MX2022006424A - Analogos de equinocandina y metodo de preparacion de los mismos. - Google Patents

Analogos de equinocandina y metodo de preparacion de los mismos.

Info

Publication number
MX2022006424A
MX2022006424A MX2022006424A MX2022006424A MX2022006424A MX 2022006424 A MX2022006424 A MX 2022006424A MX 2022006424 A MX2022006424 A MX 2022006424A MX 2022006424 A MX2022006424 A MX 2022006424A MX 2022006424 A MX2022006424 A MX 2022006424A
Authority
MX
Mexico
Prior art keywords
echinocandin
preparation
method therefor
analogues
preventing
Prior art date
Application number
MX2022006424A
Other languages
English (en)
Inventor
Wei Jiang
Jian Huang
Lingjian Zhu
Weicou Cao
Original Assignee
Shanghai Senhui Medicine Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Senhui Medicine Co Ltd filed Critical Shanghai Senhui Medicine Co Ltd
Publication of MX2022006424A publication Critical patent/MX2022006424A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un análogo de equinocandina y a un método de preparación del mismo. El compuesto se puede usar para prevenir o tratar infecciones fúngicas, o para prevenir, estabilizar o inhibir el crecimiento fúngico o matar hongos. Un compuesto ejemplar está representado por la Formula I, en donde las definiciones de los grupos R1, R2, R3 y G son como se revelan en la descripción. (ver Fórmula).
MX2022006424A 2019-12-06 2020-12-04 Analogos de equinocandina y metodo de preparacion de los mismos. MX2022006424A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN201911241526 2019-12-06
CN201911249226 2019-12-09
CN202010165349 2020-03-11
CN202010799506 2020-08-11
CN202011164541 2020-10-27
CN202011371550 2020-11-30
PCT/CN2020/133815 WO2021110125A1 (zh) 2019-12-06 2020-12-04 棘白菌素类似物及其制备方法

Publications (1)

Publication Number Publication Date
MX2022006424A true MX2022006424A (es) 2022-06-22

Family

ID=76222453

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022006424A MX2022006424A (es) 2019-12-06 2020-12-04 Analogos de equinocandina y metodo de preparacion de los mismos.

Country Status (11)

Country Link
US (1) US20230159591A1 (es)
EP (1) EP4063381A4 (es)
JP (1) JP2023504389A (es)
KR (1) KR20220110513A (es)
CN (1) CN114616238A (es)
AU (1) AU2020397311A1 (es)
BR (1) BR112022010441A2 (es)
CA (1) CA3161287A1 (es)
MX (1) MX2022006424A (es)
TW (1) TW202134257A (es)
WO (1) WO2021110125A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022253297A1 (zh) * 2021-06-03 2022-12-08 上海森辉医药有限公司 一种阿尼芬净衍生物的制备方法
WO2024088301A1 (zh) * 2022-10-25 2024-05-02 江苏恒瑞医药股份有限公司 一种棘白素类似物的药物组合物及其制备方法
CN116903706B (zh) * 2023-06-13 2024-05-17 深圳市祥根生物有限公司 一种棘白菌素类药物及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
US5914313A (en) * 1991-10-17 1999-06-22 Merck & Co., Inc. 1- 4-hydroxy-5-aminoethyloxy-N2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
WO2011025875A1 (en) * 2009-08-27 2011-03-03 Seachaid Pharmaceuticals, Inc. Echinocandin derivatives
CN106279369B (zh) 2011-03-03 2020-02-11 奇达拉治疗公司 抗真菌剂及其应用
WO2016201283A1 (en) * 2015-06-12 2016-12-15 Cidara Therapeutics, Inc. Antifungal agents
US20180256673A1 (en) 2015-09-16 2018-09-13 Cidara Therapeutics, Inc. Methods for treating fungal infections
CN108883152A (zh) * 2016-01-08 2018-11-23 奇达拉治疗公司 防止和治疗肺孢子虫感染的方法
WO2018102407A1 (en) 2016-11-29 2018-06-07 Cidara Therapeutics, Inc Methods for preventing fungal infections

Also Published As

Publication number Publication date
WO2021110125A1 (zh) 2021-06-10
CA3161287A1 (en) 2021-06-10
EP4063381A4 (en) 2023-04-26
KR20220110513A (ko) 2022-08-08
TW202134257A (zh) 2021-09-16
US20230159591A1 (en) 2023-05-25
JP2023504389A (ja) 2023-02-03
BR112022010441A2 (pt) 2022-09-06
EP4063381A1 (en) 2022-09-28
CN114616238A (zh) 2022-06-10
AU2020397311A1 (en) 2022-07-14

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