see catgut because of not being organized absorption in clinical practice, and final phenomenon of being ostracised out in the human body makes the patient be subjected to misery, makes troubles to clinical treatment.
The tradition catgut is made and is roughly comprised three key steps: at first be processing sheep casing material, it comprises with being equivalent to triple 0.2% sodium peroxide of casing weight handles Intestinum caprae seu ovis, soak 2 hours with defat with the duple 1% sodium peroxide liquid of its casing weight afterwards, this process takes 26 hours.Next is that the casing that will handle well cuts system line and bleaching, the intestinal band of bleaching is cleaned to be placed on ordinary water soak (10～15 minutes) in 0.05%～0.1% sulphuric acid liquid, and this process takes 72 hours.Be chrome tanning at last, the intestinal band that is about to handle well is immersed in intestinal and weighs and added in 0.3% formaldehyde chrome tanning in 1.5 times of 2.5% chromium solution 16 hours, handles 2 hours with 1% sodium bicarbonate solution afterwards.This method entire making process need reach 104～116 hours, must use volatility, zest reagent (as sulphuric acid, formaldehyde etc.), and needs the chromium compound of higher concentration.Water consumption is big during cleaning, simultaneously environment is had certain pollution.
For overcoming the existing deficiency of above-mentioned stitching thread, the inventor has been developed into a kind of new surgical sutures through years of researches and practice.This stitching thread selects for use people's fetal membrane as raw material, forms through defat fat, deproteinization, the chrome tanning system of soaking.For this reason, the invention provides a kind ofly can absorb naturally, need not take out stitches, novel stitching thread that postoperative does not have pain, no clear scar, provide a kind of new material source in particular for the surgical sutures that is used to sew up viscera tissue.
The sutural processing technology of section comprises outside the present invention:
1. the processing of fetal membrane:, clean also and in 1% sodium hydroxide solution, soaked 12 hours with the rete layer of the fresh fetal membrane of people's term labor; Scrape the fat on striping surface; Soaked 24 hours in 1% heavy sodium chloride solution of film at 10 times after weighing, in order to slough the protein on film surface.This process takes 36 hours.
2. cut bar and chrome tanning: film is layered on the work top, scraped the protein on film surface, be slit into the amniotic membrane bar of the various different in width of 0.33mm～33mm according to the thickness of film, the difference of size, promptly weigh afterwards and be immersed in 10 times and in the heavy chromic oxide solution of bar, carry out chrome tanning.Behind the chrome tanning 24 hours, put into 0.05 times of heavy sodium bicarbonate of bar and continue to soak 24 hours.Soak chromium concn from 0.05%～1% according to the difference of purposes, its pH value is between 5～7.
Internal organs and ophthalmic line, soaking chromium concn is 0.8%～1%, pH value is 5; Seam skin line soaks chromium concn between 0.05～0.1%, and pH value is 7, and it is 48 hours that this chrome tanning process takes.
3. twist thread: clean with clear water and soak after the amniotic membrane bar that chromium handled, place the immersion of 0.1% bromo geramine solution to twist thread in 30 minutes.Before twisting thread, indoor ultraviolet air exposure sterilization 20 minutes, operator are with 0.1% bromo geramine vacuole hands 3～5 minutes and brush hands to elbow joint.
Total 84.5 hours consuming time of stitching thread processing technology of the present invention, few 32 hours consuming time of more traditional catgut.Used medicine is simple in the processing technology, mainly is sodium hydroxide, sodium chloride, sodium bicarbonate and a small amount of bromo geramine, can not produce too much pollution to environment, in the chrome tanning process, soaks chromium concn and is up to 1%, has reduced the consumption of chromium compound.
Because what adopt is a kind of new material, used medicine is different with traditional gutstring.Particularly selecting people's fetal membrane for use is raw material, for a new material source has been found in the making of surgical sutures.
Surgical sutures of the present invention can be used for clinical each section's operation stitching, has it and absorbs naturally, the characteristics of need not take out stitches, postoperative not having pain, no clear scar.
Through 60 catguts and this new molded lines animal contrast test, in the position portion of the liver of white mouse, stomach, blue tail, stitching between the while, 20 days laparotomy explorations of postoperative, this new molded lines is absorbed, and wound healing is good; Catgut is still high-visible.Position portion at the liver of rabbit, stomach, cornea, back is sewed up simultaneously, get 22 days local organizations of rabbit back postoperative and do pathological section, this new molded lines is not seen inflammatory cell, is organized absorption fully, and catgut is not absorbed, and partial groups is woven with a spot of various inflammatory cell infiltration; Especially sew up comparatively satisfiedly with rabbit cornea contrast, postoperative 38 days is observed with 6 times of magnifieres, and wound healing is good, no cicatrix, and eyeball is smooth to become clear, and catgut is still high-visible.Following table 1 is to use new surgical stitching thread of the present invention to make the result of the effect observation of animal wound stitching.
| Stitching thread | The suture site | Canis familiaris L. (3 example) | White mouse (23 example) | Rabbit (34 example) | ||||||
| * time | Cicatrix | The repulsion time | * time | Cicatrix | The repulsion time | * time | Cicatrix | The repulsion time | ||
| New molded lines | Liver | 19 | Do not have | Do not have | 18 | Do not have | Do not have | 18 | Do not have | Do not have |
| Stomach | 20 | Do not have | Do not have | 18 | Do not have | Do not have | 19 | Do not have | Do not have | |
| Cornea | 16 | Do not have | Do not have | 17 | Do not have | Do not have | 16 | Do not have | Do not have | |
| Back | 7 | Do not have | Do not have | 7 | Do not have | Do not have | 6 | Do not have | Do not have | |
| Catgut | Liver | 85 | Have | Have | 90 | Have | Have | 90 | Have | Have |
| Stomach | 80 | Have | Have | 85 | Have | Have | 80 | Have | Have | |
| Cornea | 80 | Have | Have | 85 | Have | Have | 87 | Have | Have | |
| Back | 75 | Have | Have | 75 | Have | Have | 80 | Have | Have | |
* be that the average absorbed natural law of back two kinds of stitching thread is sewed up in this treated animal wound contrast.
Can find out that from table 1 novel line absorption time short, it is good that postoperative does not have cicatrix, no rejection, wound healing.And the absorbed time of catgut is long, and the wound cicatrix is more obvious.
New surgical sutures 920 routine clinical observations.920 examples in gynecological, obstetrics, the department of stomatology, Urology Surgery, general surgery, ophthalmology, decorative sursery, plastic surgery, otology, have been made, clinical observation more than a year, this new molded lines all can be absorbed, the people that the wound cicatrix disappeared in 1 year has more than 90%, and the wound does not have scleroma, and following table 2 has been summed up with these new molded lines 920 routine clinical observation situations.
| Operation names | Number | Inflammation | Pain stimulation | Toe-in * comes off day | Rejection | 1 year cutter (wound) of postoperative mouthful cicatrix | Success | Remarks |
| The total hysterectomy of abdomen formula | 11 | Do not have | Do not have | 10 | Do not have | Do not have | Success 11 people | |
| The neck tube laceration is sewed up | 10 | ″ | ″ | 7 | ″ | Do not have | ″10″ | |
| Perineorrhaphy | 150 | ″ | ″ | 6 | ″ | Do not have | ″150″ | |
| Cesarean | 50 | ″ | ″ | 7 | ″ | Do not have | ″50″ | |
| The excision of mouth mucus cyst | 121 | ″ | ″ | 7 | ″ | Light or do not have | ″120″ | 1 people is obvious because of being the scar diathesis cicatrix |
| The bicker wound is sewed up | 19 | ″ | ″ | 6 | ″ | Do not have | ″19″ | |
| Thyroid time full excision | 8 | ″ | ″ | 8 | ″ | Light or do not have | ″7″ | 1 people is obvious because of being the scar diathesis cicatrix |
| The appendicitis operation | 50 | ″ | ″ | 8 | ″ | ″ | ″45″ | 5 people are burst at the seams because of route selection is meticulous |
| The scalp wound is sewed up | 123 | ″ | ″ | 7 | ″ | ″ | ″120″ | 3 people are obvious because of being the scar diathesis cicatrix |
| Brothers' wound is sewed up | 131 | ″ | ″ | 7 | ″ | ″ | ″122″ | 9 people are burst at the seams because of route selection is meticulous |
| The ureteral calculus excision | 4 | ″ | ″ | 7 | ″ | Do not have | ″4″ | |
| The long excision of phimosis | 9 | ″ | ″ | 7 | ″ | ″ | ″9″ | |
| The nasal bone anaplasty | 4 | ″ | ″ | 7 | ″ | ″ | ″4″ | |
| Facial trauma is sewed up | 201 | ″ | ″ | 7 | ″ | Light or do not have | ″193″ | 8 people are obvious because of being the scar diathesis cicatrix |
| Harelip suture | 4 | ″ | ″ | 8 | ″ | Do not have | ″4″ | |
| The lid injury suture | 18 | ″ | ″ | 7 | ″ | ″ | ″18″ | |
| Bulbar conjunctiva laceration suture | 4 | ″ | ″ | 18 | ″ | ″ | ″4″ | |
| Eye sclera wound suture | 3 | ″ | ″ | 16 | ″ | ″ | ″3″ | |
| Add up to | 920 | Do not have | Do not have | Do not have | Success 893 people | Success rate 97% |
* in the table toe-in to come off day be average date.
As seen from the above table, this line has nature and absorbs, and characteristics, success rate 97% such as the absorption phase is short, postoperative need not taken out stitches, tie lines comes off naturally, no pain, NIP and exudate, no rejection, no cicatrix or cicatrix are light.Though this new molded lines tensile strength is weaker than other stitching thread, clinical observation can be satisfied each section's requirements of operation enough.
Embodiment 1:
The making of new No. 5/0 line of surgical sutures ophthalmology.
The rete layer of the fresh fetal membrane of people's term labor is cleaned, and be immersed in 1% the sodium hydroxide solution 12 hours, scrape off the fat on film surface afterwards, be immersed in 10 times after weighing and weigh in 1% the sodium chloride solution 24 hours to film, then film is layered on the work top, scrape off the protein on film surface, then cut out the wide amniotic membrane bar of 1mm.The amniotic membrane bar be immersed in 10 times in the heavy chromic oxide solution of bar 24 hours, add 0.05 times of heavy sodium bicarbonate of bar afterwards and continue to soak 24 hours, make pH value reach 5.The amniotic membrane bar that chrome tanning is good is cleaned with clear water, is placed on to soak in 0.1% the bromo geramine liquid to take out in 30 minutes, and the amniotic membrane bar is twisted with the fingers into line, has promptly made the ophthalmic line after the drying No. 5/0.
Embodiment 2:
The making of new No. 0 line of surgical stapling linear slit skin.
With the fresh amnion of people's term labor, handle with quadrat method through above-mentioned, be slit into the wide amniotic membrane bar of 15mm, be immersed in chrome tanning in 0.08% the chromic oxide solution, become promptly to have made behind the line epidermis with No. 0 stitching thread.
Claims (4)
1, a kind of new surgical sutures is characterized in that, it be the personnel selection fetal membrane internal layer-amniotic membrane be raw material, through sloughing the fat on its surface, the albumen chrome tanning system of soaking forms.
2, new surgical sutures as claimed in claim 1 is characterized in that, the amniotic membrane that is adopted is the rete layer of the fresh fetal membrane of people's term labor.
As claim 1,2 described new surgical sutures, it is characterized in that 3, amniotic membrane is handled through fat and the albumen of sloughing the surface with 36 hours time earlier.
4, new surgical sutures as claimed in claim 3 is characterized in that, amniotic membrane is through soaking chromium concn 0.05%～1%, pH value tanning between (5～7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN85108766A CN85108766B (en) | 1985-11-22 | 1985-11-22 | Novel surgical suture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN85108766A CN85108766B (en) | 1985-11-22 | 1985-11-22 | Novel surgical suture |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN85108766A CN85108766A (en) | 1986-07-23 |
| CN85108766B true CN85108766B (en) | 1988-02-17 |
Family
ID=4796135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN85108766A Expired CN85108766B (en) | 1985-11-22 | 1985-11-22 | Novel surgical suture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN85108766B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420488C (en) * | 2003-06-03 | 2008-09-24 | 天津市久康生物工程开发有限公司 | Chitosan absorbable medical suture and manufacturing method thereof |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100379466C (en) * | 2006-05-26 | 2008-04-09 | 肖忠渊 | Surgical sewing wire for medical use |
| CN109641078A (en) * | 2016-08-24 | 2019-04-16 | 阿瑟雷克斯股份有限公司 | For repairing the tissue of damage |
| US11511017B2 (en) | 2019-03-12 | 2022-11-29 | Arthrex, Inc. | Ligament reconstruction |
| CN111905140A (en) * | 2020-05-26 | 2020-11-10 | 山东省科学院新材料研究所 | Multifunctional absorbable collagen medical suture and preparation method thereof |
-
1985
- 1985-11-22 CN CN85108766A patent/CN85108766B/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100420488C (en) * | 2003-06-03 | 2008-09-24 | 天津市久康生物工程开发有限公司 | Chitosan absorbable medical suture and manufacturing method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN85108766A (en) | 1986-07-23 |
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