CN114555571B - 作为NLRP3调节剂的N-((1,2,3,5,6,7-六氢-s-引达省-4-基)氨甲酰基)-4,5,6,7-四氢苯并呋喃-2-磺酰胺衍生物 - Google Patents

作为NLRP3调节剂的N-((1,2,3,5,6,7-六氢-s-引达省-4-基)氨甲酰基)-4,5,6,7-四氢苯并呋喃-2-磺酰胺衍生物 Download PDF

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CN114555571B
CN114555571B CN202080064480.1A CN202080064480A CN114555571B CN 114555571 B CN114555571 B CN 114555571B CN 202080064480 A CN202080064480 A CN 202080064480A CN 114555571 B CN114555571 B CN 114555571B
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pharmaceutically acceptable
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solvate
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CN114555571A (zh
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拉朱·莫汉
约翰·努斯
詹森·哈里斯
袁沈东
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Zumazhen Bioscience Co ltd
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CN202080064480.1A 2019-07-17 2020-07-16 作为NLRP3调节剂的N-((1,2,3,5,6,7-六氢-s-引达省-4-基)氨甲酰基)-4,5,6,7-四氢苯并呋喃-2-磺酰胺衍生物 Active CN114555571B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962875402P 2019-07-17 2019-07-17
US62/875,402 2019-07-17
PCT/IB2020/000634 WO2021009566A1 (en) 2019-07-17 2020-07-16 N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4,5,6,7-tetrahydrobenzofuran -2-sulfonamide derivatives and related compounds as nlpr3 modulators for the treatment of multiple sclerosis (ms)

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CN114555571A CN114555571A (zh) 2022-05-27
CN114555571B true CN114555571B (zh) 2024-08-27

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US (1) US12466800B2 (https=)
EP (1) EP3999496B1 (https=)
JP (1) JP7723652B2 (https=)
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CN (1) CN114555571B (https=)
AU (1) AU2020312800B2 (https=)
BR (1) BR112022000878A2 (https=)
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IL (1) IL289885B2 (https=)
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WO2023116812A1 (zh) * 2021-12-22 2023-06-29 瑞石生物医药有限公司 一种磺酰脲类化合物
WO2024010772A1 (en) * 2022-07-06 2024-01-11 Kodiak Sciences Inc. Nlrp3 inhibitors
CN116283533B (zh) * 2023-02-17 2024-02-23 华南理工大学 具有nlrp3抑制活性的鸡脚参酮a及其衍生物与应用

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CN114555571A (zh) 2022-05-27
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