CN114586689A - Cage is cultivateed to intelligence nude mouse - Google Patents

Abstract

The utility model relates to a cage is cultivateed to intelligence nude mouse, constitute bottom plate, roof, the curb plate of box structure and be located including splicing each other the baffle of box structure inner space, wherein the baffle will the inner space partition for the living activity space of nude mouse and with the monitoring space that the activity space keeps apart each other, the baffle is at least partly made by the printing opacity material, just still be provided with a pair ofly in the monitoring space the nude mouse carries out the detection mechanism that vital sign detected. The intelligent nude mouse cultivation cage provided by the invention can be matched with a controller carrying image acquisition and/or audio acquisition to monitor the vital signs of a nude mouse, and timely send out an acousto-optic prompt when the vital strength of the nude mouse is weakened so as to carry out experimental record or other further processing.

Description

Cage is cultivateed to intelligence nude mouse

Technical Field

The invention relates to an experimental device, in particular to an intelligent nude mouse culture cage.

Background

Nude mice (Nude Mouse) refer to experimental mice without thymus and loss of immune system. It is a mutant mouse with congenital thymic defect, which is formed by homozygosis of nude locus genes in the VIII linkage group. In particular, it has special value in the fields of oncology, immunology, safety evaluation of drugs and biological products, screening of effective drugs, and the like. But clearly, nude mice lack T cells and are vulnerable to bacterial, viral and fungal infections. Therefore, the conventional animal feeding method cannot be generally adopted for feeding nude mice. Fig. 1 shows a nude mouse cage 100 commonly used in laboratories at present, and as shown in fig. 1, the nude mouse cage structurally comprises a main body (not labeled) made of plastic and a stainless steel wire cage cover plate combined on the main body, and has a simple structure and relatively low cost. However, the inventor finds that the current nude mouse cage breeding environment is poor, and when a plurality of nude mouse cages are on a clean laminar flow frame, the nude mouse cage is difficult to observe, and the nude mouse cage cannot be timely found after death. It is seen that there is a need for improvement in the art.

Disclosure of Invention

In view of the above problems in the prior art, an object of the present invention is to provide an intelligent nude mouse cultivation cage which is easy to observe and can intelligently determine the survival status of nude mice.

In order to achieve the purpose, the intelligent nude mouse cultivation cage provided by the invention comprises a bottom plate, a top plate, side plates and a partition plate, wherein the bottom plate, the top plate and the side plates are mutually spliced to form a box body structure, the partition plate is positioned in an internal space of the box body structure, the internal space is divided into a moving space for the nude mouse to live and a monitoring space which is isolated from the moving space, at least part of the partition plate is made of a light-transmitting material, and a detection mechanism for detecting vital signs of the nude mouse is further arranged in the monitoring space.

Preferably, the detection mechanism includes a controller, and an audio acquisition device and an infrared thermal imaging device electrically connected to the controller, the audio acquisition device is configured to acquire audio information of an activity space where the nude mouse is located, the infrared thermal imaging device is configured to acquire an infrared thermal imaging video stream of the activity space where the nude mouse is located, the controller includes a neural network algorithm model, the neural network algorithm model is configured to perform analysis based on a deep convolutional neural network algorithm on the audio information and/or the infrared thermal imaging video stream, and the controller is further configured to determine whether a vital sign of the nude mouse reaches a preset critical point according to an analysis result, and if so, control the alarm unit to send out an audible and visual prompt.

Preferably, the detection mechanism further comprises an image acquisition device, the image acquisition device is configured to acquire static image information of an activity space where the nude mouse is located at preset time intervals, and the neural network algorithm model is further configured to obtain an activity track and/or an activity posture of the nude mouse in the activity space according to the static image information; the controller is also configured to judge whether the nude mouse is in a static state according to the movement track and/or the movement posture of the nude mouse in a plurality of time intervals, and if so, the controller controls the alarm unit to give out an audible and visual prompt.

Preferably, the neural network algorithm includes a first classifier for analyzing the infrared thermal imaging video stream and a second classifier for analyzing the still image information.

Preferably, the side plates include a first side plate, a second side plate, a third side plate and a fourth side plate which are spliced with each other, wherein the first side plate is opposite to the second side plate, the third side plate is opposite to the fourth side plate, and at least the first side plate is made of a light-transmitting material.

Preferably, the partition board comprises a transverse partition board in an L shape, and a first vertical partition board and a second vertical partition board which are vertically connected to two side edges of the transverse partition board, and the transverse partition board, the first vertical partition board and the second vertical partition board are all made of light-transmitting materials.

Preferably, the first vertical partition divides the movable space into a first movable space and a second movable space which are communicated with each other.

Preferably, a fourth slot is formed in the bottom plate near the fourth angular position, a sixth slot is formed in the top plate near the fourth angular position, a first inserting tenon is arranged on the third side plate near the fourth angular position, a second inserting tenon is arranged on the fourth side plate near the fourth angular position, and the first inserting tenon and the second inserting tenon are respectively in inserting fit with the fourth slot and the sixth slot.

Preferably, a first notch for forming a plug-in fit with the first side plate and the second side plate, and a first slot and a second slot perpendicular to each other are further provided on the plate surface of the third side plate near the fourth corner position thereof, the first slot is configured to form a plug-in fit with a fourth plug tongue at the end of the first vertical partition plate, and the second slot is configured to form a plug-in fit with a third plug tongue at the end of the transverse partition plate.

Preferably, the transverse partition plate is close to one side of the second side plate and is provided with a fourth inserting tenon, and the second side plate is provided with a special-shaped bayonet which is matched with the fourth inserting tenon in an inserting mode and corresponds to the position of the fourth inserting tenon.

Compared with the prior art, the intelligent nude mouse cultivation cage provided by the invention can be processed and assembled by light-transmitting materials such as acrylic materials, so that the cost is not obviously increased compared with that of the traditional nude mouse cultivation cage, and the price is expected to be lower than that of the traditional cultivation cage under the condition of mass production. More importantly, in the technical scheme provided by the invention, the controller carrying image acquisition and/or audio acquisition can be matched to monitor the vital signs of the nude mouse, and when the vital strength of the nude mouse is weakened, an acousto-optic prompt is timely sent out so as to carry out experimental record or other further processing.

Drawings

FIG. 1 is a schematic diagram of a conventional nude mouse culture cage.

FIG. 2 is a schematic perspective view of the intelligent nude mouse culture cage according to the present invention.

FIG. 3 is another perspective view of the intelligent nude mouse cultivation cage according to the present invention (with a part of the plate removed).

Fig. 4 is a schematic diagram of a three-dimensional explosion structure of the intelligent nude mouse culture cage of the present invention.

FIG. 5 is a schematic diagram of the first step of the intelligent nude mouse culture cage of the present invention when it is opened.

FIG. 6 is a schematic diagram of a second step of the intelligent nude mouse culture cage of the present invention when it is opened.

FIG. 7 is a schematic diagram of the third step of the intelligent nude mouse culture cage of the present invention when it is opened.

FIG. 8 is a schematic structural view of the detection mechanism of the intelligent nude mouse culture cage of the present invention.

FIG. 9 is a schematic structural view of a top plate of the intelligent nude mouse culture cage according to the present invention.

FIG. 10 is a schematic structural view of a bottom plate of the intelligent nude mouse culture cage according to the present invention.

Fig. 11 is a schematic structural view of a second side plate of the intelligent nude mouse culture cage according to the present invention.

Fig. 12 is a schematic structural view of a third side plate of the intelligent nude mouse culture cage according to the present invention.

Fig. 13 is a schematic structural view of a fourth side plate of the intelligent nude mouse culture cage according to the present invention.

FIG. 14 is a schematic structural view of a transverse partition plate of the intelligent nude mouse culture cage according to the present invention.

FIG. 15 is a schematic structural view of a first vertical partition plate of the intelligent nude mouse culture cage according to the present invention.

FIG. 16 is a block diagram of the structure of the detection mechanism of the intelligent nude mouse culture cage according to the present invention.

In the figure:

1-culture cage; 10-inserting plate; 11-a first side panel; 12-a third side panel; 13-a fourth side panel; 14-a base plate; 15-a second side panel; 16-a top plate; 17-a transverse partition; 18-a first vertical partition; 19-a second vertical partition; 20-a detection mechanism; 21-an image acquisition device; 22-an audio acquisition device; 23-an infrared thermal imaging device; 24-a controller; 30-a first activity space; 40-a second activity space; 50-monitoring a space; 100-conventional naked mouse cage; 101-a first tongue; 111-a second tongue; 121-a first falcon; 122-a first notch; 123-a first slot; 124-a second slot; 131-a second falcon; 132-a second notch; 133-a third slot; 141-fourth slot; 142-a third notch; 151-special-shaped bayonet; 152-fifth slot; 153-fourth notch; 154-a third falcon; 161-air holes; 162-a cross slot; 163-sixth slot; 164-seventh slot; 171-a fourth falcon; 172-a third tongue; 173-fifth notch; 174-eighth slot; 181-fourth tongue; 182-a fifth falcon; 183-sixth falcon insertion; 184-a seventh falcon; 191-a fifth tongue; 192-an eighth falcon; 241-neural network algorithm model; 1711-card slot; 1721-ninth slot; 2411-a first classifier; 2412-a second classifier.

Detailed Description

In order to make the technical solutions of the present invention better understood, the present invention will be described in detail below with reference to the accompanying drawings and specific embodiments.

Various aspects and features of the present invention are described herein with reference to the drawings.

These and other characteristics of the invention will become apparent from the following description of a preferred form of embodiment, given as a non-limiting example, with reference to the accompanying drawings.

It should also be understood that, although the invention has been described with reference to some specific examples, a person of skill in the art shall certainly be able to achieve many other equivalent forms of the invention, having the characteristics as set forth in the claims and hence all coming within the field of protection defined thereby.

The above and other aspects, features and advantages of the present invention will become more apparent in view of the following detailed description when taken in conjunction with the accompanying drawings.

As shown in fig. 2 to 8, an intelligent nude mouse cultivation cage according to an embodiment of the present invention includes a bottom plate 14, a top plate 16, side plates, and a partition board located in an internal space of a box structure, wherein the partition board divides the internal space into a living space for a nude mouse and a monitoring space 50 isolated from the living space, at least a portion of the partition board is made of a light-transmitting material, and a detection mechanism 20 for detecting vital signs of the nude mouse is further disposed in the monitoring space 50. Compared with the existing nude mouse culture cage 100 shown in fig. 1, the present invention can continuously detect the vital signs of nude mice through the detection mechanism 20. Specifically, the detecting mechanism 20 includes a controller 24, and an audio collecting device 22 and an infrared thermal imaging device 23 electrically connected to the controller 24, where the audio collecting device 22 is configured to collect audio information of an activity space where the nude mouse is located, the infrared thermal imaging device 23 is configured to collect an infrared thermal imaging video stream of the activity space where the nude mouse is located, the controller 24 includes a neural network algorithm model 241, the neural network algorithm model 241 is configured to analyze the audio information and/or the infrared thermal imaging video stream based on a deep convolutional neural network algorithm, and the controller 24 is further configured to determine whether a vital sign of the nude mouse reaches a preset critical point according to an analysis result, for example, control the alarm unit to emit an audible and visual alarm. When the specific judgment of the body sign is performed, it can be understood that, for mammals including a nude mouse, the video stream monitoring is performed by the infrared thermal imaging principle, so that the temperature field on the body of the nude mouse can be clearly presented, and further, a classifier for performing temperature screening on thermal imaging data presented in the video stream can be constructed by a mature convolutional neural network algorithm model (CNN), wherein the classifier can particularly form event monitoring on the thermal imaging data with the body temperature reduced below a dangerous temperature, if the body temperature of the nude mouse is found to be abnormal, the vital sign of the nude mouse can reach a preset critical point artificially, and at this time, the controller 24 controls another alarm unit to give out an audible and visual prompt. Generally speaking, when the survival state of the nude mouse is normal, relatively irregular activity sound exists, and aiming at the detection, in the invention, the audio acquisition device 22 can continuously acquire the audio of the nude mouse activity area, and further judge whether the audio data is blank data, if the audio data of the nude mouse activity can not be acquired except for background noise within a longer preset time range, the possibility of abnormal vital signs of the nude mouse can be judged according to the blank data, and an audible and visual prompt can be sent out. In practical applications, the implementation of audio-based monitoring, processing related to sound waves and event setting can all be implemented based on conventional algorithms. In the invention, as further explained, the vital sign monitoring based on the infrared thermal imaging principle and the monitoring based on audio acquisition can be mutually proved as sufficient necessary conditions, so that the detection accuracy is improved.

Meanwhile, preferably, the detecting mechanism 20 further includes an image capturing device 21, the image capturing device 21 is configured to capture static image information of an activity space where the nude mouse is located at preset time intervals, and the neural network algorithm model 241 is further configured to derive an activity track and/or an activity posture of the nude mouse in the activity space according to the static image information; the controller 24 is further configured to determine whether the nude mouse is in a static state according to the movement track and/or movement posture of the nude mouse in a plurality of time intervals, and if so, control the alarm unit to emit an audible and visual alarm. Similar to algorithms for analyzing thermal imaging data, still images acquired during still image acquisition may also be based on sophisticated classification algorithms. This link is also a supplement to the above two means, and aims to determine whether the nude mouse is expected to move in situ, and if so, to prove the abnormality of the vital signs of the nude mouse. Therefore, in this modification, the neural network algorithm 241 may specifically include a first classifier 2411 for analyzing the infrared thermal imaging video stream, and a second classifier 2412 for analyzing the still image information.

Fig. 4 is a schematic perspective view illustrating an explosion structure of an intelligent nude mouse cultivation cage 1 according to the present invention, wherein, as shown in the figure, in fact, for convenience of assembly, the side panels include a first side panel 11, a second side panel 15, a third side panel 12 and a fourth side panel 13 which are spliced with each other, wherein the first side panel 11 is opposite to the second side panel 15, the third side panel 12 is opposite to the fourth side panel 13, and at least the first side panel 11 is made of a light-transmitting material. The first side plate 11, the second side plate 15, the third side plate 12, and the fourth side plate 13 may be made of a transparent material such as acrylic, which is convenient for observation. Meanwhile, the partition board comprises a transverse partition board 17 constructed in an L shape, a first vertical partition board 18 and a second vertical partition board 19 which are vertically connected to two side edges of the transverse partition board 17, and the transverse partition board 17, the first vertical partition board 18 and the second vertical partition board 19 are made of light-transmitting materials which are the same as the side boards. Wherein the first vertical partition 18 divides the activity space into a first activity space 30 and a second activity space 40 which are communicated with each other.

As shown in fig. 9 to 15, the intelligent nude mouse cultivation cage according to the present invention may be implemented by a plurality of sheets in a socket engagement with each other, and specifically, a fourth insertion groove 141 is provided on the bottom plate 14 near a fourth angular position thereof, a sixth insertion groove 163 is provided on the top plate 16 near a fourth angular position thereof, a first insertion falcon 121 is provided on the third side plate 12 near a fourth angular position thereof, a second insertion falcon 131 is provided on the fourth side plate 13 near a fourth angular position thereof, and the first insertion falcon 121 and the second insertion falcon 131 are respectively in socket engagement with the fourth insertion groove 141 and the sixth insertion groove 163. The top plate 16 is further provided with an air hole 161, a cross slot 162 and a seventh slot 164, the air hole 161 corresponds to the activity space and keeps the air circulation of the living area of the nude mouse, and the seventh slot 164 is configured to form a plug-in fit with the bottom of the second side plate 15.

In addition, a first notch 122 for forming a plug fit with the first side plate 11 and the second side plate 15, and a first slot 123 and a second slot 124 perpendicular to each other are further provided on the plate surface of the third side plate 12 near the fourth corner position thereof, the first slot 123 is configured to form a plug fit with a fourth plug tongue 181 at the end of the first vertical partition plate 18, and the second slot 124 is configured to form a plug fit with a third plug tongue 172 at the end of the transverse partition plate 17. The first vertical partition 18 is provided at one end with a fourth tongue 181, a fifth tongue 182, a sixth tongue 183 and a seventh tongue 184, wherein the fourth tongue 181 is engaged with the first slot 123, and the fifth tongue 182 is engaged with the cross-shaped slot 162 and is slidable in the cross-shaped slot 162. The sixth insertion tenon 183 is engaged with the fifth notch 173 formed in the transverse partition 17, and the seventh insertion tenon 184 is engaged with the eighth insertion groove 174 formed in the transverse partition 17. Fourth side panel 13 is also provided with a second slot 132 and a third slot 133, second slot 132 and first slot 122 being configured to mate with a third pin 154 on second side panel 15.

In addition, the lateral partition 17 is provided with a fourth inserting tenon 171 near one side of the second side plate 15, and the fourth inserting tenon 171 is an L-shaped clamping member having at least one clamping groove 1711. The second side plate 15 is provided with a special-shaped bayonet 151 in a plug-in fit with the fourth pin 171, corresponding to the position of the fourth pin 171.

A fifth tongue 191 is provided on one side of the second vertical partition 19 and an eighth tongue 192 is provided on the other side, the eighth tongue 192 also forming a plug-in fit with the cross slot 162. The fifth tongue 191 forms a plug-in fit with the fifth slot 152 on the second side plate 15. And the second side plate 15 is also provided with fourth notches 153 at two opposite sides, and the fourth notches 153 are clamped into the first notches 122 and the second notches 132.

In addition, a ninth slot 1721 is disposed on a portion of the third tongue 172 extending out of the second slot 124, an insertion plate 10 is inserted into the ninth slot 1721, the insertion plate 10 at least has a first tongue 101, and the first tongue 101 is inserted into the ninth slot 1721 to lock the transverse partition 17.

Fig. 5 to 7 illustrate the disassembling process of the intelligent nude mouse cultivation cage according to the present invention, and as shown in the drawings, when the nude mouse cultivation cage is disassembled, the insertion plate 10 is removed, and then the fourth insertion tongue 181 of the first vertical partition plate 18 and the third insertion tongue 172 of the transverse partition plate 17 are pushed inward. Referring to fig. 6, the second side plate 15 can now be completely pulled up and removed. The transverse partition 17 and the first and second vertical partitions 18 and 19 can then be removed in sequence from the open side.

The above embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and the scope of the present invention is defined by the claims. Various modifications and equivalents may be made by those skilled in the art within the spirit and scope of the present invention, and such modifications and equivalents should also be considered as falling within the scope of the present invention.

Claims (10)

1. Cage is cultivateed to intelligence nude mouse, constitutes bottom plate, roof, curb plate and is located of box structure inner space including splicing each other the baffle of box structure inner space, wherein the baffle will inner space partition for the nude mouse life the activity space and with the monitoring space that the activity space keeps apart each other, the baffle is at least partly made by the printing opacity material, just still be provided with a pair in the monitoring space the nude mouse carries out the detection mechanism that vital sign detected.

2. The intelligent nude mouse cultivation cage of claim 1, wherein the detection mechanism comprises a controller, and an audio collection device and an infrared thermal imaging device electrically connected to the controller, the audio collection device is configured to collect audio information of an activity space where a nude mouse is located, the infrared thermal imaging device is configured to collect an infrared thermal imaging video stream of the activity space where the nude mouse is located, the controller comprises a neural network algorithm model, the neural network algorithm model is configured to perform analysis based on a deep convolutional neural network algorithm on the audio information and/or the infrared thermal imaging video stream, and the controller is further configured to determine whether a vital sign of the nude mouse reaches a preset critical point according to an analysis result, and if so, control the alarm unit to emit an audible and visual alarm.

3. The intelligent nude mouse cultivation cage of claim 2, wherein the detection mechanism further comprises an image capturing device configured to capture static image information of an activity space where the nude mouse is located at preset time intervals, and the neural network algorithm model is further configured to derive an activity track and/or an activity posture of the nude mouse in the activity space according to the static image information; the controller is also configured to judge whether the nude mouse is in a static state according to the movement track and/or the movement posture of the nude mouse in a plurality of time intervals, and if so, the controller controls the alarm unit to give out an audible and visual prompt.

4. The intelligent nude mouse culture cage of claim 3, wherein the neural network algorithm includes a first classifier for analyzing the infrared thermal imaging video stream and a second classifier for analyzing the still image information.

5. The intelligent nude mouse cultivation cage of claim 1, wherein the side plates comprise a first side plate, a second side plate, a third side plate and a fourth side plate, wherein the first side plate, the second side plate, the third side plate and the fourth side plate are connected to each other, the first side plate is opposite to the second side plate, the third side plate is opposite to the fourth side plate, and at least the first side plate is made of a light-transmitting material.

6. The intelligent nude mouse culturing cage of claim 5, wherein the partition comprises a transverse partition constructed in an "L" shape, and a first vertical partition and a second vertical partition vertically connected to two sides of the transverse partition, and the transverse partition, the first vertical partition and the second vertical partition are made of light-transmitting materials.

7. The intelligent nude mouse cultivation cage of claim 6, wherein the first vertical partition divides the activity space into a first activity space and a second activity space that are in communication.

8. The intelligent nude mouse culturing cage of claim 5, wherein the bottom plate is provided with a fourth slot near a fourth angular position thereof, the top plate is provided with a sixth slot near a fourth angular position thereof, the third side plate is provided with a first inserting falcon near a fourth angular position thereof, the fourth side plate is provided with a second inserting falcon near a fourth angular position thereof, and the first inserting falcon and the second inserting falcon are respectively in inserting fit with the fourth slot and the sixth slot.

9. The intelligent nude mouse cultivation cage of claim 5, wherein the third side plate has a first notch on the plate surface near the four corners thereof for forming a plug-in fit with the first side plate and the second side plate, and a first slot and a second slot perpendicular to each other, wherein the first slot is configured to form a plug-in fit with a fourth plug tongue at the end of the first vertical partition plate, and the second slot is configured to form a plug-in fit with a third plug tongue at the end of the transverse partition plate.

10. The intelligent nude mouse cultivation cage of claim 9, wherein the lateral partition is provided with a fourth inserting falcon adjacent to one side of the second side plate, and the second side plate is provided with a special-shaped bayonet which is in inserting fit with the fourth inserting falcon corresponding to the position of the fourth inserting falcon.

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