CN114617787B - High-stability composition for protecting whitening agent and application thereof - Google Patents
High-stability composition for protecting whitening agent and application thereof Download PDFInfo
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- CN114617787B CN114617787B CN202111442662.0A CN202111442662A CN114617787B CN 114617787 B CN114617787 B CN 114617787B CN 202111442662 A CN202111442662 A CN 202111442662A CN 114617787 B CN114617787 B CN 114617787B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Abstract
The application relates to the field of A61K cosmetics, and in particular provides a high-stability composition for protecting a whitening agent and application thereof. Compared with the prior art, the whitening skin care product prepared by adopting the auxiliary agents such as the poria cocos extract, the turmeric root extract and the like has good whitening effect, and meanwhile, the composition also has excellent compatibility and stability of component raw materials, so that the composition has good application prospect in the field of whitening cosmetics.
Description
Technical Field
The application relates to the field of A61K cosmetics, and in particular provides a high-stability composition for protecting a whitening agent and application thereof.
Background
Skin is a protective barrier for our body, the first line of defense we resist against extraneous "aggressors". Modern people's pace of life is fast and many things affecting people's moods and moods can bring positive or negative pressure to your body. We may face stress from society, psychological stress, physical stress, and also environmental stress. When a person is stressed, the stress hormone (such as cortisol and melanin) in the body is increased, and meanwhile, the skin is blackened due to excessive precipitation of skin melanin which is easily caused by tissue necrosis at the damaged position of the skin. Thus, in recent years, whitening products are receiving increasing attention and popularity in the consumer market.
The prior art (CN 201910064750.8) provides a whitening composition and a product comprising the same, and a skin cream is prepared by blending a whitening component with a skin conditioner component and a plant extract component, and is claimed to have a synergistic whitening effect and a low-irritation effect, and is easy to absorb. However, the compatibility of the related whitening component with the component of the plant extract is poor, and the stability problem of the composition caused by the combination of various preparation raw materials is not considered in the patent, and the phenomena of discoloration, bacteria breeding, phase separation and the like of the composition are easily caused by long-term storage and storage.
Therefore, there is a need to develop a composition and a product thereof which have excellent compatibility of component materials and stability while having good whitening effect.
Disclosure of Invention
The first aspect of the present application provides a highly stable composition for protecting a whitening agent, which comprises the following raw materials, by mass: 50-70% of a whitening agent, 7-15% of an organic ester and the balance of octocrylene.
The whitening agent is at least one of 3-o-ethyl ascorbic acid, resorcinol, nicotinamide, glutathione, isohexadecanol, fruit acid and azalea acid.
As a preferable embodiment, the whitening agent is 3-o-ethyl ascorbic acid or resorcinol.
As a more preferable embodiment, the whitening agent is 3-o-ethyl ascorbic acid.
The organic ester is at least one of ethylhexyl methoxycinnamate, cetyl ethyl hexanoate and sorbitan olive oleate.
As a preferable scheme, the weight ratio of the organic ester to the octocrylene of the whitening agent is 65-70: 10-12: 20-30.
As a more preferable scheme, the weight ratio of the organic ester to the octocrylene of the whitening agent is 68:11:21.
according to the application, through reasonable compounding of the 3-o-ethyl ascorbic acid, the ethylhexyl methoxycinnamate and the octocrylene, the whitening effect of the composition is effectively improved, the stability effect of the whitening agent in the composition is effectively improved, and the hygroscopicity phenomenon of the composition is reduced. The inventors speculate that: when the mass ratio of the three is 68:11:21, the added ethylhexyl methoxycinnamate can effectively wrap the surface of the 3-o-ethyl ascorbic acid to the content of the bilayer so as to form a tiny wrapping phase, so that the connection flocculation phenomenon of the 3-o-ethyl ascorbic acid is prevented, and the 3-o-ethyl ascorbic acid can be uniformly dispersed on the surface of skin through good skin fluidity when the 3-o-ethyl ascorbic acid is used as myophilic ethylhexyl methoxycinnamate; and at the moment, the addition of the octocrylene can be simultaneously wrapped in the inner part and the inner side of the wrapping layer, and can effectively absorb illumination energy when being used as an ultraviolet absorbing sun-screening agent, reduce the formation and release of active electrons and finally reduce the oxidation of illumination on the wrapping layer and the ascorbic acid, thereby further improving the stability of the composition.
As a preferable scheme, the refractive index of the octocrylene is 1.56-1.57 and 20 ℃.
As a preferred embodiment, the method for preparing the highly stable composition comprises the steps of:
(1) Heating the whitening agent and the octocrylene to 75-85 ℃, and uniformly stirring to obtain a uniform phase A;
(2) Cooling the homogeneous phase A to 50-55 ℃, adding organic ester, homogenizing and stirring, and cooling to room temperature to obtain the high-stability composition.
In a second aspect, the present application provides the use of a highly stable composition for protecting a whitening agent, for use in a whitening skin care product.
The third aspect of the application provides a whitening skin care product, which comprises the following raw materials in percentage by mass: 2-5% of a high-stability composition, 5-8% of an organic alcohol agent, 0.05-3% of a humectant, 0.1-1% of a plant extract, 3-9% of a skin conditioner, 3-10% of an auxiliary agent and the balance of deionized water.
The organic alcohol agent is at least one of 1, 3-propylene glycol, 1, 2-pentanediol, phenoxyethanol, 4-tert-butylcyclohexanol, bisabolol, 1, 2-hexanediol, octanediol, cetyl alcohol, arachidyl alcohol, xylitol and sorbitol.
As a preferable scheme, the humectant is at least one of glycerin, ethylhexyl glycerin, sodium alginate, polyethylene glycol and hyaluronic acid.
As a more preferred embodiment, the humectant is a combination of glycerin and ethylhexyl glycerin.
As a preferable scheme, the mass ratio of the glycerol to the ethylhexyl glycerol is 1-1.5:0.1-0.3.
As a more preferable scheme, the mass ratio of the glycerol to the ethylhexyl glycerol is 1.1:0.2.
The plant extract is at least one of reed extract, poria extract, curcuma rhizome extract, withania somnifera extract, herba Centellae extract, folium Artemisiae Argyi extract, orchid extract, herba Saxifragae extract, herba Sidae Rhombifoliae extract, sakura extract, flos Nelumbinis extract, and Lavender extract.
As a preferred scheme, the plant extract is reed extract, poria extract, turmeric root extract.
As a preferable scheme, the weight ratio of the poria cocos extract, the turmeric root extract and the high-stability composition is 0.1-0.2:0.1-0.3: 3-4.
As a preferred embodiment, the mass ratio of the poria cocos extract, turmeric root extract and the highly stable composition is 0.1:0.1:3.5.
in the application, the applicant finds that although the addition of the high-stability composition can obviously improve the whitening performance and the overall stability of the skin care product, when the addition of the octocrylene in the raw materials is used, more oxygen free radicals are released when the skin surface is subjected to strong light, and the existence of the oxygen free radicals can obviously improve the aging speed of the skin, so that the effect of the skin care product on skin protection is reduced. The inventors have found that when the poria cocos extract and the turmeric root extract are combined with the high stability composition in a mass ratio of 0.1:0.1: at 3.5, the above can be significantly improved. The inventors speculate that: when the weight ratio is in use, the triterpenes and the flavonoid components in the poria cocos extract and the curcuma longa root extract are synergistic, so that the action activity of the extract is improved, the removal speed of oxygen free radicals of the triterpenes and the flavonoid components can be effectively improved under the synergistic action, and the pachyman component in the poria cocos extract is matched, so that the free efficiency of the oxygen free radicals on the skin surface can be effectively inhibited, the free speed is reduced, the powder promotion effect of the oxidation components on melanin is further reduced, and the whitening durability of the skin care product is improved.
As a preferred embodiment, the skin conditioning agent is niacinamide, isohexadecane, stearyl alcohol, tocopheryl acetate, C13-14 isoparaffins, pentaerythritol tetrakis (di-t-butylhydroxyhydrocinnamate), mao Ruilv fruit oil.
As a preferred embodiment, the auxiliary agents are pH regulators, emulsifiers, film formers, chelating agents and preservatives.
As a preferable scheme, the auxiliary agent comprises, by mass, 0.1-0.6% of a pH regulator, 1-4% of an emulsifier, 3-5% of a film forming agent, 0.1-0.2% of a chelating agent and 0.05-0.1% of a preservative.
As a preferred embodiment, the pH adjuster is hydroxyethylpiperazine ethane sulfonic acid, sodium citrate, and citric acid.
As a preferred embodiment, the emulsifier is sorbitan stearate, polyacrylate crosslinked polymer-6, PEG-100 stearate.
As a preferred embodiment, the film forming agent is polydimethylsiloxane.
As a preferred embodiment, the chelating agent is any one of disodium EDTA and tetrasodium EDTA.
As a preferred embodiment, the preservative is sodium benzoate.
As a preferable scheme, the mass ratio of the high-stability composition to the nicotinamide to the polydimethylsiloxane is 3-4:2-3:4-5.
As a more preferred embodiment, the mass of the highly stable composition, nicotinamide, polydimethylsiloxane is 3.5:2:4.
Further, the present inventors have found that although the ascorbic acid-based whitening agent in the highly stable composition has good stability, the skin care product prepared is liable to have an unstable effect on the skin care product system when exposed to external environment and strong light irradiation when being applied to the skin surface, and unexpectedly found that the stability in use of the skin surface of the skin care product is further improved when the mass ratio of the highly stable composition to nicotinamide and polydimethylsiloxane is 3.5:2:4. The inventors speculate that: when the mass ratio of the niacinamide to the polydimethylsiloxane is 3.5:2:4, the content level of the ceramide and the free fatty acid in skin can be effectively improved, and a good film forming effect is provided for the skin care product; the nicotinamide can also effectively promote the carrier effect of free substances on the ascorbic acid whitening agent, so that the dynamic flow stability of the ascorbic acid whitening agent on the skin surface is improved; further, the presence of a suitable amount of polydimethylsiloxane at this time can act as a good film former in skin care product systems, and the presence of a uniform oil phase film can act as a flow base and protective layer for the whitening agent oily protective film and carrier.
As a preferable technical scheme, the preparation method of the whitening skin care product comprises the following steps:
(1) Adding the high-stability composition into a main preparation pot, starting to homogenize the bottom of the main preparation pot by 10-50Hz, slowly adding the organic alcohol agent raw material onto a liquid level vortex, homogenizing for 10-20 minutes until the organic alcohol agent raw material is uniformly dispersed, and starting to heat;
(2) Stirring and heating to 50-65 ℃, stirring for 10-20 minutes, adding a humectant, a plant extract, a skin conditioning agent and an auxiliary agent, and stirring to a uniform phase;
(3) Heating deionized water to 50-60 ℃, mixing and homogenizing the deionized water and the uniform phase;
(4) Cooling to room temperature after stirring, taking materials, detecting, and filtering and discharging through 200-mesh filter cloth after passing the materials, thus obtaining the whitening skin care product.
Compared with the prior art, the application has the following beneficial effects:
1. the high-stability composition prepared by the application not only effectively improves the whitening effect of the composition, but also effectively improves the stability effect of the whitening agent in the composition and reduces the hygroscopicity phenomenon of the composition when the 3-o-ethyl ascorbic acid, the ethylhexyl methoxycinnamate and the octocrylene with the mass ratio of 68:11:21 are added;
2. the whitening skin care product containing the high-stability composition, which is prepared by the application, can effectively reduce the free efficiency of oxygen free radicals on the surface of skin and improve the whitening durability of the skin care product when the poria cocos extract and the turmeric root extract are added into the skin care product, especially when the mass ratio of the poria cocos extract to the turmeric root extract to the high-stability composition is 0.1:0.1:3.5;
3. the whitening skin care product containing the high-stability composition can promote the interaction of free substances on the skin surface and the ascorbic acid whitening agent, improve the dynamic stability of the ascorbic acid on the skin surface and improve the overall stability of the skin care product when nicotinamide and polydimethylsiloxane are added into the skin care product, especially when the mass ratio of the nicotinamide to the polydimethylsiloxane to the high-stability composition is 3.5:2:4;
4. the whitening skin care product containing the high-stability composition is prepared by adding active ingredients such as reed extract, poria cocos extract, turmeric root extract, pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate), hydroxyethyl piperazine ethane sulfonic acid and the like into a system, and through mutual synergistic effect, the skin care product has excellent whitening effect, meanwhile, each component has good compatibility, and meanwhile, the product has excellent storage stability, and has potential application value in the field of whitening skin care products.
Drawings
FIG. 1 is a graph showing the results of one month stability test of the skin care products prepared in example 1 and comparative example 1 according to the present application (A is the skin care product prepared in example 1, and B is the skin care product prepared in comparative example 1).
Detailed Description
Examples
Embodiment 1 in a first aspect provides a highly stable composition for protecting a whitening agent, the raw materials comprising, in mass percent: 50% of whitening agent, 7% of organic ester and the balance of octocrylene.
The whitening agent is 3-o-ethyl ascorbic acid, and the CAS number of the 3-o-ethyl ascorbic acid is 86404-04-8;
the organic ester is methoxy ethyl hexyl cinnamate, and the CAS number of the methoxy ethyl hexyl cinnamate is 5466-77-3;
the octocrylene has a CAS number of 6197-30-4 and is purchased from Guangzhou City Lichun trade company;
the preparation method of the high-stability composition comprises the following steps:
(1) Heating the whitening agent and the octocrylene to 80 ℃, and uniformly stirring to obtain a uniform phase A;
(2) Cooling the homogeneous phase A to 53 ℃, adding the organic ester, homogenizing and stirring, and cooling to room temperature to obtain the high-stability composition.
The second aspect of the embodiment provides a whitening skin care product, which comprises the following raw materials in percentage by mass: 2% of high-stability composition, 5% of organic alcohol agent, 0.05% of humectant, 0.1% of plant extract, 3% of skin conditioning agent, 3% of auxiliary agent and the balance of deionized water.
The organic alcohol agent comprises, by mass, 3% of 1, 3-propanediol, 0.5% of 1, 2-pentanediol, 0.5% of phenoxyethanol, 0.5% of 4-tert-butylcyclohexanol, 0.2% of bisabolol, 0.1% of 1, 2-hexanediol, 0.1% of octanediol, 0.05% of cetyl alcohol and 0.05% of arachidyl alcohol; the CAS number of the 1, 3-propanediol is 504-63-2,1, 2-pentanediol is 5343-92-0, the CAS number of the phenoxyethanol is 122-99-6, 4-tert-butylcyclohexanol is 98-52-2, the CAS number of the bisabolol is 515-69-5,1,2-hexanediol is 6920-22-5, the CAS number of the octanediol is 1117-86-8, the CAS number of the cetyl alcohol is 36653-82-4, and the CAS number of the arachidyl alcohol is 629-96-9;
the humectant is glycerin and ethylhexyl glycerin, the mass ratio of glycerin to ethylhexyl glycerin is 1.1:0.2, the CAS number of the glycerin is 6197-30-4, and the CAS number of the ethylhexyl glycerin is 70445-33-9;
the plant extracts are reed extracts, poria extracts and turmeric root extracts, and the mass ratio of the reed extracts to the poria extracts to the turmeric root extracts is 0.02:0.05:0.03; the reed extract is purchased from Sanyuan Tian domain biological products limited company, the poria cocos extract is purchased from Fengshi North biotechnology limited company, and the turmeric root extract is purchased from Shaanxi Xintian domain biological technology limited company;
the skin conditioning agent comprises, by mass, 1% of nicotinamide, 1% of isohexadecane, 0.2% of stearyl alcohol, 0.5% of tocopheryl acetate, 0.1% of C13-14 isoparaffin, 0.1% of pentaerythritol tetra (di-tert-butyl hydroxy hydrocinnamate) and 0.1% of Mao Ruilv fruit oil; the nicotinamide has a CAS number of 98-92-0, isohexadecane has a CAS number of 4390-04-9, stearyl alcohol has a CAS number of 112-92-5, C13-14 isoparaffin has a CS number of 246538-79-3, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) has a CAS number of 6683-19-8, and Mao Ruilv fruit oil is available from Wohan Peng's Biotechnology Co., ltd;
the auxiliary agent comprises 0.1% of pH regulator, 1% of emulsifier, 3% of film forming agent, 0.1% of chelating agent and 0.05% of preservative according to mass percentage.
The pH regulator comprises, by mass, 0.05% of hydroxyethyl piperazine ethane sulfonic acid, 0.02% of sodium citrate and 0.03% of citric acid; the CAS number of the hydroxyethyl piperazine ethane sulfonic acid is 7365-45-9, the CAS number of the sodium citrate is 68-04-2, and the CAS number of the citric acid is 77-92-9;
the emulsifier is 0.2% of sorbitan stearate, 0.6% of polyacrylate crosslinked polymer and 0.2% of PEG-100 stearate; the CAS number of the sorbitan stearate is 1338-41-6; polyacrylate crosslinked polymer-6 was purchased from joll (guangzhou) biotechnology limited under the model number SEPIMA ZEN; PEG-100 stearate is purchased from Jiangsu sea-An petrochemical plant, and the model is SG-100;
the film forming agent is polydimethylsiloxane, and is purchased from Anhui Aijia silicone oil limited company, and the model is D5;
the chelating agent is disodium EDTA, and the CAS number of the disodium EDTA is 6381-92-6;
the preservative is sodium benzoate, and the CAS number of the sodium benzoate is 532-32-1;
the preparation method of the whitening skin care product comprises the following steps:
(1) Adding the high-stability composition into a main preparation pot, starting to homogenize at 35Hz at the bottom, slowly adding the organic alcohol agent raw material onto a liquid level vortex, homogenizing for 15 minutes until the organic alcohol agent raw material is uniformly dispersed, and starting to heat;
(2) Stirring and heating to 55deg.C, stirring for 15 min, adding humectant, plant extract, skin conditioner and adjuvant, and stirring to uniform phase;
(3) Heating deionized water to 55 ℃, mixing water ion water with the uniform phase, homogenizing and stirring;
(4) Cooling to room temperature after stirring, taking materials, detecting, and filtering and discharging through 200-mesh filter cloth after passing the materials, thus obtaining the whitening skin care product.
Example 2
Embodiment 2 in a first aspect provides a highly stable composition for protecting whitening agents, the raw materials comprising, in mass percent: 70% of whitening agent, 15% of organic ester and the balance of octocrylene.
The whitening agent is 3-o-ethyl ascorbic acid, and the CAS number of the 3-o-ethyl ascorbic acid is 86404-04-8;
the organic ester is methoxy ethyl hexyl cinnamate, and the CAS number of the methoxy ethyl hexyl cinnamate is 5466-77-3;
the octocrylene has a CAS number of 6197-30-4 and is purchased from Guangzhou City Lichun trade company;
the preparation method of the highly stable composition is the same as in example 1.
The second aspect of the embodiment provides a whitening skin care product, which comprises the following raw materials in percentage by mass: 5% of high-stability composition, 8% of organic alcohol agent, 3% of humectant, 1% of plant extract, 9% of skin conditioning agent, 10% of auxiliary agent and the balance of deionized water.
The organic alcohol agent comprises, by mass, 6% of 1, 3-propanediol, 0.5% of 1, 2-pentanediol, 0.5% of phenoxyethanol, 0.5% of 4-tert-butylcyclohexanol, 0.2% of bisabolol, 0.1% of 1, 2-hexanediol, 0.1% of octanediol, 0.05% of cetyl alcohol and 0.05% of arachidyl alcohol; the CAS number of the 1, 3-propanediol is 504-63-2,1, 2-pentanediol is 5343-92-0, the CAS number of the phenoxyethanol is 122-99-6, 4-tert-butylcyclohexanol is 98-52-2, the CAS number of the bisabolol is 515-69-5,1,2-hexanediol is 6920-22-5, the CAS number of the octanediol is 1117-86-8, the CAS number of the cetyl alcohol is 36653-82-4, and the CAS number of the arachidyl alcohol is 629-96-9;
the humectant is glycerin, ethylhexyl glycerin, the mass ratio of glycerin to ethylhexyl glycerin is 2:1, the CAS number of the glycerin is 6197-30-4, and the CAS number of the ethylhexyl glycerin is 70445-33-9;
the plant extracts are reed extract, poria extract and turmeric root extract, and the mass ratio of reed extract to poria extract to turmeric root extract is 0.5:0.4:0.01; the reed extract is purchased from Sanyuan Tian domain biological products limited company, the poria cocos extract is purchased from Fengshi North biotechnology limited company, and the turmeric root extract is purchased from Shaanxi Xintian domain biological technology limited company;
the skin conditioning agent comprises, by mass, 3% of nicotinamide, 3% of isohexadecane, 1.2% of stearyl alcohol, 1.5% of tocopheryl acetate, 0.1% of C13-14 isoparaffin, 0.1% of pentaerythritol tetra (bis-tert-butylhydroxyhydrocinnamate), and 0.1% of Mao Ruilv fruit oil; the nicotinamide has a CAS number of 98-92-0, isohexadecane has a CAS number of 4390-04-9, stearyl alcohol has a CAS number of 112-92-5, C13-14 isoparaffin has a CS number of 246538-79-3, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) has a CAS number of 6683-19-8, and Mao Ruilv fruit oil is available from Wohan Peng's Biotechnology Co., ltd;
the auxiliary agent comprises, by mass, 0.4% of a pH regulator, 4% of an emulsifier, 5% of a film forming agent, 0.2% of a chelating agent and 0.1% of a preservative.
The pH regulator comprises, by mass, 0.1% of hydroxyethyl piperazine ethane sulfonic acid, 0.15% of sodium citrate and 0.15% of citric acid; the CAS number of the hydroxyethyl piperazine ethane sulfonic acid is 7365-45-9, the CAS number of the sodium citrate is 68-04-2, and the CAS number of the citric acid is 77-92-9;
the emulsifier is 2% of sorbitan stearate, 1.6% of polyacrylate crosslinked polymer and 0.4% of PEG-100 stearate by mass percent; the CAS number of the sorbitan stearate is 1338-41-6; polyacrylate crosslinked polymer-6 was purchased from joll (guangzhou) biotechnology limited under the model number SEPIMA ZEN; PEG-100 stearate is purchased from Jiangsu sea-An petrochemical plant, and the model is SG-100;
the film forming agent is polydimethylsiloxane, and is purchased from Anhui Aijia silicone oil limited company, and the model is D5;
the chelating agent is disodium EDTA, and the CAS number of the disodium EDTA is 6381-92-6;
the preservative is sodium benzoate, and the CAS number of the sodium benzoate is 532-32-1;
the preparation method of the whitening skin care product is the same as that of the example 1.
Example 3
Embodiment 3 in a first aspect, a highly stable composition for protecting a whitening agent is provided, the raw materials comprising, in mass percent: 68% of whitening agent, 11% of organic ester and the balance of octocrylene.
The whitening agent is 3-o-ethyl ascorbic acid, and the CAS number of the 3-o-ethyl ascorbic acid is 86404-04-8;
the organic ester is methoxy ethyl hexyl cinnamate, and the CAS number of the methoxy ethyl hexyl cinnamate is 5466-77-3;
the octocrylene has a CAS number of 6197-30-4 and is purchased from Guangzhou City Lichun trade company;
the preparation method of the highly stable composition is the same as in example 1.
The second aspect of the embodiment provides a whitening skin care product, which comprises the following raw materials in percentage by mass: 3.5% of high-stability composition, 7% of organic alcohol agent, 1.3% of humectant, 0.3% of plant extract, 6.5% of skin conditioning agent, 6.75% of auxiliary agent and the balance of deionized water.
The organic alcohol agent comprises, by mass, 5% of 1, 3-propanediol, 0.5% of 1, 2-pentanediol, 0.5% of phenoxyethanol, 0.5% of 4-tert-butylcyclohexanol, 0.2% of bisabolol, 0.1% of 1, 2-hexanediol, 0.1% of octanediol, 0.05% of cetyl alcohol and 0.05% of arachidyl alcohol; the CAS number of the 1, 3-propanediol is 504-63-2,1, 2-pentanediol is 5343-92-0, the CAS number of the phenoxyethanol is 122-99-6, 4-tert-butylcyclohexanol is 98-52-2, the CAS number of the bisabolol is 515-69-5,1,2-hexanediol is 6920-22-5, the CAS number of the octanediol is 1117-86-8, the CAS number of the cetyl alcohol is 36653-82-4, and the CAS number of the arachidyl alcohol is 629-96-9;
the humectant is glycerin and ethylhexyl glycerin, the mass ratio of glycerin to ethylhexyl glycerin is 1.1:0.2, the CAS number of the glycerin is 6197-30-4, and the CAS number of the ethylhexyl glycerin is 70445-33-9;
the plant extracts are reed extracts, poria extracts and turmeric root extracts, and the mass ratio of the reed extracts to the poria extracts to the turmeric root extracts is 0.1:0.1:0.1; the reed extract is purchased from Sanyuan Tian domain biological products limited company, the poria cocos extract is purchased from Fengshi North biotechnology limited company, and the turmeric root extract is purchased from Shaanxi Xintian domain biological technology limited company;
the skin conditioner comprises, by mass, 2% of nicotinamide, 2% of isohexadecane, 1.2% of stearyl alcohol, 1% of tocopheryl acetate, 0.1% of C13-14 isoparaffin, 0.1% of pentaerythritol tetra (di-tert-butylhydroxyhydrocinnamate) and 0.1% of Mao Ruilv fruit oil; the nicotinamide has a CAS number of 98-92-0, isohexadecane has a CAS number of 4390-04-9, stearyl alcohol has a CAS number of 112-92-5, C13-14 isoparaffin has a CS number of 246538-79-3, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) has a CAS number of 6683-19-8, and Mao Ruilv fruit oil is available from Wohan Peng's Biotechnology Co., ltd;
the auxiliary agent comprises, by mass, 0.3% of a pH regulator, 2.3% of an emulsifying agent, 4% of a film forming agent, 0.1% of a chelating agent and 0.05% of a preservative.
The pH regulator comprises, by mass, 0.2% of hydroxyethyl piperazine ethane sulfonic acid, 0.05% of sodium citrate and 0.05% of citric acid; the CAS number of the hydroxyethyl piperazine ethane sulfonic acid is 7365-45-9, the CAS number of the sodium citrate is 68-04-2, and the CAS number of the citric acid is 77-92-9;
the emulsifier is 1.2% of sorbitan stearate, 0.6% of polyacrylate crosslinked polymer and 0.5% of PEG-100 stearate by mass percent; the CAS number of the sorbitan stearate is 1338-41-6; polyacrylate crosslinked polymer-6 was purchased from joll (guangzhou) biotechnology limited under the model number SEPIMA ZEN; PEG-100 stearate is purchased from Jiangsu sea-An petrochemical plant, and the model is SG-100;
the film forming agent is polydimethylsiloxane, and is purchased from Anhui Aijia silicone oil limited company, and the model is D5;
the chelating agent is disodium EDTA, and the CAS number of the disodium EDTA is 6381-92-6;
the preservative is sodium benzoate, and the CAS number of the sodium benzoate is 532-32-1;
the preparation method of the whitening skin care product is the same as that of the example 1.
Comparative example 1
Comparative example 1 embodiment the same as in example 3 was carried out except that the highly stable composition was not added with organic ester and octocrylene, and 3-o-ethyl ascorbic acid was directly added to the skin care product.
Comparative example 2
Comparative example 2 the embodiment is the same as example 3, except that the mass ratio of the whitening agent, the organic ester and the octocrylene in the highly stable composition is 55:20:15
Comparative example 3
Comparative example 3 the embodiment is the same as example 3 except that the mass ratio of poria extract, turmeric extract to highly stable composition is 0.4:0.01:3.5.
comparative example 4
Comparative example 4 the embodiment is the same as example 3, except that the mass ratio of poria extract, turmeric extract to highly stable composition is 0.6:0.2:3.5.
comparative example 5
Comparative example 5 the embodiment is the same as example 3 except that the mass ratio of the highly stable composition, nicotinamide, polydimethylsiloxane is 6:1:2.
Comparative example 6
Comparative example 6 the embodiment is the same as example 3 except that the mass ratio of the highly stable composition, nicotinamide, polydimethylsiloxane is 2:1:3.
Comparative example 7
Comparative example 7 the embodiment is the same as example 3 except that the mass ratio of the highly stable composition, nicotinamide, polydimethylsiloxane is 1:5:2.
Evaluation of Performance
Stability test:
and (3) preserving the prepared skin care product by using a glass container, placing the skin care product in a constant temperature cabinet at 40 ℃ for 1 month, taking out the sample, comparing the sample with the skin care product just prepared, and when the skin care product has obvious moisture absorption and hydration after being preserved for 1 month, marking the skin care product as unqualified products and testing 100 samples in each example and comparative example.
When 5 or less samples failed, it was designated as A,
less than or equal to 15 are marked as B,
greater than 15 are noted as C, and the measured data are shown in Table 1;
TABLE 1
Claims (5)
1. The whitening skin care product comprises the following raw materials in percentage by mass: 2-5% of high-stability composition, 5-8% of organic alcohol agent, 0.05-3% of humectant, 0.1-1% of plant extract, 3-9% of skin conditioner, 3-10% of auxiliary agent and the balance of deionized water; wherein, the raw materials of the high-stability composition comprise the following components in percentage by mass: 50-70% of whitening agent, 7-15% of organic ester and the balance of octocrylene; wherein the whitening agent is 3-o-ethyl ascorbic acid; the organic ester is at least one of ethylhexyl methoxycinnamate, cetyl ethyl hexanoate and sorbitan olive oleate; the organic alcohol agent is 1, 3-propanediol, 1, 2-pentanediol, phenoxyethanol, 4-tertiary butyl cyclohexanol, bisabolol, 1, 2-hexanediol, octanediol, cetyl alcohol and arachidyl alcohol; the humectant is a composition of glycerin and ethylhexyl glycerin; the plant extract is reed extract, poria extract and turmeric root extract, and the mass ratio of the poria extract to the turmeric root extract to the high-stability composition is 0.1-0.2:0.1-0.3: 3 to 4; the skin conditioning agent is nicotinamide, isohexadecane, stearyl alcohol, tocopheryl acetate, C13-14 isoparaffin, pentaerythritol tetrakis (bis-tert-butylhydroxyhydrocinnamate) and Mao Ruilv fruit oil; the auxiliary agent comprises a pH regulator, an emulsifying agent, a film forming agent, a chelating agent and a preservative, wherein the pH regulator is 0.1-0.6%, the emulsifying agent is 1-4%, the film forming agent is 3-5%, the chelating agent is 0.1-0.2% and the preservative is 0.05-0.1%; the pH regulator is hydroxyethyl piperazine ethane sulfonic acid, sodium citrate and citric acid; the emulsifier is sorbitan stearate, polyacrylate crosslinked polymer-6 and PEG-100 stearate; the film forming agent is polydimethylsiloxane; the chelating agent is disodium EDTA or tetrasodium EDTA; the mass ratio of the high-stability composition to the nicotinamide to the polydimethylsiloxane is 3-4:2-3:4-5.
2. The whitening skin care product according to claim 1, wherein the mass ratio of the whitening agent, the organic ester and the octocrylene is 68:11:21.
3. the whitening skin care product according to claim 1, wherein the mass ratio of glycerin to ethylhexyl glycerin is 1.1:0.2.
4. The whitening skin care product according to claim 1, wherein the mass ratio of the poria cocos extract, the turmeric root extract and the high stability composition is 0.1:0.1:3.5.
5. The whitening skin care product according to claim 1, wherein the mass of the high stability composition, nicotinamide, and polydimethylsiloxane is 3.5:2:4.
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| CN109820786A (en) * | 2019-04-03 | 2019-05-31 | 栾云鹏 | One kind can repair skin injury type suncream |
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| CN105816394A (en) * | 2016-05-18 | 2016-08-03 | 广州丹奇日用化工厂有限公司 | BB cream containing hericium erinaceus extract |
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