CN114557402A - Acidifier for repairing intestinal mucosa and preparation process thereof - Google Patents
Acidifier for repairing intestinal mucosa and preparation process thereof Download PDFInfo
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- CN114557402A CN114557402A CN202210188210.2A CN202210188210A CN114557402A CN 114557402 A CN114557402 A CN 114557402A CN 202210188210 A CN202210188210 A CN 202210188210A CN 114557402 A CN114557402 A CN 114557402A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
- A23K40/35—Making capsules specially adapted for ruminants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The invention provides an acidifier for repairing intestinal mucosa, which comprises the following effective components in part by weight: 1-5 parts of fibronectin and 15-30 parts of citric acid. In the invention, a coating wall material is dissolved in water to form a wall material coating solution, effective components of fibronectin and citric acid are mixed and then are embedded into a carrier to obtain an acidifier core, and finally the acidifier core is coated by the wall material coating solution to obtain the acidifier for repairing intestinal mucosa. The acidifying agent for repairing intestinal mucosa provided by the invention perfectly combines fibrin and citric acid, and the prescription not only can rapidly repair damaged gastrointestinal mucosa, but also can reduce acidity of a feed system, make up for gastric acid deficiency of animal cubs, improve the digestibility of feed protein, reduce the pH value of the gastrointestinal tract, and inhibit the growth of harmful pathogenic microorganisms, so that the immunity can be improved, the growth of animals can be promoted, and the health state of the animals can be improved.
Description
Technical Field
The invention relates to the technical field of feed additives, in particular to an acidifier for repairing intestinal mucosa and a preparation process thereof.
Background
The feed acidifier is an important additive which is juxtaposed with probiotics, enzyme preparations, microecologics and the like after antibiotics, and is an environment-friendly additive without residues, drug resistance and toxic action. The acidifier can reduce acidity of feed system, compensate for gastric acid deficiency of animal cubs, improve feed protein digestibility, reduce gastrointestinal pH value, and inhibit growth and reproduction of harmful pathogenic microorganisms such as Escherichia coli and Salmonella. The addition of an acidifier in the feed can improve the immunity and growth performance of animals, and the acidifier is widely applied to poultry, ruminants, pigs and aquaculture at present.
Fibronectin (Fn) is a high molecular weight glycoprotein in the extracellular matrix, and exists mainly in three forms, namely plasma Fibronectin produced by hepatocytes or endothelial cells, cellular Fibronectin secreted and synthesized by fibroblasts and early mesenchymal cells, and fetal Fibronectin in placenta and amniotic tissues. Fibronectin is widely involved in the processes of skin dermal cell migration, adhesion, proliferation, hemostasis, aging, damaged skin tissue repair and the like, mobilizes a mononuclear phagocyte system in blood to remove harmful substances at the damaged tissue, and has the effect of a growth factor. Fibronectin, as a necessary matrix for cell culture, can improve the anchorage rate and the confluence rate of various cells, shorten the cell confluence time, ensure that the morphological structure of the cells is good, enhance the metabolic rate and obviously improve the synthesis speed of DNA, RNA and protein. Fibronectin promotes the increase of the colony rate of cells and the increase of the survival rate of primary culture. A number of studies and clinical applications have demonstrated that FN plays a very important role in the repair and healing of wound mucosa, is capable of rapidly repairing damaged gastrointestinal mucosa, and has the efficacy of protecting gastrointestinal mucosa.
Currently, fibronectin has found wide application in the fields of cell culture, nerve repair, and clinical infusion. Fibronectin also has great potential in the field of animal breeding. Therefore, the development of cellular fibronectin repair of intestinal mucosa for tissue regeneration in culture technology can be used as a safe and effective high-tech veterinary technology and scheme. The use, sale and report of fibronectin and citric acid complexing agents are not found at present.
Disclosure of Invention
Aiming at the defects and shortcomings of the prior art, the invention provides the acidifier for repairing intestinal mucosa, which has the advantages of higher bioavailability, strong repairing effect, no toxic or side effect, capability of quickly repairing damaged gastrointestinal mucosa, capability of reducing acidity of a feed system, making up for gastric acid deficiency of animal cubs, improvement of feed protein digestibility, reduction of the pH value of gastrointestinal tracts and inhibition of growth of harmful pathogenic microorganisms, thereby improving immunity, promoting animal growth, improving the health state of animals, achieving the purpose of reducing resistance and replacing resistance and indirectly improving the safety of human food.
In order to achieve the purpose, the invention adopts the technical scheme that: it comprises the following steps:
an acidifier for repairing intestinal mucosa comprises the following effective components in percentage by weight: 1-5 parts of fibronectin and 15-30 parts of citric acid.
In a preferred formula of the invention, the weight composition of the effective components is as follows: fibronectin 3 parts, citric acid 20 parts.
The preparation process of the acidifier for repairing intestinal mucosa comprises the following steps:
(1) preparing a wall material coating liquid: completely dissolving 5-20 parts of sodium alginate and 5-20 parts of chitosan in 70-100 parts of water, then adding 5-10 parts of triacetin and 5-20 parts of polyvinyl propionate, and stirring with 1-10 parts of soybean protein powder to obtain a wall material coating solution;
(2) preparation of acidulant cores: heating 15-30 parts of citric acid substances to 50-60 ℃, adding 1-5 parts of fibronectin to form a uniform mixture, embedding the mixture into 20-30 parts of silicon dioxide, and rapidly cooling to obtain a core;
(3) preparation of microencapsulated acidifier: the mass ratio of the core of the acidifying agent to the coating wall material is 60-85%: slowly adding an acidifier core into an emulsification stirring tank filled with a wall material coating liquid according to the proportion of 20-40%, controlling the temperature at 45-60 ℃, and emulsifying at 2000-2500 r/min for 30-80 min; spraying the emulsion with pressure, wherein the inlet air temperature is 150-175 ℃, the outlet air temperature is 70-95 ℃, and the pressure is 1-5 Mpa, discharging, and sieving to obtain the acidifier for repairing intestinal mucosa.
The cattle and sheep feed generally needs to be added with a proper amount of acidifier, and under normal conditions, a certain amount of beneficial bacteria and harmful bacteria exist in animal bodies, and the animal husbandry is in a relative balance state. If harmful flora invades or proliferates in large quantities, the equilibrium state is broken, and the health of animals is affected. The acidic environment is beneficial to the growth of beneficial bacteria and not beneficial to the growth of harmful bacteria. The acidifying agent is added into the feed, so that the intestinal environment of animals can be artificially improved to be in a slightly acidic state, a suitable living environment is created for beneficial bacteria, meanwhile, invasion and reproduction of harmful bacteria are inhibited, and the occurrence probability of diseases such as animal diarrhea is reduced. In addition, the gastric acid secretion of animals in the young animal stage is less, and the acidifier added into the feed can improve the acid environment of the digestive tract, is beneficial to feed softening and nutrient dissolution, and improves the digestibility of the feed. The acidifying agents commonly used at present are two types, namely organic acidifying agents and inorganic acidifying agents. The feed acidifier is an important additive which is juxtaposed with probiotics, enzyme preparations, microecologics and the like after antibiotics, and is an environment-friendly additive without residues, drug resistance and toxic action. The acidifier can reduce acidity of feed system, compensate for gastric acid deficiency of animal cubs, improve feed protein digestibility, reduce gastrointestinal pH value, and inhibit growth and reproduction of harmful pathogenic microorganisms such as Escherichia coli and Salmonella. The addition of an acidifier in the feed can improve the immunity and growth performance of animals, and the acidifier is widely applied to poultry, ruminants, pigs and aquaculture at present. Citric acid is a strong organic acid, can dissociate H + in aqueous solution, is acidic, and is mainly used for spice or as acidulant of beverage.
Fibronectin is widely involved in the processes of skin dermal cell migration, adhesion, proliferation, hemostasis, aging, damaged skin tissue repair and the like, mobilizes a mononuclear phagocyte system in blood to remove harmful substances at the damaged tissue, and has the effect of a growth factor. Fibronectin plays an important role in the repair and healing of wound mucosa, can rapidly repair damaged gastrointestinal mucosa, and has the effect of protecting the gastrointestinal mucosa. The prescription of the invention applies the citric acid and the fibronectin together to the breeding technology, so that the fibronectin and the citric acid play a synergistic effect, the acidity of a feed system can be reduced, the gastric acid deficiency of animal cubs can be compensated, the digestibility of feed protein can be improved, the pH value of gastrointestinal tracts can be reduced, the growth and the reproduction of harmful pathogenic microorganisms such as escherichia coli and salmonella can be inhibited, meanwhile, the effects of repairing intestinal mucosa and promoting the regeneration of intestinal mucosa tissues can be achieved for animals suffering from intestinal mucosa injury, and the invention has a remarkable effect on the health of the animals.
The acidulant prepared by the invention selects sodium alginate, chitosan and soybean protein powder as auxiliary materials, can provide nutrition for animals and can also improve the immunity of the animals, and coating raw materials such as triacetin, polyvinyl propionate and the like are selected to cover the unpleasant smell of the main agent of the acidulant, obviously improve the taste of the product, improve the palatability of the medicine and enable the livestock and poultry to accept the medicine.
Compared with the prior art, the invention has the following beneficial effects:
(1) the acidifier for repairing intestinal mucosa perfectly combines fibronectin and citric acid, and the prescription not only can quickly repair damaged gastrointestinal mucosa, but also can reduce acidity of a feed system, make up for gastric acid deficiency of animal cubs, improve the digestibility of feed protein, reduce the pH value of the gastrointestinal tract and inhibit the growth of harmful pathogenic microorganisms, so that the acidifier can improve immunity, promote the growth of animals and improve the health state of the animals.
(2) The acidulant prepared by the invention selects sodium alginate, chitosan and soybean protein powder as auxiliary materials, not only can provide nutrition for animals, but also can improve the immunity of the animals.
(3) The acidulant prepared by the invention adopts coating raw materials such as triacetin, polyvinyl propionate and the like, so that the taste sense of the product is obviously improved while the unpleasant odor of the main agent of the acidulant is prevented from overflowing, the palatability of the medicament is improved, and the acidulant is more easily accepted by livestock and poultry.
(4) The preparation has good stability, easy storage, convenient administration, high bioavailability, strong repairing effect, and no adverse side effect.
(5) The preparation method combines the traditional process and the modern process, combines simple equipment and modern equipment, has strong operability, large or small scale and remarkable economic benefit.
Detailed Description
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples. Various substitutions and alterations according to the general knowledge and the conventional means in the art are included in the scope of the present invention without departing from the technical idea of the present invention.
Example 1
An acidifier for repairing intestinal mucosa comprises the following effective components in percentage by weight: in a preferred formula of the invention, the weight composition of the effective components is as follows: fibronectin 3 parts and citric acid 20 parts.
The preparation process of the acidifier for repairing intestinal mucosa comprises the following steps:
(1) preparing a wall material coating solution: completely dissolving 10 parts of sodium alginate and 10 parts of chitosan in 80 parts of water, then adding 8 parts of triacetin and 10 parts of polyvinyl propionate, and stirring with 8 parts of soybean protein powder to obtain a wall material coating solution;
(2) preparation of acidulant cores: heating 20 parts of citric acid substances to 55 ℃, adding 3 parts of fibronectin to form a uniform mixture, embedding the mixture into 25 parts of silicon dioxide, and rapidly cooling to obtain a core;
(3) preparation of microencapsulated acidifier: the mass ratio of the acidifier core to the coating wall material is 65%: slowly adding acidulant core at the ratio of 30% into an emulsifying and stirring tank filled with wall material coating liquid, controlling the temperature at 55 ℃, emulsifying at 2300r/min for 60 min; spraying the emulsion under pressure, wherein the air inlet temperature is 165 ℃, the air outlet temperature is 85 ℃, and the pressure is 4Mpa, discharging, and sieving to obtain the acidifier for repairing intestinal mucosa.
Example 2
An acidifier for repairing intestinal mucosa comprises the following effective components in percentage by weight: fibronectin 1 part and citric acid 15 parts.
The preparation process of the acidifier for repairing intestinal mucosa comprises the following steps:
(1) preparing a wall material coating solution: completely dissolving 5 parts of sodium alginate and 5 parts of chitosan in 70 parts of water, then adding 5 parts of triacetin and 5 parts of polyvinyl propionate, and stirring with 1 part of soybean protein powder to obtain a wall material coating solution;
(2) preparation of acidulant cores: heating 15 parts of citric acid substances to 50 ℃, adding 1 part of fibronectin to form a uniform mixture, embedding the mixture into 20 parts of silicon dioxide, and rapidly cooling to obtain a core;
(3) preparation of microencapsulated acidifier: according to the mass ratio of the core of the acidifier to the coating wall material of 60%: slowly adding acidifier core at a ratio of 20% into an emulsifying and stirring tank filled with wall material coating liquid, controlling the temperature at 45 deg.C, emulsifying at 2000r/min for 30 min; spraying the emulsion under pressure, wherein the air inlet temperature is 150 ℃, the air outlet temperature is 70 ℃, and the pressure is 1Mpa, discharging, and sieving to obtain the acidifier for repairing intestinal mucosa.
Example 3
An acidifier for repairing intestinal mucosa comprises the following effective components in percentage by weight: 5 parts of fibronectin and 30 parts of citric acid.
The preparation process of the acidifier for repairing intestinal mucosa comprises the following steps:
(1) preparing a wall material coating solution: completely dissolving 20 parts of sodium alginate and 20 parts of chitosan in 100 parts of water, adding 10 parts of triacetin and 20 parts of polyvinyl propionate, and stirring with 10 parts of soybean protein powder to obtain a wall material coating solution;
(2) preparation of acidulant cores: heating 30 parts of citric acid substances to 60 ℃, adding 5 parts of fibronectin to form a uniform mixture, embedding the mixture into 30 parts of silicon dioxide, and rapidly cooling to obtain a core;
(3) preparation of microcapsule acidifier: the mass ratio of the core of the acidifier to the coating wall material is 85%: slowly adding acidifier core at a ratio of 40% into an emulsifying and stirring tank filled with wall material coating liquid, controlling the temperature at 60 deg.C, and emulsifying at 2500r/min for 80 min; spraying the emulsion under pressure, wherein the inlet air temperature is 175 ℃, the outlet air temperature is 95 ℃, and the pressure is 5Mpa, discharging, and sieving to obtain the acidifier for repairing intestinal mucosa.
The above-mentioned embodiments are only preferred embodiments of the present invention, and should not be used to limit the scope of the present invention, so that all equivalent changes made by the contents of the claims of the present invention should be included in the scope of the claims of the present invention.
Claims (3)
1. An acidifier for repairing intestinal mucosa is characterized by comprising the following effective components in percentage by weight: 1-5 parts of fibronectin and 15-30 parts of citric acid.
2. An acidifier for repairing intestinal mucosa according to claim 1, wherein the formulation comprises the following active ingredients in percentage by weight: fibronectin 3 parts and citric acid 20 parts.
3. A process for the preparation of an acidifier for repairing intestinal mucosa according to claim 1, comprising the steps of:
(1) preparing a wall material coating solution: completely dissolving 5-20 parts of sodium alginate and 5-20 parts of chitosan in 70-100 parts of water, then adding 5-10 parts of triacetin and 5-20 parts of polyvinyl propionate, and stirring with 1-10 parts of soybean protein powder to obtain a wall material coating solution;
(2) preparation of acidulant cores: heating 15-30 parts of citric acid substances to 50-60 ℃, adding 1-5 parts of fibronectin to form a uniform mixture, embedding the mixture into 20-30 parts of silicon dioxide, and rapidly cooling to obtain a core;
(3) preparation of microencapsulated acidifier: the mass ratio of the core of the acidifying agent to the coating wall material is 60-85%: slowly adding an acidifier core into an emulsification stirring tank filled with a wall material coating liquid according to the proportion of 20-40%, controlling the temperature at 45-60 ℃, and emulsifying at 2000-2500 r/min for 30-80 min; spraying the emulsion with pressure, wherein the inlet air temperature is 150-175 ℃, the outlet air temperature is 70-95 ℃, and the pressure is 1-5 Mpa, discharging, and sieving to obtain the acidifier for repairing intestinal mucosa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210188210.2A CN114557402A (en) | 2022-02-28 | 2022-02-28 | Acidifier for repairing intestinal mucosa and preparation process thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210188210.2A CN114557402A (en) | 2022-02-28 | 2022-02-28 | Acidifier for repairing intestinal mucosa and preparation process thereof |
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| CN114557402A true CN114557402A (en) | 2022-05-31 |
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| CN202210188210.2A Pending CN114557402A (en) | 2022-02-28 | 2022-02-28 | Acidifier for repairing intestinal mucosa and preparation process thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105661064A (en) * | 2016-01-08 | 2016-06-15 | 北京海正兴潮生物技术有限公司 | Feed additive for promoting growth and increasing lean meat percentage of pigs, feed and method |
| CN109673847A (en) * | 2018-12-29 | 2019-04-26 | 广州智特奇生物科技股份有限公司 | A kind of preparation process of intestinal sustained releasing acidulant |
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- 2022-02-28 CN CN202210188210.2A patent/CN114557402A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105661064A (en) * | 2016-01-08 | 2016-06-15 | 北京海正兴潮生物技术有限公司 | Feed additive for promoting growth and increasing lean meat percentage of pigs, feed and method |
| CN109673847A (en) * | 2018-12-29 | 2019-04-26 | 广州智特奇生物科技股份有限公司 | A kind of preparation process of intestinal sustained releasing acidulant |
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