CN114555060A - 具有水溶性黏膜黏附性聚合物的离子交换组合物 - Google Patents

具有水溶性黏膜黏附性聚合物的离子交换组合物 Download PDF

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Publication number
CN114555060A
CN114555060A CN202080071199.0A CN202080071199A CN114555060A CN 114555060 A CN114555060 A CN 114555060A CN 202080071199 A CN202080071199 A CN 202080071199A CN 114555060 A CN114555060 A CN 114555060A
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CN
China
Prior art keywords
water
tablet
oral tablet
soluble anionic
particles
Prior art date
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Pending
Application number
CN202080071199.0A
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English (en)
Chinese (zh)
Inventor
肯特·阿尔宾·涅尔森
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Fertin Pharma AS
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Fertin Pharma AS
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Application filed by Fertin Pharma AS filed Critical Fertin Pharma AS
Publication of CN114555060A publication Critical patent/CN114555060A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN202080071199.0A 2019-10-11 2020-10-09 具有水溶性黏膜黏附性聚合物的离子交换组合物 Pending CN114555060A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16/599,991 US20210106516A1 (en) 2019-10-11 2019-10-11 Ion-Exchange Composition With Water-Soluble Mucoadhesive Polymers
US16/599,991 2019-10-11
PCT/DK2020/050280 WO2021069044A1 (en) 2019-10-11 2020-10-09 An ion-exchange composition with water-soluble mucoadhesive polymers

Publications (1)

Publication Number Publication Date
CN114555060A true CN114555060A (zh) 2022-05-27

Family

ID=73198078

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080071199.0A Pending CN114555060A (zh) 2019-10-11 2020-10-09 具有水溶性黏膜黏附性聚合物的离子交换组合物

Country Status (6)

Country Link
US (1) US20210106516A1 (https=)
EP (1) EP4041191A1 (https=)
JP (1) JP7763166B2 (https=)
CN (1) CN114555060A (https=)
CA (1) CA3153792A1 (https=)
WO (1) WO2021069044A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022234522A1 (en) * 2021-05-06 2022-11-10 Nicoventures Trading Limited Oral compositions and related methods for reducing throat irritation
CA3233375A1 (en) 2021-09-30 2023-04-06 Michael Zawadzki Oral product with a basic amine and an ion pairing agent
US12295412B2 (en) 2022-01-28 2025-05-13 Altria Client Services Llc Oral pouch product
JP2026509969A (ja) * 2023-01-27 2026-03-26 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 活性成分の経口送達のためのシステム
WO2024156323A1 (en) * 2023-01-27 2024-08-02 Fertin Pharma A/S An adhesive oral disc for sustained release of cannabinoids
DK182278B1 (en) * 2023-07-07 2026-02-04 Fertin Pharma As Dissolvable orally adhering tablet
DK182273B1 (en) * 2023-07-07 2026-01-30 Fertin Pharma As Dissolvable orally adhering nicotine tablet
WO2025011727A1 (en) * 2023-07-07 2025-01-16 Fertin Pharma A/S Dissolvable orally adhering nicotine tablet

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042941A2 (en) * 1996-05-13 1997-11-20 Novartis Consumer Health S.A. Buccal delivery system
WO2000025757A1 (en) * 1998-10-29 2000-05-11 Merck & Co., Inc. Sustained release delivery of highly water-soluble compounds
US20050181050A1 (en) * 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
EP2233134A1 (en) * 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
WO2012083947A1 (en) * 2010-12-21 2012-06-28 Fertin Pharma A/S Chewing gum composition comprising cross-linked polyacrylic acid
CN104271137A (zh) * 2012-03-26 2015-01-07 阿特法克特里公司 包含封装在水不溶性袋中的粉末的尼古丁口服递送产品,其中所述粉末包括尼古丁和口香糖组合物
US20170172995A1 (en) * 2015-09-08 2017-06-22 Venkateswara Rao Repaka Pharmaceutical compositions of Nicotine and process for preparation thereof
WO2018113916A1 (en) * 2016-12-20 2018-06-28 Fertin Pharma A/S A mucoadhesive oromucosal formulation comprising a nicotine complex
CN109952092A (zh) * 2016-11-18 2019-06-28 费尔廷制药公司 包含独立的黏合剂和赤藓糖醇的片剂
CN109963553A (zh) * 2016-11-18 2019-07-02 费尔廷制药公司 经口递送载剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3901248A (en) 1970-07-22 1975-08-26 Leo Ab Chewable smoking substitute composition
WO2005053691A2 (en) * 2003-12-02 2005-06-16 Fertin Pharma A/S Nicotine delivery product and method for producing it
WO2005055945A2 (en) * 2003-12-08 2005-06-23 Gel-Del Technologies, Inc. Mucoadhesive drug delivery devices and methods of making and using thereof
CA2758618C (en) * 2009-04-24 2017-03-28 Omya Development Ag Particulate material for controlled release of active ingredients
US10632076B2 (en) * 2016-11-18 2020-04-28 Fertin Pharma A/S Tablet comprising separate binder and erythritol
US11058633B2 (en) * 2018-05-17 2021-07-13 Fertin Pharma A/S Disintegrating oral tablet suitable for active pharmaceutical ingredients

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997042941A2 (en) * 1996-05-13 1997-11-20 Novartis Consumer Health S.A. Buccal delivery system
WO2000025757A1 (en) * 1998-10-29 2000-05-11 Merck & Co., Inc. Sustained release delivery of highly water-soluble compounds
US20050181050A1 (en) * 2004-01-28 2005-08-18 Collegium Pharmaceutical, Inc. Dosage forms using drug-loaded ion exchange resins
EP2233134A1 (en) * 2009-03-27 2010-09-29 McNeil AB Multi-portion intra-oral dosage form with organoleptic properties
WO2012083947A1 (en) * 2010-12-21 2012-06-28 Fertin Pharma A/S Chewing gum composition comprising cross-linked polyacrylic acid
CN104271137A (zh) * 2012-03-26 2015-01-07 阿特法克特里公司 包含封装在水不溶性袋中的粉末的尼古丁口服递送产品,其中所述粉末包括尼古丁和口香糖组合物
US20170172995A1 (en) * 2015-09-08 2017-06-22 Venkateswara Rao Repaka Pharmaceutical compositions of Nicotine and process for preparation thereof
CN109952092A (zh) * 2016-11-18 2019-06-28 费尔廷制药公司 包含独立的黏合剂和赤藓糖醇的片剂
CN109963553A (zh) * 2016-11-18 2019-07-02 费尔廷制药公司 经口递送载剂
WO2018113916A1 (en) * 2016-12-20 2018-06-28 Fertin Pharma A/S A mucoadhesive oromucosal formulation comprising a nicotine complex

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CALUM R PARK ET AL: "Development and evaluation of a biphasic buccal adhesive tablet for nicotine replacement therapy", 《INTERNATIONAL JOURNAL OF PHARMACEUTICS》, vol. 237, 31 December 2002 (2002-12-31), pages 215 - 226, XP002279251, DOI: 10.1016/S0378-5173(02)00041-8 *
国家食品药品监督管理局药品审评中心编: "《药品技术评价文集》", 中国医药科技出版社, pages: 226 *

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Publication number Publication date
CA3153792A1 (en) 2021-04-15
EP4041191A1 (en) 2022-08-17
US20210106516A1 (en) 2021-04-15
JP2022552491A (ja) 2022-12-16
WO2021069044A1 (en) 2021-04-15
JP7763166B2 (ja) 2025-10-31

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