CN114555795B - 酮还原酶多肽及多核苷酸 - Google Patents

酮还原酶多肽及多核苷酸 Download PDF

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Publication number
CN114555795B
CN114555795B CN202080067803.2A CN202080067803A CN114555795B CN 114555795 B CN114555795 B CN 114555795B CN 202080067803 A CN202080067803 A CN 202080067803A CN 114555795 B CN114555795 B CN 114555795B
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Chinese (zh)
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CN114555795A (zh
Inventor
杰克·梁
南希塔·苏布兰马尼安
沙琳·奇恩
大卫·威廉·霍曼
卡蒂·惠伦
马修·布莱克·琼斯
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Codexis Inc
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Codexis Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN202080067803.2A 2019-09-26 2020-09-24 酮还原酶多肽及多核苷酸 Active CN114555795B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962906268P 2019-09-26 2019-09-26
US62/906,268 2019-09-26
PCT/US2020/052396 WO2021061915A2 (en) 2019-09-26 2020-09-24 Ketoreductase polypeptides and polynucleotides

Publications (2)

Publication Number Publication Date
CN114555795A CN114555795A (zh) 2022-05-27
CN114555795B true CN114555795B (zh) 2025-05-27

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CN202080067803.2A Active CN114555795B (zh) 2019-09-26 2020-09-24 酮还原酶多肽及多核苷酸

Country Status (11)

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US (1) US20230287360A1 (https=)
EP (1) EP4034644A4 (https=)
JP (1) JP2022549852A (https=)
KR (1) KR20220066952A (https=)
CN (1) CN114555795B (https=)
CA (1) CA3155659A1 (https=)
CL (1) CL2022000671A1 (https=)
CO (1) CO2022005038A2 (https=)
IL (1) IL291552A (https=)
MX (1) MX2022003684A (https=)
WO (1) WO2021061915A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11591625B2 (en) 2018-09-26 2023-02-28 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
CN112930402A (zh) 2018-09-26 2021-06-08 卡拉马祖控股股份有限公司 改性啤酒花产品的酶法生产

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010025238A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2198018B1 (en) * 2007-09-13 2013-11-20 Codexis, Inc. Ketoreductase polypeptides for the reduction of acetophenones
EP2203557B1 (en) * 2007-09-28 2012-02-29 Codexis, Inc. Ketoreductase polypeptides and uses thereof
US20110117252A1 (en) * 2009-11-13 2011-05-19 Kalamazoo Holdings, Inc. Process for the preparation of tetrahydroisohumulone compositions
HUE038800T2 (hu) * 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
CN104342412B (zh) * 2013-08-09 2018-12-21 南京朗恩生物科技有限公司 用于生产(s)-4-氯-3-羟基丁酸乙酯的酮还原酶突变体
US11591625B2 (en) * 2018-09-26 2023-02-28 Kalamazoo Holdings, Inc. Enzymatic process for production of modified hop products
JP7261874B2 (ja) * 2018-09-26 2023-04-20 カラマズー・ホールディングス・インコーポレイテッド 変性されたホップ生成物の製造のための酵素的方法
CN112930402A (zh) * 2018-09-26 2021-06-08 卡拉马祖控股股份有限公司 改性啤酒花产品的酶法生产

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010025238A2 (en) * 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine

Also Published As

Publication number Publication date
KR20220066952A (ko) 2022-05-24
EP4034644A2 (en) 2022-08-03
JP2022549852A (ja) 2022-11-29
CL2022000671A1 (es) 2022-11-11
US20230287360A1 (en) 2023-09-14
CA3155659A1 (en) 2021-04-01
IL291552A (en) 2022-05-01
WO2021061915A3 (en) 2021-05-06
WO2021061915A2 (en) 2021-04-01
EP4034644A4 (en) 2023-11-01
CO2022005038A2 (es) 2022-05-31
MX2022003684A (es) 2022-04-25
CN114555795A (zh) 2022-05-27

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