CN114616238A - 棘白菌素类似物及其制备方法 - Google Patents
棘白菌素类似物及其制备方法 Download PDFInfo
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- CN114616238A CN114616238A CN202080075108.0A CN202080075108A CN114616238A CN 114616238 A CN114616238 A CN 114616238A CN 202080075108 A CN202080075108 A CN 202080075108A CN 114616238 A CN114616238 A CN 114616238A
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- Prior art keywords
- lower alkyl
- compound
- integer
- pharmaceutically acceptable
- hydrogen
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Abstract
涉及棘白菌素类似物及其制备方法，该类化合物可用于预防或者治疗真菌感染，或者用于预防、稳定或抑制真菌生长或杀死真菌，示例化合物如式I所示，其中R1、R2、R3及G基团的定义如说明书中所述。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (13)
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| CN201911241526 | 2019-12-06 | ||
| CN2019112415268 | 2019-12-06 | ||
| CN2019112492264 | 2019-12-09 | ||
| CN201911249226 | 2019-12-09 | ||
| CN2020101653496 | 2020-03-11 | ||
| CN202010165349 | 2020-03-11 | ||
| CN2020107995069 | 2020-08-11 | ||
| CN202010799506 | 2020-08-11 | ||
| CN202011164541 | 2020-10-27 | ||
| CN202011164541X | 2020-10-27 | ||
| CN2020113715506 | 2020-11-30 | ||
| CN202011371550 | 2020-11-30 | ||
| PCT/CN2020/133815 WO2021110125A1 (zh) | 2019-12-06 | 2020-12-04 | 棘白菌素类似物及其制备方法 |
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| US (1) | US20230159591A1 (zh) |
| EP (1) | EP4063381A4 (zh) |
| JP (1) | JP2023504389A (zh) |
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| CN (1) | CN114616238A (zh) |
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| MX (1) | MX2022006424A (zh) |
| TW (1) | TW202134257A (zh) |
| WO (1) | WO2021110125A1 (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116903706A (zh) * | 2023-06-13 | 2023-10-20 | 深圳市祥根生物有限公司 | 一种棘白菌素类药物及其制备方法和用途 |
| WO2024088301A1 (zh) * | 2022-10-25 | 2024-05-02 | 江苏恒瑞医药股份有限公司 | 一种棘白素类似物的药物组合物及其制备方法 |
| CN116903706B (zh) * | 2023-06-13 | 2024-05-17 | 深圳市祥根生物有限公司 | 一种棘白菌素类药物及其制备方法和用途 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117255797A (zh) * | 2021-06-03 | 2023-12-19 | 上海森辉医药有限公司 | 一种阿尼芬净衍生物的制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2704030A1 (de) * | 1976-02-12 | 1977-08-18 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| US5652213A (en) * | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| WO2016201283A1 (en) * | 2015-06-12 | 2016-12-15 | Cidara Therapeutics, Inc. | Antifungal agents |
| CN108883152A (zh) * | 2016-01-08 | 2018-11-23 | 奇达拉治疗公司 | 防止和治疗肺孢子虫感染的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5914313A (en) * | 1991-10-17 | 1999-06-22 | Merck & Co., Inc. | 1- 4-hydroxy-5-aminoethyloxy-N2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof |
| JP2013503179A (ja) * | 2009-08-27 | 2013-01-31 | シーチェイド ファーマシューティカルズ，インコーポレーテッド | エキノキャンディン誘導体 |
| HUE036778T2 (hu) | 2011-03-03 | 2018-07-30 | Cidara Therapeutics Inc | Gombaellenes szerek és alkalmazásuk |
| WO2017049102A1 (en) | 2015-09-16 | 2017-03-23 | Cidara Therapeutics, Inc. | Methods for treating fungal infections |
| WO2018102407A1 (en) | 2016-11-29 | 2018-06-07 | Cidara Therapeutics, Inc | Methods for preventing fungal infections |
-
2020
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- 2020-12-04 WO PCT/CN2020/133815 patent/WO2021110125A1/zh unknown
- 2020-12-04 AU AU2020397311A patent/AU2020397311A1/en active Pending
- 2020-12-04 KR KR1020227021867A patent/KR20220110513A/ko unknown
- 2020-12-04 MX MX2022006424A patent/MX2022006424A/es unknown
- 2020-12-04 BR BR112022010441A patent/BR112022010441A2/pt unknown
- 2020-12-04 TW TW109142863A patent/TW202134257A/zh unknown
- 2020-12-04 EP EP20897067.3A patent/EP4063381A4/en active Pending
- 2020-12-04 CA CA3161287A patent/CA3161287A1/en active Pending
- 2020-12-04 CN CN202080075108.0A patent/CN114616238A/zh active Pending
- 2020-12-04 JP JP2022530717A patent/JP2023504389A/ja active Pending
Patent Citations (4)
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| DE2704030A1 (de) * | 1976-02-12 | 1977-08-18 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| US5652213A (en) * | 1995-05-26 | 1997-07-29 | Eli Lilly And Company | Cyclic peptide antifungal agents |
| WO2016201283A1 (en) * | 2015-06-12 | 2016-12-15 | Cidara Therapeutics, Inc. | Antifungal agents |
| CN108883152A (zh) * | 2016-01-08 | 2018-11-23 | 奇达拉治疗公司 | 防止和治疗肺孢子虫感染的方法 |
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| Title |
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| JAMISON, J.A等: "The Synthesis and Antifungal Activity of Nitrogen Containing Hemiaminal Ethers of LY303366", THE JOURNAL OF ANTIBIOTICS, vol. 51, no. 2, 28 February 1998 (1998-02-28), pages 239, XP002126600 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024088301A1 (zh) * | 2022-10-25 | 2024-05-02 | 江苏恒瑞医药股份有限公司 | 一种棘白素类似物的药物组合物及其制备方法 |
| CN116903706A (zh) * | 2023-06-13 | 2023-10-20 | 深圳市祥根生物有限公司 | 一种棘白菌素类药物及其制备方法和用途 |
| CN116903706B (zh) * | 2023-06-13 | 2024-05-17 | 深圳市祥根生物有限公司 | 一种棘白菌素类药物及其制备方法和用途 |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112022010441A2 (pt) | 2022-09-06 |
| EP4063381A1 (en) | 2022-09-28 |
| TW202134257A (zh) | 2021-09-16 |
| AU2020397311A1 (en) | 2022-07-14 |
| CA3161287A1 (en) | 2021-06-10 |
| EP4063381A4 (en) | 2023-04-26 |
| WO2021110125A1 (zh) | 2021-06-10 |
| KR20220110513A (ko) | 2022-08-08 |
| JP2023504389A (ja) | 2023-02-03 |
| US20230159591A1 (en) | 2023-05-25 |
| MX2022006424A (es) | 2022-06-22 |
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