CN114588074A - Anti-aging whitening moisturizing mask and preparation method thereof - Google Patents
Anti-aging whitening moisturizing mask and preparation method thereof Download PDFInfo
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- CN114588074A CN114588074A CN202210410900.8A CN202210410900A CN114588074A CN 114588074 A CN114588074 A CN 114588074A CN 202210410900 A CN202210410900 A CN 202210410900A CN 114588074 A CN114588074 A CN 114588074A
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- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000012744 reinforcing agent Substances 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 229940104256 sodium taurate Drugs 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8188—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bonds, and at least one being terminated by a bond to sulfur or by a hertocyclic ring containing sulfur; Compositions of derivatives of such polymers
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- A61Q19/08—Anti-ageing preparations
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
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Abstract
The invention relates to the technical field of cosmetics, and particularly discloses an anti-aging whitening moisturizing mask. The anti-aging whitening moisturizing mask comprises mask base cloth and mask liquid. The mask liquid comprises the following raw materials: glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water. The anti-aging whitening moisturizing mask prepared by the invention has the advantages of mild raw materials, almost no stimulation to skin, simple preparation process operation, good stability of active ingredients, high skin utilization rate, multiple effects of anti-aging whitening moisturizing and the like.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an anti-aging whitening moisturizing mask and a preparation method thereof.
Background
The cosmetics are daily chemical industrial products which are smeared, sprayed or other similar methods on any parts (skin, hair, nails, lips and the like) of the surface of a human body so as to achieve the purposes of cleaning, removing bad smell, protecting skin, beautifying and modifying. The facial mask is an auxiliary cosmetic which is applied to human face skin, can quickly replenish water and moisturize the skin in a short time and can nourish the skin. In recent years, with the continuous improvement of living standard, the consumption concept of people is changed, more and more consumers of the facial mask are provided, and the consumer population is also younger, so the facial mask becomes one of common cosmetics in the market at present.
The mask has the main effects that a barrier is formed firstly in more than ten minutes of contact with the skin, pollutants in the skin and the external environment are separated, the temperature of the epidermis rises, pores expand, the oxygen content of the skin is increased, then the speed of metabolism is accelerated, substances such as sweat, grease and the like in the skin on the surface layer are favorably discharged, and finally essence in the mask enters the stratum corneum of the skin, so that the skin is moist and rich in elasticity and luster. Common masks are simply classified into three categories according to efficacy: (1) moisturizing facial mask: the mechanism of the facial mask is mainly that the water retention property of the moisturizing agent is utilized to enhance the water adsorption capacity of cells in the cuticle of the facial skin, so that the effects of moisturizing are achieved; (2) whitening facial masks: mainly adds natural substances with tyrosinase inhibiting activity, such as arbutin, white mulberry root-bark extract, curcumin and other plant extracts to inhibit the activity of tyrosine and other enzymes, thereby influencing the formation of cell melanin; (3) functional facial mask: the facial mask containing natural plant components is applied more, and the specific plant extract is added, so that the facial mask has a specific effect and has good performance in treating symptoms such as acne, chloasma and dermatitis.
However, facial mask efficacy derives primarily from the components of the facial mask solution. The facial mask fluid generally has two phases, namely a hydrophilic phase and a lipophilic phase, in order to absorb water in the environment and prevent water in stratum corneum cells from losing through the skin. The components of the facial mask liquid comprise a humectant, a thickening agent, a film forming agent, an antiallergic drug, a preservative, a chelating agent and the like.
The invention patent with application number 201910368218.5 discloses a preparation method of a whitening anti-aging facial mask containing betulinic acid, which comprises facial mask liquid and facial mask paper, wherein the facial mask liquid comprises the following components in percentage by mass: 1-5% of betulinic acid, 1-7% of lavender essential oil, 1-7% of rose essential oil, 10-17% of jojoba oil, 10-20% of hyaluronic acid and the balance of deionized water. The anti-aging whitening mask can supplement energy for cells, activate various physiological activities of facial skin, promote metabolism and enhance cell activity, thereby achieving the anti-aging whitening effects of supplementing nutrition to skin cells and promoting growth. However, the mask has no moisturizing effect, but it is difficult to satisfy consumers who have a high demand for the mask effect.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides an anti-aging whitening moisturizing mask and a preparation method thereof.
In order to solve the technical problems, the invention adopts the technical scheme that:
an anti-aging whitening moisturizing mask comprises a mask base cloth and a mask liquid.
The mask liquid comprises the following raw materials: 6-10 wt% of glycerol, 1-4 wt% of 1, 3-butanediol, 0.5-2 wt% of 1, 2-pentanediol, 0.3-0.8 wt% of acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, 0.3-0.7 wt% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2-7 wt% of trehalose, 0.2-0.8 wt% of xanthan gum, 0.5-1.2 wt% of polysorbate-60, 0.4-0.9 wt% of sodium hyaluronate, 0.1-0.5 wt% of serine, 0.2-0.5 wt% of arginine, 4-8 wt% of vitamin C or vitamin C nanocapsule, and the balance of water.
Vitamin C is a polyhydroxy compound, has a structure similar to glucose, is a water-soluble vitamin necessary for normal life activities of a human body because of having the function of treating scurvy, is called ascorbic acid as another name, helps to construct a biological system through various physiological functions, such as hydroxylation reaction in collagen synthesis, enables skin to be rich in luster, and delays aging; meanwhile, the vitamin C can promote the utilization of carbohydrates by a human body and the absorption of non-heme iron, and has the function of preventing anemia and the like.
Vitamin C is an antioxidant that prevents damage to essential macromolecules in the body by scavenging harmful free radicals caused by environmental contamination and possibly infectious organisms. However, vitamin C also has some disadvantages, for example, difficulty in penetrating into the stratum corneum through the epidermis; the crystalline state is relatively stable, but due to its antioxidant effect, vitamin C is rapidly oxidized to dehydroascorbic acid and hydrolyzed in alkaline environment to form irreversible 2, 3-L-diketogulonate, which greatly limits its application in cosmetics. Therefore, the present invention encapsulates vitamin C in nanoparticles to form nanocapsules to protect the active compound from the external environment (including pH, light, heat, oxygen, etc.), and to promote vitamin C to exert its own effects better.
The preparation method of the vitamin C nano capsule comprises the following steps:
h1, adding 1-3 parts by weight of modified chitosan into 80-120 parts by weight of water, and uniformly mixing to obtain a solution a; adding 0.5-2 parts by weight of vitamin C into 90-110 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 4-8 parts by weight of the solution C into 40-55 parts by weight of the solution a under the nitrogen atmosphere, then placing the solution in an ultrasonic frequency range of 30-40kHz and an ultrasonic power range of 300-400W for ultrasonic treatment for 5-20min, dialyzing after the ultrasonic treatment is finished, and freeze-drying the product to obtain the vitamin C nanocapsule.
Further, the preparation method of the vitamin C nano capsule comprises the following steps:
h1, adding 1-3 parts by weight of modified chitosan into 80-120 parts by weight of water, and uniformly mixing to obtain a solution a; adding 3-6 parts by weight of cross-linking agent into 85-110 parts by weight of water, and performing ultrasonic dispersion to obtain dispersion liquid b; adding 0.5-2 parts by weight of vitamin C into 90-110 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 10-20 parts by weight of the solution C into 40-60 parts by weight of the solution a under the nitrogen atmosphere, then placing the solution in a shaker with the ultrasonic frequency of 30-40kHz and the ultrasonic power of 300-400W for ultrasonic treatment for 5-20min, then adding 40-55 parts by weight of the dispersion b, placing the solution in the shaker, reacting in the dark at the temperature of 20-30 ℃ and the speed of 45-80r/min for 8-16H, dialyzing after the reaction is finished, and freezing and drying the product to obtain the vitamin C nanocapsule.
The modified chitosan is prepared by the following method: adding 1-3 parts by weight of chitosan into 90-110 parts by weight of 0.5-1.5 wt% acetic acid aqueous solution, stirring at the rotation speed of 500 plus 1000rpm, heating to 40-60 ℃, adding 0.5-2 parts by weight of modifier after 15-40min, keeping stirring for 8-16h, centrifuging and washing the product after the stirring is finished, and drying to obtain the modified chitosan.
Chitosan is a renewable polyelectrolyte which has no toxic and side effects and good biocompatibility and widely exists in nature, and the application of the chitosan is limited because the chitosan can only be dissolved in an acidic solution. Therefore, the invention adopts the modifier to modify the chitosan so as to improve the water solubility of the chitosan.
The high affinity of vitamin C to the modified chitosan neutralizes the cationic charge on the surface of the modified chitosan, the prepared nanocapsules have larger grain diameter, the stability of the nanocapsules is reduced, and the aggregation of the nanocapsules is induced. Therefore, in order to reduce the particle size of the nanocapsule and improve the stability, the present invention further adds a cross-linking agent to prepare the vitamin C nanocapsule.
The modifier is glycidol trimethyl ammonium chloride and/or (tri-bromopropyl) trimethyl ammonium bromide.
Preferably, the modifier is a mixture of glycidol trimethyl ammonium chloride and (tri-bromopropyl) trimethyl ammonium bromide, wherein the mass ratio of the glycidol trimethyl ammonium chloride to the (tri-bromopropyl) trimethyl ammonium bromide is (2-5) to (1-3).
The invention adopts both glycidol trimethyl ammonium chloride and (tri-bromopropyl) trimethyl ammonium bromide as modifiers, and mainly probably, the glycidol trimethyl ammonium chloride can generate cations to conjugate with chitosan through the reaction with epoxide ring, while the (tri-bromopropyl) trimethyl ammonium bromide can directly react with amino on C2 position of the chitosan, and the glycidol trimethyl ammonium chloride and the (tri-bromopropyl) trimethyl ammonium bromide jointly act to effectively improve the solubility and the adhesiveness of the chitosan and utilize the combination of common quaternary ammonium groups and negatively charged vitamin C through electrostatic interaction, thereby realizing the effective protection of the vitamin C.
The cross-linking agent is any one of phosphorylated cellulose nanocrystals and sodium tripolyphosphate.
Sodium tripolyphosphate is an ionic cross-linking agent, has three phosphate groups (triple negative charges), and chitosan has hydroxyl and amino groups, so that the amino groups are easily protonated and can be combined with the negative phosphate groups, and therefore, the sodium tripolyphosphate is often used as a cross-linking agent for chitosan. However, the chitosan complex prepared using sodium tripolyphosphate is a metastable system, has poor mechanical properties, and has a high dependence on pH.
Preferably, the cross-linking agent is a phosphorylated cellulose nanocrystal.
The phosphorylated cellulose nanocrystal is prepared by the following method:
s1, adding 4-9 parts by weight of microcrystalline cellulose into 90-110 parts by weight of 2-4mol/L hydrochloric acid, heating to 90-105 ℃, stirring at the rotating speed of 500-800rpm for 2-5h, then adding 180-220 parts by weight of water, continuing stirring for 20-40min, standing for 2-5h, pouring out the supernatant, centrifuging and washing the product, and drying to obtain cellulose nanocrystal;
s2, adding 2-5 parts by weight of the cellulose nanocrystal obtained in the step S1 into 40-60 parts by weight of 70-80 wt% phosphoric acid solution, heating to 60-75 ℃, stirring at the rotation speed of 600-1000rpm for 4-7h, then adding 95-110 parts by weight of water, continuing stirring for 10-30min, filtering, washing the product, and drying to obtain the phosphorylated cellulose nanocrystal.
The invention adopts phosphoric acid to hydrolyze the cellulose nanocrystal, the surface of the cellulose nanocrystal is endowed with strong negative charges of the cellulose nanocrystal through the modification of phosphate groups, and the cellulose nanocrystal is used as a strong reinforcing agent of a polymer matrix, hydrogen bonds between hydroxyl groups and amino groups on modified chitosan and hydrogen bonds between hydroxyl groups on the phosphorylated nanocellulose microcrystal have strong intermolecular and intramolecular interaction, and the complexation between the phosphorylated nanocellulose microcrystal and the modified chitosan obviously improves the mechanical property of the nanocapsule, is beneficial to improving the interaction between vitamin C and a matrix and promoting the effective release of the vitamin C.
The vitamin C nanocapsule prepared by adopting the modified chitosan and the phosphorylated cellulose nanocrystallines has good vitamin C packaging stability due to chemical bonding. The phosphorylated cellulose nano-crystallite is used as a filling cross-linking agent of a matrix of the modified chitosan, the mechanical strength of the vitamin C nano-capsule can be effectively improved, meanwhile, the modified chitosan and the phosphorylated cellulose nano-crystallite have strong adhesion, and can be attached to the skin cuticle, the nano-capsule is degraded and burst along with the approach of the temperature of the mask and the surface temperature of the human skin, the internal vitamin C can be effectively released, and the vitamin C can be effectively absorbed and utilized by the skin.
The invention also provides a preparation method of the anti-aging whitening moisturizing mask, which comprises the following steps:
(1) mixing glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water, heating to 50-65 ℃, stirring for 15-40min, then vacuum homogenizing for 3-8min, adding vitamin C or vitamin C nanocapsules, and vacuum stirring uniformly to obtain a mask liquid;
(2) and (3) soaking the mask base cloth in the mask liquid for 20-40min to obtain the anti-aging whitening moisturizing mask.
The invention has the beneficial effects that: the anti-aging whitening moisturizing mask prepared by the invention has the advantages of mild raw materials, almost no stimulation to skin, simple preparation process operation, good stability of active ingredients, high skin utilization rate, multiple effects of anti-aging whitening moisturizing and the like.
Detailed Description
The above summary of the present invention is described in further detail below with reference to specific embodiments, but it should not be understood that the scope of the above subject matter of the present invention is limited to the following examples.
Introduction of some raw materials in this application:
acrylic/C10-30 alkyl acrylate crosspolymer, available from Wuhan eosin Biotech, Inc.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, CAS No.: 111286-86-3.
Chitosan, degree of deacetylation > 80%, was provided by seiranbo biotechnology limited.
Glycidyltrimethylammonium chloride, CAS number: 3033-77-0.
(tris-bromopropyl) trimethylammonium bromide, CAS No.: 3779-42-8.
Example 1
An anti-aging whitening moisturizing mask comprises a mask base cloth and a mask liquid.
The mask liquid comprises the following raw materials: 8 wt% glycerol, 2 wt% 1, 3-butanediol, 1 wt% 1, 2-pentanediol, 0.5 wt% acrylates/C10-30 alkyl acrylate crosspolymer, 0.5 wt% hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 4 wt% trehalose, 0.5 wt% xanthan gum, 0.8 wt% polysorbate-60, 0.6 wt% sodium hyaluronate, 0.3 wt% serine, 0.35 wt% arginine, 5 wt% vitamin C, and the balance water.
The mask base cloth is 384 ultrathin silk mask cloth.
An anti-aging whitening moisture mask and a preparation method thereof, comprising the following steps:
(1) mixing glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/acryloyl dimethyl sodium taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water, heating to 60 ℃, stirring for 30min, then carrying out vacuum homogenization for 5min, adding vitamin C, and carrying out vacuum stirring uniformly to obtain a mask liquid;
(2) and (3) soaking the mask base cloth in the mask liquid for 30min to obtain the anti-aging whitening moisturizing mask.
Example 2
An anti-aging whitening moisturizing mask comprises a mask base cloth and a mask liquid.
The mask liquid comprises the following raw materials: 8 wt% glycerol, 2 wt% 1, 3-butanediol, 1 wt% 1, 2-pentanediol, 0.5 wt% acrylates/C10-30 alkyl acrylate crosspolymer, 0.5 wt% hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 4 wt% trehalose, 0.5 wt% xanthan gum, 0.8 wt% polysorbate-60, 0.6 wt% sodium hyaluronate, 0.3 wt% serine, 0.35 wt% arginine, 5 wt% vitamin C nanocapsules, and the balance water.
The preparation method of the vitamin C nano capsule comprises the following steps:
h1, adding 2 parts by weight of modified chitosan into 100 parts by weight of water, and uniformly mixing to obtain a solution a; adding 1.5 parts by weight of vitamin C into 100 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 15 parts by weight of the solution C into 50 parts by weight of the solution a under the nitrogen atmosphere, then performing ultrasonic treatment for 10min under the ultrasonic frequency of 35kHz and the ultrasonic power of 350W, dialyzing after the ultrasonic treatment is finished, and freeze-drying the product to obtain the vitamin C nanocapsule.
The modified chitosan is prepared by the following method: adding 1.6 parts by weight of chitosan into 100 parts by weight of acetic acid aqueous solution with mass fraction of 1 wt%, stirring at the rotating speed of 800rpm, heating to 50 ℃, adding 1 part by weight of modifier after 30min, keeping stirring for 12h, centrifuging and washing the product after the stirring is finished, and drying to obtain the modified chitosan.
The modifier is glycidol trimethyl ammonium chloride.
The mask base cloth is 384 ultrathin silk mask cloth.
An anti-aging whitening moisture mask and a preparation method thereof, comprising the following steps:
(1) mixing glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water, heating to 60 ℃, stirring for 30min, then vacuum homogenizing for 5min, adding vitamin C nanocapsules, and vacuum stirring uniformly to obtain a mask liquid;
(2) and (3) soaking the mask base cloth in the mask liquid for 30min to obtain the anti-aging whitening moisturizing mask.
Example 3
An anti-aging whitening moisturizing mask comprises a mask base cloth and a mask liquid.
The mask liquid comprises the following raw materials: 8 wt% of glycerol, 2 wt% of 1, 3-butanediol, 1 wt% of 1, 2-pentanediol, 0.5 wt% of acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, 0.5 wt% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 4 wt% of trehalose, 0.5 wt% of xanthan gum, 0.8 wt% of polysorbate-60, 0.6 wt% of sodium hyaluronate, 0.3 wt% of serine, 0.35 wt% of arginine, 5 wt% of vitamin C nanocapsules, and the balance of water.
The preparation method of the vitamin C nano capsule comprises the following steps:
h1, adding 2 parts by weight of modified chitosan into 100 parts by weight of water, and uniformly mixing to obtain a solution a; adding 1.5 parts by weight of vitamin C into 100 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 15 parts by weight of the solution C into 50 parts by weight of the solution a under the nitrogen atmosphere, then performing ultrasonic treatment for 10min under the ultrasonic frequency of 35kHz and the ultrasonic power of 350W, dialyzing after the ultrasonic treatment is finished, and freeze-drying the product to obtain the vitamin C nanocapsule.
The modified chitosan is prepared by the following method: adding 1.6 parts by weight of chitosan into 100 parts by weight of acetic acid aqueous solution with mass fraction of 1 wt%, stirring at the rotating speed of 800rpm, heating to 50 ℃, adding 1 part by weight of modifier after 30min, keeping stirring for 12h, centrifuging and washing the product after the stirring is finished, and drying to obtain the modified chitosan.
The modifier is (tri-bromopropyl) trimethyl ammonium bromide.
The mask base cloth is 384 ultrathin silk mask cloth.
An anti-aging whitening moisture mask and a preparation method thereof, comprising the following steps:
(1) mixing glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water, heating to 60 ℃, stirring for 30min, then vacuum homogenizing for 5min, adding vitamin C nanocapsules, and vacuum stirring uniformly to obtain a mask liquid;
(2) and (3) soaking the mask base cloth in the mask liquid for 30min to obtain the anti-aging whitening moisturizing mask.
Example 4
An anti-aging whitening moisturizing mask comprises a mask base cloth and a mask liquid.
The mask liquid comprises the following raw materials: 8 wt% of glycerol, 2 wt% of 1, 3-butanediol, 1 wt% of 1, 2-pentanediol, 0.5 wt% of acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, 0.5 wt% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 4 wt% of trehalose, 0.5 wt% of xanthan gum, 0.8 wt% of polysorbate-60, 0.6 wt% of sodium hyaluronate, 0.3 wt% of serine, 0.35 wt% of arginine, 5 wt% of vitamin C nanocapsules, and the balance of water.
The preparation method of the vitamin C nano capsule comprises the following steps:
h1, adding 2 parts by weight of modified chitosan into 100 parts by weight of water, and uniformly mixing to obtain a solution a; adding 1.5 parts by weight of vitamin C into 100 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 15 parts by weight of the solution C into 50 parts by weight of the solution a under the nitrogen atmosphere, then performing ultrasonic treatment for 10min under the ultrasonic frequency of 35kHz and the ultrasonic power of 350W, dialyzing after the ultrasonic treatment is finished, and freeze-drying the product to obtain the vitamin C nanocapsule.
The modified chitosan is prepared by the following method: adding 1.6 parts by weight of chitosan into 100 parts by weight of acetic acid aqueous solution with mass fraction of 1 wt%, stirring at the rotating speed of 800rpm, heating to 50 ℃, adding 1 part by weight of modifier after 30min, keeping stirring for 12h, centrifuging and washing the product after the stirring is finished, and drying to obtain the modified chitosan.
The modifier is a mixture of glycidol trimethyl ammonium chloride and (tri-bromopropyl) trimethyl ammonium bromide, wherein the mass ratio of the glycidol trimethyl ammonium chloride to the (tri-bromopropyl) trimethyl ammonium bromide is 3: 2.
The mask base cloth is 384 ultrathin silk mask cloth.
An anti-aging whitening moisturizing mask and a preparation method thereof comprise the following steps:
(1) mixing glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water, heating to 60 ℃, stirring for 30min, then vacuum homogenizing for 5min, adding vitamin C nanocapsules, and vacuum stirring uniformly to obtain a mask liquid;
(2) and (3) soaking the mask base cloth in the mask liquid for 30min to obtain the anti-aging whitening moisturizing mask.
Example 5
An anti-aging whitening moisturizing mask comprises a mask base cloth and a mask liquid.
The mask liquid comprises the following raw materials: 8 wt% of glycerol, 2 wt% of 1, 3-butanediol, 1 wt% of 1, 2-pentanediol, 0.5 wt% of acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, 0.5 wt% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 4 wt% of trehalose, 0.5 wt% of xanthan gum, 0.8 wt% of polysorbate-60, 0.6 wt% of sodium hyaluronate, 0.3 wt% of serine, 0.35 wt% of arginine, 5 wt% of vitamin C nanocapsules, and the balance of water.
The preparation method of the vitamin C nano capsule comprises the following steps:
h1, adding 2 parts by weight of modified chitosan into 100 parts by weight of water, and uniformly mixing to obtain a solution a; adding 4 parts by weight of cross-linking agent into 100 parts by weight of water, and performing ultrasonic dispersion to obtain a dispersion liquid b; adding 1.5 parts by weight of vitamin C into 100 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 15 parts by weight of the solution C into 50 parts by weight of the solution a under the nitrogen atmosphere, then placing the solution a under the ultrasonic frequency of 35kHz and the ultrasonic power of 350W for ultrasonic treatment for 10min, then adding 50 parts by weight of the dispersion b, placing the solution b into a shaking table, carrying out light-shielding reaction at the temperature of 25 ℃ at the speed of 60r/min for 12H, dialyzing after the reaction is finished, and freeze-drying the product to obtain the vitamin C nanocapsule.
The modified chitosan is prepared by the following method: adding 1.6 parts by weight of chitosan into 100 parts by weight of acetic acid aqueous solution with mass fraction of 1 wt%, stirring at the rotating speed of 800rpm, heating to 50 ℃, adding 1 part by weight of modifier after 30min, keeping stirring for 12h, centrifuging and washing the product after the stirring is finished, and drying to obtain the modified chitosan.
The modifier is a mixture of glycidol trimethyl ammonium chloride and (tri-bromopropyl) trimethyl ammonium bromide, wherein the mass ratio of the glycidol trimethyl ammonium chloride to the (tri-bromopropyl) trimethyl ammonium bromide is 3: 2.
The cross-linking agent is sodium tripolyphosphate.
The mask base cloth is 384 ultrathin silk mask cloth.
An anti-aging whitening moisture mask and a preparation method thereof, comprising the following steps:
(1) mixing glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water, heating to 60 ℃, stirring for 30min, then vacuum homogenizing for 5min, adding vitamin C nanocapsules, and vacuum stirring uniformly to obtain a mask liquid;
(2) and (3) soaking the mask base cloth in the mask liquid for 30min to obtain the anti-aging whitening moisturizing mask.
Example 6
An anti-aging whitening moisturizing mask comprises a mask base cloth and a mask liquid.
The mask liquid comprises the following raw materials: 8 wt% of glycerol, 2 wt% of 1, 3-butanediol, 1 wt% of 1, 2-pentanediol, 0.5 wt% of acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, 0.5 wt% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 4 wt% of trehalose, 0.5 wt% of xanthan gum, 0.8 wt% of polysorbate-60, 0.6 wt% of sodium hyaluronate, 0.3 wt% of serine, 0.35 wt% of arginine, 5 wt% of vitamin C nanocapsules, and the balance of water.
The preparation method of the vitamin C nano capsule comprises the following steps:
h1, adding 2 parts by weight of modified chitosan into 100 parts by weight of water, and uniformly mixing to obtain a solution a; adding 4 parts by weight of cross-linking agent into 100 parts by weight of water, and performing ultrasonic dispersion to obtain a dispersion liquid b; adding 1.5 parts by weight of vitamin C into 100 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 15 parts by weight of the solution C into 50 parts by weight of the solution a under the nitrogen atmosphere, then placing the solution in a shaker for ultrasonic treatment for 10min under the ultrasonic frequency of 35kHz and the ultrasonic power of 350W, then adding 50 parts by weight of the dispersion b, placing the solution in the shaker, carrying out light-shielding reaction for 12H at the temperature of 25 ℃ at the speed of 60r/min, dialyzing after the reaction is finished, and freeze-drying the product to obtain the vitamin C nanocapsule.
The modified chitosan is prepared by the following method: adding 1.6 parts by weight of chitosan into 100 parts by weight of acetic acid aqueous solution with mass fraction of 1 wt%, stirring at the rotating speed of 800rpm, heating to 50 ℃, adding 1 part by weight of modifier after 30min, keeping stirring for 12h, centrifuging and washing the product after the stirring is finished, and drying to obtain the modified chitosan.
The modifier is a mixture of glycidol trimethyl ammonium chloride and (tri-bromopropyl) trimethyl ammonium bromide, wherein the mass ratio of the glycidol trimethyl ammonium chloride to the (tri-bromopropyl) trimethyl ammonium bromide is 3: 2.
The cross-linking agent is phosphorylated cellulose nanocrystals.
The phosphorylated cellulose nanocrystal is prepared by the following method:
s1, adding 6 parts by weight of microcrystalline cellulose into 100 parts by weight of 3mol/L hydrochloric acid, heating to 100 ℃, stirring at a rotating speed of 600rpm for 3 hours, then adding 200 parts by weight of water, continuously stirring for 30min, standing for 3 hours, pouring out supernatant, centrifuging and washing a product, and drying to obtain cellulose nanocrystals;
s2, adding 3 parts by weight of the cellulose nanocrystal obtained in the step S1 into 50 parts by weight of phosphoric acid solution with the mass fraction of 75 wt%, heating to 70 ℃, stirring at the rotating speed of 800rpm for 5 hours, then adding 100 parts by weight of water, continuing stirring for 20 minutes, filtering, washing and drying the product to obtain the phosphorylated cellulose nanocrystal.
The mask base cloth is 384 ultrathin silk mask cloth.
An anti-aging whitening moisture mask and a preparation method thereof, comprising the following steps:
(1) mixing glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water, heating to 60 ℃, stirring for 30min, then vacuum homogenizing for 5min, adding vitamin C nanocapsules, and vacuum stirring uniformly to obtain a mask liquid;
(2) and (3) soaking the mask base cloth in the mask liquid for 30min to obtain the anti-aging whitening moisturizing mask.
Test example 1
Natural aging of skin is mainly caused by a chain oxidation reaction due to excessive free radicals, and thus one of the main indicators for evaluating cosmetic aging resistance is to measure the amount of scavenging ability for free radicals. The anti-aging efficacy evaluation of the invention is determined by DPPH free radical scavenging experiment, and specifically comprises the following steps:
taking the facial mask solution prepared in each example as a sample to be tested, firstly, adding 1mL of the sample to be tested into a 10mL centrifuge tube, then adding 1mL of DPPH solution prepared by 0.2mmo1/L ethanol, and mixing the DPPH solution and the DPPH solutionAfter being homogenized, the mixture reacts for 30min under the condition of keeping out of the light, and then the light absorption value A is measured at 517nmiAnd simultaneously measuring the light absorption value A of a mixed solution of 1mL of DPPH solution and 1mL of ethanol0Because the added sample to be measured has a certain light absorption value, and the influence on the measurement result is considered, the DPPH ethanol solution is replaced by the same amount of ethanol, the steps are repeated, and the measured light absorption value is the background value A of the solutionjThen, the DPPH radical clearance calculation formula is:
DPPH radical scavenging ratio (%) - [ A [ ]0-(Ai-Aj)]/A0×100％
Wherein A isiThe light absorption value is the light absorption value after the sample to be detected is added; a. thejThe light absorption value of the sample to be detected and the equal amount of ethanol mixed solution is obtained; a. the0The absorbance value of the mixed solution of DPPH solution and equal amount of ethanol is shown.
Table 1 anti-aging efficacy test results
The above results show that, compared with example 1, examples 2 to 6 have better anti-aging effect, and it is mainly possible that vitamin C, as an antioxidant, is easily affected by the processing environment during the preparation process, resulting in a great reduction in the anti-oxidation performance, but after the vitamin C is prepared into the nanocapsules, the stability of the vitamin C is effectively improved, thereby facilitating the anti-oxidation performance of the vitamin C in the mask liquid. Examples 5 and 6 are superior in anti-aging efficacy to example 4, probably because vitamin C nanocapsules prepared by adding a cross-linking agent have a small and uniform particle size and high stability; further, compared with the case of using sodium tripolyphosphate as a cross-linking agent in the embodiment 5, the phosphorylated cellulose nanocrystals are used as a cross-linking agent in the embodiment 6, so that the anti-aging effect is further improved, probably because the hydrogen bonds between the hydroxyl groups and the amino groups on the modified chitosan and the hydrogen bonds between the hydroxyl groups on the phosphorylated nanocellulose microcrystallines have strong intermolecular and intramolecular interactions, and the mechanical properties of the nanocapsules are remarkably improved by the complexation between the phosphorylated nanocellulose microcrystallines and the modified chitosan, which is beneficial to improving the interaction between vitamin C and the matrix and promoting the effective release of the vitamin C.
Test example 2
The whitening efficacy evaluation is determined by adopting a tyrosinase inhibition rate experiment, and specifically comprises the following steps: taking the anti-aging whitening skin care product prepared in each embodiment as a sample to be tested, firstly, preparing 100U/mL tyrosinase solution, 0.015 mol/L-tyrosine solution and 0.5mg/mL sample solution to be tested by using 100mM phosphate buffer solution with pH of 6.8; then 1.0mL of the sample solution to be tested, 0.5mL of the tyrosinase solution and 2.5mL of 100mM phosphate buffer solution with pH of 6.8 are added into a 10mL test tube with a plug and mixed uniformly, after heating in a water bath at 37 ℃ for 10min, 1.0mL of the L-tyrosine solution is added and heating is continued in the water bath at 37 ℃ for 10min, and the absorbance is measured at the wavelength of 475 nm. Each group of examples was tested in parallel for 5 groups and averaged. Tyrosinase activity inhibition calculation formula:
tyrosinase inhibition rate ═ 1- (C-D)/(A-B) ] × 100%
Wherein, A: adding the absorbance of the tyrosinase solution and the absorbance of the sample solution to be detected; b: the absorbance of the solution without the sample to be detected and the tyrosinase solution; c: adding the absorbance of the sample solution to be detected and the tyrosinase solution; d: adding the absorbance of the sample solution to be detected and the tyrosinase solution.
Table 2 whitening efficacy test results
Tyrosinase is a key substance for melanin synthesis, and the generation of melanin can be effectively controlled by inhibiting the activity of tyrosinase. The invention adopts the vitamin C to be directly combined with the tyrosinase, so that the action site of the vitamin C and the tyrosinase is lost, the tyrosinase is subjected to non-destructive inhibition, and the tyrosinase is not modified, so that the generation of melanin is effectively controlled, and the whitening effect is realized.
The vitamin C nanocapsule prepared by adopting the modified chitosan and the phosphorylated cellulose nanocrystallines has good vitamin C packaging stability due to chemical bonding. The phosphorylated cellulose nano-microcrystal is used as a filling cross-linking agent of a matrix of the modified chitosan, the mechanical strength of the vitamin C nano-microcapsule can be effectively improved, meanwhile, the modified chitosan and the phosphorylated cellulose nano-microcrystal have strong adhesion, and can be attached to the skin cuticle, the nanocapsules are degraded and burst along with the approach of the temperature of the mask to the surface temperature of the skin of a human body, the internal vitamin C can be effectively released, the vitamin C can be promoted to be efficiently absorbed and utilized by the skin, and further multiple effects of resisting aging, whitening, moisturizing and the like of the mask are realized.
Claims (9)
1. An anti-aging whitening moisturizing mask is characterized by comprising mask base cloth and mask liquid; the mask liquid comprises the following raw materials: glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water.
2. The anti-aging whitening and moisturizing mask as claimed in claim 1, wherein the mask solution further comprises vitamin C or vitamin C nanocapsules.
3. The mask as claimed in claim 2, wherein the vitamin C nanocapsule is prepared by a method comprising the steps of:
h1, adding 1-3 parts by weight of modified chitosan into 80-120 parts by weight of water, and uniformly mixing to obtain a solution a; adding 0.5-2 parts by weight of vitamin C into 90-110 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 4-8 parts by weight of the solution C into 40-55 parts by weight of the solution a under nitrogen atmosphere, carrying out ultrasonic treatment, dialyzing after the ultrasonic treatment, and freeze-drying the product to obtain the vitamin C nano-capsule.
4. The mask as claimed in claim 2, wherein the vitamin C nanocapsule is prepared by a method comprising the steps of:
h1, adding 1-3 parts by weight of modified chitosan into 80-120 parts by weight of water, and uniformly mixing to obtain a solution a; adding 3-6 parts by weight of cross-linking agent into 85-110 parts by weight of water, and performing ultrasonic dispersion to obtain dispersion liquid b; adding 0.5-2 parts by weight of vitamin C into 90-110 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 10-20 parts by weight of the solution C into 40-60 parts by weight of the solution a under nitrogen atmosphere, carrying out ultrasonic treatment, adding 40-55 parts by weight of the dispersion b, putting into a shaking table for reaction, dialyzing after the reaction is finished, and freeze-drying the product to obtain the vitamin C nanocapsule.
5. The anti-aging whitening and moisturizing mask as claimed in claim 3 or 4, wherein the modified chitosan is prepared by the following method: adding 1-3 parts by weight of chitosan into 90-110 parts by weight of acetic acid aqueous solution, stirring and simultaneously heating, adding 0.5-2 parts by weight of modifier after 15-40min, keeping stirring, centrifuging and washing the product after the stirring is finished, and drying to obtain the modified chitosan.
6. The mask of claim 4, wherein the cross-linking agent is any one of a phosphorylated cellulose nanocrystal and sodium tripolyphosphate.
7. The anti-aging whitening moisturizing mask as claimed in claim 6, wherein the phosphorylated cellulose nanocrystals are prepared by the following method:
s1, adding 4-9 parts by weight of microcrystalline cellulose into 90-110 parts by weight of hydrochloric acid, heating and stirring for 2-5h, then adding 180-220 parts by weight of water, continuously stirring for 20-40min, standing, pouring out supernatant, centrifuging and washing a product, and drying to obtain cellulose nanocrystals;
s2, adding 2-5 parts by weight of the cellulose nanocrystal obtained in the step S1 into 40-60 parts by weight of phosphoric acid solution, heating and stirring for 4-7 hours, then adding 95-110 parts by weight of water, continuing stirring, filtering, washing a product, and drying to obtain the phosphorylated cellulose nanocrystal.
8. The method for preparing the anti-aging whitening moisture mask as claimed in claims 1 to 7, comprising the steps of:
(1) mixing glycerol, 1, 3-butanediol, 1, 2-pentanediol, acrylic acid (ester)/C10-30 alkyl acrylate cross-linked polymer, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, trehalose, xanthan gum, polysorbate-60, sodium hyaluronate, serine, arginine and water, heating and stirring, then carrying out vacuum homogenization, adding vitamin C or vitamin C nanocapsules, and carrying out vacuum stirring uniformly to obtain a mask liquid;
(2) and (3) immersing the mask base cloth into the mask liquid to obtain the anti-aging whitening moisturizing mask.
9. The vitamin C nanocapsule is characterized by comprising the following steps:
h1, adding 1-3 parts by weight of modified chitosan into 80-120 parts by weight of water, and uniformly mixing to obtain a solution a; adding 3-6 parts by weight of cross-linking agent into 85-110 parts by weight of water, and performing ultrasonic dispersion to obtain dispersion liquid b; adding 0.5-2 parts by weight of vitamin C into 90-110 parts by weight of water, and uniformly mixing to obtain a solution C;
h2, adding 10-20 parts by weight of the solution C into 40-60 parts by weight of the solution a under nitrogen atmosphere, carrying out ultrasonic treatment, adding 40-55 parts by weight of the dispersion b, putting into a shaking table for reaction, dialyzing after the reaction is finished, and freeze-drying the product to obtain the vitamin C nanocapsule.
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Effective date of registration: 20231222 Address after: Unit 09-11, Room 3801, No. 17, the Pearl River West Road, Tianhe District, Guangzhou, Guangdong 510620 Patentee after: Guangzhou Kefubao Technology Co.,Ltd. Address before: 250000 No. 12, Gongye Road, Licheng District, Jinan City, Shandong Province Patentee before: Sun Tingsheng |