CN114569668A - Preparation method of physalin refined from calyx seu fructus physalis for treating pharyngitis and tonsillitis - Google Patents
Preparation method of physalin refined from calyx seu fructus physalis for treating pharyngitis and tonsillitis Download PDFInfo
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- 201000007100 Pharyngitis Diseases 0.000 title claims abstract description 37
- XACHQDDXHDTRLX-GMPBGBGESA-N Physalien Natural products O=C(O[C@H]1CC(C)(C)C(/C=C/C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C=2C(C)(C)C[C@H](OC(=O)CCCCCCCCCCCCCCC)CC=2C)\C)/C)\C)/C)=C(C)C1)CCCCCCCCCCCCCCC XACHQDDXHDTRLX-GMPBGBGESA-N 0.000 title claims abstract description 26
- 229930184989 physalin Natural products 0.000 title claims abstract description 26
- XACHQDDXHDTRLX-HZXCUAKRSA-N zeaxanthin dipalmitate Chemical compound CC1(C)CC(OC(=O)CCCCCCCCCCCCCCC)CC(C)=C1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CC(OC(=O)CCCCCCCCCCCCCCC)CC1(C)C XACHQDDXHDTRLX-HZXCUAKRSA-N 0.000 title claims abstract description 26
- 244000064622 Physalis edulis Species 0.000 title claims abstract description 25
- 241001164374 Calyx Species 0.000 title claims abstract description 24
- 206010044008 tonsillitis Diseases 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
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Abstract
The invention discloses a preparation method of physalin which is a calyx seu fructus physalis refined product for treating pharyngitis and tonsillitis, and the physalin is prepared from the following raw materials in parts by weight: 10-15 parts of calyx seu fructus physalis, 20-30 parts of honeysuckle, 10-15 parts of dandelion, 10-15 parts of herba violae, 8-12 parts of trichosanthes root, 8-12 parts of thunberg fritillary bulb, 4-6 parts of mint, 8-12 parts of burdock, 8-12 parts of radix scrophulariae, 10-15 parts of radix rehmanniae recen, 10-15 parts of radix isatidis and 5-10 parts of fructus forsythiae. The physalin is extracted from calyx seu fructus physalis serving as a main raw material, and then honeysuckle, dandelion, bunge corydalis herb, trichosanthes root, thunberg fritillary bulb, mint, great burdock achene, figwort root, rehmannia root, radix isatidis and forsythia are added, wherein the physalin extracted from calyx seu fructus physalis has good medicinal value, has the effects of clearing away heat and toxic materials, relieving swelling and sore throat, nourishing yin and moistening dryness, promoting the production of body fluid and removing stasis, can relieve sore throat, is used for treating tonsillitis and chronic pharyngitis, and solves the problem of common treatment effect of the traditional medicines on pharyngitis and tonsillitis.
Description
Technical Field
The invention relates to the technical field of calyx seu fructus physalis, in particular to a preparation method of calyx seu fructus physalis refined product physalis extract for treating pharyngitis and tonsillitis.
Background
Pharyngitis is nonspecific inflammation of pharynx, is a general name of inflammation generated by various microorganisms infecting pharynx, can exist independently, can coexist with rhinitis, tonsillitis and laryngitis, or is a prodromal symptom of certain diseases, can be divided into acute pharyngitis and chronic pharyngitis, the acute pharyngitis is acute inflammation of pharynx mucosa and submucosal tissue, pharynx lymphoid tissue is often involved, the early stage of inflammation can be limited, the acute pharyngitis and the chronic pharyngitis can usually relate to the whole pharynx cavity along with the progress of diseases, the common intersection of autumn, winter and spring is mainly characterized by dry pharynx, burning sensation, pain, obvious swallowing pain, congestion and swelling of pharynx and the like, the chronic pharyngitis can be divided into chronic simple pharyngitis, chronic hypertrophic pharyngitis and atrophic pharyngitis, wherein the chronic simple pharyngitis is more common, the pathological changes are mainly in the mucosa, the chronic congestion of pharynx mucosa, the proliferation of mucosa and submucosal connective tissue under the mucosa, and mucous gland can be hypertrophic, the secretion function is hyperfunction, mucus secretion is increased, patients often expectorate phlegm in pharynx, or feel foreign body sensation in pharynx, cough can not be produced, pharynx can not be descended, adults are common, the disease course is long, recurrence is easy, symptoms are stubborn, and cure is difficult.
Disclosure of Invention
The invention aims to provide a preparation method of physalin which is a calyx seu fructus physalis refined product for treating pharyngitis and tonsillitis, has the advantage of good treatment effect on the pharyngitis and the tonsillitis, and solves the problem of common treatment effect of the traditional medicine on the pharyngitis and the tonsillitis.
In order to achieve the purpose, the invention provides the following technical scheme: the preparation method of physalin which is a calyx seu fructus physalis refined product for treating pharyngitis and tonsillitis comprises the following raw materials in parts by weight: 10-15 parts of calyx seu fructus physalis, 20-30 parts of honeysuckle, 10-15 parts of dandelion, 10-15 parts of herba violae, 8-12 parts of trichosanthes root, 8-12 parts of thunberg fritillary bulb, 4-6 parts of mint, 8-12 parts of burdock, 8-12 parts of radix scrophulariae, 10-15 parts of radix rehmanniae recen, 10-15 parts of radix isatidis and 5-10 parts of fructus forsythiae.
A method for preparing calyx seu fructus physalis refined extract physalin for treating pharyngitis and tonsillitis comprises the following steps;
A. taking 10 parts of calyx seu fructus physalis, cleaning, fully drying, and grinding into powder by a grinder;
B. b, putting the powder obtained in the step A into an extraction solvent containing complex enzyme and surfactant, adjusting the pH value to be 4-6, and then extracting by utilizing ultrasonic to obtain an extracting solution;
C. filtering the extracting solution obtained in the step B, concentrating the filtrate under reduced pressure, freeze-drying to obtain an extract A, and drying the filter residue;
D. c, adding the filter residue obtained in the step C into water containing an antioxidant, adjusting the pH value to be 3-5, and performing reflux extraction;
E. d, filtering the extracting solution obtained in the step D, concentrating the filtrate under reduced pressure, and freeze-drying to obtain an extract B;
F. c, uniformly mixing the extract A obtained in the step C and the extract B obtained in the step E to obtain physalin;
G. taking 20 parts of honeysuckle, 10 parts of dandelion, 10 parts of bunge corydalis herb, 8 parts of trichosanthes root, 8 parts of thunberg fritillary bulb, 4 parts of mint, 8 parts of burdock, 8 parts of figwort root, 10 parts of raw rehmannia root, 10 parts of isatis root and 5 parts of weeping forsythia, cleaning, airing and grinding into powder by using a grinder;
H. and D, mixing and stirring the powder obtained in the step G and the physalin obtained in the step F, and then steaming and boiling at high temperature for 6 hours to obtain the paste capable of treating pharyngitis and tonsillitis.
Preferably, the temperature of the high-temperature cooking in the step H is between 160 and 230 ℃.
Compared with the prior art, the invention has the following beneficial effects:
the physalin is extracted from calyx seu fructus physalis serving as a main raw material, and then honeysuckle, dandelion, bunge corydalis herb, trichosanthes root, thunberg fritillary bulb, mint, great burdock achene, figwort root, rehmannia root, radix isatidis and forsythia are added, wherein the physalin extracted from calyx seu fructus physalis has good medicinal value, has the effects of clearing away heat and toxic materials, relieving swelling and sore throat, nourishing yin and moistening dryness, promoting the production of body fluid and removing stasis, can relieve sore throat, is used for treating tonsillitis and chronic pharyngitis, and solves the problem of common treatment effect of the traditional medicines on pharyngitis and tonsillitis.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The first embodiment is as follows:
A. taking 15 parts of calyx seu fructus physalis, cleaning, fully drying, and grinding into powder by a grinder;
B. b, putting the powder obtained in the step A into an extraction solvent containing complex enzyme and surfactant, adjusting the pH value to be 4-6, and then extracting by utilizing ultrasonic to obtain an extracting solution;
C. filtering the extracting solution obtained in the step B, concentrating the filtrate under reduced pressure, freeze-drying to obtain an extract A, and drying the filter residue;
D. c, adding the filter residue obtained in the step C into water containing an antioxidant, adjusting the pH value to be 3-5, and performing reflux extraction;
E. d, filtering the extracting solution obtained in the step D, concentrating the filtrate under reduced pressure, and freeze-drying to obtain an extract B;
F. c, uniformly mixing the extract A obtained in the step C and the extract B obtained in the step E to obtain physalin;
G. taking 30 parts of honeysuckle, 15 parts of dandelion, 15 parts of bunge corydalis herb, 12 parts of trichosanthes root, 12 parts of thunberg fritillary bulb, 6 parts of mint, 12 parts of burdock, 12 parts of figwort root, 15 parts of raw rehmannia root, 15 parts of isatis root and 10 parts of weeping forsythia, cleaning, airing and grinding into powder by using a grinder;
H. and D, mixing and stirring the powder obtained in the step G and the physalin obtained in the step F, and then steaming and boiling at high temperature for 6 hours to obtain a paste capable of treating pharyngitis and tonsillitis.
Example two:
A. taking 12 parts of calyx seu fructus physalis, cleaning, fully drying, and grinding into powder by a grinding machine;
B. b, putting the powder obtained in the step A into an extraction solvent containing complex enzyme and surfactant, adjusting the pH value to be 4-6, and then extracting by utilizing ultrasonic to obtain an extracting solution;
C. filtering the extracting solution obtained in the step B, concentrating the filtrate under reduced pressure, freeze-drying to obtain an extract A, and drying the filter residue;
D. c, adding the filter residue obtained in the step C into water containing an antioxidant, adjusting the pH value to be 3-5, and performing reflux extraction;
E. d, filtering the extracting solution obtained in the step D, concentrating the filtrate under reduced pressure, and freeze-drying to obtain an extract B;
F. c, uniformly mixing the extract A obtained in the step C and the extract B obtained in the step E to obtain physalin;
G. taking 16 parts of honeysuckle, 8 parts of dandelion, 8 parts of bunge corydalis herb, 8 parts of trichosanthes root, 6 parts of thunberg fritillary bulb, 3 parts of mint, 6 parts of burdock, 6 parts of figwort root, 8 parts of radix rehmanniae recen, 8 parts of radix isatidis and 4 parts of fructus forsythiae, cleaning, airing and grinding into powder by using a grinder;
H. and D, mixing and stirring the powder obtained in the step G and the physalin obtained in the step F, and then steaming and boiling at high temperature for 6 hours to obtain the paste capable of treating pharyngitis and tonsillitis.
Example three:
A. taking 10 parts of calyx seu fructus physalis, cleaning, fully drying, and grinding into powder by a grinder;
B. b, putting the powder obtained in the step A into an extraction solvent containing complex enzyme and surfactant, adjusting the pH value to be 4-6, and then extracting by utilizing ultrasonic to obtain an extracting solution;
C. filtering the extracting solution obtained in the step B, concentrating the filtrate under reduced pressure, freeze-drying to obtain an extract A, and drying the filter residue;
D. c, adding the filter residue obtained in the step C into water containing an antioxidant, adjusting the pH value to be 3-5, and performing reflux extraction;
E. d, filtering the extracting solution obtained in the step D, concentrating the filtrate under reduced pressure, and freeze-drying to obtain an extract B;
F. c, uniformly mixing the extract A obtained in the step C and the extract B obtained in the step E to obtain physalin;
G. taking 20 parts of honeysuckle, 10 parts of dandelion, 10 parts of bunge corydalis herb, 8 parts of trichosanthes root, 8 parts of thunberg fritillary bulb, 4 parts of mint, 8 parts of burdock, 8 parts of figwort root, 10 parts of raw rehmannia root, 10 parts of isatis root and 5 parts of weeping forsythia, cleaning, airing and grinding into powder by using a grinder;
H. and D, mixing and stirring the powder obtained in the step G and the physalin obtained in the step F, and then steaming and boiling at high temperature for 6 hours to obtain the paste capable of treating pharyngitis and tonsillitis.
Example three:
A. taking 14 parts of calyx seu fructus physalis, cleaning, fully drying, and grinding into powder by a grinding machine;
B. b, putting the powder obtained in the step A into an extraction solvent containing complex enzyme and surfactant, adjusting the pH value to be 4-6, and then extracting by utilizing ultrasonic to obtain an extracting solution;
C. filtering the extracting solution obtained in the step B, concentrating the filtrate under reduced pressure, freeze-drying to obtain an extract A, and drying the filter residue;
D. c, adding the filter residue obtained in the step C into water containing an antioxidant, adjusting the pH value to be 3-5, and performing reflux extraction;
E. d, filtering the extracting solution obtained in the step D, concentrating the filtrate under reduced pressure, and freeze-drying to obtain an extract B;
F. c, uniformly mixing the extract A obtained in the step C and the extract B obtained in the step E to obtain physalin;
G. taking 18 parts of honeysuckle, 9 parts of dandelion, 9 parts of bunge corydalis herb, 7 parts of trichosanthes root, 7 parts of thunberg fritillary bulb, 3 parts of mint, 7 parts of burdock, 7 parts of figwort root, 9 parts of raw rehmannia root, 9 parts of isatis root and 4 parts of weeping forsythia, cleaning, airing and grinding into powder by using a grinder;
H. and D, mixing and stirring the powder obtained in the step G and the physalin obtained in the step F, and then steaming and boiling at high temperature for 6 hours to obtain the paste capable of treating pharyngitis and tonsillitis.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (3)
1. The preparation method of physalin which is a calyx seu fructus physalis refined product for treating pharyngitis and tonsillitis comprises the following steps: the composition is characterized by comprising the following raw materials in parts by weight: 10-15 parts of calyx seu fructus physalis, 20-30 parts of honeysuckle, 10-15 parts of dandelion, 10-15 parts of herba violae, 8-12 parts of trichosanthes root, 8-12 parts of thunberg fritillary bulb, 4-6 parts of mint, 8-12 parts of burdock, 8-12 parts of radix scrophulariae, 10-15 parts of radix rehmanniae recen, 10-15 parts of radix isatidis and 5-10 parts of fructus forsythiae.
2. The preparation method of physalin which is a calyx seu fructus physalis refined product for treating pharyngitis and tonsillitis is characterized in that: comprises the following steps;
A. taking 10 parts of calyx seu fructus physalis, cleaning, fully drying, and grinding into powder by a grinder;
B. b, putting the powder obtained in the step A into an extraction solvent containing complex enzyme and surfactant, adjusting the pH value to be 4-6, and then extracting by utilizing ultrasonic to obtain an extracting solution;
C. filtering the extracting solution obtained in the step B, concentrating the filtrate under reduced pressure, freeze-drying to obtain an extract A, and drying the filter residue;
D. c, adding the filter residue obtained in the step C into water containing an antioxidant, adjusting the pH value to be 3-5, and performing reflux extraction;
E. d, filtering the extracting solution obtained in the step D, concentrating the filtrate under reduced pressure, and freeze-drying to obtain an extract B;
F. c, uniformly mixing the extract A obtained in the step C and the extract B obtained in the step E to obtain physalin;
G. taking 20 parts of honeysuckle, 10 parts of dandelion, 10 parts of bunge corydalis herb, 8 parts of trichosanthes root, 8 parts of thunberg fritillary bulb, 4 parts of mint, 8 parts of burdock, 8 parts of figwort root, 10 parts of raw rehmannia root, 10 parts of isatis root and 5 parts of weeping forsythia, cleaning, airing and grinding into powder by using a grinder;
H. and D, mixing and stirring the powder obtained in the step G and the physalin obtained in the step F, and then steaming and boiling at high temperature for 6 hours to obtain the paste capable of treating pharyngitis and tonsillitis.
3. The method for preparing physalin from calyx seu fructus physalis refined extract for treating pharyngitis and tonsillitis as claimed in claim 2, wherein: the temperature of the high-temperature cooking in the step H is between 160 and 230 ℃.
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