CN114526977A - Intercommunication device and cell capture staining instrument thereof - Google Patents

Abstract

The application relates to a communication device and a cell capturing and dyeing instrument thereof, which comprise a frame and a placing seat for placing a piece to be communicated, wherein the placing seat is connected to the frame in a sliding manner, and the frame is provided with a first driving mechanism capable of driving the placing seat to slide out of or into the frame; the movable plate is movably arranged on the frame, a sample outlet butt joint is arranged on the movable plate, and the frame is provided with a second driving mechanism capable of driving the movable plate to drive the sample outlet butt joint to be in butt joint communication with a sample inlet hole of a to-be-communicated piece in the frame. This application has the effect that improves and treat that the intercommunication piece docks the intercommunication efficiency.

Description

Intercommunication device and cell capture staining instrument thereof

Technical Field

The application relates to the field of biological detection equipment, in particular to a communication device and a cell capturing and dyeing instrument thereof.

Background

The micro-fluidic chip is also called micro total analysis system or lab-on-a-chip, which is a process of sample preparation, biological and chemical reaction, separation and detection, etc. related to the fields of chemistry, biology, etc.

The micro-fluidic chip generally comprises a substrate and a structure, wherein the substrate is usually made of glass and silicon chip materials, the structure is mostly a micro-scale fluid channel (namely a micro-channel) built by high polymer materials (such as PDMS, PMMA, PC and the like), and the surface of the micro-fluidic chip is effectively modified due to high hydrophobicity, so that the micro-fluidic chip has a reactive functional group and an affinity ligand, and the function and application field of the micro-fluidic chip are determined. The modified chip can be used for sample analysis in the fields of chemistry, biology, medicine and the like, and the target substance is always required to be dyed and identified after staying in the chip so as to analyze the object to be detected, so that the uniform and efficient dyeing is very important for accurate judgment of the sample.

For example, in the preparation process of the waiting communicating member of the microfluidic chip, the collected sample is usually injected into the microchannel of the microfluidic chip from the sample inlet of the microfluidic chip by using a syringe pump mechanism, and the existing mode of communicating the syringe pump mechanism with the sample inlet of the microfluidic chip is usually manual butt-joint communication, so that the defect of low butt-joint efficiency exists, and therefore the waiting communicating member needs to be improved.

Disclosure of Invention

In order to improve the efficiency of the butt joint communication of the parts to be communicated, the first aspect provides a communication device.

The application provides a intercommunication device adopts following technical scheme: a communication device comprises a frame and a placing seat for placing a piece to be communicated, wherein the placing seat is connected to the frame in a sliding manner, and the frame is provided with a first driving mechanism capable of driving the placing seat to slide out of or into the frame;

the frame activity is provided with the movable plate, be provided with out the appearance butt joint on the movable plate, the frame is provided with the second actuating mechanism that can drive the movable plate and drive out the appearance butt joint and wait the sample inlet hole butt joint intercommunication of intercommunication piece in the frame.

Through adopting above-mentioned technical scheme, treat that the intercommunication piece is placed on placing the seat, place the seat through the drive of first actuating mechanism and drive and treat that the intercommunication piece slides in the frame, second actuating mechanism drive movable plate drives out a kind butt joint and treats the appearance hole butt joint of intercommunication piece, compares artifical manual butt joint intercommunication and treats the intercommunication piece and compare, very big improvement treat the efficiency of intercommunication piece butt joint intercommunication.

Preferably, the placing seat is provided with at least one accommodating groove for accommodating the piece to be communicated, and the sample inlet hole and the sample outlet butt joint of the piece to be communicated are arranged oppositely.

Through adopting above-mentioned technical scheme, treat that the communicating piece is placed in the storage tank, treat the communicating piece through the storage tank and carry on spacingly, treat that the appearance hole of communicating piece is just right with out the appearance butt joint, drive out the appearance butt joint through second actuating mechanism drive movable plate along the straight line direction with just right appearance hole butt joint of treating the communicating piece, thereby improve out the accurate butt joint in appearance butt joint and the appearance hole of treating the communicating piece, can reduce the side direction extrusion in addition and lead to treating the inside production gas of communicating piece, thereby the quality of treating the preparation of communicating piece is treated in the influence.

Preferably, treat that the communicating piece passes through an inner wall of frame and is spacing in the storage tank, place the seat and offer with the communicating mouth of stepping down of storage tank, the butt joint that gives out the appearance passes through second actuating mechanism and lets a mouthful butt joint with the appearance hole of treating the communicating piece of stepping up.

Through adopting above-mentioned technical scheme, treat the communicating piece through the inner wall of storage tank and frame and carry on spacingly to improve out a kind butt joint and treat the stability of communicating piece intercommunication.

Preferably, the first driving mechanism comprises a first motor and a first lead screw, the first motor is installed on one side of the frame, the first lead screw is coaxially and fixedly arranged with an output shaft of the first motor, the first lead screw is in threaded connection with the placing seat, the placing seat is connected with the frame in a sliding manner through a first linear guide rail, and the first linear guide rail is arranged in parallel with the first lead screw.

Through adopting above-mentioned technical scheme, the first lead screw of first motor drive rotates to drive and first lead screw threaded connection place the seat through first linear guide roll-off or slide in the frame, thereby conveniently treat getting of communicating piece and put.

Preferably, the second driving mechanism comprises a second motor and a second screw rod, the second motor is mounted on the frame, the second screw rod is coaxially and fixedly arranged with an output shaft of the second motor, the second screw rod drives the moving plate to be close to or far away from the placing seat, and the moving plate is connected with the frame in a sliding manner through a second linear guide rail.

Through adopting above-mentioned technical scheme, the second motor passes through the second lead screw drive movable plate and moves along second linear guide to improve the stability of the appearance butt joint of going out on the movable plate and the entering hole butt joint of treating the intercommunication piece.

Preferably, the second driving mechanism further comprises a cross arm vertically arranged in the frame, and the cross arm is driven to rotate by a second motor and a second screw rod so as to push the moving plate to move up and down.

By adopting the technical scheme, the second motor drives the cross arm arranged in the frame to rotate through the second screw rod, so that the moving plate is pushed to move up and down, and the installation space in the moving direction of the moving plate is reduced.

Preferably, the protruding spacing portion that is provided with of lateral wall of play appearance butt joint, the movable plate is fixed with the mounting panel, communicating mounting hole has been seted up to movable plate and mounting panel corresponding position, go out appearance butt joint and pass the mounting hole and extend the movable plate, be located movable plate and mounting panel junction the week side wall of mounting hole is provided with the spacing groove, spacing position is in the spacing inslot.

Through adopting above-mentioned technical scheme, go out the spacing portion on the appearance butt joint lateral wall and install in the spacing groove of movable plate and mounting panel junction to improve the stability that the appearance butt joint was installed on the movable plate.

Preferably, gaps exist between the sample outlet butt joint and the mounting hole and between the limiting part and the limiting groove.

By adopting the technical scheme, gaps are arranged between the sample outlet butt joint and the mounting hole and between the limiting part and the limiting groove, so that when small dislocation exists between the sample inlet hole and the sample outlet butt joint, accurate butt joint communication between the sample inlet hole and the sample outlet butt joint can be realized.

Preferably, the accommodating grooves are arranged in a plurality of intervals, the accommodating grooves are arranged along the upper surface of the accommodating seat, and the upper surfaces of the accommodating seats at the two sides of the accommodating grooves are provided with downwards-recessed sheet taking grooves.

Through adopting above-mentioned technical scheme, set up a plurality of storage tanks to treat the butt joint intercommunication of intercommunication piece in batches.

Preferably, the upper surface of the frame is provided with an observation port corresponding to the containing groove.

Through adopting above-mentioned technical scheme, the viewing aperture on the frame is convenient to be observed the intercommunication piece of treating in the storage tank.

Preferably, the member to be communicated is a microfluidic chip.

Through adopting above-mentioned technical scheme, the micro-fluidic chip is placed on placing the seat, places the seat through the drive of first actuating mechanism and drives the micro-fluidic chip and slide in the frame, and second actuating mechanism drive movable plate drives out the appearance butt joint and dock with the appearance hole of micro-fluidic chip mutually, compares artifical manual butt joint intercommunication and compares, very big improvement the efficiency that the micro-fluidic chip butt joint was communicated.

Preferably, a waste liquid collecting hopper is arranged at the bottom of the movable plate, a communicating hole is formed in the movable plate corresponding to the liquid outlet hole of the microfluidic chip and communicated with the waste liquid collecting hopper, a liquid collecting hole is formed in the movable plate and communicated with the waste liquid collecting hopper, and the edge of the upper surface of the movable plate is gradually inclined downwards towards the liquid collecting hole.

By adopting the technical scheme, when the sample outlet butt joint is not in butt joint with the microfluidic chip, waste liquid discharged by the sample outlet butt joint flows into the waste liquid collecting hopper through the liquid collecting hole in the movable plate, and when the sample outlet butt joint is in butt joint with the microfluidic chip, the liquid discharging hole is communicated with the communicating hole, so that the waste liquid cleaned by the internal channel of the microfluidic chip can be conveniently collected into the waste liquid collecting hopper.

Preferably, the waste liquid collecting hopper is communicated with a waste liquid tank, the waste liquid tank is connected with a waste liquid pump through a pipeline, the waste liquid tank is provided with a liquid level sensor, and the liquid level sensor controls the work of the waste liquid pump through a controller.

Through adopting above-mentioned technical scheme, liquid level sensor detects the too many backs of waste liquid in the waste liquid incasement, through the work of controller control waste liquid pump, takes out the waste liquid in the waste liquid incasement.

In a second aspect, the present application provides a cell capture staining apparatus.

The cell capturing staining instrument provided by the application adopts the following technical scheme:

the utility model provides a cell staining catches appearance, includes intercommunication device and casing, the intercommunication device is installed on the casing, the appearance end of giving a sample to the joint passes through the pipeline intercommunication with the injection pump mechanism in the casing.

Through adopting above-mentioned technical scheme, treat that the intercommunication piece is placed on placing the seat, place the seat through the drive of first actuating mechanism and drive and treat that the intercommunication piece slides in the frame, second actuating mechanism drive movable plate drives out a kind butt joint and treats the appearance hole butt joint of intercommunication piece, compares artifical manual butt joint intercommunication and treats the intercommunication piece and compare, very big improvement treat the efficiency of intercommunication piece butt joint intercommunication. And the sample is injected into the member to be communicated through the injection pump mechanism for preparation, thereby improving the preparation efficiency of the member to be communicated.

Preferably, an information identifier for identifying label information on the to-be-communicated piece is arranged in the shell, and the information identifier controls the injection pump mechanism to work through the controller.

Through adopting above-mentioned technical scheme, the information identification ware is treated the label information on the communicating piece and is discerned to make injection pump mechanism will correspond the sample and pour into the corresponding communicating piece of treating, thereby improve the accuracy of treating the preparation of communicating piece.

Preferably, a driving component for driving the information identifier to sequentially identify the information of the plurality of pieces to be communicated is arranged in the shell;

the drive assembly comprises a mounting bracket, a third motor, a third screw rod and a mounting seat, the mounting bracket is fixed in the shell, the third motor is installed on one side of the mounting bracket, the third screw rod is rotatably connected to the mounting bracket, an output shaft of the third motor is fixedly connected with the third screw rod in a coaxial mode, the mounting seat is connected with the third screw rod in a threaded mode and connected with the mounting bracket in a sliding mode through a third linear guide rail, the information identifier is installed on the mounting seat, the information identifier faces the label information of the communicated piece, and the label information is located at an observation port.

Through adopting above-mentioned technical scheme, third motor drive third lead screw drives the mount pad and removes along linear guide to treat the intercommunication piece to placing in a plurality of storage tanks and carry out information recognition, thereby improve recognition efficiency.

Drawings

Fig. 1 is a schematic view of the overall structure of a communication device in the embodiment of the present application.

Fig. 2 is a schematic overall structure diagram of the placing seat of the communication device in an open state according to the embodiment of the present application.

Fig. 3 is a schematic structural view of the inside of the frame in the embodiment of the present application.

Fig. 4 is a schematic view of the mounting structure of the moving plate and the second driving mechanism in the frame in the embodiment of the present application.

Fig. 5 is a schematic structural diagram of another view angle of the moving plate and the second driving mechanism in the frame in the embodiment of the present application.

Fig. 6 is a top view of the moving plate in the embodiment of the present application.

Fig. 7 is a cross-sectional view a-a of fig. 6.

Fig. 8 is an exploded view of the bottom of the movable plate and the waste liquid collecting hopper in the embodiment of the present application.

FIG. 9 is a schematic diagram showing the overall structure of the cell-capturing staining apparatus according to the embodiment of the present application.

Fig. 10 is a schematic view of an installation structure of the communication device and the information identifier in the embodiment of the present application.

Fig. 11 is a schematic view of an installation structure of the information identifier and the driving assembly of the present application.

Description of reference numerals: 1. a frame; 11. a base plate; 111. a window; 12. a top plate; 121. a viewing port; 13. a first infrared sensor; 14. a wheel seat; 141. a roller; 15. a vertical plate; 16. a connecting plate; 161. a second lug; 2. a placing seat; 21. a microfluidic chip; 22. a containing groove; 221. a let position port; 23. a slice taking groove; 24. connecting blocks; 25. a yielding channel; 26. mounting blocks; 27. a first trigger; 3. a first drive mechanism; 31. a first motor; 32. a first lead screw; 33. a first linear guide rail; 4. moving the plate; 41. sampling and butting joints; 411. a limiting part; 42. a first lug; 43. a vertical block; 44. a guide block; 45. mounting a plate; 46. mounting holes; 461. a limiting groove; 47. a seal ring; 48. a communicating hole; 49. a liquid collecting hole; 5. a second drive mechanism; 51. a second motor; 52. a second lead screw; 53. a second linear guide; 54. a cross arm; 541. a first arm; 542. a second arm; 543. a pushing block; 544. a moving block; 6. a waste liquid collecting hopper; 61. a waste liquid tank; 62. a liquid level sensor; 7. a housing; 71. a sliding cover; 8. an information identifier; 9. a drive assembly; 91. mounting a bracket; 92. a third motor; 93. a third screw rod; 94. a mounting seat; 95. and a third linear guide rail.

Detailed Description

The present application is described in further detail below with reference to figures 1-11.

The embodiment of the application discloses a communication device. Referring to fig. 1 and 2, the device comprises a frame 1 and a placing seat 2 for placing a to-be-communicated piece, wherein the placing seat 2 is connected to the frame 1 in a sliding manner, and the frame 1 is provided with a first driving mechanism 3 capable of driving the placing seat 2 to slide out of or into the frame 1. Frame 1 includes bottom plate 11 and roof 12, and roof 12 lower surface both sides are protruding setting downwards and pass through screw and bottom plate 11 fixed connection to form the space that seat 2 was placed in the holding. The member to be communicated in this embodiment is a microfluidic chip 21. In other embodiments the member to be communicated may be a slide into which the internal channel is injected with the sample.

Preferably, referring to fig. 2, at least one accommodating groove 22 for accommodating the to-be-connected component is formed in the upper surface of the placing seat 2. In this embodiment, four accommodating grooves 22 are provided, and the four accommodating grooves 22 are disposed at intervals along the upper surface of the placing base 2. The upper surface of the placing seat 2 at the two sides of the containing groove 22 is provided with a sheet taking groove 23 which is concave downwards. The upper surface of the top plate 12 is provided with an observation port 121 corresponding to the containing groove 22, and the to-be-communicated piece in the containing groove 22 can be observed conveniently through the observation port 121. The micro-fluidic chip 21 is limited in the containing groove 22 through an inner wall of the frame 1. Specifically, the microfluidic chip 21 is stably located in the containing groove 22 through the lower surface limit of the top plate 12.

Referring to fig. 3, the first driving mechanism 3 includes a first motor 31 and a first lead screw 32, the first motor 31 is installed on one side of the frame 1, the first lead screw 32 is coaxially and fixedly disposed with an output shaft of the first motor 31, and the first lead screw 32 is in threaded connection with the placing base 2. Specifically, place fixed being provided with in seat 2 one side with first lead screw 32 threaded connection's connecting block 24, place seat 2 and offer the passageway 25 of stepping down that supplies first lead screw 32 activity to wear to establish. The placing seat 2 is connected with the frame 1 in a sliding manner through a first linear guide rail 33, and the first linear guide rail 33 is arranged in parallel with the first screw rod 32. The two first linear guide rails 33 are arranged on the bottom plate 11 located on two sides of the placing seat 2, the two sides of the placing seat 2 are both provided with the mounting blocks 26 outwards integrally, the first linear guide rails 33 are fixedly mounted on the bottom plate 11, and the first sliding blocks of the first linear guide rails 33 are fixedly mounted on the lower surfaces of the mounting blocks 26. The first infrared sensor 13 is arranged on one side of the bottom plate 11, and the first trigger 27 is arranged on the placing seat 2. The placing seat 2 drives the first screw rod 32 through the first motor 31 to enable the placing seat 2 to slide into the frame 1, meanwhile, the first trigger piece 27 triggers the first infrared sensor 13 to send out a sensing signal, the sensing signal of the first infrared sensor 13 controls the first motor 31 to stop working through the controller, and the placing seat 2 is located at a set position in the frame 1.

Referring to fig. 3 and 4, two wheel seats 14 are fixedly installed on the front side of the bottom plate 11 at intervals along the length direction, a roller 141 is rotatably connected to the wheel seat 14, and the lower surface of the placing seat 2 contacts with the wheel surface of the roller 141. The frame 1 is movably provided with a moving plate 4, the moving plate 4 is provided with a sample outlet butt joint 41, and the bottom plate 11 is provided with a window 111 for the moving plate 4 to move through. The frame 1 is provided with a second driving mechanism 5 which can drive the moving plate 4 to drive the sample outlet butt joint 41 to be in butt joint communication with the sample inlet hole of the microfluidic chip 21 in the frame 1. The second driving mechanism 5 drives the moving plate 4 to drive the sample outlet butt joint 41 to butt joint with the sample inlet hole of the micro-fluidic chip 21, and compared with manual butt joint and communication of the micro-fluidic chip 21, the efficiency of butt joint and communication of the micro-fluidic chip 21 is greatly improved.

Referring to fig. 3 and 4, the bottom of the containing groove 22 is provided with a relief opening 221 communicated with the outside, and the sample outlet butt joint 41 passes through the relief opening 221 through the second driving mechanism 5 to butt joint with the sample inlet hole of the microfluidic chip 21. And the sample inlet hole of the microfluidic chip 21 in this embodiment is opposite to the sample outlet butt joint 41. The micro-fluidic chip 21 is placed in the accommodating groove 22, the micro-fluidic chip 21 is limited by the accommodating groove 22, the sample inlet of the micro-fluidic chip 21 is opposite to the sample outlet butt joint 41, the moving plate 4 is driven by the second driving mechanism 5 to drive the sample outlet butt joint 41 to butt joint with the sample inlet of the micro-fluidic chip 21, which is opposite to the sample outlet butt joint 41, in the straight line direction, so that the sample outlet butt joint 41 is accurately butted with the sample inlet of the micro-fluidic chip 21, and in addition, the situation that the sample outlet butt joint 41 and the sample inlet of the micro-fluidic chip 21 form lateral extrusion is avoided, so that gas enters the micro-fluidic chip 21, and the preparation quality of the micro-fluidic chip 21 is influenced.

Referring to fig. 4 and 5, the second driving mechanism 5 includes a second motor 51 and a second screw 52, the second motor 51 is mounted on the frame 1, specifically, the frame 1 further includes two risers 15 vertically and fixedly mounted on the lower surface of the bottom plate 11 at intervals, and the second motor 51 is fixedly mounted on the side walls of one of the risers 15. The second screw 52 is coaxially and fixedly arranged with an output shaft of the second motor 51, the second screw 52 drives the moving plate 4 to be close to or far away from the placing seat 2, the moving plate 4 is connected with the frame 1 through the second linear guide rails 53 in a sliding manner, the second linear guide rails 53 are arranged in two numbers, the second guide rails of the two second linear guide rails 53 are respectively vertically arranged on the side walls opposite to the two vertical plates 15, the second sliding blocks of the two second linear guide rails 53 are respectively and fixedly arranged on the side walls on two sides of the moving plate 4, and the second guide rails are vertically arranged with the second screw 52. The second motor 51 drives the moving plate 4 to move along the second guide rail through the second lead screw 52, so as to improve the stability of the butt joint of the sample outlet butt joint 41 on the moving plate 4 and the sample inlet hole of the to-be-communicated piece.

Referring to fig. 5 and 8, the second driving mechanism 5 further includes a cross arm 54 vertically disposed in the frame 1, and the cross arm 54 is driven to rotate by the second motor 51 and the second lead screw 52 to push the moving plate 4 to move up and down. The second motor 51 drives the cross arm 54 installed in the frame 1 to rotate through the second lead screw 52, thereby pushing the moving plate 4 to move up and down, thereby reducing an installation space in a moving direction of the moving plate 4. Specifically, a connecting plate 16 is fixed between the two risers 15, and a cross arm 54 is provided between the connecting plate 16 and the moving plate 4. The cross arm 54 comprises a first arm 541 and a second arm 542, the first arm 541 and the second arm 542 are connected in a cross rotation manner, a first lug 42 is fixedly arranged on the surface of the moving plate 4, one end of the first arm 541 is hinged with the first lug 42, the second screw 52 is in threaded connection with a pushing block 543, and the other end of the first arm 541 is hinged with the pushing block 543. The connecting plate 16 is fixedly provided with a second lug 161, the first lug 42 and the second lug 161 are oppositely arranged, one end of a second arm 542 is hinged with the second lug 161, a moving block 544 is connected with the moving plate 4 opposite to the pushing block 543 in a sliding manner, and the other end of the second arm 542 is hinged with the moving block 544. Specifically, two vertical blocks 43 are fixed on the lower surface of the moving plate 4 at intervals along the moving direction of the moving block 544, a guide block 44 is fixedly connected between the two vertical blocks 43, the guide block 44 is parallel to the moving plate 4, and the moving block 544 is connected between the guide block 44 and the moving plate 4 in a sliding manner.

Referring to fig. 6 and 7, two sample outlet butt joints 41 are provided corresponding to one microfluidic chip 21, and two sample outlet butt joints 41 are provided corresponding to two sample inlet holes of the microfluidic chip 21. The side wall of the sample outlet butt joint 41 is convexly provided with a limiting part 411, the moving plate 4 is fixed with the mounting plate 45, the corresponding positions of the moving plate 4 and the mounting plate 45 are provided with communicated mounting holes 46, the sample outlet butt joint 41 penetrates through the mounting holes 46 to extend out of the moving plate 4, the side wall of the mounting hole 46 at the joint of the moving plate 4 and the mounting plate 45 is provided with a limiting groove 461, the limiting part 411 is positioned in the limiting groove 461, and the mounting plate 45 is arranged in a split mode in the axial lead direction of the mounting hole 46. Gaps are formed between the sample application abutment 41 and the mounting hole 46, and between the stopper 411 and the stopper groove 461. Therefore, when the sample inlet hole and the sample outlet butt joint 41 have small dislocation, the sample inlet hole and the sample outlet butt joint 41 can be accurately butted and communicated. The sampling butt joint 41 is sleeved with a sealing ring 47, and the sealing ring 47 is positioned on the surface of the moving plate 4.

Referring to fig. 6 and 8, a waste liquid collecting hopper 6 is arranged at the bottom of the movable plate 4, a communicating hole 48 is arranged in the liquid outlet hole of the movable plate 4 corresponding to the microfluidic chip 21, the communicating hole 48 is communicated with the waste liquid collecting hopper 6, a liquid collecting hole 49 is formed in the movable plate 4, the liquid collecting hole 49 is communicated with the waste liquid collecting hopper 6, and the edge of the upper surface of the movable plate 4 is gradually inclined downwards towards the liquid collecting hole 49. When the sample outlet butt joint 41 is separated from the sample inlet of the microfluidic chip 21, the waste liquid discharged from the sample outlet butt joint 41 flows into the waste liquid collecting hopper 6 through the liquid collecting hole 49 on the moving plate 4, and when the sample outlet butt joint 41 is in butt joint with the microfluidic chip 21, the liquid outlet hole is communicated with the communicating hole 48, so that the waste liquid cleaned by the internal channel of the microfluidic chip 21 can be conveniently collected into the waste liquid collecting hopper 6.

Referring to fig. 3 and 8, the waste liquid collecting hopper 6 is communicated with a waste liquid tank 61, the waste liquid tank 61 is connected with a waste liquid pump (not shown in the figure) through a pipeline, the waste liquid tank 61 is provided with a liquid level sensor 62, and the liquid level sensor 62 controls the operation of the waste liquid pump through a controller. After the liquid level sensor 62 detects that the waste liquid in the waste liquid tank 61 is too much, the controller controls the waste liquid pump to work, and the waste liquid in the waste liquid tank 61 is pumped out.

The implementation principle of a communication device in the embodiment of the application is as follows: the microfluidic chip 21 is placed in the containing groove 22 of the placing seat 2, the placing seat 2 is driven by the first driving mechanism 3 to enter the frame 1, then the second driving mechanism 5 drives the moving plate 4 to drive the sample outlet butt joint 41 to be in butt joint and communicated with the sample inlet hole of the microfluidic chip 21, and compared with the manual butt joint and communication of the microfluidic chip 21, the butt joint and communication efficiency of the microfluidic chip 21 is greatly improved.

The embodiment also discloses a cell capture staining instrument. Referring to fig. 9, comprising the housing 7 and the above-mentioned communication device, the communication device is mounted on the housing 7, and the sample inlet end of the sample outlet butt 41 is communicated with the injection pump mechanism in the housing 7 through a pipeline.

Referring to fig. 9 and 10, a sliding cover 71 covering the communicating device is slidably disposed on the housing 7, an information identifier 8 for identifying label information on the microfluidic chip 21 is disposed in the sliding cover 71, and the information identifier 8 controls the operation of the injection pump mechanism through the controller. In this embodiment, the label information is a barcode information label, and the information identifier 8 is a barcode scanner. The information identifier 8 identifies label information on the microfluidic chip 21, so that the injection pump mechanism injects a corresponding sample into the corresponding microfluidic chip 21, thereby improving the accuracy of preparation of the microfluidic chip 21.

Referring to fig. 9 and 11, a driving assembly 9 for driving the information identifier 8 to sequentially identify information of the microfluidic chips 21 is disposed in the sliding cover 71. The driving assembly 9 includes a mounting bracket 91, a third motor 92, a third lead screw 93 and a mounting seat 94, the mounting bracket 91 is fixed in the housing 7, the third motor 92 is installed on one side of the mounting bracket 91, the third lead screw 93 is rotatably connected to the mounting bracket 91, an output shaft of the third motor 92 is coaxially and fixedly connected to the third lead screw 93, the mounting seat 94 is in threaded connection with the third lead screw 93 and is connected to the mounting bracket 91 through a third linear guide 95 in a sliding manner, a third guide of the third linear guide 95 is fixedly installed on the mounting bracket 91, the third guide is parallel to the third lead screw 93, and a third slider of the third linear guide 95 is fixedly installed on the mounting seat 94. The information identifier 8 is mounted on the mounting seat 94, and the information identifier 8 faces the label information of the microfluidic chip 21, which is located at the viewing port 121. The third motor 92 drives the third screw 93 to drive the mounting seat 94 to move along the third linear guide rail 95, so that information identification is performed on the to-be-communicated pieces placed in the plurality of accommodating grooves 22, and therefore identification efficiency is improved.

The implementation principle of the cell capture staining instrument in the embodiment of the application is as follows: the micro-fluidic chip 21 is placed in the containing groove 22 of the placing seat 2, the placing seat 2 is driven by the first driving mechanism 3 to enter the frame 1, the pipeline is cleaned by the injection pump mechanism, then the micro-fluidic chip 21 flows into the waste liquid collecting hopper 6 through the liquid collecting hole 49 formed in the moving plate 4, then the sample outlet butt joint 41 on the moving plate 4 is driven by the second driving mechanism 5 to be in butt joint communication with the sample inlet hole of the micro-fluidic chip 21 through the controller, the internal channel of the micro-fluidic chip 21 is cleaned by the injection pump mechanism, then the waste liquid is discharged into the waste liquid collecting hopper 6 through the communicating hole 48 in butt joint communication with the liquid outlet hole, after the micro-fluidic chip 21 is cleaned, the collected sample is injected into the internal channel of the micro-fluidic chip 21 by the injection pump mechanism to prepare the sample, and therefore the preparation efficiency of the sample of the micro-fluidic chip 21 is improved.

The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.

Claims (16)

1. A communication device, characterized by: the connecting device comprises a frame (1) and a placing seat (2) for placing a to-be-connected piece, wherein the placing seat (2) is connected to the frame (1) in a sliding manner, and the frame (1) is provided with a first driving mechanism (3) capable of driving the placing seat (2) to slide out of or into the frame (1);

the movable type sample collection device is characterized in that a movable plate (4) is movably arranged on the frame (1), a sample outlet butt joint (41) is arranged on the movable plate (4), and the frame (1) is provided with a second driving mechanism (5) which can drive the movable plate (4) to drive the sample outlet butt joint (41) to be in butt joint communication with a sample inlet hole of a to-be-communicated piece in the frame (1).

2. A communication device according to claim 1, wherein: the placing seat (2) is at least provided with a containing groove (22) for containing a piece to be communicated, and the sample inlet hole and the sample outlet butt joint (41) of the piece to be communicated are arranged oppositely.

3. A communication device according to claim 2, wherein: treat that the communicating piece is spacing in storage tank (22) through an inner wall of frame (1), place seat (2) and offer with storage tank (22) communicating let a mouthful (221), appearance butt joint (41) pass through second actuating mechanism (5) and let a mouthful (221) and wait to communicate the appearance hole butt joint of piece.

4. A communication device according to claim 1, wherein: the first driving mechanism (3) comprises a first motor (31) and a first screw rod (32), the first motor (31) is installed on one side of the frame (1), the first screw rod (32) is coaxially and fixedly arranged with an output shaft of the first motor (31), the first screw rod (32) is in threaded connection with the placing seat (2), the placing seat (2) is connected with the frame (1) in a sliding mode through a first linear guide rail (33), and the first linear guide rail (33) is arranged in parallel with the first screw rod (32).

5. A communication device according to claim 1, wherein: the second driving mechanism (5) comprises a second motor (51) and a second screw rod (52), the second motor (51) is installed on the frame (1), the second screw rod (52) and an output shaft of the second motor (51) are coaxially and fixedly arranged, the second screw rod (52) drives the moving plate (4) to be close to or far away from the placing seat (2), and the moving plate (4) is connected with the frame (1) in a sliding mode through a second linear guide rail (53).

6. A communication device according to claim 5, wherein: the second driving mechanism (5) further comprises a cross arm (54) vertically arranged in the frame (1), and the cross arm (54) is driven to rotate through a second motor (51) and a second screw rod (52) so as to push the moving plate (4) to move up and down.

7. A communication device according to claim 1, wherein: the lateral wall arch of play appearance abutment (41) is provided with spacing portion (411), movable plate (4) are fixed with mounting panel (45), communicating mounting hole (46) have been seted up to movable plate (4) and mounting panel (45) corresponding position, play appearance abutment (41) pass mounting hole (46) and extend movable plate (4), are located movable plate (4) and mounting panel (45) junction the week side wall of mounting hole (46) is provided with spacing groove (461), spacing portion (411) are located spacing groove (461).

8. A communication device according to claim 7, wherein: gaps are reserved between the sample outlet butt joint (41) and the mounting hole (46) and between the limiting part (411) and the limiting groove (461).

9. A communication device according to claim 2, wherein: the containing groove (22) is provided with a plurality of containing grooves (22) which are arranged along the upper surface of the containing seat (2) at intervals, and the upper surfaces of the containing seats (2) at two sides of the containing groove (22) are provided with downward-sunken sheet taking grooves (23).

10. A communication device according to claim 9, wherein: the upper surface of the frame (1) is provided with an observation opening (121) corresponding to the containing groove (22).

11. A communication device according to any of claims 1-10, wherein: the part to be communicated is a micro-fluidic chip (21).

12. A communication device according to claim 9, wherein: the liquid collecting device is characterized in that a waste liquid collecting hopper (6) is arranged at the bottom of the movable plate (4), a communicating hole (48) is formed in the movable plate (4) corresponding to a liquid outlet hole of the microfluidic chip (21), the communicating hole (48) is communicated with the waste liquid collecting hopper (6), a liquid collecting hole (49) is formed in the movable plate (4), the liquid collecting hole (49) is communicated with the waste liquid collecting hopper (6), and the edge of the upper surface of the movable plate (4) is gradually inclined downwards towards the liquid collecting hole (49).

13. A communication device according to claim 12, wherein: waste liquid collecting hopper (6) intercommunication has waste liquid case (61), waste liquid case (61) have the waste liquid pump through the tube coupling, waste liquid case (61) are provided with level sensor (62), level sensor (62) pass through controller control waste liquid pump work.

14. A cell staining capture instrument, characterized in that: comprising a communication device according to any of claims 1-13 mounted on a housing (7) and a housing (7), the sample inlet end of the sample outlet docking head (41) being in communication with a syringe pump mechanism inside the housing (7) via a conduit.

15. A cell capture staining instrument as claimed in claim 14, wherein: an information identifier (8) used for identifying label information on the piece to be communicated is arranged in the shell (7), and the information identifier (8) controls the work of the injection pump mechanism through a controller.

16. A cell capture staining instrument as claimed in claim 15, wherein: a driving component (9) for driving an information recognizer (8) to sequentially recognize information of a plurality of pieces to be communicated is arranged in the shell (7);

drive assembly (9) are including installing support (91), third motor (92), third lead screw (93) and mount pad (94), installing support (91) are fixed in casing (7), install in installing support (91) one side third motor (92), third lead screw (93) are rotated and are connected on installing support (91), the output shaft and the coaxial fixed connection of third lead screw (93) of third motor (92), mount pad (94) and third lead screw (93) threaded connection slide with installing support (91) through third linear guide (95) simultaneously and are connected, information identification ware (8) are installed on mount pad (94), information identification ware (8) are towards the label information of treating the communicating piece, label information is located viewing aperture (121) department.

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