CN114615992A - 表达t调节性细胞的抗cd83嵌合抗原受体 - Google Patents

表达t调节性细胞的抗cd83嵌合抗原受体 Download PDF

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CN114615992A
CN114615992A CN202080063859.0A CN202080063859A CN114615992A CN 114615992 A CN114615992 A CN 114615992A CN 202080063859 A CN202080063859 A CN 202080063859A CN 114615992 A CN114615992 A CN 114615992A
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M.达维拉
B.贝茨
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H Li Moffett Cancer Center And Institute Co ltd
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CN202080063859.0A 2019-08-16 2020-08-14 表达t调节性细胞的抗cd83嵌合抗原受体 Pending CN114615992A (zh)

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US201962888055P 2019-08-16 2019-08-16
US62/888,055 2019-08-16
PCT/US2020/046439 WO2021034689A1 (en) 2019-08-16 2020-08-14 Anti-cd83 chimeric antigen receptor expressing t regulatory cells

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US (1) US20220289862A1 (https=)
EP (1) EP4013447A4 (https=)
JP (1) JP7701908B2 (https=)
CN (1) CN114615992A (https=)
AU (1) AU2020333659A1 (https=)
CA (1) CA3147837A1 (https=)
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Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019165156A1 (en) 2018-02-23 2019-08-29 H. Lee Moffitt Cancer Center And Research Institute Inc. Cd83-binding chimeric antigen receptors
AU2020334893A1 (en) * 2019-08-16 2022-02-24 H. Lee Moffitt Cancer Center And Research Institute Inc. Chimeric antigen receptors for treating myeloid malignancies
WO2023122643A1 (en) * 2021-12-22 2023-06-29 Regents Of The University Of Minnesota Cd83 and allo- and autoimmune conditions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013150592A (ja) * 2011-07-01 2013-08-08 Genentech Inc 自己免疫疾患を治療するための抗cd83アゴニスト抗体の使用
CN103906766A (zh) * 2011-07-01 2014-07-02 弗·哈夫曼-拉罗切有限公司 抗cd83激动剂抗体用于治疗自身免疫疾病的用途
CN105531289A (zh) * 2013-02-01 2016-04-27 全氏生物有限公司 抗cd83抗体及其用途
CN109153714A (zh) * 2016-03-04 2019-01-04 诺华股份有限公司 表达多重嵌合抗原受体(car)分子的细胞及其用途
WO2019056106A1 (en) * 2017-09-20 2019-03-28 The University Of British Columbia NOVEL ANTI-HLA-A2 ANTIBODIES AND USES THEREOF

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040185040A1 (en) * 2001-11-21 2004-09-23 Celltech R & D Limited Modulating immune responses
US9228172B2 (en) * 2008-06-19 2016-01-05 The Trustees Of The University Of Pennsylvania Inducible regulatory T-cell generation for hematopoietic transplants
AU2016274989A1 (en) * 2015-06-12 2017-11-02 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
KR20180019725A (ko) * 2015-06-23 2018-02-26 메모리얼 슬로안-케터링 캔서 센터 신규의 피디 1 면역 조절제
WO2019136335A1 (en) * 2018-01-05 2019-07-11 Gencyte Therapeutics, Inc. Precision molecular adaptor system for car-t immunotherapy
WO2019141774A1 (en) * 2018-01-19 2019-07-25 Miltenyi Biotec Gmbh Regulatory t cell expressing a chimeric antigen receptor
EP3749334B1 (en) * 2018-02-08 2024-12-11 The Board of Trustees of the Leland Stanford Junior University Allogenic hematopoietic stem cell transplantation
WO2019165156A1 (en) * 2018-02-23 2019-08-29 H. Lee Moffitt Cancer Center And Research Institute Inc. Cd83-binding chimeric antigen receptors

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013150592A (ja) * 2011-07-01 2013-08-08 Genentech Inc 自己免疫疾患を治療するための抗cd83アゴニスト抗体の使用
CN103906766A (zh) * 2011-07-01 2014-07-02 弗·哈夫曼-拉罗切有限公司 抗cd83激动剂抗体用于治疗自身免疫疾病的用途
CN105531289A (zh) * 2013-02-01 2016-04-27 全氏生物有限公司 抗cd83抗体及其用途
CN109153714A (zh) * 2016-03-04 2019-01-04 诺华股份有限公司 表达多重嵌合抗原受体(car)分子的细胞及其用途
WO2019056106A1 (en) * 2017-09-20 2019-03-28 The University Of British Columbia NOVEL ANTI-HLA-A2 ANTIBODIES AND USES THEREOF

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MOFFITT CANCER CENTER: "CD83 Targeting Chimeric Antigen Receptor Expressing T cell (CAR-T) to prevent GVHD", Retrieved from the Internet <URL:https://otmc.moffitt.org/media/4888/18ma007-cd83-gvhd-tom.pdf> *

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EP4013447A4 (en) 2024-05-29
US20220289862A1 (en) 2022-09-15
CA3147837A1 (en) 2021-02-25
JP2022544581A (ja) 2022-10-19
AU2020333659A1 (en) 2022-02-24
EP4013447A1 (en) 2022-06-22
JP7701908B2 (ja) 2025-07-02

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